ABL2.md
... ...
@@ -0,0 +1,25 @@
1
+# [ABL2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0.69 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |2.14 |0 |
20
+|DLBCL |No |No |0.00 |0 |
21
+|FL |No |No |0.00 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Kalmbach S](https://pubmed.ncbi.nlm.nih.gov/37563306)
... ...
\ No newline at end of file
ACAD9.md
... ...
@@ -0,0 +1,27 @@
1
+# [ACAD9]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.358 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |5.352 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
ACE.md
... ...
@@ -0,0 +1,27 @@
1
+# [ACE]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |3.943 |0 |
22
+|DLBCL |No |No |0.545 |0 |
23
+|FL |No |No |1.256 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
ACTB.md
... ...
@@ -1,3 +1,4 @@
1
+# [ACTB]
1 2
2 3
## Mutation tier
3 4
ADAMTS5.md
... ...
@@ -0,0 +1,27 @@
1
+# [ADAMTS5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.77 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.451 |5.235 |
22
+|DLBCL |No |No |3.276 |0.000 |
23
+|FL |No |No |2.666 |0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
ADNP.md
... ...
@@ -0,0 +1,27 @@
1
+# [ADNP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.15 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.200 |17.917 |
22
+|DLBCL |No |No |1.866 | 0.000 |
23
+|FL |No |No |2.254 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
AGO4.md
... ...
@@ -0,0 +1,27 @@
1
+# [AGO4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.15 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.183 | 0.000 |
22
+|DLBCL |No |No |0.000 |11.202 |
23
+|FL |No |No |0.000 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
ALPK2.md
... ...
@@ -0,0 +1,27 @@
1
+# [ALPK2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.93 |
14
+|BL |Thomas cohort |5.10 |
15
+|BL |Panea cohort |9.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.951 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |1.538 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
ANKRD17.md
... ...
@@ -0,0 +1,28 @@
1
+# [ANKRD17]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.9 |
14
+|DLBCL |Schmitz cohort|4.3 |
15
+|DLBCL |Reddy cohort |3.8 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.047 |8.897 |
23
+|DLBCL |No |No |1.492 |4.437 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
ARHGEF1.md
... ...
@@ -0,0 +1,27 @@
1
+# [ARHGEF1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.93 |
14
+|BL |Thomas cohort |2.00 |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.954 |0.000 |
22
+|DLBCL |No |No |2.662 |9.372 |
23
+|FL |No |No |3.865 |0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2014 by [Muppidi JR](https://pubmed.ncbi.nlm.nih.gov/25274307)
... ...
\ No newline at end of file
ARID1A.md
... ...
@@ -1,3 +1,4 @@
1
+# [ARID1A]
1 2
2 3
## Mutation tier
3 4
... ...
@@ -34,4 +35,4 @@
34 35
35 36
36 37
> [!NOTE]
37
-> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
0
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
ARID1B.md
... ...
@@ -0,0 +1,28 @@
1
+# [ARID1B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |5.0 |
14
+|DLBCL |Schmitz cohort|6.0 |
15
+|DLBCL |Reddy cohort |3.3 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.659 | 4.236 |
23
+|DLBCL |No |No |0.969 |13.782 |
24
+|FL |No |No |0.747 |11.009 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
ARID5B.md
... ...
@@ -0,0 +1,28 @@
1
+# [ARID5B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.6 |
14
+|DLBCL |Schmitz cohort|4.3 |
15
+|DLBCL |Reddy cohort |4.3 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.378 |0 |
23
+|DLBCL |No |No |2.263 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
ATM.md
... ...
@@ -1,3 +1,4 @@
1
+# [ATM]
1 2
2 3
## Mutation tier
3 4
ATP2C2.md
... ...
@@ -0,0 +1,27 @@
1
+# [ATP2C2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.7 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.473 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |3.759 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
ATP6AP1.md
... ...
@@ -0,0 +1,22 @@
1
+# [ATP6AP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|4.85 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No | 0.000 | 0.000 |
20
+|DLBCL |No |No | 0.000 | 0.000 |
21
+|FL |No |Yes |50.635 |72.487 |
22
+
ATP6V1B2.md
... ...
@@ -0,0 +1,22 @@
1
+# [ATP6V1B2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|7.39 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No | 5.989 |0 |
20
+|DLBCL |No |No | 1.297 |0 |
21
+|FL |No |Yes |72.658 |0 |
22
+
ATR.md
... ...
@@ -0,0 +1,28 @@
1
+# [ATR]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.5 |
14
+|DLBCL |Schmitz cohort|4.9 |
15
+|DLBCL |Reddy cohort |2.8 |
16
+|DLBCL |Chapuy cohort |3.8 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.459 |0.000 |
23
+|DLBCL |No |No |1.146 |3.261 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
B2M.md
... ...
@@ -1,3 +1,4 @@
1
+# [B2M]
1 2
2 3
## Mutation tier
3 4
... ...
@@ -27,3 +28,4 @@
27 28
|BL |No |No | 9.379 | 56.571 |
28 29
|DLBCL |No |Yes |60.843 |340.788 |
29 30
|FL |No |Yes |54.190 |326.834 |
31
+
BACH2.md
... ...
@@ -0,0 +1,32 @@
1
+# [BACH2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort |0.40 |
15
+|BL |Panea cohort |5.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |Yes |No |0.652 | 0.000 |
22
+|DLBCL |Yes |No |0.949 | 0.000 |
23
+|FL |Yes |No |0.000 |28.997 |
24
+
25
+## aSHM regions
26
+
27
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
28
+|--------|----------|--------|------|------------------|
29
+|chr6 |90981034 |91016134|TSS |NA |
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
BCL10.md
... ...
@@ -0,0 +1,31 @@
1
+# [BCL10]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|0.23 |
16
+|BL |Thomas cohort |0.40 |
17
+|BL |Panea cohort | NA |
18
+|DLBCL |GAMBL genomes |4.10 |
19
+|DLBCL |Schmitz cohort |7.70 |
20
+|DLBCL |Reddy cohort |3.10 |
21
+|DLBCL |Chapuy cohort |6.40 |
22
+|FL |GAMBL genomes |2.31 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 3.224 | 0.000 |
29
+|DLBCL |No |Yes |13.754 |106.692 |
30
+|FL |No |Yes | 0.000 |223.832 |
31
+
BCL11A.md
... ...
@@ -0,0 +1,34 @@
1
+# [BCL11A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|2.54 |
15
+|BL |Thomas cohort |1.70 |
16
+|BL |Panea cohort |5.90 |
17
+|DLBCL |GAMBL genomes |3.60 |
18
+|DLBCL |Schmitz cohort |4.50 |
19
+|DLBCL |Reddy cohort |1.60 |
20
+|DLBCL |Chapuy cohort |3.40 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |No |4.455 | 0.000 |
27
+|DLBCL |Yes |Yes |5.279 |69.578 |
28
+|FL |Yes |No |1.180 | 0.000 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
33
+|--------|----------|--------|------|------------------|
34
+|chr2 |60773789 |60783486|TSS |active_promoter |
BCL2.md
... ...
@@ -0,0 +1,37 @@
1
+# [BCL2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 0.46 |
16
+|BL |Thomas cohort | 0.00 |
17
+|BL |Panea cohort | 1.00 |
18
+|DLBCL |GAMBL genomes |22.10 |
19
+|DLBCL |Schmitz cohort |10.60 |
20
+|DLBCL |Reddy cohort |12.90 |
21
+|DLBCL |Chapuy cohort |15.80 |
22
+|FL |GAMBL genomes |50.35 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No |0.000 |0 |
29
+|DLBCL |Yes |Yes |2.645 |0 |
30
+|FL |Yes |No |1.197 |0 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chr18 |60796984 |60814103|intron|strong_enhancer |
37
+|chr18 |60982728 |60988342|TSS |active_promoter |
BCL2L11.md
... ...
@@ -0,0 +1,29 @@
1
+# [BCL2L11]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort |2.10 |
15
+|BL |Panea cohort |1.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |Yes |Yes |15.763 |114.229 |
22
+|DLBCL |Yes |No | 5.483 | 0.000 |
23
+|FL |Yes |No | 0.000 | 0.000 |
24
+
25
+## aSHM regions
26
+
27
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
28
+|--------|----------|---------|------|------------------|
29
+|chr2 |111874854 |111882174|TSS |active_promoter |
BCL6.md
... ...
@@ -0,0 +1,44 @@
1
+# [BCL6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 5.08 |
16
+|BL |Thomas cohort | 3.40 |
17
+|BL |Panea cohort | 7.90 |
18
+|DLBCL |GAMBL genomes |13.30 |
19
+|DLBCL |Schmitz cohort | 9.80 |
20
+|DLBCL |Reddy cohort | 6.40 |
21
+|DLBCL |Chapuy cohort | 5.10 |
22
+|FL |GAMBL genomes | 5.77 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 7.427 | 0.000 |
29
+|DLBCL |Yes |Yes |25.672 |60.803 |
30
+|FL |Yes |Yes |27.215 |62.162 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end |region |regulatory_comment|
35
+|--------|----------|---------|------------|------------------|
36
+|chr3 |187458526 |187464632|TSS |NA |
37
+|chr3 |187615533 |187625659|Intergenic-1|NA |
38
+|chr3 |187625659 |187638101|Intergenic-2|NA |
39
+|chr3 |187657518 |187665996|Intergenic-3|NA |
40
+|chr3 |187675741 |187690717|Intergenic-4|NA |
41
+|chr3 |187690717 |187705000|Intergenic-5|NA |
42
+
43
+> [!NOTE]
44
+> First described in BL in 2019 by [Grande BM](https://pubmed.ncbi.nlm.nih.gov/30617194). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119). First described in FL in 2023 by [Dreval K](https://pubmed.ncbi.nlm.nih.gov/37084389)
... ...
\ No newline at end of file
BCL7A.md
... ...
@@ -0,0 +1,39 @@
1
+# [BCL7A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 5.31 |
16
+|BL |Thomas cohort | 5.50 |
17
+|BL |Panea cohort | 5.00 |
18
+|DLBCL |GAMBL genomes | 8.80 |
19
+|DLBCL |Schmitz cohort |10.60 |
20
+|DLBCL |Reddy cohort | 8.40 |
21
+|DLBCL |Chapuy cohort | 6.40 |
22
+|FL |GAMBL genomes |13.86 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |Yes | 9.127 | 46.248 |
29
+|DLBCL |Yes |Yes |22.635 | 0.000 |
30
+|FL |Yes |Yes |55.348 |146.110 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
35
+|--------|----------|---------|------|------------------|
36
+|chr12 |122456912 |122464036|TSS |poised_promoter |
37
+
38
+> [!NOTE]
39
+> First described in BL in 2019 by [Grande BM](https://pubmed.ncbi.nlm.nih.gov/30617194)
... ...
\ No newline at end of file
BCOR.md
... ...
@@ -0,0 +1,25 @@
1
+# [BCOR]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.9 |
14
+|DLBCL |Schmitz cohort|7.7 |
15
+|DLBCL |Reddy cohort |2.5 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.341 |0 |
23
+|DLBCL |No |No |2.471 |0 |
24
+|FL |No |No |1.743 |0 |
25
+
BCR.md
... ...
@@ -0,0 +1,37 @@
1
+# [BCR]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 6.0 |
15
+|BL |Thomas cohort | 6.4 |
16
+|BL |Panea cohort |10.9 |
17
+|DLBCL |GAMBL genomes | 4.5 |
18
+|DLBCL |Schmitz cohort | 6.4 |
19
+|DLBCL |Reddy cohort | 3.9 |
20
+|DLBCL |Chapuy cohort | 4.3 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |No |2.733 |2.641 |
27
+|DLBCL |Yes |No |1.249 |3.642 |
28
+|FL |Yes |No |7.439 |0.000 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
33
+|--------|----------|--------|------|------------------|
34
+|chr22 |23522060 |23528313|TSS |NA |
35
+
36
+> [!NOTE]
37
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
BIRC6.md
... ...
