Changes in 09e88bb: add header

				BL_genes.md
			
          @@ -13,43 +13,43 @@ link-citations: true

           ### *29 total*

          -|Gene|Tier| Earliest reference | Other references|

          +|Gene|Tier| First BL evidence | Other entities |

           |:-:|:-:|:-|:-|

          -|[ARID1A](ARID1A)|1|[@loveGeneticLandscapeMutations2012]|[@wienandGenomicAnalysesFlowsorted2019b; @krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013]|

          -|[BCL7A](BCL7A)|1, aSHM|[@grandeGenomewideDiscoverySomatic2019]|[@reichelFlowSortingExome2015a; @krysiakRecurrentSomaticMutations2017b; @arthurGenomewideDiscoverySomatic2018]|

          +|[ARID1A](ARID1A)|1|[@loveGeneticLandscapeMutations2012]|[@krysiakRecurrentSomaticMutations2017b; @zhangGeneticHeterogeneityDiffuse2013; @rossiCodingGenomeSplenic2012c; @wienandGenomicAnalysesFlowsorted2019b]|

          +|[BCL7A](BCL7A)|1, aSHM|[@grandeGenomewideDiscoverySomatic2019]|[@arthurGenomewideDiscoverySomatic2018; @reichelFlowSortingExome2015a; @krysiakRecurrentSomaticMutations2017b]|

           |[BMP7](BMP7)|1|[@paneaWholeGenomeLandscape2019]||

          -|[CCND3](CCND3)|1|[@richterRecurrentMutationID32012a]|[@deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011; @jalladesExomeSequencingIdentifies2017]|

          +|[CCND3](CCND3)|1|[@richterRecurrentMutationID32012a]|[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @morinFrequentMutationHistonemodifying2011]|

           |[CHD8](CHD8)|1|[@grandeGenomewideDiscoverySomatic2019]|[@reddyGeneticFunctionalDrivers2017]|

          -|[DDX3X](DDX3X)|1|[@schmitzBurkittLymphomaPathogenesis2012]|[@schmitzGeneticsPathogenesisDiffuse2018a; @mottokIntegrativeGenomicAnalysis2019b]|

          +|[DDX3X](DDX3X)|1|[@schmitzBurkittLymphomaPathogenesis2012]|[@mottokIntegrativeGenomicAnalysis2019b; @schmitzGeneticsPathogenesisDiffuse2018a]|

           |[EIF4A1](EIF4A1)|1|[@paneaWholeGenomeLandscape2019]||

           |[EPPK1](EPPK1)|1|[@paneaWholeGenomeLandscape2019]||

          -|[FBXO11](FBXO11)|1|[@richterRecurrentMutationID32012a]|[@parryWholeExomeSequencing2013; @hubschmannMutationalMechanismsShaping2021b]|

          -|[FOXO1](FOXO1)|1|[@schmitzBurkittLymphomaPathogenesis2012]|[@dunsCharacterizationDLBCLPMBL2021b; @morinFrequentMutationHistonemodifying2011]|

          -|[GNA13](GNA13)|1|[@loveGeneticLandscapeMutations2012]|[@morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015a]|

          +|[FBXO11](FBXO11)|1|[@richterRecurrentMutationID32012a]|[@hubschmannMutationalMechanismsShaping2021b; @parryWholeExomeSequencing2013]|

          +|[FOXO1](FOXO1)|1|[@schmitzBurkittLymphomaPathogenesis2012]|[@morinFrequentMutationHistonemodifying2011; @dunsCharacterizationDLBCLPMBL2021b]|

          +|[GNA13](GNA13)|1|[@loveGeneticLandscapeMutations2012]|[@reichelFlowSortingExome2015a; @morinFrequentMutationHistonemodifying2011]|

           |[GNAI2](GNAI2)|1|[@grandeGenomewideDiscoverySomatic2019]|[@morinMutationalStructuralAnalysis2013]|

           |[HNRNPU](HNRNPU)|1, aSHM|[@paneaWholeGenomeLandscape2019]|[@reddyGeneticFunctionalDrivers2017]|

          -|[ID3](ID3)|1|[@richterRecurrentMutationID32012a]|[@spinaGeneticsNodalMarginal2016b; @schmitzBurkittLymphomaPathogenesis2012]|

          -|[KMT2D](KMT2D)|1|[@grandeGenomewideDiscoverySomatic2019]|[@rossiCodingGenomeSplenic2012c; @morinFrequentMutationHistonemodifying2011; @beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020]|

          -|[MYC](MYC)|1, aSHM|[@johnstonCmycHypermutationBurkitt1992]|[@jalladesExomeSequencingIdentifies2017; @pasqualucciHypermutationMultipleProtooncogenes2001a; @dunsCharacterizationDLBCLPMBL2021b]|

          +|[ID3](ID3)|1|[@richterRecurrentMutationID32012a]|[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b]|

          +|[KMT2D](KMT2D)|1|[@grandeGenomewideDiscoverySomatic2019]|[@rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011]|

