ACTB.md
... ...
@@ -45,7 +45,7 @@ timeline
45 45
|:--------:|:----------:|:--------:|:---------------------------------------------------------------------------------------:|:------------------:|
46 46
|chr7 |5568297 |5570856 |[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr7%3A5568297%2D5570856)|active_promoter |
47 47
48
- ## ACTB Hotspots
48
+## ACTB Hotspots
49 49
50 50
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
51 51
| :---:| :---: | :--: | :---: |
ALPK2.md
... ...
@@ -32,7 +32,7 @@ timeline
32 32
33 33
34 34
35
- ## ALPK2 Hotspots
35
+## ALPK2 Hotspots
36 36
37 37
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
38 38
| :---:| :---: | :--: | :---: |
ATP6V1B2.md
... ...
@@ -31,7 +31,7 @@ timeline
31 31
32 32
33 33
34
- ## ATP6V1B2 Hotspots
34
+## ATP6V1B2 Hotspots
35 35
36 36
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
37 37
| :---:| :---: | :--: | :---: |
B2M.md
... ...
@@ -47,7 +47,7 @@ timeline
47 47
48 48
49 49
50
- ## B2M Hotspots
50
+## B2M Hotspots
51 51
52 52
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
53 53
| :---:| :---: | :--: | :---: |
BCL10.md
... ...
@@ -43,7 +43,7 @@ timeline
43 43
|FL |No |Yes | 0.000 |223.832 |
44 44
45 45
46
- ## BCL10 Hotspots
46
+## BCL10 Hotspots
47 47
48 48
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
49 49
| :---:| :---: | :--: | :---: |
BCL11A.md
... ...
@@ -37,7 +37,7 @@ BCL11A (B-cell lymphoma/leukemia 11A) is a transcription factor involved in the
37 37
38 38
39 39
40
- ## BCL11A Hotspots
40
+## BCL11A Hotspots
41 41
42 42
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
43 43
| :---:| :---: | :--: | :---: |
BCL2.md
... ...
@@ -54,7 +54,7 @@ timeline
54 54
55 55
56 56
57
- ## BCL2 Hotspots
57
+## BCL2 Hotspots
58 58
59 59
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
60 60
| :---:| :---: | :--: | :---: |
BCL6.md
... ...
@@ -54,7 +54,7 @@ timeline
54 54
55 55
56 56
57
- ## BCL6 Hotspots
57
+## BCL6 Hotspots
58 58
59 59
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
60 60
| :---:| :---: | :--: | :---: |
BCOR.md
... ...
@@ -40,7 +40,7 @@ timeline
40 40
41 41
42 42
43
- ## BCOR Hotspots
43
+## BCOR Hotspots
44 44
45 45
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
46 46
| :---:| :---: | :--: | :---: |
BCR.md
... ...
@@ -31,7 +31,7 @@ BCR (Breakpoint Cluster Region Protein) is one of [a number of genes](https://gi
31 31
32 32
33 33
34
- ## BCR Hotspots
34
+## BCR Hotspots
35 35
36 36
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
37 37
| :---:| :---: | :--: | :---: |
BIRC6.md
... ...
@@ -42,7 +42,7 @@ timeline
42 42
|DLBCL |No |No |1.795 |5.011 |
43 43
|FL |No |No |2.997 |7.132 |
44 44
45
- ## BIRC6 Hotspots
45
+## BIRC6 Hotspots
46 46
47 47
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
48 48
| :---:| :---: | :--: | :---: |
BMP7.md
... ...
@@ -33,7 +33,7 @@ timeline
33 33
34 34
35 35
36
- ## BMP7 Hotspots
36
+## BMP7 Hotspots
37 37
38 38
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
39 39
| :---:| :---: | :--: | :---: |
BRAF.md
... ...
@@ -42,7 +42,7 @@ timeline
42 42
43 43
44 44
45
- ## BRAF Hotspots
45
+## BRAF Hotspots
46 46
47 47
**V600E** The V600E mutation, which is common in other cancers including hairy cell leukemia, is observed in some DLBCL patients. This mutation mimics phosphorylation and leads to constitutive activation of the BRAF kinase. As a result, the V600E mutant continuously activates the MAPK/ERK signaling pathway, promoting cell proliferation and survival even in the absence of growth signals.
