DLBCL_genes.md
... ...
@@ -11,59 +11,59 @@ link-citations: true
11 11
12 12
## Tier 1 DLBCL genes
13 13
14
-### *126 total*
14
+### *125 total*
15 15
16 16
|Gene|Tier| First DLBCL evidence | Other entities |
17 17
|:-:|:-:|:--|:-|
18 18
|[ACTB](ACTB)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@wienandGenomicAnalysesFlowsorted2019b]|
19 19
|[ACTG1](ACTG1)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@deschGenotypingCirculatingTumor2020; @spinaGeneticsNodalMarginal2016b]|
20
-|[ARID1A](ARID1A)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c; @wienandGenomicAnalysesFlowsorted2019b; @loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b]|
20
+|[ARID1A](ARID1A)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@loveGeneticLandscapeMutations2012; @wienandGenomicAnalysesFlowsorted2019b; @krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c]|
21 21
|[ATM](ATM)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@beaLandscapeSomaticMutations2013; @braggioGenomicAnalysisMarginal2012]|
22 22
|[B2M](B2M)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]|
23
-|[BCL10](BCL10)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b; @spinaGeneticsNodalMarginal2016b]|
23
+|[BCL10](BCL10)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@spinaGeneticsNodalMarginal2016b; @russler-germainMutationsAssociatedProgression2023b]|
24 24
|[BCL2](BCL2)|1|[Tanaka et al](papers/tanakaFrequentIncidenceSomatic1992)[@tanakaFrequentIncidenceSomatic1992]|[@sarkozyMutationalLandscapeGray2021a; @burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011]|
25 25
|[BCL6](BCL6)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|
26
-|[BCL7A](BCL7A)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019]|
26
+|[BCL7A](BCL7A)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @reichelFlowSortingExome2015a]|
27 27
|[BIRC6](BIRC6)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@sarkozyMutationalLandscapeGray2021a]|
28 28
|[BRAF](BRAF)|1|[Tiacci et al](papers/tiacciBRAFMutationsHairycell2011a)[@tiacciBRAFMutationsHairycell2011a]|[@loveGeneticLandscapeMutations2012]|
29 29
|[BTG1](BTG1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@sarkozyMutationalLandscapeGray2021a; @burkhardtClinicalRelevanceMolecular2022b]|
30 30
|[BTG2](BTG2)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|
31 31
|[BTK](BTK)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@krysiakRecurrentSomaticMutations2017b]|
32
-|[CARD11](CARD11)|1|[Lenz et al](papers/lenzOncogenicCARD11Mutations2008)[@lenzOncogenicCARD11Mutations2008]|[@wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012a; @morinFrequentMutationHistonemodifying2011]|
33
-|[CCND3](CCND3)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@richterRecurrentMutationID32012a; @jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]|
32
+|[CARD11](CARD11)|1|[Lenz et al](papers/lenzOncogenicCARD11Mutations2008)[@lenzOncogenicCARD11Mutations2008]|[@yanBCRTLRSignaling2012a; @morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016]|
33
+|[CCND3](CCND3)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a; @deschGenotypingCirculatingTumor2020]|
34 34
|[CD58](CD58)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@schneiderAlterationsCD58Gene2015a]|
35 35
|[CD70](CD70)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b]|
36 36
|[CD79B](CD79B)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|
37
-|[CD83](CD83)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@dunsCharacterizationDLBCLPMBL2021b; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b]|
38
-|[CDKN2A](CDKN2A)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019; @spinaGeneticsNodalMarginal2016b]|
39
-|[CREBBP](CREBBP)|1|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013; @dunsCharacterizationDLBCLPMBL2021b]|
37
+|[CD83](CD83)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@russler-germainMutationsAssociatedProgression2023b; @paneaWholeGenomeLandscape2019; @dunsCharacterizationDLBCLPMBL2021b]|
38
+|[CDKN2A](CDKN2A)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@spinaGeneticsNodalMarginal2016b; @grandeGenomewideDiscoverySomatic2019]|
39
+|[CREBBP](CREBBP)|1|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@parryWholeExomeSequencing2013; @loveGeneticLandscapeMutations2012; @dunsCharacterizationDLBCLPMBL2021b]|
40 40
|[CXCR4](CXCR4)|1|[Khodabakhshi et al](papers/khodabakhshiRecurrentTargetsAberrant2012)[@khodabakhshiRecurrentTargetsAberrant2012]|[@krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019]|
41 41
|[CXCR5](CXCR5)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@mottokIntegrativeGenomicAnalysis2019b]|
42
-|[DDX3X](DDX3X)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@schmitzBurkittLymphomaPathogenesis2012; @mottokIntegrativeGenomicAnalysis2019b]|
43
-|[DTX1](DTX1)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c; @gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012]|
42