          +|[MYC](MYC)|1, aSHM|[@johnstonCmycHypermutationBurkitt1992]|[@jalladesExomeSequencingIdentifies2017; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]|

           |[P2RY8](P2RY8)|1|[@muppidiLossSignalingGa132014b]|[@lohrDiscoveryPrioritizationSomatic2012a]|

           |[PHF6](PHF6)|1|[@thomasGeneticSubgroupsInform2023]|[@reddyGeneticFunctionalDrivers2017]|

           |[PTEN](PTEN)|1|[@loveGeneticLandscapeMutations2012]||

           |[RFX7](RFX7)|1|[@grandeGenomewideDiscoverySomatic2019]||

           |[RHOA](RHOA)|1|[@richterRecurrentMutationID32012a]||

           |[SIN3A](SIN3A)|1|[@grandeGenomewideDiscoverySomatic2019]|[@rossiCodingGenomeSplenic2012c]|

          -|[SMARCA4](SMARCA4)|1|[@richterRecurrentMutationID32012a]|[@nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b; @zhangGeneticHeterogeneityDiffuse2013]|

          +|[SMARCA4](SMARCA4)|1|[@richterRecurrentMutationID32012a]|[@zhangGeneticHeterogeneityDiffuse2013; @krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b]|

           |[TCF3](TCF3)|1|[@schmitzBurkittLymphomaPathogenesis2012]||

           |[TCL1A](TCL1A)|1, aSHM|[@grandeGenomewideDiscoverySomatic2019]||

           |[TFAP4](TFAP4)|1|[@grandeGenomewideDiscoverySomatic2019]||

          -|[TP53](TP53)|1|[@wildaInactivationARFMDM2p53Pathway2004]|[@tiacciPervasiveMutationsJAKSTAT2018b; @beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012c]|

          +|[TP53](TP53)|1|[@wildaInactivationARFMDM2p53Pathway2004]|[@morinFrequentMutationHistonemodifying2011; @beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b]|

           |[USP7](USP7)|1|[@grandeGenomewideDiscoverySomatic2019]||

          -|[WNK1](WNK1)|1|[@thomasGeneticSubgroupsInform2023]|[@hubschmannMutationalMechanismsShaping2021b; @jalladesExomeSequencingIdentifies2017]|

          +|[WNK1](WNK1)|1|[@thomasGeneticSubgroupsInform2023]|[@jalladesExomeSequencingIdentifies2017; @hubschmannMutationalMechanismsShaping2021b]|

           ## Tier 2 BL genes

           ### *157 total*

          -|Gene|Tier| Earliest reference | Other references|

          +|Gene|Tier| First BL evidence | Other entities |

           |:-:|:-:|:-|:-|

           |[ACAD9](ACAD9)|2|[@loveGeneticLandscapeMutations2012]||

           |[ACE](ACE)|2|[@loveGeneticLandscapeMutations2012]||

          @@ -69,13 +69,13 @@ link-citations: true

           |[C16orf48](C16orf48)|2|[@schmitzBurkittLymphomaPathogenesis2012]||

           |[C6orf27](C6orf27)|2|[@loveGeneticLandscapeMutations2012]||

           |[CAD](CAD)|2|[@loveGeneticLandscapeMutations2012]||

          -|[CARD11](CARD11)|2|[@paneaWholeGenomeLandscape2019]|[@lenzOncogenicCARD11Mutations2008; @yanBCRTLRSignaling2012a; @morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016]|

          +|[CARD11](CARD11)|2|[@paneaWholeGenomeLandscape2019]|[@lenzOncogenicCARD11Mutations2008; @wuGeneticHeterogeneityPrimary2016; @morinFrequentMutationHistonemodifying2011; @yanBCRTLRSignaling2012a]|

           |[CARD4](CARD4)|2|[@loveGeneticLandscapeMutations2012]||

           |[CCNF](CCNF)|2|[@abateDistinctViralMutational2015a]||

           |[CCT6B](CCT6B)|2|[@loveGeneticLandscapeMutations2012]||

           |[CD79A](CD79A)|2|[@burkhardtClinicalRelevanceMolecular2022b]|[@rossiCodingGenomeSplenic2012c]|

           |[CD79B](CD79B)|2|[@paneaWholeGenomeLandscape2019]|[@morinFrequentMutationHistonemodifying2011]|

          -|[CD83](CD83)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@morinMutationalStructuralAnalysis2013; @dunsCharacterizationDLBCLPMBL2021b; @russler-germainMutationsAssociatedProgression2023b]|

          +|[CD83](CD83)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@dunsCharacterizationDLBCLPMBL2021b; @morinMutationalStructuralAnalysis2013; @russler-germainMutationsAssociatedProgression2023b]|

           |[CDC73](CDC73)|2|[@loveGeneticLandscapeMutations2012]|[@reddyGeneticFunctionalDrivers2017]|

           |[CDH17](CDH17)|2|[@loveGeneticLandscapeMutations2012]||

           |[CDKN2A](CDKN2A)|2|[@grandeGenomewideDiscoverySomatic2019]|[@morinMutationalStructuralAnalysis2013; @spinaGeneticsNodalMarginal2016b]|

