MCL1.md
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# MCL1
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-<<Warn("The variants reported in this gene in DLBCL failed QC")>>
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## Overview
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MCL1 (Myeloid Cell Leukemia 1) is a member of the BCL2 family of proteins that play a critical role in inhibiting apoptosis. It is frequently overexpressed and sometimes mutated in DLBCL.<sup>1,2</sup> Recurrent chromosomal gains and amplifications of the MCL1 locus occur are frequent in ABC-DLBCLs.<sup>1</sup> MCL1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
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## MCL1 Expression
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![](images/gene_expression/MCL1_by_pathology.svg)
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+## Representative Mutations
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+### DLBCL
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+![](primary/Reddy_MCL1_2.svg)
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+**Rating**
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+&starf; &starf; &star; &star; &star;
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+![](primary/Reddy_MCL1_3.svg)
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+**Rating**
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+&starf; &starf; &star; &star; &star;
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## All Mutations
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[Reddy_2074T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_2074T.html)