DLBCL_genes.md
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@@ -112,7 +112,7 @@ link-citations: true
112 112
|[RB1](RB1)|Tier 1 GE[@morinMutationalStructuralAnalysis2013]|[Morin et al](papers/morinMutationalStructuralAnalysis2013)|[@zhangGenomicLandscapeMantle2014]||
113 113
|[RFX7](RFX7)|Tier 1 GE[@arthurGenomewideDiscoverySomatic2018]|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)|[@grandeGenomewideDiscoverySomatic2019]||
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|[RHOA](RHOA)|Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@ohayreInactivatingMutationsGNA132016]|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)|[@richterRecurrentMutationID32012a]||
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-|[RRAGC](RRAGC)|Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a]|[Okosun et al](papers/okosunRecurrentMTORC1activatingRRAGC2016a)|||
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+|[RRAGC](RRAGC)|Tier 1 GE[@okosunRecurrentMTORC1activatingRRAGC2016a], FE[@ortega-molinaOncogenicRagGTPase2019b]|[Okosun et al](papers/okosunRecurrentMTORC1activatingRRAGC2016a)|||
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|[S1PR2](S1PR2)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@muppidiLossSignalingGa132014b]||
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|[SETD1B](SETD1B)|Tier 1 GE[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)|||
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|[SF3B1](SF3B1)|Tier 1 GE[@reddyGeneticFunctionalDrivers2017]|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)|[@loveGeneticLandscapeMutations2012]||
morinlab.bib
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+@article{ortega-molinaOncogenicRagGTPase2019b,
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+ title = {Oncogenic {{Rag GTPase}} Signaling Enhances {{B}} Cell Activation and Drives Follicular Lymphoma Sensitive to Pharmacological Inhibition of {{mTOR}}},
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+ author = {Ortega-Molina, Ana and Deleyto-Seldas, Nerea and Carreras, Joaquim and Sanz, Alba and Lebrero-Fernández, Cristina and Menéndez, Camino and Vandenberg, Andrew and Fernández-Ruiz, Beatriz and Marín-Arraiza, Leyre and family=Calle Arregui, given=Celia, prefix=de la, useprefix=true and Belén Plata-Gómez, Ana and Caleiras, Eduardo and family=Martino, given=Alba, prefix=de, useprefix=true and Martínez-Martín, Nuria and Troulé, Kevin and Piñeiro-Yáñez, Elena and Nakamura, Naoya and Araf, Shamzah and Victora, Gabriel D. and Okosun, Jessica and Fitzgibbon, Jude and Efeyan, Alejo},
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+ date = {2019-08},
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+ journaltitle = {Nature Metabolism},
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+ shortjournal = {Nat Metab},
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+ volume = {1},
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+ number = {8},
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+ eprint = {31579886},
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+ eprinttype = {pmid},
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+ pages = {775--789},
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+ issn = {2522-5812},
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+ doi = {10.1038/s42255-019-0098-8},
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+ abstract = {The humoral immune response demands that B cells undergo a sudden anabolic shift and high cellular nutrient levels which are required to sustain the subsequent proliferative burst. Follicular lymphoma (FL) originates from B cells that have participated in the humoral response, and 15\% of FL samples harbor point, activating mutations in RRAGC, an essential activator of mTORC1 downstream of the sensing of cellular nutrients. The impact of recurrent RRAGC mutations in B cell function and lymphoma is unexplored. RRAGC mutations, targeted to the endogenous locus in mice, confer a partial insensitivity to nutrient deprivation, but strongly exacerbate B cell responses and accelerate lymphomagenesis, while creating a selective vulnerability to pharmacological inhibition of mTORC1. This moderate increase in nutrient signaling synergizes with paracrine cues from the supportive T cell microenvironment that activates B cells via the PI3K-Akt-mTORC1 axis. Hence, Rragc mutations sustain induced germinal centers and murine and human FL in the presence of decreased T cell help. Our results support a model in which activating mutations in the nutrient signaling pathway foster lymphomagenesis by corrupting a nutrient-dependent control over paracrine signals from the T cell microenvironment.},
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+ langid = {english},
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+ pmcid = {PMC6774795},
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+ keywords = {Animals,apoptosis,B cell lymphoma,B lymphocytes,cell growth,germinal center,GTP Phosphohydrolases,Humans,Lymphocyte Activation,Lymphoma Follicular,Mice,Mice Transgenic,mTOR,nutrient signaling,rapamycin,RRAGC,Signal Transduction,T follicular helper,TOR Serine-Threonine Kinases},
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+ file = {/Users/rmorin/Zotero/storage/26JEZPT2/Ortega-Molina et al. - 2019 - Oncogenic Rag GTPase signaling enhances B cell act.pdf}
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+}
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+
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@article{thomasMutationalAnalysisIkappaBalpha2004,
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title = {Mutational Analysis of the {{IkappaBalpha}} Gene in Activated {{B}} Cell-like Diffuse Large {{B-cell}} Lymphoma},
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author = {Thomas, Roman K. and Wickenhauser, Claudia and Tawadros, Samir and Diehl, Volker and Küppers, Ralf and Wolf, Jürgen and Schmitz, Roland},