          @@ -85,13 +85,13 @@ link-citations: true

           |[CPXM2](CPXM2)|2|[@burkhardtClinicalRelevanceMolecular2022b]||

           |[CREBBP](CREBBP)|2|[@loveGeneticLandscapeMutations2012]|[@parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011a; @dunsCharacterizationDLBCLPMBL2021b]|

           |[CTCF](CTCF)|2|[@paneaWholeGenomeLandscape2019]||

          -|[CXCR4](CXCR4)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@khodabakhshiRecurrentTargetsAberrant2012; @krysiakRecurrentSomaticMutations2017b]|

          +|[CXCR4](CXCR4)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@krysiakRecurrentSomaticMutations2017b; @khodabakhshiRecurrentTargetsAberrant2012]|

           |[CYB5D1](CYB5D1)|2|[@loveGeneticLandscapeMutations2012]||

           |[CYP4F22](CYP4F22)|2|[@loveGeneticLandscapeMutations2012]||

           |[DHCR7](DHCR7)|2|[@schmitzBurkittLymphomaPathogenesis2012]||

           |[DLGAP1](DLGAP1)|2|[@loveGeneticLandscapeMutations2012]||

           |[DNMT1](DNMT1)|2|[@paneaWholeGenomeLandscape2019]||

          -|[DTX1](DTX1)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@gomezUltraDeepSequencingReveals2023; @schmitzGeneticsPathogenesisDiffuse2018a; @rossiCodingGenomeSplenic2012c]|

          +|[DTX1](DTX1)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@rossiCodingGenomeSplenic2012c; @schmitzGeneticsPathogenesisDiffuse2018a; @gomezUltraDeepSequencingReveals2023]|

           |[E2F2](E2F2)|2|[@burkhardtClinicalRelevanceMolecular2022b]||

           |[EBF1](EBF1)|2, aSHM|[@thomasGeneticSubgroupsInform2023]|[@reichelFlowSortingExome2015a; @bohleRoleEarlyBcell2013]|

           |[EDNRB](EDNRB)|2|[@burkhardtClinicalRelevanceMolecular2022b]||

          @@ -100,12 +100,12 @@ link-citations: true

           |[ELP2](ELP2)|2|[@schmitzBurkittLymphomaPathogenesis2012]||

           |[EML2](EML2)|2|[@loveGeneticLandscapeMutations2012]||

           |[ENTPD3](ENTPD3)|2|[@loveGeneticLandscapeMutations2012]||

          -|[EP300](EP300)|2|[@paneaWholeGenomeLandscape2019]|[@pasqualucciInactivatingMutationsAcetyltransferase2011a; @rossiCodingGenomeSplenic2012c]|

          +|[EP300](EP300)|2|[@paneaWholeGenomeLandscape2019]|[@rossiCodingGenomeSplenic2012c; @pasqualucciInactivatingMutationsAcetyltransferase2011a]|

           |[EPHB2](EPHB2)|2|[@loveGeneticLandscapeMutations2012]||

           |[ERAP1](ERAP1)|2|[@burkhardtClinicalRelevanceMolecular2022b]||

           |[ETS1](ETS1)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@morinFrequentMutationHistonemodifying2011]|

           |[EXOSC6](EXOSC6)|2|[@schmitzBurkittLymphomaPathogenesis2012]||

          -|[EZH2](EZH2)|2|[@loveGeneticLandscapeMutations2012]|[@morinSomaticMutationsAltering2010a; @mottokIntegrativeGenomicAnalysis2019b]|

          +|[EZH2](EZH2)|2|[@loveGeneticLandscapeMutations2012]|[@mottokIntegrativeGenomicAnalysis2019b; @morinSomaticMutationsAltering2010a]|

           |[FAM129B](FAM129B)|2|[@loveGeneticLandscapeMutations2012]||

           |[FGFR3](FGFR3)|2|[@loveGeneticLandscapeMutations2012]||

           |[FLYWCH1](FLYWCH1)|2|[@schmitzBurkittLymphomaPathogenesis2012]||

          @@ -116,8 +116,8 @@ link-citations: true

           |[GRIK5](GRIK5)|2|[@loveGeneticLandscapeMutations2012]||

           |[GTSE1](GTSE1)|2|[@schmitzBurkittLymphomaPathogenesis2012]||

           |[HIST1H1C](HIST1H1C)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@morinFrequentMutationHistonemodifying2011]|

          -|[HIST1H1E](HIST1H1E)|2, aSHM|[@grandeGenomewideDiscoverySomatic2019]|[@krysiakRecurrentSomaticMutations2017b; @morinMutationalStructuralAnalysis2013; @reichelFlowSortingExome2015a]|

          -|[HIST1H2AG](HIST1H2AG)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c; @morinMutationalStructuralAnalysis2013]|