48 48
BTG1.md
... ...
@@ -49,7 +49,7 @@ timeline
49 49
|:--------:|:----------:|:--------:|:------------------------------------------------------------------------------------------:|:------------------:|
50 50
|chr12 |92537999 |92539598|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr12%3A92537999%2D92539598)|active_promoter |
51 51
52
- ## BTG1 Hotspots
52
+## BTG1 Hotspots
53 53
54 54
*Q36H* Conditional knock-in mouse models expressing the BTG1 Q36H mutation in B cells have shown that these mutations lead to earlier onset of lymphoma, shorter survival, and dysplastic B cell infiltration into non-lymphoid organs. These findings reinforce the role of BTG1 mutations in enhancing lymphoma aggressiveness.<sup>3</sup>
55 55
CAD.md
... ...
@@ -33,7 +33,7 @@ timeline
33 33
34 34
35 35
36
- ## CAD Hotspots
36
+## CAD Hotspots
37 37
38 38
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
39 39
| :---:| :---: | :--: | :---: |
CARD11.md
... ...
@@ -46,7 +46,7 @@ timeline
46 46
|FL |No |Yes |28.329 |27.096 |
47 47
48 48
49
- ## CARD11 Hotspots
49
+## CARD11 Hotspots
50 50
51 51
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
52 52
| :---:| :---: | :--: | :---: |
CD70.md
... ...
@@ -40,7 +40,7 @@ timeline
40 40
|FL |No |No | 0.000 |106.251 |
41 41
42 42
43
- ## CD70 Hotspots
43
+## CD70 Hotspots
44 44
45 45
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
46 46
| :---:| :---: | :--: | :---: |
CD79A.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
37 37
38 38
39
- ## CD79A Hotspots
39
+## CD79A Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
CD79B.md
... ...
@@ -41,7 +41,7 @@ timeline
41 41
|FL |No |No |10.310 | 0.000 |
42 42
43 43
44
- ## CD79B Hotspots
44
+## CD79B Hotspots
45 45
46 46
Mutations at Y196 enhance B-cell receptor (BCR) signaling by preventing the negative regulatory feedback provided by Lyn kinase, a feedback inhibitor of BCR signaling. This results in continuous activation of the NF-κB pathway, promoting tumor cell survival and proliferation.<sup>4</sup>
47 47
CREBBP.md
... ...
@@ -47,7 +47,7 @@ timeline
47 47
|FL |No |Yes |43.869 |112.938 |
48 48
49 49
50
- ## CREBBP Hotspots
50
+## CREBBP Hotspots
51 51
52 52
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
53 53
| :---:| :---: | :--: | :---: |
CTSS.md
... ...
@@ -32,7 +32,7 @@ timeline
32 32
33 33
34 34
35
- ## CTSS Hotspots
35
+## CTSS Hotspots
36 36
37 37
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
38 38
| :---:| :---: | :--: | :---: |
DAZAP1.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
|FL |No |No |0 |53.351 |
37 37
38 38
39
- ## DAZAP1 Hotspots
39
+## DAZAP1 Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
DNM2.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
|FL |No |No |10.522 |0.000 |
35 35
36 36
37
- ## DNM2 Hotspots
37
+## DNM2 Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |
DTX1.md
... ...
@@ -51,7 +51,7 @@ timeline
51 51
|chr12 |113492311 |113497546|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr12%3A113492311%2D113497546)|NA |
52 52
53 53
54
- ## DTX1 Hotspots
54
+## DTX1 Hotspots
55 55
56 56
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
57 57
| :---:| :---: | :--: | :---: |
DUSP2.md
... ...
@@ -46,7 +46,7 @@ timeline
46 46
47 47
48 48
49
- ## DUSP2 Hotspots
49
+## DUSP2 Hotspots
50 50
51 51
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
52 52
| :---:| :---: | :--: | :---: |
EBF1.md
... ...
@@ -51,7 +51,7 @@ timeline
51 51
52 52
53 53
54
- ## EBF1 Hotspots
54
+## EBF1 Hotspots
55 55
56 56
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
57 57
| :---:| :---: | :--: | :---: |
EEF1A1.md
... ...