+|[DDX3X](DDX3X)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@mottokIntegrativeGenomicAnalysis2019b; @schmitzBurkittLymphomaPathogenesis2012]|
43
+|[DTX1](DTX1)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@loveGeneticLandscapeMutations2012; @gomezUltraDeepSequencingReveals2023; @rossiCodingGenomeSplenic2012c]|
44 44
|[DUSP2](DUSP2)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@dunsCharacterizationDLBCLPMBL2021b]|
45
-|[EBF1](EBF1)|1|[Bohle et al](papers/bohleRoleEarlyBcell2013)[@bohleRoleEarlyBcell2013]|[@reichelFlowSortingExome2015a; @thomasGeneticSubgroupsInform2023]|
45
+|[EBF1](EBF1)|1|[Bohle et al](papers/bohleRoleEarlyBcell2013)[@bohleRoleEarlyBcell2013]|[@thomasGeneticSubgroupsInform2023; @reichelFlowSortingExome2015a]|
46 46
|[EEF1A1](EEF1A1)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@reichelFlowSortingExome2015a]|
47 47
|[EP300](EP300)|1|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@rossiCodingGenomeSplenic2012c]|
48 48
|[ETS1](ETS1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|
49 49
|[ETV6](ETV6)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
50 50
|[EZH2](EZH2)|1|[Morin et al](papers/morinSomaticMutationsAltering2010a)[@morinSomaticMutationsAltering2010a]|[@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]|
51 51
|[FAS](FAS)|1|[Scholl et al](papers/schollMutationsRegionFAS2007)[@schollMutationsRegionFAS2007]|[@spinaGeneticsNodalMarginal2016b]|
52
-|[FBXO11](FBXO11)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@richterRecurrentMutationID32012a; @parryWholeExomeSequencing2013]|
52
+|[FBXO11](FBXO11)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@parryWholeExomeSequencing2013; @richterRecurrentMutationID32012a]|
53 53
|[FBXW7](FBXW7)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
54 54
|[FOXO1](FOXO1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]|
55 55
|[GNA13](GNA13)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012; @reichelFlowSortingExome2015a]|
56 56
|[GNAI2](GNAI2)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019]|
57 57
|[GRB2](GRB2)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]||
58 58
|[GRHPR](GRHPR)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||
59
-|[HIST1H1B](HIST1H1B)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@krysiakRecurrentSomaticMutations2017b; @sarkozyMutationalLandscapeGray2021a]|
59
+|[HIST1H1B](HIST1H1B)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@sarkozyMutationalLandscapeGray2021a; @krysiakRecurrentSomaticMutations2017b]|
60 60
|[HIST1H1C](HIST1H1C)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|
61 61
|[HIST1H1D](HIST1H1D)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b; @jalladesExomeSequencingIdentifies2017]|
62
-|[HIST1H1E](HIST1H1E)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @reichelFlowSortingExome2015a]|
62
+|[HIST1H1E](HIST1H1E)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b]|
63 63
|[HIST1H2AC](HIST1H2AC)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b]|
64 64
|[HIST1H2AM](HIST1H2AM)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019]|
65
-|[HIST1H2BC](HIST1H2BC)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@mottokIntegrativeGenomicAnalysis2019b; @krysiakRecurrentSomaticMutations2017b]|
66
-|[HIST1H2BK](HIST1H2BK)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]|
65
+|[HIST1H2BC](HIST1H2BC)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b; @mottokIntegrativeGenomicAnalysis2019b]|
66
+|[HIST1H2BK](HIST1H2BK)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]|
67 67
|[HIST1H3B](HIST1H3B)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@reichelFlowSortingExome2015a]|
68 68
|[HIST2H2BE](HIST2H2BE)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]||
69 69
|[HLA-A](HLA-A)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@deschGenotypingCirculatingTumor2020]|
... ...
@@ -81,8 +81,8 @@ link-citations: true
81 81
|[KLF2](KLF2)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]|
82 82
|[KLHL14](KLHL14)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
83 83
|[KLHL6](KLHL6)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@ganapathiGeneticLandscapeDural2016]|
84
-|[KMT2C](KMT2C)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019; @sarkozyMutationalLandscapeGray2021a]|
85
-|[KMT2D](KMT2D)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013; @grandeGenomewideDiscoverySomatic2019; @deschGenotypingCirculatingTumor2020; @rossiCodingGenomeSplenic2012c]|
84
+|[KMT2C](KMT2C)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a; @zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019]|
85
+|[KMT2D](KMT2D)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c; @deschGenotypingCirculatingTumor2020]|
86 86
|[KRAS](KRAS)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
87 87
|[LCOR](LCOR)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||
88 88
|[LRRN3](LRRN3)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a]|
... ...