          +|[HIST1H1E](HIST1H1E)|2, aSHM|[@grandeGenomewideDiscoverySomatic2019]|[@morinMutationalStructuralAnalysis2013; @krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]|

          +|[HIST1H2AG](HIST1H2AG)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@rossiCodingGenomeSplenic2012c; @morinMutationalStructuralAnalysis2013; @krysiakRecurrentSomaticMutations2017b]|

           |[HIST1H2AM](HIST1H2AM)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@krysiakRecurrentSomaticMutations2017b]|

           |[HIST1H2BK](HIST1H2BK)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@rossiCodingGenomeSplenic2012c]|

           |[HIST1H3D](HIST1H3D)|2, aSHM|[@paneaWholeGenomeLandscape2019]||

          @@ -139,7 +139,7 @@ link-citations: true

           |[KIFC3](KIFC3)|2|[@loveGeneticLandscapeMutations2012]||

           |[KLHL26](KLHL26)|2|[@burkhardtClinicalRelevanceMolecular2022b]||

           |[KLHL6](KLHL6)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@ganapathiGeneticLandscapeDural2016; @morinFrequentMutationHistonemodifying2011]|

          -|[KMT2C](KMT2C)|2|[@zhouSporadicEndemicBurkitt2019]|[@zhangGeneticHeterogeneityDiffuse2013; @zhangGenomicLandscapeMantle2014; @sarkozyMutationalLandscapeGray2021a]|

          +|[KMT2C](KMT2C)|2|[@zhouSporadicEndemicBurkitt2019]|[@zhangGenomicLandscapeMantle2014; @zhangGeneticHeterogeneityDiffuse2013; @sarkozyMutationalLandscapeGray2021a]|

           |[LTB](LTB)|2, aSHM|[@paneaWholeGenomeLandscape2019]|[@deschGenotypingCirculatingTumor2020; @chapuyMolecularSubtypesDiffuse2018b]|

           |[MAP3K6](MAP3K6)|2|[@loveGeneticLandscapeMutations2012]||

           |[MCL1](MCL1)|2|[@paneaWholeGenomeLandscape2019]|[@reddyGeneticFunctionalDrivers2017; @dunsCharacterizationDLBCLPMBL2021b]|

          @@ -150,9 +150,9 @@ link-citations: true

           |[MYH10](MYH10)|2|[@loveGeneticLandscapeMutations2012]||

           |[MYO18A](MYO18A)|2|[@schmitzBurkittLymphomaPathogenesis2012]||

           |[NBEAL1](NBEAL1)|2|[@loveGeneticLandscapeMutations2012]||

          -|[NCOR2](NCOR2)|2|[@schmitzBurkittLymphomaPathogenesis2012]|[@sarkozyMutationalLandscapeGray2021a; @spinaGeneticsNodalMarginal2016b]|

          +|[NCOR2](NCOR2)|2|[@schmitzBurkittLymphomaPathogenesis2012]|[@spinaGeneticsNodalMarginal2016b; @sarkozyMutationalLandscapeGray2021a]|

           |[NOA1](NOA1)|2|[@burkhardtClinicalRelevanceMolecular2022b]||

          -|[NOTCH1](NOTCH1)|2|[@loveGeneticLandscapeMutations2012]|[@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c; @pasqualucciAnalysisCodingGenome2011]|

          +|[NOTCH1](NOTCH1)|2|[@loveGeneticLandscapeMutations2012]|[@pasqualucciAnalysisCodingGenome2011; @beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]|

           |[NOTCH2](NOTCH2)|2|[@paneaWholeGenomeLandscape2019]|[@troenNOTCH2MutationsMarginal2008; @beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]|

           |[NRXN2](NRXN2)|2|[@loveGeneticLandscapeMutations2012]||

           |[P2RY2](P2RY2)|2|[@loveGeneticLandscapeMutations2012]||

          @@ -163,7 +163,7 @@ link-citations: true

           |[PDCD11](PDCD11)|2|[@schmitzBurkittLymphomaPathogenesis2012]||

           |[PDZRN3](PDZRN3)|2|[@paneaWholeGenomeLandscape2019]||

           |[PIK3R1](PIK3R1)|2|[@paneaWholeGenomeLandscape2019]|[@zhangGeneticHeterogeneityDiffuse2013]|

          -|[PIM1](PIM1)|2, aSHM|[@burkhardtClinicalRelevanceMolecular2022b]|[@dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]|