@@ -0,0 +1,31 @@
1
+# [BIRC6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 6.0 |
16
+|BL |Thomas cohort | 3.8 |
17
+|BL |Panea cohort |14.9 |
18
+|DLBCL |GAMBL genomes | 6.3 |
19
+|DLBCL |Schmitz cohort |10.0 |
20
+|DLBCL |Reddy cohort | 6.4 |
21
+|DLBCL |Chapuy cohort | 4.7 |
22
+|FL |GAMBL genomes | 3.7 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No |0.862 |1.339 |
29
+|DLBCL |No |No |1.795 |5.011 |
30
+|FL |No |No |2.997 |7.132 |
31
+
BMP7.md
... ...
@@ -0,0 +1,27 @@
1
+# [BMP7]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|6.47 |
14
+|BL |Thomas cohort |8.90 |
15
+|BL |Panea cohort |5.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |Yes |5.863 |16.044 |
22
+|DLBCL |No |No |6.236 |10.787 |
23
+|FL |No |No |1.371 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
BRAF.md
... ...
@@ -0,0 +1,32 @@
1
+# [BRAF]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|2.77 |
15
+|BL |Thomas cohort | NA |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes |2.50 |
18
+|DLBCL |Schmitz cohort |3.40 |
19
+|DLBCL |Reddy cohort |2.00 |
20
+|DLBCL |Chapuy cohort |5.60 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |4.754 |0 |
27
+|DLBCL |No |No |5.565 |0 |
28
+|FL |No |No |4.680 |0 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2012 by [Lohr JG](https://pubmed.ncbi.nlm.nih.gov/22343534)
... ...
\ No newline at end of file
BRD4.md
... ...
@@ -0,0 +1,27 @@
1
+# [BRD4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.342 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
BRINP3.md
... ...
@@ -0,0 +1,28 @@
1
+# [BRINP3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.7 |
14
+|DLBCL |Schmitz cohort|3.4 |
15
+|DLBCL |Reddy cohort |3.3 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |4.218 |0.00 |
23
+|DLBCL |No |No |1.138 |0.00 |
24
+|FL |No |No |1.586 |6.33 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
BTBD3.md
... ...
@@ -0,0 +1,28 @@
1
+# [BTBD3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.7 |
14
+|DLBCL |Schmitz cohort|1.9 |
15
+|DLBCL |Reddy cohort |1.8 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |5.604 |0 |
23
+|DLBCL |No |No |0.722 |0 |
24
+|FL |No |No |2.655 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
BTG1.md
... ...
@@ -0,0 +1,39 @@
1
+# [BTG1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 0.46 |
16
+|BL |Thomas cohort | NA |
17
+|BL |Panea cohort | NA |
18
+|DLBCL |GAMBL genomes | 9.70 |
19
+|DLBCL |Schmitz cohort |14.50 |
20
+|DLBCL |Reddy cohort | 7.50 |
21
+|DLBCL |Chapuy cohort |14.50 |
22
+|FL |GAMBL genomes | 6.47 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No |0.000 |0.000 |
29
+|DLBCL |Yes |No |0.498 |1.085 |
30
+|FL |Yes |No |4.407 |6.147 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chr12 |92537999 |92539598|TSS |active_promoter |
37
+
38
+> [!NOTE]
39
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
BTG2.md
... ...
@@ -0,0 +1,39 @@
1
+# [BTG2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 4.85 |
16
+|BL |Thomas cohort | 4.20 |
17
+|BL |Panea cohort | 9.90 |
18
+|DLBCL |GAMBL genomes |14.00 |
19
+|DLBCL |Schmitz cohort |17.20 |
20
+|DLBCL |Reddy cohort | 9.20 |
21
+|DLBCL |Chapuy cohort | 6.00 |
22
+|FL |GAMBL genomes | 4.39 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No |6.152 |42.280 |
29
+|DLBCL |Yes |Yes |3.562 |10.265 |
30
+|FL |Yes |No |6.073 | 0.000 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
35
+|--------|----------|---------|------|------------------|
36
+|chr1 |203274698 |203275778|intron|active_promoter |
37
+
38
+> [!NOTE]
39
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119). First described in FL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
BTK.md
... ...
@@ -0,0 +1,27 @@
1
+# [BTK]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |5.40 |
15
+|DLBCL |Schmitz cohort|3.60 |
16
+|DLBCL |Reddy cohort |3.10 |
17
+|DLBCL |Chapuy cohort |2.10 |
18
+|FL |GAMBL genomes |6.93 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No | 0.964 | 8.202 |
25
+|DLBCL |No |Yes |18.082 |28.027 |
26
+|FL |No |Yes |39.808 |35.548 |
27
+
C10orf12.md
... ...
@@ -0,0 +1,24 @@
1
+# [C10orf12]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.46 |
14
+|BL |Thomas cohort |0.00 |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.452 |27.236 |
22
+|DLBCL |No |Yes |1.140 |38.506 |
23
+|FL |No |Yes |3.190 |81.421 |
24
+
C6orf27.md
... ...
@@ -0,0 +1,24 @@
1
+# [C6orf27]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|NA |
14
+|BL |Thomas cohort |NA |
15
+|BL |Panea cohort |NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+
22
+
23
+> [!NOTE]
24
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
CAD.md
... ...
@@ -0,0 +1,27 @@
1
+# [CAD]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.93 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.965 |0 |
22
+|DLBCL |No |No |1.949 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
CARD11.md
... ...
@@ -0,0 +1,31 @@
1
+# [CARD11]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 4.16 |
16
+|BL |Thomas cohort | 1.70 |
17
+|BL |Panea cohort |10.90 |
18
+|DLBCL |GAMBL genomes | 9.90 |
19
+|DLBCL |Schmitz cohort |15.30 |
20
+|DLBCL |Reddy cohort | 7.80 |
21
+|DLBCL |Chapuy cohort | 8.10 |
22
+|FL |GAMBL genomes |14.78 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 5.307 | 0.000 |
29
+|DLBCL |No |Yes |16.898 | 0.000 |
30
+|FL |No |Yes |28.329 |27.096 |
31
+
CARD4.md
... ...
@@ -0,0 +1,24 @@
1
+# [CARD4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|NA |
14
+|BL |Thomas cohort |NA |
15
+|BL |Panea cohort |NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+
22
+
23
+> [!NOTE]
24
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
CASP8.md
... ...
@@ -0,0 +1,28 @@
1
+# [CASP8]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.7 |
14
+|DLBCL |Schmitz cohort|1.1 |
15
+|DLBCL |Reddy cohort |1.2 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |12.972 |0 |
23
+|DLBCL |No |No | 6.371 |0 |
24
+|FL |No |No | 8.788 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
CBLB.md
... ...
@@ -0,0 +1,28 @@
1
+# [CBLB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.6 |
14
+|DLBCL |Schmitz cohort|2.8 |
15
+|DLBCL |Reddy cohort |1.6 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.956 |0 |
23
+|DLBCL |No |No |2.519 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
CCL4.md
... ...
@@ -0,0 +1,28 @@
1
+# [CCL4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | NA |
14
+|DLBCL |Schmitz cohort|1.5 |
15
+|DLBCL |Reddy cohort |0.6 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |3.891 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
CCND3.md
... ...
@@ -0,0 +1,34 @@
1
+# [CCND3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|27.48 |
16
+|BL |Thomas cohort |28.00 |
17
+|BL |Panea cohort |17.80 |
18
+|DLBCL |GAMBL genomes | 6.80 |
19
+|DLBCL |Schmitz cohort | 9.80 |
20
+|DLBCL |Reddy cohort | 3.80 |
21
+|DLBCL |Chapuy cohort | 4.70 |
22
+|FL |GAMBL genomes | 3.23 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes |97.799 |360.774 |
29
+|DLBCL |No |Yes |19.557 | 60.833 |
30
+|FL |No |No |24.611 | 0.000 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2012 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/22885699). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119). First described in FL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
CCNF.md
... ...
@@ -0,0 +1,27 @@
1
+# [CCNF]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.194 |0 |
22
+|DLBCL |No |No |1.303 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2015 by [Abate F](https://pubmed.ncbi.nlm.nih.gov/26468873)
... ...
\ No newline at end of file
CCT6B.md
... ...
@@ -0,0 +1,27 @@
1
+# [CCT6B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.15 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.893 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
CD22.md
... ...
@@ -0,0 +1,28 @@
1
+# [CD22]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|1.7 |
15
+|DLBCL |Reddy cohort |2.8 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |4.287 |0 |
23
+|DLBCL |No |No |1.951 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
CD274.md
... ...
@@ -0,0 +1,28 @@
1
+# [CD274]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|2.3 |
15
+|DLBCL |Reddy cohort |1.3 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |5.538 | 0.000 |
23
+|DLBCL |No |No |2.633 |49.045 |
24
+|FL |No |No |4.631 |42.709 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
CD36.md
... ...
@@ -0,0 +1,25 @@
1
+# [CD36]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.5 |
14
+|DLBCL |Schmitz cohort|4.9 |
15
+|DLBCL |Reddy cohort |2.8 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |4.616 |0.000 |
23
+|DLBCL |No |No |0.822 |7.247 |
24
+|FL |No |No |1.559 |0.000 |
25
+
CD58.md
... ...
@@ -0,0 +1,29 @@
1
+# [CD58]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 0.92 |
15
+|BL |Thomas cohort | 0.80 |
16
+|BL |Panea cohort | 2.00 |
17
+|DLBCL |GAMBL genomes | 8.40 |
18
+|DLBCL |Schmitz cohort |10.00 |
19
+|DLBCL |Reddy cohort | 2.80 |
20
+|DLBCL |Chapuy cohort | 6.80 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |3.10 | 32.536 |
27
+|DLBCL |No |Yes |8.62 |292.453 |
28
+|FL |No |Yes |0.00 |107.458 |
29
+
CD70.md
... ...
@@ -0,0 +1,31 @@
1
+# [CD70]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|0.92 |
16
+|BL |Thomas cohort |0.40 |
17
+|BL |Panea cohort |3.00 |
18
+|DLBCL |GAMBL genomes |5.60 |
19
+|DLBCL |Schmitz cohort |9.40 |
20
+|DLBCL |Reddy cohort |6.90 |
21
+|DLBCL |Chapuy cohort |7.70 |
22
+|FL |GAMBL genomes |1.15 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 2.199 | 0.000 |
29
+|DLBCL |No |Yes |28.493 |249.836 |
30
+|FL |No |No | 0.000 |106.251 |
31
+
CD79A.md
... ...
@@ -0,0 +1,27 @@
1
+# [CD79A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.23 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.000 | 0.000 |
22
+|DLBCL |No |No |1.810 |16.146 |
23
+|FL |No |No |3.676 |33.801 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
CD79B.md
... ...
@@ -0,0 +1,31 @@
1
+# [CD79B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 1.39 |
16
+|BL |Thomas cohort | 0.00 |
17
+|BL |Panea cohort | 4.00 |
18
+|DLBCL |GAMBL genomes | 9.50 |
19
+|DLBCL |Schmitz cohort |14.90 |
20
+|DLBCL |Reddy cohort | 8.30 |
21
+|DLBCL |Chapuy cohort |15.40 |
22
+|FL |GAMBL genomes | 2.77 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 0.000 | 0.000 |
29
+|DLBCL |No |Yes |16.616 |41.932 |
30
+|FL |No |No |10.310 | 0.000 |
31
+
CD83.md
... ...
@@ -0,0 +1,39 @@
1
+# [CD83]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|1.15 |
16
+|BL |Thomas cohort |1.70 |
17
+|BL |Panea cohort | NA |
18
+|DLBCL |GAMBL genomes |4.50 |
19
+|DLBCL |Schmitz cohort |5.70 |
20
+|DLBCL |Reddy cohort |5.80 |
21
+|DLBCL |Chapuy cohort |7.30 |
22
+|FL |GAMBL genomes |1.85 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No |4.396 | 0.000 |
29
+|DLBCL |Yes |No |4.794 |14.227 |
30
+|FL |Yes |No |0.000 |25.732 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment |
35
+|--------|----------|--------|------|-------------------------------|
36
+|chr6 |14118026 |14120025|TSS |active_promoter-strong_enhancer|
37
+
38
+> [!NOTE]
39
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966). First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
CDC73.md
... ...
@@ -0,0 +1,32 @@
1
+# [CDC73]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|2.54 |
15
+|BL |Thomas cohort | NA |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes |0.70 |
18
+|DLBCL |Schmitz cohort |0.60 |
19
+|DLBCL |Reddy cohort |0.70 |
20
+|DLBCL |Chapuy cohort |1.30 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |3.951 |0 |
27
+|DLBCL |No |No |1.702 |0 |
28
+|FL |No |No |3.603 |0 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
CDH17.md
... ...