@@ -40,7 +40,7 @@ timeline
40 40
|DLBCL |No |No | 3.556 |24.091 |
41 41
|FL |No |Yes |47.451 | 0.000 |
42 42
43
- ## EEF1A1 Hotspots
43
+## EEF1A1 Hotspots
44 44
45 45
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
46 46
| :---:| :---: | :--: | :---: |
EP300.md
... ...
@@ -45,7 +45,7 @@ timeline
45 45
46 46
47 47
48
- ## EP300 Hotspots
48
+## EP300 Hotspots
49 49
50 50
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
51 51
| :---:| :---: | :--: | :---: |
EPPK1.md
... ...
@@ -32,7 +32,7 @@ timeline
32 32
|FL |No |No |2.802 |0.0 |
33 33
34 34
35
- ## EPPK1 Hotspots
35
+## EPPK1 Hotspots
36 36
37 37
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
38 38
| :---:| :---: | :--: | :---: |
ETS1.md
... ...
@@ -46,7 +46,7 @@ timeline
46 46
|chr11 |128339774 |128345731|[intron](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr11%3A128339774%2D128345731)|enhancer |
47 47
|chr11 |128388492 |128394163|[TSS-2](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr11%3A128388492%2D128394163) |active_promoter |
48 48
49
- ## ETS1 Hotspots
49
+## ETS1 Hotspots
50 50
51 51
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
52 52
| :---:| :---: | :--: | :---: |
ETV6.md
... ...
@@ -42,7 +42,7 @@ timeline
42 42
43 43
44 44
45
- ## ETV6 Hotspots
45
+## ETV6 Hotspots
46 46
47 47
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
48 48
| :---:| :---: | :--: | :---: |
EZH2.md
... ...
@@ -50,7 +50,7 @@ timeline
50 50
51 51
52 52
53
- ## EZH2 Hotspots
53
+## EZH2 Hotspots
54 54
55 55
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
56 56
| :---:| :---: | :--: | :---: |
FOXO1.md
... ...
@@ -46,7 +46,7 @@ timeline
46 46
47 47
48 48
49
- ## FOXO1 Hotspots
49
+## FOXO1 Hotspots
50 50
51 51
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
52 52
| :---:| :---: | :--: | :---: |
FUBP1.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
35 35
36 36
37
- ## FUBP1 Hotspots
37
+## FUBP1 Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |
GNA13.md
... ...
@@ -45,7 +45,7 @@ timeline
45 45
46 46
47 47
48
- ## GNA13 Hotspots
48
+## GNA13 Hotspots
49 49
50 50
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
51 51
| :---:| :---: | :--: | :---: |
GNAI2.md
... ...
@@ -44,7 +44,7 @@ timeline
44 44
|FL |No |Yes |55.205 | 0.000 |
45 45
46 46
47
- ## GNAI2 Hotspots
47
+## GNAI2 Hotspots
48 48
49 49
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
50 50
| :---:| :---: | :--: | :---: |
HIST1H1E.md
... ...
@@ -47,7 +47,7 @@ timeline
47 47
|FL |No |Yes |10.043 |0.000 |
48 48
49 49
50
- ## HIST1H1E Hotspots
50
+## HIST1H1E Hotspots
51 51
52 52
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
53 53
| :---:| :---: | :--: | :---: |
HIST1H2AC.md
... ...
@@ -1,6 +1,6 @@
1 1
# HIST1H2AC
2 2
This gene encodes the H2A protein, one of the core proteins comprising nucleosomes. Although relatively common in DLBCL, little is known about the function of these mutations.
3
- ## History
3
+## History
4 4
```mermaid
5 5
%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
6 6
timeline
... ...
@@ -37,7 +37,7 @@ timeline
37 37
38 38
39 39
40
- ## HIST1H2AC Hotspots
40
+## HIST1H2AC Hotspots
41 41
42 42
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
43 43
| :---:| :---: | :--: | :---: |
HIST1H2AG.md
... ...