          +|[PIM1](PIM1)|2, aSHM|[@burkhardtClinicalRelevanceMolecular2022b]|[@pasqualucciHypermutationMultipleProtooncogenes2001a; @dunsCharacterizationDLBCLPMBL2021b]|

           |[PLCG2](PLCG2)|2|[@paneaWholeGenomeLandscape2019]||

           |[POLRMT](POLRMT)|2|[@loveGeneticLandscapeMutations2012]||

           |[POR](POR)|2|[@loveGeneticLandscapeMutations2012]||

...	...	@@ -13,43 +13,43 @@ link-citations: true
13	13
14	14	### 29 total
15	15
16		-\|Gene\|Tier\| Earliest reference \| Other references\|
	16	+\|Gene\|Tier\| First BL evidence \| Other entities \|
17	17	\|:-:\|:-:\|:-\|:-\|
18		-\|[ARID1A](ARID1A)\|1\|[@loveGeneticLandscapeMutations2012]\|[@wienandGenomicAnalysesFlowsorted2019b; @krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013]\|
19		-\|[BCL7A](BCL7A)\|1, aSHM\|[@grandeGenomewideDiscoverySomatic2019]\|[@reichelFlowSortingExome2015a; @krysiakRecurrentSomaticMutations2017b; @arthurGenomewideDiscoverySomatic2018]\|
	18	+\|[ARID1A](ARID1A)\|1\|[@loveGeneticLandscapeMutations2012]\|[@krysiakRecurrentSomaticMutations2017b; @zhangGeneticHeterogeneityDiffuse2013; @rossiCodingGenomeSplenic2012c; @wienandGenomicAnalysesFlowsorted2019b]\|
	19	+\|[BCL7A](BCL7A)\|1, aSHM\|[@grandeGenomewideDiscoverySomatic2019]\|[@arthurGenomewideDiscoverySomatic2018; @reichelFlowSortingExome2015a; @krysiakRecurrentSomaticMutations2017b]\|
20	20	\|[BMP7](BMP7)\|1\|[@paneaWholeGenomeLandscape2019]\|\|
21		-\|[CCND3](CCND3)\|1\|[@richterRecurrentMutationID32012a]\|[@deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011; @jalladesExomeSequencingIdentifies2017]\|
	21	+\|[CCND3](CCND3)\|1\|[@richterRecurrentMutationID32012a]\|[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @morinFrequentMutationHistonemodifying2011]\|
22	22	\|[CHD8](CHD8)\|1\|[@grandeGenomewideDiscoverySomatic2019]\|[@reddyGeneticFunctionalDrivers2017]\|
23		-\|[DDX3X](DDX3X)\|1\|[@schmitzBurkittLymphomaPathogenesis2012]\|[@schmitzGeneticsPathogenesisDiffuse2018a; @mottokIntegrativeGenomicAnalysis2019b]\|
	23	+\|[DDX3X](DDX3X)\|1\|[@schmitzBurkittLymphomaPathogenesis2012]\|[@mottokIntegrativeGenomicAnalysis2019b; @schmitzGeneticsPathogenesisDiffuse2018a]\|
24	24	\|[EIF4A1](EIF4A1)\|1\|[@paneaWholeGenomeLandscape2019]\|\|
25	25	\|[EPPK1](EPPK1)\|1\|[@paneaWholeGenomeLandscape2019]\|\|
26		-\|[FBXO11](FBXO11)\|1\|[@richterRecurrentMutationID32012a]\|[@parryWholeExomeSequencing2013; @hubschmannMutationalMechanismsShaping2021b]\|
27		-\|[FOXO1](FOXO1)\|1\|[@schmitzBurkittLymphomaPathogenesis2012]\|[@dunsCharacterizationDLBCLPMBL2021b; @morinFrequentMutationHistonemodifying2011]\|
28		-\|[GNA13](GNA13)\|1\|[@loveGeneticLandscapeMutations2012]\|[@morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015a]\|
	26	+\|[FBXO11](FBXO11)\|1\|[@richterRecurrentMutationID32012a]\|[@hubschmannMutationalMechanismsShaping2021b; @parryWholeExomeSequencing2013]\|
	27	+\|[FOXO1](FOXO1)\|1\|[@schmitzBurkittLymphomaPathogenesis2012]\|[@morinFrequentMutationHistonemodifying2011; @dunsCharacterizationDLBCLPMBL2021b]\|
	28	+\|[GNA13](GNA13)\|1\|[@loveGeneticLandscapeMutations2012]\|[@reichelFlowSortingExome2015a; @morinFrequentMutationHistonemodifying2011]\|
29	29	\|[GNAI2](GNAI2)\|1\|[@grandeGenomewideDiscoverySomatic2019]\|[@morinMutationalStructuralAnalysis2013]\|
30	30	\|[HNRNPU](HNRNPU)\|1, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@reddyGeneticFunctionalDrivers2017]\|
31		-\|[ID3](ID3)\|1\|[@richterRecurrentMutationID32012a]\|[@spinaGeneticsNodalMarginal2016b; @schmitzBurkittLymphomaPathogenesis2012]\|
32		-\|[KMT2D](KMT2D)\|1\|[@grandeGenomewideDiscoverySomatic2019]\|[@rossiCodingGenomeSplenic2012c; @morinFrequentMutationHistonemodifying2011; @beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020]\|
33		-\|[MYC](MYC)\|1, aSHM\|[@johnstonCmycHypermutationBurkitt1992]\|[@jalladesExomeSequencingIdentifies2017; @pasqualucciHypermutationMultipleProtooncogenes2001a; @dunsCharacterizationDLBCLPMBL2021b]\|
	31	+\|[ID3](ID3)\|1\|[@richterRecurrentMutationID32012a]\|[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b]\|