@@ -0,0 +1,27 @@
1
+# [CDH17]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.000 |0.000 |
22
+|DLBCL |No |No |0.635 |6.343 |
23
+|FL |No |No |0.000 |0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
CDKN2A.md
... ...
@@ -0,0 +1,26 @@
1
+# [CDKN2A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|1.85 |
15
+|BL |Thomas cohort |3.00 |
16
+|BL |Panea cohort |3.00 |
17
+|DLBCL |GAMBL genomes |2.90 |
18
+|DLBCL |Schmitz cohort |6.00 |
19
+|DLBCL |Reddy cohort |1.00 |
20
+|DLBCL |Chapuy cohort |1.70 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+
CDKN2C.md
... ...
@@ -0,0 +1,27 @@
1
+# [CDKN2C]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.54 |
14
+|BL |Thomas cohort |3.40 |
15
+|BL |Panea cohort |3.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |16.525 |50.872 |
22
+|DLBCL |No |No | 3.474 | 0.000 |
23
+|FL |No |No | 0.000 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2023 by [Thomas N](https://pubmed.ncbi.nlm.nih.gov/36201743)
... ...
\ No newline at end of file
CHD1.md
... ...
@@ -0,0 +1,28 @@
1
+# [CHD1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|3.0 |
15
+|DLBCL |Reddy cohort |2.9 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.674 |2.751 |
23
+|DLBCL |No |No |1.993 |4.965 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
CHD4.md
... ...
@@ -0,0 +1,27 @@
1
+# [CHD4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.93 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.781 |0 |
22
+|DLBCL |No |No |3.513 |0 |
23
+|FL |No |No |1.815 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
CHD8.md
... ...
@@ -0,0 +1,32 @@
1
+# [CHD8]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 8.78 |
15
+|BL |Thomas cohort | 8.50 |
16
+|BL |Panea cohort |16.80 |
17
+|DLBCL |GAMBL genomes | 1.80 |
18
+|DLBCL |Schmitz cohort | 3.60 |
19
+|DLBCL |Reddy cohort | 2.90 |
20
+|DLBCL |Chapuy cohort | 3.00 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |3.551 |14.940 |
27
+|DLBCL |No |No |1.619 | 0.000 |
28
+|FL |No |No |1.344 |12.679 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2023 by [Thomas N](https://pubmed.ncbi.nlm.nih.gov/36201743). First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
CHST2.md
... ...
@@ -0,0 +1,28 @@
1
+# [CHST2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|2.3 |
15
+|DLBCL |Reddy cohort |0.7 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.786 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
CIITA.md
... ...
@@ -0,0 +1,33 @@
1
+# [CIITA]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.5 |
14
+|DLBCL |Schmitz cohort|6.6 |
15
+|DLBCL |Reddy cohort |4.3 |
16
+|DLBCL |Chapuy cohort |4.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |1.029 |0.000 |
23
+|DLBCL |Yes |No |0.648 |4.031 |
24
+|FL |Yes |No |2.701 |0.000 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment |
29
+|--------|----------|--------|------|-------------------------------|
30
+|chr16 |10970795 |10975465|TSS |active_promoter-strong_enhancer|
31
+
32
+> [!NOTE]
33
+> First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
CILP.md
... ...
@@ -0,0 +1,25 @@
1
+# [CILP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0.46 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |0.915 |0 |
20
+|DLBCL |No |No |0.460 |0 |
21
+|FL |No |No |0.000 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
COL4A2.md
... ...
@@ -0,0 +1,27 @@
1
+# [COL4A2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.16 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.564 |0 |
22
+|DLBCL |No |No |1.209 |0 |
23
+|FL |No |No |1.043 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
COQ7.md
... ...
@@ -0,0 +1,28 @@
1
+# [COQ7]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.2 |
14
+|DLBCL |Schmitz cohort|0.6 |
15
+|DLBCL |Reddy cohort |0.5 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.304 |0 |
23
+|DLBCL |No |No |2.025 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
CPXM2.md
... ...
@@ -0,0 +1,27 @@
1
+# [CPXM2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.570 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |1.307 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
CREBBP.md
... ...
@@ -0,0 +1,34 @@
1
+# [CREBBP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 6.00 |
16
+|BL |Thomas cohort | 3.00 |
17
+|BL |Panea cohort |12.90 |
18
+|DLBCL |GAMBL genomes |21.40 |
19
+|DLBCL |Schmitz cohort |17.90 |
20
+|DLBCL |Reddy cohort |12.10 |
21
+|DLBCL |Chapuy cohort |16.70 |
22
+|FL |GAMBL genomes |65.13 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 1.357 | 3.999 |
29
+|DLBCL |No |Yes |13.231 | 65.302 |
30
+|FL |No |Yes |43.869 |112.938 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in FL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
CRIP1.md
... ...
@@ -0,0 +1,28 @@
1
+# [CRIP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.2 |
14
+|DLBCL |Schmitz cohort|1.9 |
15
+|DLBCL |Reddy cohort |0.7 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |4.617 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
CTCF.md
... ...
@@ -0,0 +1,27 @@
1
+# [CTCF]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.0 |
14
+|BL |Thomas cohort |1.7 |
15
+|BL |Panea cohort |6.9 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |5.383 |0 |
22
+|DLBCL |No |No |4.542 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
CTSS.md
... ...
@@ -0,0 +1,22 @@
1
+# [CTSS]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|3.93 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No | 0.000 | 0.000 |
20
+|DLBCL |No |No | 2.851 | 0.000 |
21
+|FL |No |Yes |71.282 |54.511 |
22
+
CXCR4.md
... ...
@@ -0,0 +1,37 @@
1
+# [CXCR4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|2.08 |
15
+|BL |Thomas cohort |2.10 |
16
+|BL |Panea cohort |2.00 |
17
+|DLBCL |GAMBL genomes |2.70 |
18
+|DLBCL |Schmitz cohort |2.60 |
19
+|DLBCL |Reddy cohort |1.50 |
20
+|DLBCL |Chapuy cohort |2.60 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |No |4.603 | 0.000 |
27
+|DLBCL |Yes |No |3.731 |18.727 |
28
+|FL |Yes |No |0.000 | 0.000 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
33
+|--------|----------|---------|------|------------------|
34
+|chr2 |136874728 |136875461|intron|weak_promoter |
35
+
36
+> [!NOTE]
37
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2012 by [Khodabakhshi AH](https://pubmed.ncbi.nlm.nih.gov/23131835)
... ...
\ No newline at end of file
CXCR5.md
... ...
@@ -0,0 +1,33 @@
1
+# [CXCR5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.5 |
14
+|DLBCL |Schmitz cohort|4.0 |
15
+|DLBCL |Reddy cohort |2.1 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |2.351 | 0.000 |
23
+|DLBCL |Yes |No |1.785 | 0.000 |
24
+|FL |Yes |No |2.934 |76.955 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
29
+|--------|----------|---------|------|------------------|
30
+|chr11 |118754458 |118756514|TSS |NA |
31
+
32
+> [!NOTE]
33
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
CYB5D1.md
... ...
@@ -0,0 +1,27 @@
1
+# [CYB5D1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.23 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0 |0 |
22
+|DLBCL |No |No |0 |0 |
23
+|FL |No |No |0 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
CYP2A6.md
... ...
@@ -0,0 +1,25 @@
1
+# [CYP2A6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0.23 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |1.079 |0 |
20
+|DLBCL |No |No |0.000 |0 |
21
+|FL |No |No |0.000 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
CYP4F22.md
... ...
@@ -0,0 +1,27 @@
1
+# [CYP4F22]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.467 |9.614 |
22
+|DLBCL |No |No |1.320 |0.000 |
23
+|FL |No |No |0.000 |0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
DAZAP1.md
... ...
@@ -0,0 +1,25 @@
1
+# [DAZAP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort|5.3 |
15
+|DLBCL |Reddy cohort |1.6 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0 | 0.000 |
23
+|DLBCL |No |No |0 |35.642 |
24
+|FL |No |No |0 |53.351 |
25
+
DCAF6.md
... ...
@@ -0,0 +1,28 @@
1
+# [DCAF6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.1 |
14
+|DLBCL |Schmitz cohort|2.3 |
15
+|DLBCL |Reddy cohort |1.3 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.969 |0 |
23
+|DLBCL |No |No |3.355 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
DDX10.md
... ...
@@ -0,0 +1,28 @@
1
+# [DDX10]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|1.5 |
15
+|DLBCL |Reddy cohort |0.8 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.927 |0.000 |
23
+|DLBCL |No |No |0.000 |7.884 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
DDX3X.md
... ...
@@ -0,0 +1,39 @@
1
+# [DDX3X]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|44.34 |
16
+|BL |Thomas cohort |48.70 |
17
+|BL |Panea cohort |39.60 |
18
+|DLBCL |GAMBL genomes | 8.60 |
19
+|DLBCL |Schmitz cohort | 4.70 |
20
+|DLBCL |Reddy cohort | 4.50 |
21
+|DLBCL |Chapuy cohort | 5.60 |
22
+|FL |GAMBL genomes | 2.54 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |Yes |19.270 |125.826 |
29
+|DLBCL |Yes |No | 3.193 | 8.744 |
30
+|FL |Yes |No |11.136 | 21.489 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region |regulatory_comment|
35
+|--------|----------|--------|----------|------------------|
36
+|chrX |42800580 |42804184|intergenic|NA |
37
+
38
+> [!NOTE]
39
+> First described in BL in 2012 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/22885699). First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966). First described in FL in 2023 by [Dreval K](https://pubmed.ncbi.nlm.nih.gov/37084389)
... ...
\ No newline at end of file
DICER1.md
... ...
@@ -0,0 +1,28 @@
1
+# [DICER1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|2.3 |
15
+|DLBCL |Reddy cohort |1.1 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.609 |0 |
23
+|DLBCL |No |No |0.818 |0 |
24
+|FL |No |No |2.448 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
DLGAP1.md
... ...
@@ -0,0 +1,27 @@
1
+# [DLGAP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.501 |0 |
22
+|DLBCL |No |No |1.143 |0 |
23
+|FL |No |No |0.682 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
DNMT1.md
... ...
@@ -0,0 +1,27 @@
1
+# [DNMT1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort |1.70 |
15
+|BL |Panea cohort |5.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.947 |0.000 |
22
+|DLBCL |No |No |0.000 |6.494 |
23
+|FL |No |No |2.053 |0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
DNMT3A.md
... ...
@@ -0,0 +1,28 @@
1
+# [DNMT3A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.7 |
14
+|DLBCL |Schmitz cohort|2.1 |
15
+|DLBCL |Reddy cohort |1.4 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0 |0 |
23
+|DLBCL |No |No |0 |0 |
24
+|FL |No |No |0 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
DOCK1.md
... ...
@@ -0,0 +1,28 @@
1
+# [DOCK1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | 3.8 |
14
+|DLBCL |Schmitz cohort|10.2 |
15
+|DLBCL |Reddy cohort | 4.9 |
16
+|DLBCL |Chapuy cohort | 6.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.528 |0 |
23
+|DLBCL |No |No |1.001 |0 |
24
+|FL |No |No |1.838 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
DTX1.md
... ...
@@ -0,0 +1,39 @@
1
+# [DTX1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 5.54 |
16
+|BL |Thomas cohort | 5.90 |
17
+|BL |Panea cohort | 8.90 |
18
+|DLBCL |GAMBL genomes |10.20 |
19
+|DLBCL |Schmitz cohort |13.60 |
20
+|DLBCL |Reddy cohort | 5.90 |
21
+|DLBCL |Chapuy cohort |11.50 |
22
+|FL |GAMBL genomes | 5.54 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No |5.556 |14.253 |
29
+|DLBCL |Yes |Yes |2.228 | 4.244 |
30
+|FL |Yes |No |6.305 | 0.000 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
35
+|--------|----------|---------|------|------------------|
36
+|chr12 |113492311 |113497546|TSS |NA |
37
+
38
+> [!NOTE]
39
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
DUSP2.md
... ...