@@ -43,7 +43,7 @@ timeline
43 43
44 44
45 45
46
- ## HIST1H2AG Hotspots
46
+## HIST1H2AG Hotspots
47 47
48 48
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
49 49
| :---:| :---: | :--: | :---: |
HIST1H2AM.md
... ...
@@ -40,7 +40,7 @@ timeline
40 40
|FL |No |No |1.845 |0 |
41 41
|BL |No |No |2.149 |0 |
42 42
43
- ## HIST1H2AM Hotspots
43
+## HIST1H2AM Hotspots
44 44
45 45
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
46 46
| :---:| :---: | :--: | :---: |
HIST1H2BC.md
... ...
@@ -41,7 +41,7 @@ timeline
41 41
42 42
43 43
44
- ## HIST1H2BC Hotspots
44
+## HIST1H2BC Hotspots
45 45
46 46
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
47 47
| :---:| :---: | :--: | :---: |
HIST1H3B.md
... ...
@@ -38,7 +38,7 @@ timeline
38 38
39 39
40 40
41
- ## HIST1H3B Hotspots
41
+## HIST1H3B Hotspots
42 42
43 43
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
44 44
| :---:| :---: | :--: | :---: |
HIST1H3D.md
... ...
@@ -33,7 +33,7 @@ timeline
33 33
34 34
35 35
36
- ## HIST1H3D Hotspots
36
+## HIST1H3D Hotspots
37 37
38 38
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
39 39
| :---:| :---: | :--: | :---: |
HIST1H3J.md
... ...
@@ -33,7 +33,7 @@ timeline
33 33
34 34
35 35
36
- ## HIST1H3J Hotspots
36
+## HIST1H3J Hotspots
37 37
38 38
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
39 39
| :---:| :---: | :--: | :---: |
HLA-A.md
... ...
@@ -40,7 +40,7 @@ timeline
40 40
41 41
42 42
43
- ## HLA-A Hotspots
43
+## HLA-A Hotspots
44 44
45 45
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
46 46
| :---:| :---: | :--: | :---: |
HLA-B.md
... ...
@@ -43,7 +43,7 @@ timeline
43 43
44 44
45 45
46
- ## HLA-B Hotspots
46
+## HLA-B Hotspots
47 47
48 48
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
49 49
| :---:| :---: | :--: | :---: |
HNRNPH1.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
|DLBCL |No |No |2.337 |10.139 |
37 37
|FL |No |No |0.000 | 0.000 |
38 38
39
- ## HNRNPH1 Hotspots
39
+## HNRNPH1 Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
HVCN1.md
... ...
@@ -41,7 +41,7 @@ timeline
41 41
42 42
43 43
44
- ## HVCN1 Hotspots
44
+## HVCN1 Hotspots
45 45
46 46
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
47 47
| :---:| :---: | :--: | :---: |
IKZF3.md
... ...
@@ -46,7 +46,7 @@ timeline
46 46
|chr17 |38015776 |38024832|[TSS-2](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr17%3A38015776%2D38024832)|NA |
47 47
48 48
49
- ## IKZF3 Hotspots
49
+## IKZF3 Hotspots
50 50
51 51
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
52 52
| :---:| :---: | :--: | :---: |
IL4R.md
... ...
@@ -43,7 +43,7 @@ timeline
43 43
44 44
45 45
46
- ## IL4R Hotspots
46
+## IL4R Hotspots
47 47
48 48
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
49 49
| :---:| :---: | :--: | :---: |
IRF4.md
... ...
@@ -45,7 +45,7 @@ timeline
45 45
46 46
47 47
48
- ## IRF4 Hotspots
48
+## IRF4 Hotspots
49 49
50 50
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
51 51
| :---:| :---: | :--: | :---: |
IRF8.md
... ...
@@ -49,7 +49,7 @@ timeline
49 49
|chr16 |85931918 |85933977|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr16%3A85931918%2D85933977)|active_promoter |
50 50
51 51
52
- ## IRF8 Hotspots
52
+## IRF8 Hotspots
53 53
54 54
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
55 55
| :---:| :---: | :--: | :---: |
ITPKB.md
... ...