	32	+\|[KMT2D](KMT2D)\|1\|[@grandeGenomewideDiscoverySomatic2019]\|[@rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011]\|
	33	+\|[MYC](MYC)\|1, aSHM\|[@johnstonCmycHypermutationBurkitt1992]\|[@jalladesExomeSequencingIdentifies2017; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]\|
34	34	\|[P2RY8](P2RY8)\|1\|[@muppidiLossSignalingGa132014b]\|[@lohrDiscoveryPrioritizationSomatic2012a]\|
35	35	\|[PHF6](PHF6)\|1\|[@thomasGeneticSubgroupsInform2023]\|[@reddyGeneticFunctionalDrivers2017]\|
36	36	\|[PTEN](PTEN)\|1\|[@loveGeneticLandscapeMutations2012]\|\|
37	37	\|[RFX7](RFX7)\|1\|[@grandeGenomewideDiscoverySomatic2019]\|\|
38	38	\|[RHOA](RHOA)\|1\|[@richterRecurrentMutationID32012a]\|\|
39	39	\|[SIN3A](SIN3A)\|1\|[@grandeGenomewideDiscoverySomatic2019]\|[@rossiCodingGenomeSplenic2012c]\|
40		-\|[SMARCA4](SMARCA4)\|1\|[@richterRecurrentMutationID32012a]\|[@nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b; @zhangGeneticHeterogeneityDiffuse2013]\|
	40	+\|[SMARCA4](SMARCA4)\|1\|[@richterRecurrentMutationID32012a]\|[@zhangGeneticHeterogeneityDiffuse2013; @krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b]\|
41	41	\|[TCF3](TCF3)\|1\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
42	42	\|[TCL1A](TCL1A)\|1, aSHM\|[@grandeGenomewideDiscoverySomatic2019]\|\|
43	43	\|[TFAP4](TFAP4)\|1\|[@grandeGenomewideDiscoverySomatic2019]\|\|
44		-\|[TP53](TP53)\|1\|[@wildaInactivationARFMDM2p53Pathway2004]\|[@tiacciPervasiveMutationsJAKSTAT2018b; @beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012c]\|
	44	+\|[TP53](TP53)\|1\|[@wildaInactivationARFMDM2p53Pathway2004]\|[@morinFrequentMutationHistonemodifying2011; @beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b]\|
45	45	\|[USP7](USP7)\|1\|[@grandeGenomewideDiscoverySomatic2019]\|\|
46		-\|[WNK1](WNK1)\|1\|[@thomasGeneticSubgroupsInform2023]\|[@hubschmannMutationalMechanismsShaping2021b; @jalladesExomeSequencingIdentifies2017]\|
	46	+\|[WNK1](WNK1)\|1\|[@thomasGeneticSubgroupsInform2023]\|[@jalladesExomeSequencingIdentifies2017; @hubschmannMutationalMechanismsShaping2021b]\|
47	47
48	48	## Tier 2 BL genes
49	49
50	50	### 157 total
51	51
52		-\|Gene\|Tier\| Earliest reference \| Other references\|
	52	+\|Gene\|Tier\| First BL evidence \| Other entities \|
53	53	\|:-:\|:-:\|:-\|:-\|
54	54	\|[ACAD9](ACAD9)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
55	55	\|[ACE](ACE)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
...	...	@@ -69,13 +69,13 @@ link-citations: true
69	69	\|[C16orf48](C16orf48)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
70	70	\|[C6orf27](C6orf27)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
71	71	\|[CAD](CAD)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
72		-\|[CARD11](CARD11)\|2\|[@paneaWholeGenomeLandscape2019]\|[@lenzOncogenicCARD11Mutations2008; @yanBCRTLRSignaling2012a; @morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016]\|
	72	+\|[CARD11](CARD11)\|2\|[@paneaWholeGenomeLandscape2019]\|[@lenzOncogenicCARD11Mutations2008; @wuGeneticHeterogeneityPrimary2016; @morinFrequentMutationHistonemodifying2011; @yanBCRTLRSignaling2012a]\|
73	73	\|[CARD4](CARD4)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
74	74	\|[CCNF](CCNF)\|2\|[@abateDistinctViralMutational2015a]\|\|
75	75	\|[CCT6B](CCT6B)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
76	76	\|[CD79A](CD79A)\|2\|[@burkhardtClinicalRelevanceMolecular2022b]\|[@rossiCodingGenomeSplenic2012c]\|
77	77	\|[CD79B](CD79B)\|2\|[@paneaWholeGenomeLandscape2019]\|[@morinFrequentMutationHistonemodifying2011]\|
78		-\|[CD83](CD83)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@morinMutationalStructuralAnalysis2013; @dunsCharacterizationDLBCLPMBL2021b; @russler-germainMutationsAssociatedProgression2023b]\|
	78	+\|[CD83](CD83)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@dunsCharacterizationDLBCLPMBL2021b; @morinMutationalStructuralAnalysis2013; @russler-germainMutationsAssociatedProgression2023b]\|
