CCND3.md
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@@ -38,9 +38,9 @@ CCND3 (Cyclin D3) is a gene that encodes a protein involved in the regulation of
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## CCND3 Hotspots
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### Exon 5 Hotspot
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-E283 (Glutamic Acid 283): One of the most frequently mutated sites in CCND3. Mutations at this site can result in enhanced cyclin D3 stability and increased cell cycle progression.
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+T283 (Threonine 283): One of the most frequently mutated sites in CCND3. Mutations at this site can result in enhanced cyclin D3 stability and increased cell cycle progression.
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-D290 (Aspartic Acid 290): Another common mutation in exon 5. Mutations here are associated with similar functional impacts as E283, promoting uncontrolled cell proliferation.
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+I290 (Isoleucine 290): Another common mutation in exon 5. Mutations here are associated with similar functional impacts as E283, promoting uncontrolled cell proliferation.
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### Exon 1 and Exon 2
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While exon 5 is the primary hotspot, mutations in exon 1 and exon 2 have also been observed, though less frequently. These mutations can affect the regulatory regions of the gene, potentially increasing levels of CCND3 by promoting stability of the protein.