GRB2.md
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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-|BL |2 |relevance in BL not firmly established|
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|DLBCL |1 |high-confidence DLBCL gene |
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+|BL |2 |relevance in BL seems unlikely|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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|Entity|source |frequency (%)|
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|:------:|:---------------------:|:-------------:|
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-|BL |GAMBL genomes+capture|0.46 |
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-|BL |Thomas cohort |0.40 |
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-|BL |Panea cohort |1.00 |
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|DLBCL |GAMBL genomes |3.25 |
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|DLBCL |Schmitz cohort |2.77 |
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|DLBCL |Reddy cohort |1.50 |
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|DLBCL |Chapuy cohort |2.99 |
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+|BL |GAMBL genomes+capture|0.46 |
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+|BL |Thomas cohort |0.40 |
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+|BL |Panea cohort |1.00 |
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## Mutation pattern and selective pressure estimates
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|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
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|:------:|:----:|:---------------------:|:----------------:|:----------------:|
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-|BL |No |No | 7.253 | 0.000 |
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|DLBCL |No |Yes |33.029 |168.982 |
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|FL |No |No | 8.575 | 0.000 |
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+|BL |No |No | 7.253 | 0.000 |
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> [!NOTE]