@@ -93,17 +93,17 @@ link-citations: true
93 93
|[MPEG1](MPEG1)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||
94 94
|[MS4A1](MS4A1)|1|[Rushton et al](papers/rushtonGeneticEvolutionaryPatterns2020)[@rushtonGeneticEvolutionaryPatterns2020]|[@mottokIntegrativeGenomicAnalysis2019b]|
95 95
|[MTOR](MTOR)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019]|
96
-|[MYC](MYC)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@jalladesExomeSequencingIdentifies2017; @dunsCharacterizationDLBCLPMBL2021b; @johnstonCmycHypermutationBurkitt1992]|
96
+|[MYC](MYC)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@dunsCharacterizationDLBCLPMBL2021b; @jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992]|
97 97
|[MYD88](MYD88)|1|[Ngo et al](papers/ngoOncogenicallyActiveMYD882011a)[@ngoOncogenicallyActiveMYD882011a]|[@yanBCRTLRSignaling2012a]|
98 98
|[NFKBIA](NFKBIA)|1|[Lake et al](papers/lakeMutationsNFKBIAEncoding2009)[@lakeMutationsNFKBIAEncoding2009]|[@russler-germainMutationsAssociatedProgression2023b; @wienandGenomicAnalysesFlowsorted2019b]|
99
-|[NFKBIE](NFKBIE)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]|[@pararajalingamCodingNoncodingDrivers2020; @mansouriFrequentNFKBIEDeletions2016]|
99
+|[NFKBIE](NFKBIE)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]|[@mansouriFrequentNFKBIEDeletions2016; @pararajalingamCodingNoncodingDrivers2020]|
100 100
|[NFKBIZ](NFKBIZ)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]||
101 101
|[NOL9](NOL9)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@spinaGeneticsNodalMarginal2016b]|
102 102
|[NOTCH1](NOTCH1)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@loveGeneticLandscapeMutations2012; @beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]|
103
-|[NOTCH2](NOTCH2)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]|
103
+|[NOTCH2](NOTCH2)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013]|
104 104
|[OSBPL10](OSBPL10)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
105 105
|[P2RY8](P2RY8)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@muppidiLossSignalingGa132014b]|
106
-|[PIM1](PIM1)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@dunsCharacterizationDLBCLPMBL2021b; @burkhardtClinicalRelevanceMolecular2022b]|
106
+|[PIM1](PIM1)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@burkhardtClinicalRelevanceMolecular2022b; @dunsCharacterizationDLBCLPMBL2021b]|
107 107
|[PIM2](PIM2)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|[@reichelFlowSortingExome2015a]|
108 108
|[POU2AF1](POU2AF1)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@krysiakRecurrentSomaticMutations2017b]|
109 109
|[POU2F2](POU2F2)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b]|
... ...
@@ -119,9 +119,9 @@ link-citations: true
119 119
|[SF3B1](SF3B1)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@loveGeneticLandscapeMutations2012]|
120 120
|[SGK1](SGK1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b]|
121 121
|[SIN3A](SIN3A)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@rossiCodingGenomeSplenic2012c; @grandeGenomewideDiscoverySomatic2019]|
122
-|[SMARCA4](SMARCA4)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b; @richterRecurrentMutationID32012a]|
122
+|[SMARCA4](SMARCA4)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@richterRecurrentMutationID32012a; @krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b]|
123 123
|[SOCS1](SOCS1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@wenigerMutationsTumorSuppressor2006a]|
124
-|[SPEN](SPEN)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@sarkozyMutationalLandscapeGray2021a; @rossiCodingGenomeSplenic2012c]|
124
+|[SPEN](SPEN)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@rossiCodingGenomeSplenic2012c; @sarkozyMutationalLandscapeGray2021a]|
125 125
|[STAT3](STAT3)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
126 126
|[STAT6](STAT6)|1|[Yildiz et al](papers/yildizActivatingSTAT6Mutations2015c)[@yildizActivatingSTAT6Mutations2015c]|[@ritzRecurrentMutationsSTAT62009a]|
127 127
|[TAF1](TAF1)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@spinaGeneticsNodalMarginal2016b]|
... ...
