DLBCL_genes.md
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@@ -50,7 +50,7 @@ link-citations: true
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|[EZH2](EZH2)|Tier 1 GE[@morinSomaticMutationsAltering2010a], FE[@yapSomaticMutationsEZH22011b]|[Morin et al](papers/morinSomaticMutationsAltering2010a)|[@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]||
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|[FAS](FAS)|Tier 1 GE[@schollMutationsRegionFAS2007], FE[@seebergerLossFasCD952001]|[Scholl et al](papers/schollMutationsRegionFAS2007)|[@spinaGeneticsNodalMarginal2016b]||
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|[FBXO11](FBXO11)|Tier 1 GE[@hubschmannMutationalMechanismsShaping2021b], FE[@schneiderFBXO11InactivationLeads2016b]|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)|[@parryWholeExomeSequencing2013; @richterRecurrentMutationID32012a]||
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-|[FBXW7](FBXW7)|Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013]|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)|||
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+|[FBXW7](FBXW7)|Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@saffieFBXW7TriggersDegradation2020b]|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)|||
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|[FOXO1](FOXO1)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@trinhAnalysisFOXO1Mutations], CE[@trinhAnalysisFOXO1Mutations]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]||
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|[GNA13](GNA13)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@muppidiLossSignalingGa132014b]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@loveGeneticLandscapeMutations2012; @reichelFlowSortingExome2015a]||
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|[GNAI2](GNAI2)|Tier 1 GE[@morinMutationalStructuralAnalysis2013]|[Morin et al](papers/morinMutationalStructuralAnalysis2013)|[@grandeGenomewideDiscoverySomatic2019]||
morinlab.bib
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@@ -1,3 +1,23 @@
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+@article{saffieFBXW7TriggersDegradation2020b,
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+ title = {{{FBXW7 Triggers Degradation}} of {{KMT2D}} to {{Favor Growth}} of {{Diffuse Large B-cell Lymphoma Cells}}},
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+ author = {Saffie, Rizwan and Zhou, Nan and Rolland, Delphine and Önder, Özlem and Basrur, Venkatesha and Campbell, Sydney and Wellen, Kathryn E. and Elenitoba-Johnson, Kojo S. J. and Capell, Brian C. and Busino, Luca},
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+ date = {2020-06-15},
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+ journaltitle = {Cancer Research},
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+ shortjournal = {Cancer Res},
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+ volume = {80},
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+ number = {12},
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+ eprint = {32350066},
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+ eprinttype = {pmid},
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+ pages = {2498--2511},
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+ issn = {1538-7445},
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+ doi = {10.1158/0008-5472.CAN-19-2247},
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+ abstract = {Mature B-cell neoplasms are the fifth most common neoplasm. Due to significant heterogeneity at the clinical and genetic levels, current therapies for these cancers fail to provide long-term cures. The clinical success of proteasome inhibition for the treatment of multiple myeloma and B-cell lymphomas has made the ubiquitin pathway an important emerging therapeutic target. In this study, we assessed the role of the E3 ligase FBXW7 in mature B-cell neoplasms. FBXW7 targeted the frequently inactivated tumor suppressor KMT2D for protein degradation, subsequently regulating gene expression signatures related to oxidative phosphorylation (OxPhos). Loss of FBXW7 inhibited diffuse large B-cell lymphoma cell growth and further sensitized cells to OxPhos inhibition. These data elucidate a novel mechanism of regulation of KMT2D levels by the ubiquitin pathway and uncover a role of FBXW7 in regulating oxidative phosphorylation in B-cell malignancies. SIGNIFICANCE: These findings characterize FBXW7 as a prosurvival factor in B-cell lymphoma via degradation of the chromatin modifier KMT2D.},
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+ langid = {english},
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+ pmcid = {PMC7417195},
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+ keywords = {Animals,Cell Line Tumor,Cell Proliferation,Chromatin,DNA-Binding Proteins,F-Box-WD Repeat-Containing Protein 7,Female,Gene Expression Regulation Neoplastic,Gene Knockout Techniques,HEK293 Cells,Humans,Lymphoma Large B-Cell Diffuse,Mice,Neoplasm Proteins,Oxidative Phosphorylation,Proteolysis,RNA Small Interfering,Signal Transduction,Ubiquitin,Xenograft Model Antitumor Assays},
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+ file = {/Users/rmorin/Zotero/storage/5KJ466DP/Saffie et al. - 2020 - FBXW7 Triggers Degradation of KMT2D to Favor Growt.pdf}
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+}
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+
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@article{schneiderFBXO11InactivationLeads2016b,
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title = {{{FBXO11}} Inactivation Leads to Abnormal Germinal-Center Formation and Lymphoproliferative Disease},
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author = {Schneider, Christof and Kon, Ning and Amadori, Letizia and Shen, Qiong and Schwartz, Friederike H. and Tischler, Benjamin and Bossennec, Marion and Dominguez-Sola, David and Bhagat, Govind and Gu, Wei and Basso, Katia and Dalla-Favera, Riccardo},