BCL2.md
... ...
@@ -19,20 +19,12 @@ Although missense mutations may not be under positive selective pressure in the
19 19
20 20
[[include:table1_BCL2.md]]
21 21
22
-|Entity|Tier|Description |
23
-|:------:|:----:|--------------------------------------|
24
-|![DLBCL](images/icons/DLBCL_tier1.png) |1[@balSuperenhancerHypermutationAlters2022] |high-confidence DLBCL gene [@tanakaFrequentIncidenceSomatic1992]|
25
-|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene|
26
-|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@sarkozyMutationalLandscapeGray2021]|
27
-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022]|
28
-
29 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
30 23
31 24
[[include:DLBCL_BCL2.md]]
32 25
[[include:FL_BCL2.md]]
33 26
[[include:BL_BCL2.md]]
34 27
35
-
36 28
## Mutation pattern and selective pressure estimates
37 29
38 30
[[include:dnds_BCL2.md]]
... ...
@@ -45,7 +37,6 @@ Although missense mutations may not be under positive selective pressure in the
45 37
|chr18 |60982728 |60988342|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr18%3A60982728%2D60988342) |active_promoter |
46 38
47 39
48
-
49 40
## BCL2 Hotspots
50 41
51 42
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |