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### Gene Tiers
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-**Tier 2**
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+**Tier 2** Any gene described as significantly or recurrently mutated in one or more types of B-cell lymphoma is initially assigned to Tier 2 for that entity. The study describing the mutation of that gene in a particular entity is considered the originating study.
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-Any gene described as significantly or recurrently mutated in one or more types of B-cell lymphoma is initially assigned to Tier 2 for that entity. The study describing the mutation of that gene in a particular entity is considered the originating study.
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-**Tier 1**
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-Genes can transition to Tier 1 only after additional studies have demonstrated the recurrence of mutations in the same entity.
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+**Tier 1** Genes can transition to Tier 1 only after additional studies have demonstrated the recurrence of mutations in the same entity.
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### Gene Designations
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-**aSHM**
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-Denotes genes documented as being affected by aberrant somatic hypermutation (aSHM). Tier 1 and Tier 2 genes can have this designation, respectively abbreviated as *1-a* and *2-a*. For example, see [BCL7A](BCL7A).
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+**aSHM** Denotes genes documented as being affected by aberrant somatic hypermutation (aSHM). Tier 1 and Tier 2 genes can have this designation, respectively abbreviated as *1-a* and *2-a*. For example, see [BCL7A](BCL7A).
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```mermaid
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