79	79	\|[CDC73](CDC73)\|2\|[@loveGeneticLandscapeMutations2012]\|[@reddyGeneticFunctionalDrivers2017]\|
80	80	\|[CDH17](CDH17)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
81	81	\|[CDKN2A](CDKN2A)\|2\|[@grandeGenomewideDiscoverySomatic2019]\|[@morinMutationalStructuralAnalysis2013; @spinaGeneticsNodalMarginal2016b]\|
...	...	@@ -85,13 +85,13 @@ link-citations: true
85	85	\|[CPXM2](CPXM2)\|2\|[@burkhardtClinicalRelevanceMolecular2022b]\|\|
86	86	\|[CREBBP](CREBBP)\|2\|[@loveGeneticLandscapeMutations2012]\|[@parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011a; @dunsCharacterizationDLBCLPMBL2021b]\|
87	87	\|[CTCF](CTCF)\|2\|[@paneaWholeGenomeLandscape2019]\|\|
88		-\|[CXCR4](CXCR4)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@khodabakhshiRecurrentTargetsAberrant2012; @krysiakRecurrentSomaticMutations2017b]\|
	88	+\|[CXCR4](CXCR4)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@krysiakRecurrentSomaticMutations2017b; @khodabakhshiRecurrentTargetsAberrant2012]\|
89	89	\|[CYB5D1](CYB5D1)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
90	90	\|[CYP4F22](CYP4F22)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
91	91	\|[DHCR7](DHCR7)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
92	92	\|[DLGAP1](DLGAP1)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
93	93	\|[DNMT1](DNMT1)\|2\|[@paneaWholeGenomeLandscape2019]\|\|
94		-\|[DTX1](DTX1)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@gomezUltraDeepSequencingReveals2023; @schmitzGeneticsPathogenesisDiffuse2018a; @rossiCodingGenomeSplenic2012c]\|
	94	+\|[DTX1](DTX1)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@rossiCodingGenomeSplenic2012c; @schmitzGeneticsPathogenesisDiffuse2018a; @gomezUltraDeepSequencingReveals2023]\|
95	95	\|[E2F2](E2F2)\|2\|[@burkhardtClinicalRelevanceMolecular2022b]\|\|
96	96	\|[EBF1](EBF1)\|2, aSHM\|[@thomasGeneticSubgroupsInform2023]\|[@reichelFlowSortingExome2015a; @bohleRoleEarlyBcell2013]\|
97	97	\|[EDNRB](EDNRB)\|2\|[@burkhardtClinicalRelevanceMolecular2022b]\|\|
...	...	@@ -100,12 +100,12 @@ link-citations: true
100	100	\|[ELP2](ELP2)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
101	101	\|[EML2](EML2)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
102	102	\|[ENTPD3](ENTPD3)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
103		-\|[EP300](EP300)\|2\|[@paneaWholeGenomeLandscape2019]\|[@pasqualucciInactivatingMutationsAcetyltransferase2011a; @rossiCodingGenomeSplenic2012c]\|
	103	+\|[EP300](EP300)\|2\|[@paneaWholeGenomeLandscape2019]\|[@rossiCodingGenomeSplenic2012c; @pasqualucciInactivatingMutationsAcetyltransferase2011a]\|
104	104	\|[EPHB2](EPHB2)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
105	105	\|[ERAP1](ERAP1)\|2\|[@burkhardtClinicalRelevanceMolecular2022b]\|\|
106	106	\|[ETS1](ETS1)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@morinFrequentMutationHistonemodifying2011]\|
107	107	\|[EXOSC6](EXOSC6)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
108		-\|[EZH2](EZH2)\|2\|[@loveGeneticLandscapeMutations2012]\|[@morinSomaticMutationsAltering2010a; @mottokIntegrativeGenomicAnalysis2019b]\|
	108	+\|[EZH2](EZH2)\|2\|[@loveGeneticLandscapeMutations2012]\|[@mottokIntegrativeGenomicAnalysis2019b; @morinSomaticMutationsAltering2010a]\|
109	109	\|[FAM129B](FAM129B)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
110	110	\|[FGFR3](FGFR3)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
111	111	\|[FLYWCH1](FLYWCH1)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
...	...	@@ -116,8 +116,8 @@ link-citations: true
116	116	\|[GRIK5](GRIK5)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
117	117	\|[GTSE1](GTSE1)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
118	118	\|[HIST1H1C](HIST1H1C)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@morinFrequentMutationHistonemodifying2011]\|
119		-\|[HIST1H1E](HIST1H1E)\|2, aSHM\|[@grandeGenomewideDiscoverySomatic2019]\|[@krysiakRecurrentSomaticMutations2017b; @morinMutationalStructuralAnalysis2013; @reichelFlowSortingExome2015a]\|