@@ -46,7 +46,7 @@ timeline
46 46
|chr1 |226921088 |226927982|[intron-1](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr1%3A226921088%2D226927982)|enhancer |
47 47
48 48
49
- ## ITPKB Hotspots
49
+## ITPKB Hotspots
50 50
51 51
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
52 52
| :---:| :---: | :--: | :---: |
JAK1.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
37 37
38 38
39
- ## JAK1 Hotspots
39
+## JAK1 Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
KLF2.md
... ...
@@ -45,7 +45,7 @@ timeline
45 45
|:--------:|:----------:|:--------:|:------------------------------------------------------------------------------------------:|:------------------:|
46 46
|chr19 |16434978 |16439011|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr19%3A16434978%2D16439011)|intron |
47 47
48
- ## KLF2 Hotspots
48
+## KLF2 Hotspots
49 49
50 50
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
51 51
| :---:| :---: | :--: | :---: |
KLHL14.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
37 37
38 38
39
- ## KLHL14 Hotspots
39
+## KLHL14 Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
KLHL6.md
... ...
@@ -49,7 +49,7 @@ timeline
49 49
|:--------:|:----------:|:---------:|:-------------------------------------------------------------------------------------------:|:-------------------------------:|
50 50
|chr3 |183269360 |183274139|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A183269360%2D183274139)|active_promoter-strong_enhancer|
51 51
52
- ## KLHL6 Hotspots
52
+## KLHL6 Hotspots
53 53
54 54
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
55 55
| :---:| :---: | :--: | :---: |
KRAS.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
37 37
38 38
39
- ## KRAS Hotspots
39
+## KRAS Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
MAGEC1.md
... ...
@@ -31,7 +31,7 @@ timeline
31 31
32 32
33 33
34
- ## MAGEC1 Hotspots
34
+## MAGEC1 Hotspots
35 35
36 36
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
37 37
| :---:| :---: | :--: | :---: |
MAP2K1.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
37 37
38 38
39
- ## MAP2K1 Hotspots
39
+## MAP2K1 Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
MTOR.md
... ...
@@ -41,7 +41,7 @@ timeline
41 41
42 42
43 43
44
- ## MTOR Hotspots
44
+## MTOR Hotspots
45 45
46 46
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
47 47
| :---:| :---: | :--: | :---: |
MYC.md
... ...
@@ -53,7 +53,7 @@ timeline
53 53
54 54
55 55
56
- ## MYC Hotspots
56
+## MYC Hotspots
57 57
58 58
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
59 59
| :---:| :---: | :--: | :---: |
MYD88.md
... ...
@@ -40,7 +40,7 @@ timeline
40 40
41 41
42 42
43
- ## MYD88 Hotspots
43
+## MYD88 Hotspots
44 44
45 45
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
46 46
| :---:| :---: | :--: | :---: |
NCOR2.md
... ...
@@ -44,7 +44,7 @@ timeline
44 44
45 45
46 46
47
- ## NCOR2 Hotspots
47
+## NCOR2 Hotspots
48 48
49 49
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
50 50
| :---:| :---: | :--: | :---: |
NFKB1.md
... ...
@@ -29,7 +29,7 @@ Mutations in this gene are relatively rare in DLBCL overall. Some hotspots have
29 29
30 30
31 31
32
- ## NFKB1 Hotspots
32
+## NFKB1 Hotspots
33 33
34 34
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
35 35
| :---:| :---: | :--: | :---: |
NOL9.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
37 37
38 38
39
- ## NOL9 Hotspots
39
+## NOL9 Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
NOTCH1.md
... ...
@@ -43,7 +43,7 @@ timeline
43 43
|FL |No |No |2.864 |0 |
44 44
45 45
46
- ## NOTCH1 Hotspots
46
+## NOTCH1 Hotspots
47 47
48 48
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
49 49
| :---:| :---: | :--: | :---: |
NOTCH2.md
... ...
@@ -43,7 +43,7 @@ timeline
43 43
44 44
45 45
46
- ## NOTCH2 Hotspots
46
+## NOTCH2 Hotspots
47 47
48 48
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
49 49
| :---:| :---: | :--: | :---: |
PCBP1.md
... ...
@@ -39,7 +39,7 @@ timeline
39 39
40 40
41 41
42
- ## PCBP1 Hotspots
42
+## PCBP1 Hotspots
43 43
44 44
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
45 45
| :---:| :---: | :--: | :---: |
PCLO.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
|FL |No |No |0.000 |0.000 |
37 37
38 38
39
- ## PCLO Hotspots
39
+## PCLO Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
PIK3CD.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
35 35
36 36
37
- ## PIK3CD Hotspots
37
+## PIK3CD Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |
PIM1.md
... ...
@@ -50,7 +50,7 @@ timeline
50 50
51 51
52 52
53
- ## PIM1 Hotspots
53
+## PIM1 Hotspots
54 54
55 55
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
56 56
| :---:| :---: | :--: | :---: |
PLCG2.md
... ...
@@ -33,7 +33,7 @@ timeline
33 33
34 34
35 35
36
- ## PLCG2 Hotspots
36
+## PLCG2 Hotspots
37 37
38 38
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
39 39
| :---:| :---: | :--: | :---: |
POU2AF1.md
... ...
@@ -45,7 +45,7 @@ timeline
45 45
46 46
47 47
48
- ## POU2AF1 Hotspots
48
+## POU2AF1 Hotspots
49 49
50 50
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
51 51
| :---:| :---: | :--: | :---: |
POU2F2.md
... ...
@@ -37,7 +37,7 @@ timeline
37 37
38 38
39 39
40
- ## POU2F2 Hotspots
40
+## POU2F2 Hotspots
41 41
42 42
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
43 43
| :---:| :---: | :--: | :---: |
PPP4C.md
... ...
@@ -29,7 +29,7 @@ timeline
29 29
|FL |No |No |43.394 | 0.000 |
30 30
31 31
32
- ## PPP4C Hotspots
32
+## PPP4C Hotspots
33 33
34 34
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
35 35
| :---:| :---: | :--: | :---: |
PRDM1.md
... ...
@@ -38,7 +38,7 @@ timeline
38 38
39 39
40 40
41
- ## PRDM1 Hotspots
41
+## PRDM1 Hotspots
42 42
43 43
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
44 44
| :---:| :---: | :--: | :---: |
PTPRD.md
... ...
@@ -38,7 +38,7 @@ timeline
38 38
39 39
40 40
41
- ## PTPRD Hotspots
41
+## PTPRD Hotspots
42 42
43 43
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
44 44
| :---:| :---: | :--: | :---: |
RAC2.md
... ...
@@ -38,7 +38,7 @@ timeline
38 38
|DLBCL |No |No |6.256 |0 |
39 39
|FL |No |No |0.000 |0 |
40 40
41
- ## RAC2 Hotspots
41
+## RAC2 Hotspots
42 42
43 43
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
44 44
| :---:| :---: | :--: | :---: |
RHOA.md
... ...
@@ -39,7 +39,7 @@ timeline
39 39
40 40
41 41
42
- ## RHOA Hotspots
42
+## RHOA Hotspots
43 43
44 44
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
45 45
| :---:| :---: | :--: | :---: |
SETD1B.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
35 35
36 36
37
- ## SETD1B Hotspots
37
+## SETD1B Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |
SF3B1.md
... ...
@@ -38,7 +38,7 @@ timeline
38 38
39 39
40 40
41
- ## SF3B1 Hotspots
41
+## SF3B1 Hotspots
42 42
43 43
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
44 44
| :---:| :---: | :--: | :---: |
SPEN.md
... ...
@@ -37,7 +37,7 @@ timeline
37 37
38 38
39 39
40
- ## SPEN Hotspots
40
+## SPEN Hotspots
41 41
42 42
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
43 43
| :---:| :---: | :--: | :---: |
STAT3.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
35 35
36 36
37
- ## STAT3 Hotspots
37
+## STAT3 Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |
STAT6.md
... ...
@@ -41,7 +41,7 @@ timeline
41 41
42 42
43 43
44
- ## STAT6 Hotspots
44
+## STAT6 Hotspots
45 45
46 46
Recurrent mutations at the D419 amino acid residue are a common feature in DLBCL, specifically affecting the germinal center B (GCB) cell subtype. These mutations lead to the activation of the JAK/STAT signaling pathway, contributing to lymphomagenesis (Morin et al., 2015).
47 47
TBL1XR1.md
... ...
@@ -37,7 +37,7 @@ timeline
37 37
|FL |No |No |12.400 |18.940 |
38 38
39 39
40
- ## TBL1XR1 Hotspots
40
+## TBL1XR1 Hotspots
41 41
42 42
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
43 43
| :---:| :---: | :--: | :---: |
TCF3.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
35 35
36 36
37
- ## TCF3 Hotspots
37
+## TCF3 Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |
TLR2.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
|DLBCL |No |No |3.705 |0 |
35 35
|FL |No |No |0.000 |0 |
36 36
37
- ## TLR2 Hotspots
37
+## TLR2 Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |
TMEM30A.md
... ...
@@ -35,7 +35,7 @@ timeline
35 35
36 36
37 37
38
- ## TMEM30A Hotspots
38
+## TMEM30A Hotspots
39 39
40 40
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
41 41
| :---:| :---: | :--: | :---: |
TNFAIP3.md
... ...
@@ -39,7 +39,7 @@ timeline
39 39
40 40
41 41
42
- ## TNFAIP3 Hotspots
42
+## TNFAIP3 Hotspots
43 43
44 44
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
45 45
| :---:| :---: | :--: | :---: |
TNFRSF14.md
... ...
@@ -37,7 +37,7 @@ timeline
37 37
38 38
39 39
40
- ## TNFRSF14 Hotspots
40
+## TNFRSF14 Hotspots
41 41
42 42
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
43 43
| :---:| :---: | :--: | :---: |
TOX.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
35 35
36 36
37
- ## TOX Hotspots
37
+## TOX Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |
TRAF6.md
... ...
@@ -32,7 +32,7 @@ timeline
32 32
|FL |No |No |9.831 | 0.000 |
33 33
34 34
35
- ## TRAF6 Hotspots
35
+## TRAF6 Hotspots
36 36
37 37
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
38 38
| :---:| :---: | :--: | :---: |
TRRAP.md
... ...
@@ -36,7 +36,7 @@ timeline
36 36
37 37
38 38
39
- ## TRRAP Hotspots
39
+## TRRAP Hotspots
40 40
41 41
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
42 42
| :---:| :---: | :--: | :---: |
TTN.md
... ...
@@ -31,7 +31,7 @@ timeline
31 31
|FL |No |No |0.000 |0.000 |
32 32
33 33
34
- ## TTN Hotspots
34
+## TTN Hotspots
35 35
36 36
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
37 37
| :---:| :---: | :--: | :---: |
VPS13B.md
... ...
@@ -27,7 +27,7 @@
27 27
28 28
29 29
30
- ## VPS13B Hotspots
30
+## VPS13B Hotspots
31 31
32 32
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
33 33
| :---:| :---: | :--: | :---: |
WEE1.md
... ...
@@ -43,7 +43,7 @@ timeline
43 43
44 44
45 45
46
- ## WEE1 Hotspots
46
+## WEE1 Hotspots
47 47
48 48
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
49 49
| :---:| :---: | :--: | :---: |
WNK1.md
... ...
@@ -40,7 +40,7 @@ timeline
40 40
41 41
42 42
43
- ## WNK1 Hotspots
43
+## WNK1 Hotspots
44 44
45 45
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
46 46
| :---:| :---: | :--: | :---: |
WNK2.md
... ...
@@ -33,7 +33,7 @@ timeline
33 33
34 34
35 35
36
- ## WNK2 Hotspots
36
+## WNK2 Hotspots
37 37
38 38
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
39 39
| :---:| :---: | :--: | :---: |
XIRP2.md
... ...
@@ -31,7 +31,7 @@ timeline
31 31
32 32
33 33
34
- ## XIRP2 Hotspots
34
+## XIRP2 Hotspots
35 35
36 36
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
37 37
| :---:| :---: | :--: | :---: |
XPO1.md
... ...
@@ -34,7 +34,7 @@ timeline
34 34
|FL |No |No |0.000 |0 |
35 35
36 36
37
- ## XPO1 Hotspots
37
+## XPO1 Hotspots
38 38
39 39
| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
40 40
| :---:| :---: | :--: | :---: |