@@ -129,11 +129,10 @@ link-citations: true
129 129
|[TET2](TET2)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@thomasGeneticSubgroupsInform2023]|
130 130
|[TMEM30A](TMEM30A)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]||
131 131
|[TMSB4X](TMSB4X)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]||
132
-|[TNFAIP3](TNFAIP3)|1|[Compagno et al](papers/compagnoMutationsMultipleGenes2009a)[@compagnoMutationsMultipleGenes2009a]|[@rossiAlterationBIRC3Multiple2011a; @schmitzTNFAIP3A20Tumor2009a]|
132
+|[TNFAIP3](TNFAIP3)|1|[Compagno et al](papers/compagnoMutationsMultipleGenes2009a)[@compagnoMutationsMultipleGenes2009a]|[@schmitzTNFAIP3A20Tumor2009a; @rossiAlterationBIRC3Multiple2011a]|
133 133
|[TNFRSF14](TNFRSF14)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@cheungAcquiredTNFRSF14Mutations2010a; @spinaGeneticsNodalMarginal2016b]|
134 134
|[TOX](TOX)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
135
-|[TP53](TP53)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@wildaInactivationARFMDM2p53Pathway2004; @rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b; @morinFrequentMutationHistonemodifying2011; @beaLandscapeSomaticMutations2013]|
136
-|[TRRAP](TRRAP)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c]|
135
+|[TP53](TP53)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @tiacciPervasiveMutationsJAKSTAT2018b; @wildaInactivationARFMDM2p53Pathway2004; @rossiCodingGenomeSplenic2012c]|
137 136
|[UBE2A](UBE2A)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@reichelFlowSortingExome2015a]|
138 137
|[WEE1](WEE1)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@reichelFlowSortingExome2015a]|
139 138
|[XPO1](XPO1)|1|[Mareschal et al](papers/mareschalWholeExomeSequencing2016)[@mareschalWholeExomeSequencing2016]|[@jardinRecurrentMutationsExportin2016a]|
... ...
@@ -157,9 +156,9 @@ link-citations: true
157 156
|[ASXL3](ASXL3)|2|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]||
158 157
|[ATR](ATR)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
159 158
|[BCL11A](BCL11A)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||
160
-|[BCOR](BCOR)|2||[@nadeuGenomicEpigenomicInsights2020b; @jalladesExomeSequencingIdentifies2017]|
159
+|[BCOR](BCOR)|2||[@jalladesExomeSequencingIdentifies2017; @nadeuGenomicEpigenomicInsights2020b]|
161 160
|[BCR](BCR)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
162
-|[BIRC3](BIRC3)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|[@dunsCharacterizationDLBCLPMBL2021b; @rossiAlterationBIRC3Multiple2011a; @beaLandscapeSomaticMutations2013]|
161
+|[BIRC3](BIRC3)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|[@beaLandscapeSomaticMutations2013; @dunsCharacterizationDLBCLPMBL2021b; @rossiAlterationBIRC3Multiple2011a]|
163 162
|[BLK](BLK)|2|||
164 163
|[BRINP3](BRINP3)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
165 164
|[BTBD3](BTBD3)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
... ...
@@ -192,7 +191,7 @@ link-citations: true
192 191
|[FAM102A](FAM102A)|2|||
193 192
|[FANK1](FANK1)|2|||
194 193
|[FAT2](FAT2)|2|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]||
195
-|[FAT4](FAT4)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@zhangGenomicLandscapeMantle2014; @parryWholeExomeSequencing2013]|
194
+|[FAT4](FAT4)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@parryWholeExomeSequencing2013; @zhangGenomicLandscapeMantle2014]|
196 195
|[FCRL3](FCRL3)|2|||
197 196
|[FNBP1](FNBP1)|2|||
198 197
|[FOXC1](FOXC1)|2|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]||
... ...
@@ -205,7 +204,7 @@ link-citations: true
205 204
|[GSG2](GSG2)|2|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]||
206 205
|[H1FOO](H1FOO)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
207 206
|[HDAC7](HDAC7)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||
208
-|[HIST1H2AG](HIST1H2AG)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]|
207
+|[HIST1H2AG](HIST1H2AG)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c; @krysiakRecurrentSomaticMutations2017b]|
209 208
|[HIST1H2AL](HIST1H2AL)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
210 209
|[HIST1H2BO](HIST1H2BO)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
211 210
|[HLA-DMA](HLA-DMA)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||
... ...
