☰

Updated NFKBIA (markdown)

rdmorin committed 2024-05-22 16:47:23 -0700 commit 16a1f91f6a3c3dc74e2745404f5b37e507d7d8dc

				NFKBIA.md
			
          @@ -1,4 +1,6 @@

           # NFKBIA

          +## Overview

          +NFKBIA encodes IκBα, an inhibitor of NF-κB, which regulates the NF-κB signaling pathway by preventing the translocation of NF-κB to the nucleus. Mutations in NFKBIA can disrupt this regulation, leading to constitutive activation of NF-κB signaling, which has an important role in a subset of DLBCLs. Mutations and deletions in NFKBIA are observed in DLBCL and are associated with constitutive activation of the NF-κB pathway. These mutations often occur in the ABC subtype and are associated with the **ST2** genetic subgroup of DLBCL.

           ## Relevance tier by entity

...	...	@@ -1,4 +1,6 @@
1	1	# NFKBIA
	2	+## Overview
	3	+NFKBIA encodes IκBα, an inhibitor of NF-κB, which regulates the NF-κB signaling pathway by preventing the translocation of NF-κB to the nucleus. Mutations in NFKBIA can disrupt this regulation, leading to constitutive activation of NF-κB signaling, which has an important role in a subset of DLBCLs. Mutations and deletions in NFKBIA are observed in DLBCL and are associated with constitutive activation of the NF-κB pathway. These mutations often occur in the ABC subtype and are associated with the ST2 genetic subgroup of DLBCL.
2	4
3	5	## Relevance tier by entity
4	6