FL_genes.md
... ...
@@ -109,7 +109,6 @@ link-citations: true
109 109
|[HIST1H2BM](HIST1H2BM)|2, aSHM|[Krysiak et al](papers/krysiakRecurrentSomaticMutations2017b)[@krysiakRecurrentSomaticMutations2017b]||
110 110
|[HIST1H3I](HIST1H3I)|2, aSHM|[Krysiak et al](papers/krysiakRecurrentSomaticMutations2017b)[@krysiakRecurrentSomaticMutations2017b]|[@paneaWholeGenomeLandscape2019]|
111 111
|[HLA-B](HLA-B)|2||[@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]|
112
-|[HNRNPD](HNRNPD)|2|||
113 112
|[IGLL5](IGLL5)|2, aSHM|[Russler et al](papers/russler-germainMutationsAssociatedProgression2023b)[@russler-germainMutationsAssociatedProgression2023b]|[@deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]|
114 113
|[JUP](JUP)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]||
115 114
|[KIR3DL1](KIR3DL1)|2|[Russler et al](papers/russler-germainMutationsAssociatedProgression2023b)[@russler-germainMutationsAssociatedProgression2023b]||
... ...
@@ -129,7 +128,6 @@ link-citations: true
129 128
|[PRKDC](PRKDC)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@schmitzGeneticsPathogenesisDiffuse2018a]|
130 129
|[PZP](PZP)|2|[Russler et al](papers/russler-germainMutationsAssociatedProgression2023b)[@russler-germainMutationsAssociatedProgression2023b]||
131 130
|[RBM6](RBM6)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]||
132
-|[SESN1](SESN1)|2|[Oricchio et al](papers/oricchioGeneticEpigeneticInactivation2017b)[@oricchioGeneticEpigeneticInactivation2017b]||
133 131
|[SHROOM3](SHROOM3)|2|[Russler et al](papers/russler-germainMutationsAssociatedProgression2023b)[@russler-germainMutationsAssociatedProgression2023b]||
134 132
|[SRRM2](SRRM2)|2|[Russler et al](papers/russler-germainMutationsAssociatedProgression2023b)[@russler-germainMutationsAssociatedProgression2023b]|[@morinMutationalStructuralAnalysis2013]|
135 133
|[STAB2](STAB2)|2|[Russler et al](papers/russler-germainMutationsAssociatedProgression2023b)[@russler-germainMutationsAssociatedProgression2023b]||
PMAIP1.md
... ...
@@ -1,38 +0,0 @@
1
-# PMAIP1
2
-
3
-## Relevance tier by entity
4
-
5
-|Entity|Tier|Description |
6
-|:------:|:----:|--------------------------------------|
7
-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
8
-
9
-## Mutation incidence in large patient cohorts (GAMBL reanalysis)
10
-
11
-|Entity|source |frequency (%)|
12
-|:------:|:---------------------:|:-------------:|
13
-|BL |GAMBL genomes+capture|3.23 |
14
-|BL |Thomas cohort |3.00 |
15
-|BL |Panea cohort |5.00 |
16
-
17
-## Mutation pattern and selective pressure estimates
18
-
19
-|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
-|:------:|:----:|:---------------------:|:----------------:|:----------------:|
21
-|BL |No |Yes |15.382 |90.742 |
22
-|DLBCL |No |No | 0.000 | 0.000 |
23
-|FL |No |No | 0.000 | 0.000 |
24
-
25
-
26
-
27
-View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/PMAIP1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/PMAIP1_protein_hg38.html)
28
-
29
-![image](images/proteinpaint/PMAIP1_NM_021127.svg)
30
-
31
-View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/PMAIP1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/PMAIP1_hg38.html)
32
-
33
-![image](images/proteinpaint/PMAIP1.svg)
34
-## PMAIP1 Expression
35
-![image](images/gene_expression/PMAIP1_by_pathology.svg)
36
-<!-- ORIGIN: -->
37
-<!-- BL: 2 -->
38
-## References
SEPT10.md
... ...
@@ -1,37 +0,0 @@
1
-# SEPT10
2
-
3
-## Relevance tier by entity
4
-
5
-|Entity|Tier|Description |
6
-|:------:|:----:|--------------------------------------|
7
-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
8
-
9
-## Mutation incidence in large patient cohorts (GAMBL reanalysis)
10
-
11
-|Entity|source |frequency (%)|
12
-|:------:|:---------------------:|:-------------:|
13
-|BL |GAMBL genomes+capture|0.92 |
14
-|BL |Thomas cohort |2.10 |
15
-|BL |Panea cohort |2.00 |
16
-
17
-## Mutation pattern and selective pressure estimates
18
-
19
-|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
-|:------:|:----:|:---------------------:|:----------------:|:----------------:|
21
-|BL |No |No |7.224 |13.447 |
22
-|DLBCL |No |No |0.000 | 0.000 |
23
-|FL |No |No |2.834 | 0.000 |
24
-
25
-
26
-
27
-View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/SEPT10_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/SEPT10_protein_hg38.html)
28
-
29
-![image](images/proteinpaint/SEPT10_NM_144710.svg)
30
-
31
-View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/SEPT10.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/SEPT10_hg38.html)
32
-
33
-![image](images/proteinpaint/SEPT10.svg)
34
-## SEPT10 Expression
35
-![image](images/gene_expression/SEPT10_by_pathology.svg)
36
-<!-- ORIGIN: -->
37
-<!-- BL: 2 -->
SESN1.md
... ...