@@ -0,0 +1,35 @@
1
+# [DUSP2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes | 9.30 |
15
+|DLBCL |Schmitz cohort|12.60 |
16
+|DLBCL |Reddy cohort | 9.70 |
17
+|DLBCL |Chapuy cohort | 4.30 |
18
+|FL |GAMBL genomes | 2.31 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |Yes |No |1.258 |17.913 |
25
+|DLBCL |Yes |No |1.537 |12.012 |
26
+|FL |Yes |No |3.206 | 0.000 |
27
+
28
+## aSHM regions
29
+
30
+|chr_name|hg19_start|hg19_end|region |regulatory_comment|
31
+|--------|----------|--------|--------|------------------|
32
+|chr2 |96808901 |96811913|intron-1|enhancer |
33
+
34
+> [!NOTE]
35
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
E2F2.md
... ...
@@ -0,0 +1,27 @@
1
+# [E2F2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |7.419 |25.977 |
22
+|DLBCL |No |No |0.000 | 0.000 |
23
+|FL |No |No |0.000 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
EBF1.md
... ...
@@ -0,0 +1,36 @@
1
+# [EBF1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 2.08 |
16
+|BL |Thomas cohort | 1.30 |
17
+|BL |Panea cohort | 5.90 |
18
+|DLBCL |GAMBL genomes | 8.80 |
19
+|DLBCL |Schmitz cohort |10.90 |
20
+|DLBCL |Reddy cohort | 8.80 |
21
+|DLBCL |Chapuy cohort |12.80 |
22
+|FL |GAMBL genomes | 8.55 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 2.304 | 0.000 |
29
+|DLBCL |Yes |Yes |11.910 |66.114 |
30
+|FL |Yes |Yes |17.826 |91.742 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
35
+|--------|----------|---------|------|------------------|
36
+|chr5 |158500476 |158532769|TSS |active_promoter |
EDNRB.md
... ...
@@ -0,0 +1,27 @@
1
+# [EDNRB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |3.877 | 0.000 |
22
+|DLBCL |No |No |0.482 | 0.000 |
23
+|FL |No |No |2.521 |28.057 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
EEF1A1.md
... ...
@@ -0,0 +1,28 @@
1
+# [EEF1A1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.1 |
14
+|DLBCL |Schmitz cohort|3.0 |
15
+|DLBCL |Reddy cohort |2.5 |
16
+|DLBCL |Chapuy cohort |4.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No | 6.692 | 0.000 |
23
+|DLBCL |No |No | 3.556 |24.091 |
24
+|FL |No |Yes |47.451 | 0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2021 by [Mosquera Orgueira A](https://pubmed.ncbi.nlm.nih.gov/33945543)
... ...
\ No newline at end of file
EHD1.md
... ...
@@ -0,0 +1,24 @@
1
+# [EHD1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort |0.00 |
15
+|BL |Panea cohort |5.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.000 | 0.000 |
22
+|DLBCL |No |No |2.422 |16.476 |
23
+|FL |No |No |2.540 | 0.000 |
24
+
EIF2C4.md
... ...
@@ -0,0 +1,24 @@
1
+# [EIF2C4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|NA |
14
+|BL |Thomas cohort |NA |
15
+|BL |Panea cohort |NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+
22
+
23
+> [!NOTE]
24
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
EIF4A1.md
... ...
@@ -0,0 +1,27 @@
1
+# [EIF4A1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.85 |
14
+|BL |Thomas cohort |5.10 |
15
+|BL |Panea cohort |6.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |8.506 |0 |
22
+|DLBCL |No |No |2.745 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
EML2.md
... ...
@@ -0,0 +1,27 @@
1
+# [EML2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.000 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |3.717 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
ENTPD3.md
... ...
@@ -0,0 +1,27 @@
1
+# [ENTPD3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.892 |16.794 |
22
+|DLBCL |No |No |1.331 | 0.000 |
23
+|FL |No |No |0.000 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
EP300.md
... ...
@@ -0,0 +1,31 @@
1
+# [EP300]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 4.62 |
16
+|BL |Thomas cohort | 4.20 |
17
+|BL |Panea cohort | 7.90 |
18
+|DLBCL |GAMBL genomes | 9.50 |
19
+|DLBCL |Schmitz cohort | 9.80 |
20
+|DLBCL |Reddy cohort | 7.10 |
21
+|DLBCL |Chapuy cohort | 8.10 |
22
+|FL |GAMBL genomes |12.47 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 2.769 |3.550 |
29
+|DLBCL |No |No | 3.344 |7.980 |
30
+|FL |No |Yes |15.586 |7.719 |
31
+
EPHB2.md
... ...
@@ -0,0 +1,27 @@
1
+# [EPHB2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.886 |0 |
22
+|DLBCL |No |No |0.586 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
EPPK1.md
... ...
@@ -0,0 +1,27 @@
1
+# [EPPK1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture| 6.47 |
14
+|BL |Thomas cohort | 7.60 |
15
+|BL |Panea cohort |15.80 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.066 |0.0 |
22
+|DLBCL |No |No |1.164 |7.7 |
23
+|FL |No |No |2.802 |0.0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
ERAP1.md
... ...
@@ -0,0 +1,27 @@
1
+# [ERAP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |3.083 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
ETS1.md
... ...
@@ -0,0 +1,38 @@
1
+# [ETS1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 7.62 |
15
+|BL |Thomas cohort | 7.60 |
16
+|BL |Panea cohort |11.90 |
17
+|DLBCL |GAMBL genomes | 5.40 |
18
+|DLBCL |Schmitz cohort | 7.90 |
19
+|DLBCL |Reddy cohort | 4.40 |
20
+|DLBCL |Chapuy cohort | 5.60 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |No |5.097 |18.417 |
27
+|DLBCL |Yes |No |2.987 | 0.000 |
28
+|FL |Yes |No |5.163 |25.463 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
33
+|--------|----------|---------|------|------------------|
34
+|chr11 |128339774 |128345731|intron|enhancer |
35
+|chr11 |128388492 |128394163|TSS-2 |active_promoter |
36
+
37
+> [!NOTE]
38
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
ETV6.md
... ...
@@ -0,0 +1,30 @@
1
+# [ETV6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | 5.6 |
14
+|DLBCL |Schmitz cohort|10.4 |
15
+|DLBCL |Reddy cohort | 5.8 |
16
+|DLBCL |Chapuy cohort |10.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |1.527 | 0.000 |
23
+|DLBCL |Yes |Yes |2.366 |28.723 |
24
+|FL |Yes |No |2.772 | 0.000 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
29
+|--------|----------|--------|------|------------------|
30
+|chr12 |11796001 |11812968|TSS |strong_enhancer |
EXOSC6.md
... ...
@@ -0,0 +1,27 @@
1
+# [EXOSC6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.46 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0 |0 |
22
+|DLBCL |No |No |0 |0 |
23
+|FL |No |No |0 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
EZH2.md
... ...
@@ -1,21 +1,34 @@
1
-# [EZH2](https://civicdb.org/genes/63/summary)
1
+# [EZH2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
2 10
3 11
## Mutation incidence
4 12
5
-| Entity | study | frequency (%) | dN/dS (missense) | dN/dS (nonsense) |
6
-| ------------- | ----------- | ------------- | --------- | ---------- |
7
-| DLBCL | GAMBL | 12.2 | 19.8 | 0 |
8
-| FL | GAMBL | XX | XX | XX |
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 3.46 |
16
+|BL |Thomas cohort | 1.30 |
17
+|BL |Panea cohort |10.90 |
18
+|DLBCL |GAMBL genomes |12.20 |
19
+|DLBCL |Schmitz cohort | 9.10 |
20
+|DLBCL |Reddy cohort | 8.90 |
21
+|DLBCL |Chapuy cohort | 5.60 |
22
+|FL |GAMBL genomes |24.94 |
9 23
10 24
## Mutation pattern
11 25
12
-| Entity | Hotspots | aSHM |
13
-| --- | --- | --- |
14
-| DLBCL | Yes | No |
15
-| FL | Yes | No |
16
-
17
-![lollipop](https://github.com/morinlab/LLMPP/raw/main/literature/mutation_patterns/lollipop/by_seq_type/genome/gambl_reanalysis/dlbcl/EZH2.png)
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 4.992 |0 |
29
+|DLBCL |No |Yes | 19.753 |0 |
30
+|FL |No |Yes |117.987 |0 |
18 31
19
->[!NOTE]
20
-> First described in DLBCL and FL by [Morin *et al*](https://pubmed.ncbi.nlm.nih.gov/20081860/)
21 32
33
+> [!NOTE]
34
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2010 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/20081860). First described in FL in 2010 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/20081860)
... ...
\ No newline at end of file
FAM129B.md
... ...
@@ -0,0 +1,27 @@
1
+# [FAM129B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.948 | 0.000 |
22
+|DLBCL |No |No |0.000 |13.541 |
23
+|FL |No |No |2.483 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
FAS.md
... ...
@@ -0,0 +1,31 @@
1
+# [FAS]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 2.08 |
16
+|BL |Thomas cohort | 1.70 |
17
+|BL |Panea cohort | 4.00 |
18
+|DLBCL |GAMBL genomes | 8.80 |
19
+|DLBCL |Schmitz cohort |10.90 |
20
+|DLBCL |Reddy cohort | 4.70 |
21
+|DLBCL |Chapuy cohort | 9.00 |
22
+|FL |GAMBL genomes | 5.08 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 6.699 | 0.000 |
29
+|DLBCL |No |Yes |16.878 |179.289 |
30
+|FL |No |Yes | 0.000 |176.866 |
31
+
FBXO11.md
... ...
@@ -0,0 +1,32 @@
1
+# [FBXO11]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|23.79 |
15
+|BL |Thomas cohort |21.60 |
16
+|BL |Panea cohort |15.80 |
17
+|DLBCL |GAMBL genomes | 4.10 |
18
+|DLBCL |Schmitz cohort | 2.10 |
19
+|DLBCL |Reddy cohort | 2.10 |
20
+|DLBCL |Chapuy cohort | 2.60 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |14.801 |114.063 |
27
+|DLBCL |No |Yes | 2.464 | 39.449 |
28
+|FL |No |No | 8.837 | 0.000 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2023 by [Thomas N](https://pubmed.ncbi.nlm.nih.gov/36201743)
... ...
\ No newline at end of file
FBXW7.md
... ...
@@ -0,0 +1,25 @@
1
+# [FBXW7]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort|3.0 |
15
+|DLBCL |Reddy cohort |1.3 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |3.846 | 0.000 |
23
+|DLBCL |No |No |2.734 |10.734 |
24
+|FL |No |No |2.987 |22.593 |
25
+
FGFR3.md
... ...
@@ -0,0 +1,27 @@
1
+# [FGFR3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.974 |0 |
22
+|DLBCL |No |No |1.140 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
FIP1L1.md
... ...
@@ -0,0 +1,24 @@
1
+# [FIP1L1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|5.31 |
14
+|BL |Thomas cohort |2.50 |
15
+|BL |Panea cohort |2.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |Yes |1.128 |47.630 |
22
+|DLBCL |No |No |1.343 |10.476 |
23
+|FL |No |No |3.166 | 0.000 |
24
+
FLYWCH1.md
... ...
@@ -0,0 +1,27 @@
1
+# [FLYWCH1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0 |13.882 |
22
+|DLBCL |No |No |0 | 0.000 |
23
+|FL |No |No |0 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
FOXC1.md
... ...
@@ -0,0 +1,25 @@
1
+# [FOXC1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.7 |
14
+|DLBCL |Schmitz cohort|4.5 |
15
+|DLBCL |Reddy cohort |1.2 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |0.824 |0 |
24
+|FL |No |No |1.906 |0 |
25
+
FOXO1.md
... ...
@@ -0,0 +1,34 @@
1
+# [FOXO1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|23.33 |
16
+|BL |Thomas cohort |28.00 |
17
+|BL |Panea cohort |21.80 |
18
+|DLBCL |GAMBL genomes |10.60 |
19
+|DLBCL |Schmitz cohort | 7.20 |
20
+|DLBCL |Reddy cohort | 2.40 |
21
+|DLBCL |Chapuy cohort | 2.10 |
22
+|FL |GAMBL genomes |12.93 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes |14.841 | 5.170 |
29
+|DLBCL |No |No | 6.936 | 0.000 |
30
+|FL |No |Yes |18.992 |103.028 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2012 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/22885699). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119). First described in FL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
FOXP1.md
... ...