@@ -215,7 +214,7 @@ link-citations: true
215 214
|[ID3](ID3)|2|[Schmitz et al](papers/schmitzBurkittLymphomaPathogenesis2012)[@schmitzBurkittLymphomaPathogenesis2012]|[@richterRecurrentMutationID32012a; @spinaGeneticsNodalMarginal2016b]|
216 215
|[IFNGR1](IFNGR1)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||
217 216
|[IGLL5](IGLL5)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@deschGenotypingCirculatingTumor2020; @russler-germainMutationsAssociatedProgression2023b; @paneaWholeGenomeLandscape2019]|
218
-|[IKBKB](IKBKB)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@wienandGenomicAnalysesFlowsorted2019b; @rossiAlterationBIRC3Multiple2011a]|
217
+|[IKBKB](IKBKB)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@rossiAlterationBIRC3Multiple2011a; @wienandGenomicAnalysesFlowsorted2019b]|
219 218
|[IKBKE](IKBKE)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]||
220 219
|[IL16](IL16)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
221 220
|[IL6](IL6)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||
... ...
@@ -246,7 +245,7 @@ link-citations: true
246 245
|[MYOM2](MYOM2)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]||
247 246
|[NAV1](NAV1)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||
248 247
|[NCOA3](NCOA3)|2|||
249
-|[NCOR2](NCOR2)|2||[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b; @sarkozyMutationalLandscapeGray2021a]|
248
+|[NCOR2](NCOR2)|2||[@spinaGeneticsNodalMarginal2016b; @sarkozyMutationalLandscapeGray2021a; @schmitzBurkittLymphomaPathogenesis2012]|
250 249
|[NEAT1](NEAT1)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||
251 250
|[NF1](NF1)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
252 251
|[NFKB1](NFKB1)|2|||
... ...
@@ -309,7 +308,7 @@ link-citations: true
309 308
|[TLR2](TLR2)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@beaLandscapeSomaticMutations2013]|
310 309
|[TMSL3](TMSL3)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
311 310
|[TNF](TNF)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
312
-|[TRAF3](TRAF3)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@rossiAlterationBIRC3Multiple2011a; @ottoGeneticLesionsTRAF32012a]|
311
+|[TRAF3](TRAF3)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@ottoGeneticLesionsTRAF32012a; @rossiAlterationBIRC3Multiple2011a]|
313 312
|[TRAF6](TRAF6)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]||
314 313
|[TRIP12](TRIP12)|2|||
315 314
|[UBE2J1](UBE2J1)|2|||
... ...
@@ -320,7 +319,7 @@ link-citations: true
320 319
|[UNC5D](UNC5D)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
321 320
|[USP7](USP7)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|[@grandeGenomewideDiscoverySomatic2019]|
322 321
|[WDFY3](WDFY3)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||
323
-|[WNK1](WNK1)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@jalladesExomeSequencingIdentifies2017; @thomasGeneticSubgroupsInform2023]|
322
+|[WNK1](WNK1)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@thomasGeneticSubgroupsInform2023; @jalladesExomeSequencingIdentifies2017]|
324 323
|[XBP1](XBP1)|2|||
325 324
|[YY1](YY1)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
326 325
|[ZCCHC7](ZCCHC7)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||
... ...
@@ -331,7 +330,7 @@ link-citations: true
331 330
332 331
## Tier 3 DLBCL genes
333 332
334
-### *385 total*
333
+### *386 total*
335 334
336 335
|Gene|Tier| First DLBCL evidence | Other entities |
337 336
|:-:|:-:|:--|:-|
... ...
@@ -689,6 +688,7 @@ link-citations: true
689 688
|[TPRKB](TPRKB)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
690 689
|[TRIM37](TRIM37)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
691 690
|[TRIP11](TRIP11)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@reichelFlowSortingExome2015a]|
691
+|[TRRAP](TRRAP)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c]|
692 692
|[TSC2](TSC2)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
693 693
|[TSHZ2](TSHZ2)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
694 694
|[TYRO3](TYRO3)|3|[Fan et al](papers/fanComprehensiveCharacterizationDriver2020b)[@fanComprehensiveCharacterizationDriver2020b]||
TRRAP.md
... ...
@@ -20,7 +20,7 @@ timeline
20 20
|Entity|Tier|Description |
21 21
|:------:|:----:|--------------------------|
22 22
|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@rossiCodingGenomeSplenic2012c]|
23
-|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene[@zhangGeneticHeterogeneityDiffuse2013]|
23
+|![DLBCL](images/icons/DLBCL_tier1.png) |3 |Retired for DLBCL[@zhangGeneticHeterogeneityDiffuse2013]|
24 24
25 25
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
26 26