ACTG1.md
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+---
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+bibliography: 'morinlab.bib'
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+csl: 'NLM.csl'
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+link-citations: true
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+---
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+
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# ACTG1
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## Overview
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## History
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-Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschmann et al.<sup>1</sup>
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```mermaid
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%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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-|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
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-|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
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-|![FL](images/icons/FL_tier2.png)|2|relevance in FL not firmly established|
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
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+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@deschGenotypingCirculatingTumor2020]|
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+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@spinaGeneticsNodalMarginal2016b]|
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+|![FL](images/icons/FL_tier2.png)|2|relevance in FL not firmly established[@hubschmannMutationalMechanismsShaping2021b]|
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+|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene[@hubschmannMutationalMechanismsShaping2021b] |
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)