@@ -0,0 +1,38 @@
1
+# [FOXP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.7 |
14
+|DLBCL |Schmitz cohort|1.9 |
15
+|DLBCL |Reddy cohort |2.1 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |1.218 | 9.469 |
23
+|DLBCL |Yes |No |7.387 |17.777 |
24
+|FL |Yes |No |0.000 | 0.000 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region |regulatory_comment|
29
+|--------|----------|--------|---------|------------------|
30
+|chr3 |71104986 |71119518|TSS-4 |active_promoter |
31
+|chr3 |71176427 |71180960|TSS-3 |active_promoter |
32
+|chr3 |71350633 |71357665|TSS-2 |active_promoter |
33
+|chr3 |71503103 |71504870|intron-1b|intron |
34
+|chr3 |71550753 |71551478|intron-1a|intron |
35
+|chr3 |71626341 |71635648|TSS-1 |active_promoter |
36
+
37
+> [!NOTE]
38
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
FTCD.md
... ...
@@ -0,0 +1,27 @@
1
+# [FTCD]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.23 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |3.359 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
FUBP1.md
... ...
@@ -0,0 +1,28 @@
1
+# [FUBP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|1.5 |
15
+|DLBCL |Reddy cohort |1.5 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.886 | 6.918 |
23
+|DLBCL |No |No |0.000 | 9.093 |
24
+|FL |No |No |7.430 |26.002 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
FUT5.md
... ...
@@ -0,0 +1,28 @@
1
+# [FUT5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.2 |
14
+|DLBCL |Schmitz cohort|1.3 |
15
+|DLBCL |Reddy cohort |0.3 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |3.328 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
FZD3.md
... ...
@@ -0,0 +1,27 @@
1
+# [FZD3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.23 |
14
+|BL |Thomas cohort |0.00 |
15
+|BL |Panea cohort |1.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.000 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |1.522 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
GABRA2.md
... ...
@@ -0,0 +1,28 @@
1
+# [GABRA2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|2.6 |
15
+|DLBCL |Reddy cohort |1.2 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |8.135 |
23
+|DLBCL |No |No |0.502 |0.000 |
24
+|FL |No |No |1.493 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
GBP7.md
... ...
@@ -0,0 +1,25 @@
1
+# [GBP7]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0.23 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |0.582 |0 |
20
+|DLBCL |No |No |0.000 |0 |
21
+|FL |No |No |0.000 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Kalmbach S](https://pubmed.ncbi.nlm.nih.gov/37563306)
... ...
\ No newline at end of file
GGTLA4.md
... ...
@@ -0,0 +1,24 @@
1
+# [GGTLA4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|NA |
14
+|BL |Thomas cohort |NA |
15
+|BL |Panea cohort |NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+
22
+
23
+> [!NOTE]
24
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
GNA13.md
... ...
@@ -0,0 +1,34 @@
1
+# [GNA13]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|21.02 |
16
+|BL |Thomas cohort |21.60 |
17
+|BL |Panea cohort |20.80 |
18
+|DLBCL |GAMBL genomes |11.70 |
19
+|DLBCL |Schmitz cohort | 8.50 |
20
+|DLBCL |Reddy cohort |11.90 |
21
+|DLBCL |Chapuy cohort |10.30 |
22
+|FL |GAMBL genomes |10.16 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes |51.517 |966.741 |
29
+|DLBCL |No |Yes |38.484 |284.077 |
30
+|FL |No |Yes |48.688 |215.216 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119). First described in FL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
GNAI2.md
... ...
@@ -0,0 +1,34 @@
1
+# [GNAI2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|11.32 |
16
+|BL |Thomas cohort | 9.70 |
17
+|BL |Panea cohort | 8.90 |
18
+|DLBCL |GAMBL genomes | 4.70 |
19
+|DLBCL |Schmitz cohort | 6.40 |
20
+|DLBCL |Reddy cohort | 1.90 |
21
+|DLBCL |Chapuy cohort | 3.80 |
22
+|FL |GAMBL genomes | 4.16 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes |18.304 | 0.000 |
29
+|DLBCL |No |Yes |32.161 |57.623 |
30
+|FL |No |Yes |55.205 | 0.000 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2019 by [Grande BM](https://pubmed.ncbi.nlm.nih.gov/30617194)
... ...
\ No newline at end of file
GNAS.md
... ...
@@ -0,0 +1,28 @@
1
+# [GNAS]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort|3.2 |
15
+|DLBCL |Reddy cohort |1.9 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |3.064 |13.8 |
23
+|DLBCL |No |No |0.967 | 0.0 |
24
+|FL |No |No |1.581 | 0.0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
GOLGA5.md
... ...
@@ -0,0 +1,28 @@
1
+# [GOLGA5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|0.9 |
15
+|DLBCL |Reddy cohort |1.9 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.362 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |3.693 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
GPC5.md
... ...
@@ -0,0 +1,28 @@
1
+# [GPC5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|1.9 |
15
+|DLBCL |Reddy cohort |2.2 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.380 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |1.144 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
GRB2.md
... ...
@@ -0,0 +1,32 @@
1
+# [GRB2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|0.46 |
15
+|BL |Thomas cohort |0.40 |
16
+|BL |Panea cohort |1.00 |
17
+|DLBCL |GAMBL genomes |3.40 |
18
+|DLBCL |Schmitz cohort |2.80 |
19
+|DLBCL |Reddy cohort |1.50 |
20
+|DLBCL |Chapuy cohort |3.00 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No | 7.253 | 0.000 |
27
+|DLBCL |No |Yes |33.029 |168.982 |
28
+|FL |No |No | 8.575 | 0.000 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
GRHPR.md
... ...
@@ -0,0 +1,30 @@
1
+# [GRHPR]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.7 |
14
+|DLBCL |Schmitz cohort|4.5 |
15
+|DLBCL |Reddy cohort |3.6 |
16
+|DLBCL |Chapuy cohort |4.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No | 1.819 | 0.000 |
23
+|DLBCL |Yes |Yes |10.245 |60.346 |
24
+|FL |Yes |No | 0.000 | 0.000 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
29
+|--------|----------|--------|------|------------------|
30
+|chr9 |37423010 |37425279|TSS |active_promoter |
GRIK5.md
... ...
@@ -0,0 +1,27 @@
1
+# [GRIK5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.92 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.060 |0 |
22
+|DLBCL |No |No |2.412 |0 |
23
+|FL |No |No |1.801 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
GRM6.md
... ...
@@ -0,0 +1,25 @@
1
+# [GRM6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0.92 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |1.95 |0 |
20
+|DLBCL |No |No |1.43 |0 |
21
+|FL |No |No |0.00 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
GSG2.md
... ...
@@ -0,0 +1,28 @@
1
+# [GSG2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.7 |
14
+|DLBCL |Schmitz cohort|4.0 |
15
+|DLBCL |Reddy cohort |1.5 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.723 |0 |
23
+|DLBCL |No |No |3.101 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
GTSE1.md
... ...
@@ -0,0 +1,27 @@
1
+# [GTSE1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.224 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
HIST1H1B.md
... ...
@@ -0,0 +1,31 @@
1
+# [HIST1H1B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|4.62 |
16
+|BL |Thomas cohort |5.50 |
17
+|BL |Panea cohort |4.00 |
18
+|DLBCL |GAMBL genomes |9.30 |
19
+|DLBCL |Schmitz cohort |8.50 |
20
+|DLBCL |Reddy cohort |7.30 |
21
+|DLBCL |Chapuy cohort |9.80 |
22
+|FL |GAMBL genomes |5.54 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes | 6.345 |34.135 |
29
+|DLBCL |No |Yes | 5.595 | 0.000 |
30
+|FL |No |No |19.175 | 0.000 |
31
+
HIST1H1C.md
... ...
@@ -0,0 +1,34 @@
1
+# [HIST1H1C]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 4.85 |
16
+|BL |Thomas cohort | 3.80 |
17
+|BL |Panea cohort | 9.90 |
18
+|DLBCL |GAMBL genomes |11.70 |
19
+|DLBCL |Schmitz cohort | 9.80 |
20
+|DLBCL |Reddy cohort | 9.40 |
21
+|DLBCL |Chapuy cohort |12.40 |
22
+|FL |GAMBL genomes | 5.08 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No |10.205 |0 |
29
+|DLBCL |No |Yes | 9.354 |0 |
30
+|FL |No |No | 4.446 |0 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119). First described in FL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
HIST1H1D.md
... ...
@@ -0,0 +1,31 @@
1
+# [HIST1H1D]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|3.23 |
16
+|BL |Thomas cohort |4.70 |
17
+|BL |Panea cohort |4.00 |
18
+|DLBCL |GAMBL genomes |6.50 |
19
+|DLBCL |Schmitz cohort |5.70 |
20
+|DLBCL |Reddy cohort |6.10 |
21
+|DLBCL |Chapuy cohort |7.70 |
22
+|FL |GAMBL genomes |3.23 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No |8.064 |0 |
29
+|DLBCL |No |No |2.458 |0 |
30
+|FL |No |No |0.857 |0 |
31
+
HIST1H1E.md
... ...
@@ -0,0 +1,34 @@
1
+# [HIST1H1E]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 9.70 |
16
+|BL |Thomas cohort | 7.60 |
17
+|BL |Panea cohort |19.80 |
18
+|DLBCL |GAMBL genomes |16.50 |
19
+|DLBCL |Schmitz cohort |17.90 |
20
+|DLBCL |Reddy cohort |14.50 |
21
+|DLBCL |Chapuy cohort |11.50 |
22
+|FL |GAMBL genomes |12.93 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes |14.203 |0.000 |
29
+|DLBCL |No |Yes | 4.446 |6.437 |
30
+|FL |No |Yes |10.043 |0.000 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HIST1H2AC.md
... ...
@@ -0,0 +1,27 @@
1
+# [HIST1H2AC]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |5.90 |
15
+|DLBCL |Schmitz cohort|6.20 |
16
+|DLBCL |Reddy cohort |3.40 |
17
+|DLBCL |Chapuy cohort |6.40 |
18
+|FL |GAMBL genomes |2.08 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No |1.742 | 0.000 |
25
+|DLBCL |No |No |3.090 |20.364 |
26
+|FL |No |No |1.715 | 0.000 |
27
+
HIST1H2AG.md
... ...
@@ -0,0 +1,29 @@
1
+# [HIST1H2AG]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|1.39 |
15
+|BL |Thomas cohort |2.50 |
16
+|BL |Panea cohort |1.00 |
17
+|FL |GAMBL genomes |2.08 |
18
+
19
+## Mutation pattern
20
+
21
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
22
+|------|----|---------------------|----------------|----------------|
23
+|BL |No |No |3.809 |0 |
24
+|DLBCL |No |No |5.602 |0 |
25
+|FL |No |No |0.405 |0 |
26
+
27
+
28
+> [!NOTE]
29
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HIST1H2AM.md
... ...
@@ -0,0 +1,34 @@
1
+# [HIST1H2AM]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|1.85 |
16
+|BL |Thomas cohort |1.70 |
17
+|BL |Panea cohort |3.00 |
18
+|DLBCL |GAMBL genomes |6.10 |
19
+|DLBCL |Schmitz cohort |5.70 |
20
+|DLBCL |Reddy cohort |4.80 |
21
+|DLBCL |Chapuy cohort |6.00 |
22
+|FL |GAMBL genomes |3.70 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No |2.149 |0 |
29
+|DLBCL |No |No |1.844 |0 |
30
+|FL |No |No |1.845 |0 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HIST1H2BC.md
... ...
@@ -0,0 +1,30 @@
1
+# [HIST1H2BC]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |4.10 |
15
+|DLBCL |Schmitz cohort|5.50 |
16
+|DLBCL |Reddy cohort |4.30 |
17
+|DLBCL |Chapuy cohort |5.60 |
18
+|FL |GAMBL genomes |3.46 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No |2.806 |35.161 |
25
+|DLBCL |No |No |1.712 | 0.000 |
26
+|FL |No |No |1.094 | 0.000 |
27
+
28
+
29
+> [!NOTE]
30
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
HIST1H2BD.md
... ...
