Changes in 0fedffd: Updated FOXO1 (markdown)

				FOXO1.md
			
          @@ -1,4 +1,6 @@

           # FOXO1

          +## Overview

          +Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.<sup>1</sup> These mutations are common in DLBCL, BL and, to a lesser extent, FL.<sup>2,3</sup>

           ## Relevance tier by entity

          @@ -67,3 +69,8 @@ View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAM

           View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FOXO1.html)  or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FOXO1_hg38.html)

           ![image](images/proteinpaint/FOXO1.svg)

          +

          +## References

          +1. *Trinh, D., Scott, D., Morin, R., Méndez-Lago, M., An, J., Jones, S., Mungall, A., Zhao, Y., Schein, J., Steidl, C., Connors, J., Gascoyne, R., & Marra, M. (2013). Analysis of FOXO1 mutations in diffuse large B-cell lymphoma.. Blood, 121 18, 3666-74 . https://doi.org/10.1182/blood-2013-01-479865.*

          +2. *Zhou, P., Blain, A., Newman, A., Zaka, M., Chagaluka, G., Adlar, F., Offor, U., Broadbent, C., Chaytor, L., Whitehead, A., Hall, A., O'Connor, H., Noorden, S., Lampert, I., Bailey, S., Molyneux, E., Bacon, C., Bomken, S., & Rand, V. (2019). Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif.. Blood advances, 3 14, 2118-2127 . https://doi.org/10.1182/bloodadvances.2018029546.*

          +3. *Grande BM, Gerhard DS, Jiang A, Griner NB, Abramson JS, Alexander TB, Allen H, Ayers LW, Bethony JM, Bhatia K, Bowen J, Casper C, Choi JK, Culibrk L, Davidsen TM, Dyer MA, Gastier-Foster JM, Gesuwan P, Greiner TC, Gross TG, Hanf B, Harris NL, He Y, Irvin JD, Jaffe ES, Jones SJM, Kerchan P, Knoetze N, Leal FE, Lichtenberg TM, Ma Y, Martin JP, Martin MR, Mbulaiteye SM, Mullighan CG, Mungall AJ, Namirembe C, Novik K, Noy A, Ogwang MD, Omoding A, Orem J, Reynolds SJ, Rushton CK, Sandlund JT, Schmitz R, Taylor C, Wilson WH, Wright GW, Zhao EY, Marra MA, Morin RD, Staudt LM. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma. Blood. 2019 Mar 21;133(12):1313-1324. doi: 10.1182/blood-2018-09-871418. Epub 2019 Jan 7. PMID: 30617194; PMCID: PMC6428665.*

...	...	@@ -1,4 +1,6 @@
1	1	# FOXO1
	2	+## Overview
	3	+Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.<sup>1</sup> These mutations are common in DLBCL, BL and, to a lesser extent, FL.<sup>2,3</sup>
2	4
3	5	## Relevance tier by entity
4	6
...	...	@@ -67,3 +69,8 @@ View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAM
67	69	View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FOXO1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FOXO1_hg38.html)
68	70
69	71	![image](images/proteinpaint/FOXO1.svg)
	72	+
	73	+## References
	74	+1. Trinh, D., Scott, D., Morin, R., Méndez-Lago, M., An, J., Jones, S., Mungall, A., Zhao, Y., Schein, J., Steidl, C., Connors, J., Gascoyne, R., & Marra, M. (2013). Analysis of FOXO1 mutations in diffuse large B-cell lymphoma.. Blood, 121 18, 3666-74 . https://doi.org/10.1182/blood-2013-01-479865.
	75	+2. Zhou, P., Blain, A., Newman, A., Zaka, M., Chagaluka, G., Adlar, F., Offor, U., Broadbent, C., Chaytor, L., Whitehead, A., Hall, A., O'Connor, H., Noorden, S., Lampert, I., Bailey, S., Molyneux, E., Bacon, C., Bomken, S., & Rand, V. (2019). Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif.. Blood advances, 3 14, 2118-2127 . https://doi.org/10.1182/bloodadvances.2018029546.
	76	+3. Grande BM, Gerhard DS, Jiang A, Griner NB, Abramson JS, Alexander TB, Allen H, Ayers LW, Bethony JM, Bhatia K, Bowen J, Casper C, Choi JK, Culibrk L, Davidsen TM, Dyer MA, Gastier-Foster JM, Gesuwan P, Greiner TC, Gross TG, Hanf B, Harris NL, He Y, Irvin JD, Jaffe ES, Jones SJM, Kerchan P, Knoetze N, Leal FE, Lichtenberg TM, Ma Y, Martin JP, Martin MR, Mbulaiteye SM, Mullighan CG, Mungall AJ, Namirembe C, Novik K, Noy A, Ogwang MD, Omoding A, Orem J, Reynolds SJ, Rushton CK, Sandlund JT, Schmitz R, Taylor C, Wilson WH, Wright GW, Zhao EY, Marra MA, Morin RD, Staudt LM. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma. Blood. 2019 Mar 21;133(12):1313-1324. doi: 10.1182/blood-2018-09-871418. Epub 2019 Jan 7. PMID: 30617194; PMCID: PMC6428665.