Template.md
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[[_TOC_]]
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-[[include:Overview.md]]
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+[[include:Template_Overview.md]]
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-## History
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+[[include:Template_History.md]]
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-[[include:History.md]]
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-
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-## Relevance tier by entity
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-
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-|Entity|Tier|Description |
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-|:------:|:----:|--------------------------------------|
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1[@balSuperenhancerHypermutationAlters2022] |high-confidence DLBCL gene [@tanakaFrequentIncidenceSomatic1992]|
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-|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene|
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-|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@sarkozyMutationalLandscapeGray2021]|
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-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022]|
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- |
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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Template_History.md
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+## History
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+
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+```mermaid
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+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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+timeline
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+ title Publication timing
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+ 1992-01-01 : Tanaka : DLBCL
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+ 2011-07-27 : Morin : FL
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+ 2021-04-01 : Sarkozy : PMBL
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+ 2022-07-06 : Burkhardt : BL
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+```
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Template_Overview.md
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+## Overview
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+
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+BCL2 mutations are frequently found in DLBCL, particularly in the germinal center B-cell (GCB) subtype, and are often located in the flexible loop domain and outside the BCL2-homology domains.
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+These mutations are caused by the somatic hypermutation process. The presence of these mutations are strongly correlated with the presence of a translocation between BCL2 and one of the immunoglobulin loci.
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+Although missense mutations may not be under positive selective pressure in the context of lymphomagenesis, some of these mutations may interfere with the function of BCL2 antagonists.
Template_Relevance.md
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+## Relevance tier by entity
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+
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+|Entity|Tier|Description |
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+|:------:|:----:|--------------------------------------|
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+|![DLBCL](images/icons/DLBCL_tier1.png) |1[@balSuperenhancerHypermutationAlters2022] |high-confidence DLBCL gene [@tanakaFrequentIncidenceSomatic1992]|
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+|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene|
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+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@sarkozyMutationalLandscapeGray2021]|
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+|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022]|
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+ |