@@ -0,0 +1,22 @@
1
+# [HIST1H2BD]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|1.15 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |1.524 |0 |
20
+|DLBCL |No |No |0.671 |0 |
21
+|FL |No |No |1.751 |0 |
22
+
HIST1H2BG.md
... ...
@@ -0,0 +1,22 @@
1
+# [HIST1H2BG]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|2.08 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |1.350 |0 |
20
+|DLBCL |No |No |3.197 |0 |
21
+|FL |No |No |1.211 |0 |
22
+
HIST1H2BK.md
... ...
@@ -0,0 +1,32 @@
1
+# [HIST1H2BK]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|5.31 |
15
+|BL |Thomas cohort |4.70 |
16
+|BL |Panea cohort |7.90 |
17
+|DLBCL |GAMBL genomes |5.40 |
18
+|DLBCL |Schmitz cohort |4.90 |
19
+|DLBCL |Reddy cohort |4.20 |
20
+|DLBCL |Chapuy cohort |5.60 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |4.421 |0 |
27
+|DLBCL |No |No |1.567 |0 |
28
+|FL |No |No |0.760 |0 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HIST1H2BM.md
... ...
@@ -0,0 +1,25 @@
1
+# [HIST1H2BM]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0.69 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |2.367 |54.179 |
20
+|DLBCL |No |No |1.312 | 0.000 |
21
+|FL |No |No |1.980 | 0.000 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
HIST1H3B.md
... ...
@@ -0,0 +1,27 @@
1
+# [HIST1H3B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |2.00 |
15
+|DLBCL |Schmitz cohort|1.70 |
16
+|DLBCL |Reddy cohort |2.00 |
17
+|DLBCL |Chapuy cohort |2.10 |
18
+|FL |GAMBL genomes |1.62 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No |8.244 |0.000 |
25
+|DLBCL |No |No |2.108 |9.678 |
26
+|FL |No |No |1.637 |0.000 |
27
+
HIST1H3D.md
... ...
@@ -0,0 +1,27 @@
1
+# [HIST1H3D]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.31 |
14
+|BL |Thomas cohort |1.70 |
15
+|BL |Panea cohort |3.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.566 |0 |
22
+|DLBCL |No |No |2.153 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HIST1H3G.md
... ...
@@ -0,0 +1,22 @@
1
+# [HIST1H3G]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|1.62 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |1.701 |0.000 |
20
+|DLBCL |No |No |0.517 |5.984 |
21
+|FL |No |No |3.230 |0.000 |
22
+
HIST1H3H.md
... ...
@@ -0,0 +1,27 @@
1
+# [HIST1H3H]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort |1.30 |
15
+|BL |Panea cohort |5.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.791 |0 |
22
+|DLBCL |No |No |1.257 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HIST1H3I.md
... ...
@@ -0,0 +1,29 @@
1
+# [HIST1H3I]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|FL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|0.46 |
15
+|BL |Thomas cohort |0.00 |
16
+|BL |Panea cohort |2.00 |
17
+|FL |GAMBL genomes |1.15 |
18
+
19
+## Mutation pattern
20
+
21
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
22
+|------|----|---------------------|----------------|----------------|
23
+|BL |No |No |0.000 |0 |
24
+|DLBCL |No |No |5.397 |0 |
25
+|FL |No |No |0.838 |0 |
26
+
27
+
28
+> [!NOTE]
29
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
HIST1H3J.md
... ...
@@ -0,0 +1,27 @@
1
+# [HIST1H3J]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.31 |
14
+|BL |Thomas cohort |1.70 |
15
+|BL |Panea cohort |5.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |6.396 |0 |
22
+|DLBCL |No |No |1.417 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HIST1H4J.md
... ...
@@ -0,0 +1,27 @@
1
+# [HIST1H4J]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.46 |
14
+|BL |Thomas cohort |0.40 |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.955 |0 |
22
+|DLBCL |No |No |1.504 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HIST2H2BE.md
... ...
@@ -0,0 +1,25 @@
1
+# [HIST2H2BE]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.7 |
14
+|DLBCL |Schmitz cohort|3.2 |
15
+|DLBCL |Reddy cohort |2.6 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |3.780 |40.980 |
23
+|DLBCL |No |No |0.601 | 3.291 |
24
+|FL |No |No |3.156 | 0.000 |
25
+
HLA-A.md
... ...
@@ -0,0 +1,29 @@
1
+# [HLA-A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 1.39 |
15
+|BL |Thomas cohort | 1.30 |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes | 8.80 |
18
+|DLBCL |Schmitz cohort |11.10 |
19
+|DLBCL |Reddy cohort | 0.20 |
20
+|DLBCL |Chapuy cohort | 9.00 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No | 4.995 | 22.371 |
27
+|DLBCL |No |Yes |14.841 |190.534 |
28
+|FL |No |No | 0.000 | 0.000 |
29
+
HLA-B.md
... ...
@@ -0,0 +1,31 @@
1
+# [HLA-B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 3.46 |
16
+|BL |Thomas cohort | 3.80 |
17
+|BL |Panea cohort | 5.00 |
18
+|DLBCL |GAMBL genomes | 9.50 |
19
+|DLBCL |Schmitz cohort |16.40 |
20
+|DLBCL |Reddy cohort | 1.20 |
21
+|DLBCL |Chapuy cohort |10.70 |
22
+|FL |GAMBL genomes | 3.46 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes | 6.598 | 94.947 |
29
+|DLBCL |No |Yes |27.361 |222.398 |
30
+|FL |No |No | 0.000 | 88.288 |
31
+
HLA-C.md
... ...
@@ -0,0 +1,25 @@
1
+# [HLA-C]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.1 |
14
+|DLBCL |Schmitz cohort|5.5 |
15
+|DLBCL |Reddy cohort | NA |
16
+|DLBCL |Chapuy cohort |4.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.687 | 0.000 |
23
+|DLBCL |No |Yes |6.500 |33.396 |
24
+|FL |No |No |0.000 | 0.000 |
25
+
HLA-DMA.md
... ...
@@ -0,0 +1,25 @@
1
+# [HLA-DMA]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|1.3 |
15
+|DLBCL |Reddy cohort | NA |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |3.255 | 0.000 |
23
+|DLBCL |No |No |3.359 |38.853 |
24
+|FL |No |No |0.000 |76.864 |
25
+
HLA-DMB.md
... ...
@@ -0,0 +1,29 @@
1
+# [HLA-DMB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| NA |
15
+|BL |Thomas cohort |0.0 |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes |3.4 |
18
+|DLBCL |Schmitz cohort |5.1 |
19
+|DLBCL |Reddy cohort | NA |
20
+|DLBCL |Chapuy cohort |1.7 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No | 0.000 | 0.000 |
27
+|DLBCL |No |Yes |16.721 | 26.750 |
28
+|FL |No |Yes |39.781 |282.532 |
29
+
HLA-DQB1.md
... ...
@@ -0,0 +1,27 @@
1
+# [HLA-DQB1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|NA |
14
+|BL |Thomas cohort |NA |
15
+|BL |Panea cohort |NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0 |0 |
22
+|DLBCL |No |No |0 |0 |
23
+|FL |No |No |0 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
HNF1B.md
... ...
@@ -0,0 +1,28 @@
1
+# [HNF1B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.2 |
14
+|DLBCL |Schmitz cohort|2.6 |
15
+|DLBCL |Reddy cohort |0.3 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |2.652 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
HNRNPD.md
... ...
@@ -0,0 +1,27 @@
1
+# [HNRNPD]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |2.7 |
15
+|DLBCL |Schmitz cohort|2.1 |
16
+|DLBCL |Reddy cohort |1.8 |
17
+|DLBCL |Chapuy cohort |0.9 |
18
+|FL |GAMBL genomes |0.0 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No |0.000 |19.81 |
25
+|DLBCL |No |No |1.554 | 0.00 |
26
+|FL |No |No |0.000 | 0.00 |
27
+
HNRNPH1.md
... ...
@@ -0,0 +1,25 @@
1
+# [HNRNPH1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort|3.2 |
15
+|DLBCL |Reddy cohort |1.4 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.573 | 0.000 |
23
+|DLBCL |No |No |2.337 |10.139 |
24
+|FL |No |No |0.000 | 0.000 |
25
+
HNRNPU.md
... ...
@@ -0,0 +1,37 @@
1
+# [HNRNPU]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|5.77 |
15
+|BL |Thomas cohort |6.40 |
16
+|BL |Panea cohort |8.90 |
17
+|DLBCL |GAMBL genomes |1.80 |
18
+|DLBCL |Schmitz cohort |3.40 |
19
+|DLBCL |Reddy cohort |2.40 |
20
+|DLBCL |Chapuy cohort |3.40 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |Yes |1.081 |27.052 |
27
+|DLBCL |Yes |No |1.712 | 0.000 |
28
+|FL |Yes |No |4.865 |31.056 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
33
+|--------|----------|---------|------|------------------|
34
+|chr1 |245023502 |245029083|TSS |NA |
35
+
36
+> [!NOTE]
37
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
HRAS.md
... ...
@@ -0,0 +1,28 @@
1
+# [HRAS]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | NA |
14
+|DLBCL |Schmitz cohort|0.2 |
15
+|DLBCL |Reddy cohort |0.7 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0 |0 |
23
+|DLBCL |No |No |0 |0 |
24
+|FL |No |No |0 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
HVCN1.md
... ...
@@ -0,0 +1,31 @@
1
+# [HVCN1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|0.92 |
16
+|BL |Thomas cohort |0.80 |
17
+|BL |Panea cohort |2.00 |
18
+|DLBCL |GAMBL genomes |3.20 |
19
+|DLBCL |Schmitz cohort |1.90 |
20
+|DLBCL |Reddy cohort |2.30 |
21
+|DLBCL |Chapuy cohort |3.40 |
22
+|FL |GAMBL genomes |6.47 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 2.588 | 0.000 |
29
+|DLBCL |No |Yes | 7.172 | 47.127 |
30
+|FL |No |Yes |16.103 |259.368 |
31
+
ICK.md
... ...
@@ -0,0 +1,27 @@
1
+# [ICK]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.69 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.813 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
ID3.md
... ...
@@ -0,0 +1,39 @@
1
+# [ID3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |2 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|45.50 |
16
+|BL |Thomas cohort |47.00 |
17
+|BL |Panea cohort |31.70 |
18
+|DLBCL |GAMBL genomes | 2.00 |
19
+|DLBCL |Schmitz cohort | 4.70 |
20
+|DLBCL |Reddy cohort | 3.50 |
21
+|DLBCL |Chapuy cohort | 0.90 |
22
+|FL |GAMBL genomes | 0.92 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |Yes |42.419 |439.808 |
29
+|DLBCL |Yes |Yes | 0.000 | 30.520 |
30
+|FL |Yes |No | 3.497 | 0.000 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chr1 |23885584 |23885835|TSS |NA |
37
+
38
+> [!NOTE]
39
+> First described in BL in 2012 by [Richter J](https://pubmed.ncbi.nlm.nih.gov/23143595). First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
IGLL5.md
... ...
@@ -0,0 +1,36 @@
1
+# [IGLL5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |2 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|26.33 |
16
+|BL |Thomas cohort |25.00 |
17
+|BL |Panea cohort |23.80 |
18
+|DLBCL |GAMBL genomes |41.10 |
19
+|DLBCL |Schmitz cohort |36.00 |
20
+|DLBCL |Reddy cohort |16.10 |
21
+|DLBCL |Chapuy cohort | 9.00 |
22
+|FL |GAMBL genomes |35.33 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |Yes |7.850 |3.210 |
29
+|DLBCL |Yes |Yes |3.376 |5.315 |
30
+|FL |Yes |Yes |4.830 |9.846 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chr22 |23229554 |23232042|TSS |NA |
IKBKB.md
... ...
@@ -0,0 +1,28 @@
1
+# [IKBKB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|3.0 |
15
+|DLBCL |Reddy cohort |1.1 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |4.726 |0 |
23
+|DLBCL |No |No |1.593 |0 |
24
+|FL |No |No |3.189 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
IKZF3.md
... ...
