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RPL22.md
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| 1 | -# RPL22 |
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| 2 | - |
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| 3 | -## Relevance tier by entity |
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| 4 | - |
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| 5 | -|Entity|Tier|Description | |
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| 6 | -|:------:|:----:|--------------------------------------| |
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| 7 | -| |2 |relevance in BL not firmly established| |
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| 8 | - |
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| 9 | -## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
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| 10 | - |
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| 11 | -|Entity|source |frequency (%)| |
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| 12 | -|:------:|:---------------------:|:-------------:| |
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| 13 | -|BL |GAMBL genomes+capture|2.31 | |
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| 14 | -|BL |Thomas cohort |3.00 | |
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| 15 | -|BL |Panea cohort |2.00 | |
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| 16 | - |
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| 17 | -## Mutation pattern and selective pressure estimates |
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| 18 | - |
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| 19 | -|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)| |
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| 20 | -|:------:|:----:|:---------------------:|:----------------:|:----------------:| |
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| 21 | -|BL |No |Yes |16.054 |60.122 | |
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| 22 | -|DLBCL |No |No | 0.000 | 0.000 | |
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| 23 | -|FL |No |No |21.073 | 0.000 | |
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| 24 | - |
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| 25 | - |
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| 26 | - |
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| 27 | -[[include:browser_RPL22.md]] |
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| 28 | - |
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| 29 | -## Expression |
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| 30 | - |
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| 31 | -<!-- ORIGIN: --> |
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| 32 | -<!-- BL: 2 --> |
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| 33 | -## References |
ZCCHC7.md
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| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
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| 14 | -|:------:|:----:|-----------------------------------------| |
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| 15 | -| |2 | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018]| |
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| 13 | +[[include:table1_ZCCHC7]] |
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| 16 | 14 | |
| 17 | 15 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 18 | 16 | |
| 19 | -|Entity|source |frequency (%)| |
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| 20 | -|:------:|:--------------:|:-------------:| |
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| 21 | -|DLBCL |GAMBL genomes |0.57 | |
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| 22 | -|DLBCL |Schmitz cohort|0.85 | |
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| 23 | -|DLBCL |Reddy cohort |0.40 | |
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| 24 | -|DLBCL |Chapuy cohort |2.56 | |
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| 17 | +[[include:DLBCL_ZCCHC7.md]] |
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| 18 | + |
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| 25 | 19 | |
| 26 | 20 | ## Mutation pattern and selective pressure estimates |
| 27 | 21 |