@@ -1,44 +0,0 @@
1
----
2
-bibliography: 'morinlab.bib'
3
-csl: 'NLM.csl'
4
-link-citations: true
5
----
6
-# SESN1
7
-
8
-## Relevance tier by entity
9
-
10
-|Entity|Tier|Description |
11
-|:------:|:----:|--------------------------------------|
12
-|![FL](images/icons/FL_tier2.png) |2 |relevance in FL not firmly established[@oricchioGeneticEpigeneticInactivation2017b]|
13
-
14
-## Mutation incidence in large patient cohorts (GAMBL reanalysis)
15
-
16
-|Entity|source |frequency (%)|
17
-|:------:|:-------------:|:-------------:|
18
-|FL |GAMBL genomes|0.23 |
19
-
20
-## Mutation pattern and selective pressure estimates
21
-
22
-|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
-|:------:|:----:|:---------------------:|:----------------:|:----------------:|
24
-|BL |No |No |4.805 |0 |
25
-|DLBCL |No |No |1.629 |0 |
26
-|FL |No |No |0.000 |0 |
27
-
28
-
29
-
30
-
31
-View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/SESN1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/SESN1_protein_hg38.html)
32
-
33
-![](images/proteinpaint/SESN1_NM_014454.svg)
34
-
35
-View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/SESN1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/SESN1_hg38.html)
36
-
37
-![](images/proteinpaint/SESN1.svg)
38
-
39
-## SESN1 Expression
40
-![](images/gene_expression/SESN1_by_pathology.svg)
41
-<!-- ORIGIN: oricchioGeneticEpigeneticInactivation2017b -->
42
-
43
-## References
44
-<!-- FL: oricchioGeneticEpigeneticInactivation2017b -->
SYNCRIP.md
... ...
@@ -1,49 +0,0 @@
1
-# SYNCRIP
2
-
3
-## History
4
-```mermaid
5
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
6
-timeline
7
- title Publication timing
8
- 2019-09-26 : Panea : BL
9
-```
10
-
11
-## Relevance tier by entity
12
-
13
-|Entity|Tier|Description |
14
-|:------:|:----:|--------------------------------------|
15
-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
16
-
17
-## Mutation incidence in large patient cohorts (GAMBL reanalysis)
18
-
19
-|Entity|source |frequency (%)|
20
-|:------:|:---------------------:|:-------------:|
21
-|BL |GAMBL genomes+capture|3.0 |
22
-|BL |Thomas cohort |2.5 |
23
-|BL |Panea cohort |5.0 |
24
-
25
-## Mutation pattern and selective pressure estimates
26
-
27
-|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
28
-|:------:|:----:|:---------------------:|:----------------:|:----------------:|
29
-|BL |No |No | 4.806 |35.301 |
30
-|DLBCL |No |No | 2.325 |47.239 |
31
-|FL |No |No |16.820 | 0.000 |
32
-
33
-
34
-
35
-View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/SYNCRIP_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/SYNCRIP_protein_hg38.html)
36
-
37
-![](images/proteinpaint/SYNCRIP_NM_006372.svg)
38
-
39
-View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/SYNCRIP.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/SYNCRIP_hg38.html)
40
-
41
-![](images/proteinpaint/SYNCRIP.svg)
42
-
43
-## SYNCRIP Expression
44
-![](images/gene_expression/SYNCRIP_by_pathology.svg)
45
-<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->
46
-<!-- BL: paneaWholeGenomeLandscape2019 -->
47
-
48
-## References
49
-1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;
all_entities.md
... ...
@@ -509,7 +509,6 @@
509 509
|[SENP7](SENP7)|||||![PMBL](images/icons/PMBL_tier2.png)||
510 510
|[SEPTIN9](SEPTIN9)||![DLBCL](images/icons/DLBCL_tier2.png)|||||
511 511
|[SERPINA9](SERPINA9)||![DLBCL](images/icons/DLBCL_tier2.png)|||||
512
-|[SESN1](SESN1)|![FL](images/icons/FL_tier2.png)||||||
513 512
|[SETD1B](SETD1B)||![DLBCL](images/icons/DLBCL_tier1.png)|||||
514 513
|[SETD2](SETD2)||![DLBCL](images/icons/DLBCL_tier2.png)|||||
515 514
|[SETD5](SETD5)||![DLBCL](images/icons/DLBCL_tier2.png)|||![PMBL](images/icons/PMBL_tier2.png)||