@@ -0,0 +1,38 @@
1
+# [IKZF3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|1.62 |
15
+|BL |Thomas cohort |0.80 |
16
+|BL |Panea cohort |3.00 |
17
+|DLBCL |GAMBL genomes |4.30 |
18
+|DLBCL |Schmitz cohort |4.50 |
19
+|DLBCL |Reddy cohort |3.90 |
20
+|DLBCL |Chapuy cohort |4.30 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |No | 1.552 |0 |
27
+|DLBCL |Yes |No |10.924 |0 |
28
+|FL |Yes |No | 7.180 |0 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
33
+|--------|----------|--------|------|------------------|
34
+|chr17 |37928959 |37940119|TSS-1 |NA |
35
+|chr17 |38015776 |38024832|TSS-2 |NA |
36
+
37
+> [!NOTE]
38
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2017 by [Mareschal S](https://pubmed.ncbi.nlm.nih.gov/28479318)
... ...
\ No newline at end of file
IL16.md
... ...
@@ -0,0 +1,25 @@
1
+# [IL16]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.3 |
14
+|DLBCL |Schmitz cohort|3.8 |
15
+|DLBCL |Reddy cohort |2.8 |
16
+|DLBCL |Chapuy cohort |5.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.941 |0 |
23
+|DLBCL |No |No |1.966 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
IL4R.md
... ...
@@ -0,0 +1,33 @@
1
+# [IL4R]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.5 |
14
+|DLBCL |Schmitz cohort|2.1 |
15
+|DLBCL |Reddy cohort |2.5 |
16
+|DLBCL |Chapuy cohort |3.8 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |3.355 |0 |
23
+|DLBCL |Yes |No |9.640 |0 |
24
+|FL |Yes |No |0.000 |0 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
29
+|--------|----------|--------|------|------------------|
30
+|chr16 |27322895 |27329423|TSS |active_promoter |
31
+
32
+> [!NOTE]
33
+> First described in DLBCL in 2021 by [Duns G](https://pubmed.ncbi.nlm.nih.gov/33684939)
... ...
\ No newline at end of file
IL6.md
... ...
@@ -0,0 +1,28 @@
1
+# [IL6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|2.8 |
15
+|DLBCL |Reddy cohort |1.2 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |4.532 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
INO80.md
... ...
@@ -0,0 +1,28 @@
1
+# [INO80]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.4 |
14
+|DLBCL |Schmitz cohort|4.3 |
15
+|DLBCL |Reddy cohort |2.5 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.227 |0.000 |
23
+|DLBCL |No |No |2.156 |5.706 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
IRF4.md
... ...
@@ -0,0 +1,35 @@
1
+# [IRF4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |3.20 |
15
+|DLBCL |Schmitz cohort|7.00 |
16
+|DLBCL |Reddy cohort |4.40 |
17
+|DLBCL |Chapuy cohort |2.10 |
18
+|FL |GAMBL genomes |1.15 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |Yes |No | 0.000 |0 |
25
+|DLBCL |Yes |Yes |25.817 |0 |
26
+|FL |Yes |No | 0.000 |0 |
27
+
28
+## aSHM regions
29
+
30
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
31
+|--------|----------|--------|------|------------------|
32
+|chr6 |390572 |394093 |TSS |active_promoter |
33
+
34
+> [!NOTE]
35
+> First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
IRF8.md
... ...
@@ -0,0 +1,36 @@
1
+# [IRF8]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 2.31 |
16
+|BL |Thomas cohort | 1.30 |
17
+|BL |Panea cohort | 6.90 |
18
+|DLBCL |GAMBL genomes | 8.80 |
19
+|DLBCL |Schmitz cohort |10.40 |
20
+|DLBCL |Reddy cohort | 7.60 |
21
+|DLBCL |Chapuy cohort |10.30 |
22
+|FL |GAMBL genomes |12.01 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 1.360 | 0.000 |
29
+|DLBCL |Yes |Yes | 6.806 | 0.000 |
30
+|FL |Yes |Yes |28.663 |102.572 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chr16 |85931918 |85933977|TSS |active_promoter |
ITPKB.md
... ...
@@ -0,0 +1,37 @@
1
+# [ITPKB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |6.50 |
15
+|DLBCL |Schmitz cohort|6.80 |
16
+|DLBCL |Reddy cohort |6.70 |
17
+|DLBCL |Chapuy cohort |9.40 |
18
+|FL |GAMBL genomes |3.23 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |Yes |No |0.587 | 0.000 |
25
+|DLBCL |Yes |Yes |4.294 |15.744 |
26
+|FL |Yes |No |6.541 | 0.000 |
27
+
28
+## aSHM regions
29
+
30
+|chr_name|hg19_start|hg19_end |region |regulatory_comment|
31
+|--------|----------|---------|--------|------------------|
32
+|chr1 |226864857 |226873452|intron |weak_enhancer |
33
+|chr1 |226920563 |226927885|TSS |active_promoter |
34
+|chr1 |226921088 |226927982|intron-1|enhancer |
35
+
36
+> [!NOTE]
37
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
ITPR3.md
... ...
@@ -0,0 +1,27 @@
1
+# [ITPR3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.546 |0 |
22
+|DLBCL |No |No |1.349 |0 |
23
+|FL |No |No |1.332 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
JAK1.md
... ...
@@ -0,0 +1,28 @@
1
+# [JAK1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.9 |
14
+|DLBCL |Schmitz cohort|1.9 |
15
+|DLBCL |Reddy cohort |2.2 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.067 |0 |
23
+|DLBCL |No |No |4.294 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
JAK3.md
... ...
@@ -0,0 +1,28 @@
1
+# [JAK3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.4 |
14
+|DLBCL |Schmitz cohort|1.3 |
15
+|DLBCL |Reddy cohort |1.0 |
16
+|DLBCL |Chapuy cohort | NA |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.034 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
JUNB.md
... ...
@@ -0,0 +1,28 @@
1
+# [JUNB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.9 |
14
+|DLBCL |Schmitz cohort|3.2 |
15
+|DLBCL |Reddy cohort |3.5 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.009 |0.00 |
23
+|DLBCL |No |No |1.285 |8.88 |
24
+|FL |No |No |0.000 |0.00 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
KCMF1.md
... ...
@@ -0,0 +1,28 @@
1
+# [KCMF1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|1.5 |
15
+|DLBCL |Reddy cohort |1.0 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |6.003 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
KCNK10.md
... ...
@@ -0,0 +1,27 @@
1
+# [KCNK10]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.92 |
14
+|BL |Thomas cohort |0.80 |
15
+|BL |Panea cohort |1.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.406 |0 |
22
+|DLBCL |No |No |0.632 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
KIFC3.md
... ...
@@ -0,0 +1,27 @@
1
+# [KIFC3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.012 |5.98 |
22
+|DLBCL |No |No |0.000 |0.00 |
23
+|FL |No |No |2.064 |0.00 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
KIR3DL1.md
... ...
@@ -0,0 +1,25 @@
1
+# [KIR3DL1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|1.15 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |0 | 0.000 |
20
+|DLBCL |No |No |0 |25.433 |
21
+|FL |No |No |0 | 0.000 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Kalmbach S](https://pubmed.ncbi.nlm.nih.gov/37563306)
... ...
\ No newline at end of file
KLF2.md
... ...
@@ -0,0 +1,35 @@
1
+# [KLF2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |7.70 |
15
+|DLBCL |Schmitz cohort|7.00 |
16
+|DLBCL |Reddy cohort |2.10 |
17
+|DLBCL |Chapuy cohort |3.00 |
18
+|FL |GAMBL genomes |2.31 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |Yes |No |2.274 |0 |
25
+|DLBCL |Yes |No |3.067 |0 |
26
+|FL |Yes |No |9.318 |0 |
27
+
28
+## aSHM regions
29
+
30
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
31
+|--------|----------|--------|------|------------------|
32
+|chr19 |16434978 |16439011|TSS |intron |
33
+
34
+> [!NOTE]
35
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
KLHL14.md
... ...
@@ -0,0 +1,28 @@
1
+# [KLHL14]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |5.0 |
14
+|DLBCL |Schmitz cohort|6.6 |
15
+|DLBCL |Reddy cohort |4.6 |
16
+|DLBCL |Chapuy cohort |7.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No | 0.000 | 0.000 |
23
+|DLBCL |No |No | 3.154 | 2.846 |
24
+|FL |No |No |12.248 |24.944 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
KLHL21.md
... ...
@@ -0,0 +1,33 @@
1
+# [KLHL21]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.3 |
14
+|DLBCL |Schmitz cohort|4.7 |
15
+|DLBCL |Reddy cohort |2.5 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |0.000 |0 |
23
+|DLBCL |Yes |No |1.741 |0 |
24
+|FL |Yes |No |0.000 |0 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
29
+|--------|----------|--------|------|------------------|
30
+|chr1 |6661482 |6662702 |TSS |NA |
31
+
32
+> [!NOTE]
33
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
KLHL26.md
... ...
@@ -0,0 +1,27 @@
1
+# [KLHL26]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.46 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.487 |0 |
22
+|DLBCL |No |No |2.471 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
KLHL6.md
... ...
@@ -0,0 +1,36 @@
1
+# [KLHL6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|3.93 |
16
+|BL |Thomas cohort |3.00 |
17
+|BL |Panea cohort |6.90 |
18
+|DLBCL |GAMBL genomes |5.20 |
19
+|DLBCL |Schmitz cohort |9.10 |
20
+|DLBCL |Reddy cohort |6.40 |
21
+|DLBCL |Chapuy cohort |9.00 |
22
+|FL |GAMBL genomes |7.16 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 4.630 | 0.000 |
29
+|DLBCL |Yes |No | 7.379 | 6.684 |
30
+|FL |Yes |Yes |20.169 |55.914 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end |region|regulatory_comment |
35
+|--------|----------|---------|------|-------------------------------|
36
+|chr3 |183269360 |183274139|TSS |active_promoter-strong_enhancer|
KMT2C.md
... ...
@@ -0,0 +1,32 @@
1
+# [KMT2C]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|6.47 |
15
+|BL |Thomas cohort | NA |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes |2.90 |
18
+|DLBCL |Schmitz cohort |8.30 |
19
+|DLBCL |Reddy cohort |7.30 |
20
+|DLBCL |Chapuy cohort |6.40 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |0.628 |0.000 |
27
+|DLBCL |No |No |1.569 |1.911 |
28
+|FL |No |No |0.550 |0.000 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Zhou P](https://pubmed.ncbi.nlm.nih.gov/31300419). First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
KMT2D.md
... ...
@@ -0,0 +1,34 @@
1
+# [KMT2D]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|11.32 |
16
+|BL |Thomas cohort |14.00 |
17
+|BL |Panea cohort |15.80 |
18
+|DLBCL |GAMBL genomes |31.40 |
19
+|DLBCL |Schmitz cohort |34.50 |
20
+|DLBCL |Reddy cohort |22.30 |
21
+|DLBCL |Chapuy cohort |26.10 |
22
+|FL |GAMBL genomes |67.67 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes | 0.689 | 13.459 |
29
+|DLBCL |No |Yes | 3.731 | 104.190 |
30
+|FL |No |Yes |20.755 |1353.812 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2019 by [Grande BM](https://pubmed.ncbi.nlm.nih.gov/30617194). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119). First described in FL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
... ...
\ No newline at end of file
KRAS.md
... ...
@@ -0,0 +1,28 @@
1
+# [KRAS]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.6 |
14
+|DLBCL |Schmitz cohort|3.6 |
15
+|DLBCL |Reddy cohort |1.7 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |27.314 |0 |
23
+|DLBCL |No |No | 5.336 |0 |
24
+|FL |No |No | 9.959 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2012 by [Lohr JG](https://pubmed.ncbi.nlm.nih.gov/22343534)
... ...
\ No newline at end of file
LAMA5.md
... ...
@@ -0,0 +1,28 @@
1
+# [LAMA5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | 3.2 |
14
+|DLBCL |Schmitz cohort|12.1 |
15
+|DLBCL |Reddy cohort | 4.7 |
16
+|DLBCL |Chapuy cohort | 5.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0.000 |
23
+|DLBCL |No |No |2.765 |4.134 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
LCOR.md
... ...
@@ -0,0 +1,25 @@
1
+# [LCOR]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.1 |
14
+|DLBCL |Schmitz cohort|3.4 |
15
+|DLBCL |Reddy cohort |0.5 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0 |0 |
23
+|DLBCL |No |No |0 |0 |
24
+|FL |No |No |0 |0 |
25
+
LIN54.md
... ...