120		-\|[HIST1H2AG](HIST1H2AG)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c; @morinMutationalStructuralAnalysis2013]\|
	119	+\|[HIST1H1E](HIST1H1E)\|2, aSHM\|[@grandeGenomewideDiscoverySomatic2019]\|[@morinMutationalStructuralAnalysis2013; @krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]\|
	120	+\|[HIST1H2AG](HIST1H2AG)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@rossiCodingGenomeSplenic2012c; @morinMutationalStructuralAnalysis2013; @krysiakRecurrentSomaticMutations2017b]\|
121	121	\|[HIST1H2AM](HIST1H2AM)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@krysiakRecurrentSomaticMutations2017b]\|
122	122	\|[HIST1H2BK](HIST1H2BK)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@rossiCodingGenomeSplenic2012c]\|
123	123	\|[HIST1H3D](HIST1H3D)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|\|
...	...	@@ -139,7 +139,7 @@ link-citations: true
139	139	\|[KIFC3](KIFC3)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
140	140	\|[KLHL26](KLHL26)\|2\|[@burkhardtClinicalRelevanceMolecular2022b]\|\|
141	141	\|[KLHL6](KLHL6)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@ganapathiGeneticLandscapeDural2016; @morinFrequentMutationHistonemodifying2011]\|
142		-\|[KMT2C](KMT2C)\|2\|[@zhouSporadicEndemicBurkitt2019]\|[@zhangGeneticHeterogeneityDiffuse2013; @zhangGenomicLandscapeMantle2014; @sarkozyMutationalLandscapeGray2021a]\|
	142	+\|[KMT2C](KMT2C)\|2\|[@zhouSporadicEndemicBurkitt2019]\|[@zhangGenomicLandscapeMantle2014; @zhangGeneticHeterogeneityDiffuse2013; @sarkozyMutationalLandscapeGray2021a]\|
143	143	\|[LTB](LTB)\|2, aSHM\|[@paneaWholeGenomeLandscape2019]\|[@deschGenotypingCirculatingTumor2020; @chapuyMolecularSubtypesDiffuse2018b]\|
144	144	\|[MAP3K6](MAP3K6)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
145	145	\|[MCL1](MCL1)\|2\|[@paneaWholeGenomeLandscape2019]\|[@reddyGeneticFunctionalDrivers2017; @dunsCharacterizationDLBCLPMBL2021b]\|
...	...	@@ -150,9 +150,9 @@ link-citations: true
150	150	\|[MYH10](MYH10)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
151	151	\|[MYO18A](MYO18A)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
152	152	\|[NBEAL1](NBEAL1)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
153		-\|[NCOR2](NCOR2)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|[@sarkozyMutationalLandscapeGray2021a; @spinaGeneticsNodalMarginal2016b]\|
	153	+\|[NCOR2](NCOR2)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|[@spinaGeneticsNodalMarginal2016b; @sarkozyMutationalLandscapeGray2021a]\|
154	154	\|[NOA1](NOA1)\|2\|[@burkhardtClinicalRelevanceMolecular2022b]\|\|
155		-\|[NOTCH1](NOTCH1)\|2\|[@loveGeneticLandscapeMutations2012]\|[@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c; @pasqualucciAnalysisCodingGenome2011]\|
	155	+\|[NOTCH1](NOTCH1)\|2\|[@loveGeneticLandscapeMutations2012]\|[@pasqualucciAnalysisCodingGenome2011; @beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]\|
156	156	\|[NOTCH2](NOTCH2)\|2\|[@paneaWholeGenomeLandscape2019]\|[@troenNOTCH2MutationsMarginal2008; @beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]\|
157	157	\|[NRXN2](NRXN2)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
158	158	\|[P2RY2](P2RY2)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
...	...	@@ -163,7 +163,7 @@ link-citations: true
163	163	\|[PDCD11](PDCD11)\|2\|[@schmitzBurkittLymphomaPathogenesis2012]\|\|
164	164	\|[PDZRN3](PDZRN3)\|2\|[@paneaWholeGenomeLandscape2019]\|\|
165	165	\|[PIK3R1](PIK3R1)\|2\|[@paneaWholeGenomeLandscape2019]\|[@zhangGeneticHeterogeneityDiffuse2013]\|
166		-\|[PIM1](PIM1)\|2, aSHM\|[@burkhardtClinicalRelevanceMolecular2022b]\|[@dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]\|
	166	+\|[PIM1](PIM1)\|2, aSHM\|[@burkhardtClinicalRelevanceMolecular2022b]\|[@pasqualucciHypermutationMultipleProtooncogenes2001a; @dunsCharacterizationDLBCLPMBL2021b]\|
167	167	\|[PLCG2](PLCG2)\|2\|[@paneaWholeGenomeLandscape2019]\|\|
168	168	\|[POLRMT](POLRMT)\|2\|[@loveGeneticLandscapeMutations2012]\|\|
169	169	\|[POR](POR)\|2\|[@loveGeneticLandscapeMutations2012]\|\|