@@ -0,0 +1,28 @@
1
+# [LIN54]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|2.1 |
15
+|DLBCL |Reddy cohort |0.9 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.770 | 7.752 |
23
+|DLBCL |No |No |1.385 |26.297 |
24
+|FL |No |No |0.000 | 0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
LTB.md
... ...
@@ -0,0 +1,36 @@
1
+# [LTB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 3.00 |
16
+|BL |Thomas cohort | 3.00 |
17
+|BL |Panea cohort | 5.90 |
18
+|DLBCL |GAMBL genomes |11.30 |
19
+|DLBCL |Schmitz cohort | 8.50 |
20
+|DLBCL |Reddy cohort | NA |
21
+|DLBCL |Chapuy cohort | 9.80 |
22
+|FL |GAMBL genomes | 8.78 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No |4.330 | 0.000 |
29
+|DLBCL |Yes |No |2.261 |10.402 |
30
+|FL |Yes |No |5.259 |35.735 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region |regulatory_comment|
35
+|--------|----------|--------|--------|------------------|
36
+|chr6 |31548325 |31550717|intron-1|enhancer |
LYN.md
... ...
@@ -0,0 +1,25 @@
1
+# [LYN]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort|1.7 |
15
+|DLBCL |Reddy cohort |1.3 |
16
+|DLBCL |Chapuy cohort |5.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No | 1.641 | 0.000 |
23
+|DLBCL |No |No |10.031 |17.456 |
24
+|FL |No |No | 0.000 | 0.000 |
25
+
MAGEC1.md
... ...
@@ -0,0 +1,25 @@
1
+# [MAGEC1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|1.85 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |Yes |26.895 |0.000 |
20
+|DLBCL |No |No | 1.032 |4.703 |
21
+|FL |No |No | 0.000 |0.000 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Kalmbach S](https://pubmed.ncbi.nlm.nih.gov/37563306)
... ...
\ No newline at end of file
MAGT1.md
... ...
@@ -0,0 +1,28 @@
1
+# [MAGT1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.6 |
14
+|DLBCL |Schmitz cohort|3.0 |
15
+|DLBCL |Reddy cohort |1.9 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.329 | 0.000 |
23
+|DLBCL |No |No |0.000 |57.832 |
24
+|FL |No |No |0.000 | 0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MAP2K1.md
... ...
@@ -0,0 +1,27 @@
1
+# [MAP2K1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |0.70 |
15
+|DLBCL |Schmitz cohort|3.20 |
16
+|DLBCL |Reddy cohort |2.20 |
17
+|DLBCL |Chapuy cohort |2.10 |
18
+|FL |GAMBL genomes |1.39 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No | 4.318 |0 |
25
+|DLBCL |No |No |11.932 |0 |
26
+|FL |No |No | 5.696 |0 |
27
+
MAP3K6.md
... ...
@@ -0,0 +1,27 @@
1
+# [MAP3K6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.54 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.004 |0 |
22
+|DLBCL |No |No |0.442 |0 |
23
+|FL |No |No |1.344 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
MAP4K4.md
... ...
@@ -0,0 +1,28 @@
1
+# [MAP4K4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.1 |
14
+|DLBCL |Schmitz cohort|2.1 |
15
+|DLBCL |Reddy cohort |2.1 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.518 |0.000 |
23
+|DLBCL |No |No |4.689 |6.978 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MAP7D1.md
... ...
@@ -0,0 +1,25 @@
1
+# [MAP7D1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |0.000 |0 |
20
+|DLBCL |No |No |1.034 |0 |
21
+|FL |No |No |0.000 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Kalmbach S](https://pubmed.ncbi.nlm.nih.gov/37563306)
... ...
\ No newline at end of file
MARK1.md
... ...
@@ -0,0 +1,28 @@
1
+# [MARK1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|1.9 |
15
+|DLBCL |Reddy cohort |1.3 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.923 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |2.768 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MCL1.md
... ...
@@ -0,0 +1,37 @@
1
+# [MCL1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|1.85 |
15
+|BL |Thomas cohort |2.10 |
16
+|BL |Panea cohort |2.00 |
17
+|DLBCL |GAMBL genomes |2.00 |
18
+|DLBCL |Schmitz cohort |3.60 |
19
+|DLBCL |Reddy cohort |4.70 |
20
+|DLBCL |Chapuy cohort |3.40 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |No |5.101 |0.000 |
27
+|DLBCL |Yes |No |0.427 |2.401 |
28
+|FL |Yes |No |0.000 |0.000 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
33
+|--------|----------|---------|------|------------------|
34
+|chr1 |150550814 |150552135|intron|NA |
35
+
36
+> [!NOTE]
37
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MECOM.md
... ...
@@ -0,0 +1,28 @@
1
+# [MECOM]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.6 |
14
+|DLBCL |Schmitz cohort|4.0 |
15
+|DLBCL |Reddy cohort |2.1 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.490 |0 |
23
+|DLBCL |No |No |1.131 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MEF2B.md
... ...
@@ -0,0 +1,36 @@
1
+# [MEF2B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 1.39 |
16
+|BL |Thomas cohort | 0.80 |
17
+|BL |Panea cohort | 3.00 |
18
+|DLBCL |GAMBL genomes |12.00 |
19
+|DLBCL |Schmitz cohort | 9.10 |
20
+|DLBCL |Reddy cohort | 5.90 |
21
+|DLBCL |Chapuy cohort | 5.60 |
22
+|FL |GAMBL genomes |12.93 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 2.449 | 0.000 |
29
+|DLBCL |Yes |Yes | 22.928 |171.945 |
30
+|FL |Yes |Yes |111.098 | 0.000 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chr19 |19279635 |19281441|TSS |active_promoter |
MEF2C.md
... ...
@@ -0,0 +1,34 @@
1
+# [MEF2C]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |3.20 |
15
+|DLBCL |Schmitz cohort|1.90 |
16
+|DLBCL |Reddy cohort |1.70 |
17
+|DLBCL |Chapuy cohort |3.00 |
18
+|FL |GAMBL genomes |6.24 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |Yes |No | 3.687 | 0.000 |
25
+|DLBCL |Yes |No | 9.617 |13.957 |
26
+|FL |Yes |Yes |36.127 | 0.000 |
27
+
28
+## aSHM regions
29
+
30
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
31
+|--------|----------|--------|------|------------------|
32
+|chr5 |88131209 |88174373|TSS-3 |active_promoter |
33
+|chr5 |88174374 |88182243|TSS-2 |active_promoter |
34
+|chr5 |88182244 |88206620|TSS-1 |active_promoter |
MET.md
... ...
@@ -0,0 +1,28 @@
1
+# [MET]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.7 |
14
+|DLBCL |Schmitz cohort|3.8 |
15
+|DLBCL |Reddy cohort |1.7 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.327 |0 |
23
+|DLBCL |No |No |1.141 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MGA.md
... ...
@@ -0,0 +1,28 @@
1
+# [MGA]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.5 |
14
+|DLBCL |Schmitz cohort|7.2 |
15
+|DLBCL |Reddy cohort |4.7 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.443 | 3.733 |
23
+|DLBCL |No |No |1.432 |12.504 |
24
+|FL |No |No |0.000 | 0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
MKI67.md
... ...
@@ -0,0 +1,29 @@
1
+# [MKI67]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|FL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|6.00 |
15
+|BL |Thomas cohort | NA |
16
+|BL |Panea cohort | NA |
17
+|FL |GAMBL genomes |1.15 |
18
+
19
+## Mutation pattern
20
+
21
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
22
+|------|----|---------------------|----------------|----------------|
23
+|BL |No |No |1.547 |0 |
24
+|DLBCL |No |No |1.029 |0 |
25
+|FL |No |No |0.987 |0 |
26
+
27
+
28
+> [!NOTE]
29
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096). First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
MME.md
... ...
@@ -0,0 +1,27 @@
1
+# [MME]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort |0.80 |
15
+|BL |Panea cohort |5.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.702 |0 |
22
+|DLBCL |No |No |1.177 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
MPEG1.md
... ...
@@ -0,0 +1,25 @@
1
+# [MPEG1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | 3.8 |
14
+|DLBCL |Schmitz cohort| 9.1 |
15
+|DLBCL |Reddy cohort | 5.8 |
16
+|DLBCL |Chapuy cohort |10.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.434 |0.000 |
23
+|DLBCL |No |No |1.449 |1.685 |
24
+|FL |No |No |4.371 |0.000 |
25
+
MS4A1.md
... ...
@@ -0,0 +1,30 @@
1
+# [MS4A1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|1.5 |
15
+|DLBCL |Reddy cohort |1.3 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |2.434 |29.43 |
23
+|DLBCL |Yes |No |0.000 | 0.00 |
24
+|FL |Yes |No |0.000 | 0.00 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
29
+|--------|----------|--------|------|------------------|
30
+|chr11 |60223385 |60225310|TSS |active_promoter |
MSH2.md
... ...
@@ -0,0 +1,28 @@
1
+# [MSH2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.1 |
14
+|DLBCL |Schmitz cohort|0.9 |
15
+|DLBCL |Reddy cohort |1.5 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.680 |0 |
23
+|DLBCL |No |No |2.838 |0 |
24
+|FL |No |No |3.261 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MSH6.md
... ...
@@ -0,0 +1,28 @@
1
+# [MSH6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|2.6 |
15
+|DLBCL |Reddy cohort |2.6 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |3.383 |0 |
23
+|DLBCL |No |No |3.213 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MTOR.md
... ...
@@ -0,0 +1,32 @@
1
+# [MTOR]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 4.62 |
15
+|BL |Thomas cohort | 3.40 |
16
+|BL |Panea cohort |10.90 |
17
+|DLBCL |GAMBL genomes | 4.10 |
18
+|DLBCL |Schmitz cohort | 4.00 |
19
+|DLBCL |Reddy cohort | 2.40 |
20
+|DLBCL |Chapuy cohort | 2.10 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |1.204 |0 |
27
+|DLBCL |No |No |5.630 |0 |
28
+|FL |No |No |1.429 |0 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
MYB.md
... ...
@@ -0,0 +1,28 @@
1
+# [MYB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.7 |
14
+|DLBCL |Schmitz cohort|2.1 |
15
+|DLBCL |Reddy cohort |1.1 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.555 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |2.377 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
MYBPC2.md
... ...
@@ -0,0 +1,28 @@
1
+# [MYBPC2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|3.4 |
15
+|DLBCL |Reddy cohort |2.8 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.437 |6.011 |
23
+|DLBCL |No |No |0.653 |0.000 |
24
+|FL |No |No |4.460 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
MYC.md
... ...
@@ -0,0 +1,36 @@
1
+# [MYC]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|61.89 |
16
+|BL |Thomas cohort |60.20 |
17
+|BL |Panea cohort |49.50 |
18
+|DLBCL |GAMBL genomes | 9.90 |
19
+|DLBCL |Schmitz cohort | 5.30 |
20
+|DLBCL |Reddy cohort | 6.20 |
21
+|DLBCL |Chapuy cohort | 6.40 |
22
+|FL |GAMBL genomes | 0.92 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |Yes |7.754 |3.964 |
29
+|DLBCL |Yes |Yes |2.850 |2.582 |
30
+|FL |Yes |No |4.998 |0.000 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
35
+|--------|----------|---------|------|------------------|
36
+|chr8 |128748352 |128749427|TSS |active_promoter |
MYD88.md
... ...
@@ -0,0 +1,31 @@
1
+# [MYD88]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 0.46 |
16
+|BL |Thomas cohort | 0.40 |
17
+|BL |Panea cohort | 1.00 |
18
+|DLBCL |GAMBL genomes |12.90 |
19
+|DLBCL |Schmitz cohort |26.40 |
20
+|DLBCL |Reddy cohort |15.20 |
21
+|DLBCL |Chapuy cohort |21.40 |
22
+|FL |GAMBL genomes | 1.85 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 1.809 |0 |
29
+|DLBCL |No |Yes |56.390 |0 |
30
+|FL |No |No |17.159 |0 |
31
+
MYH10.md
... ...
@@ -0,0 +1,27 @@
1
+# [MYH10]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.026 |0 |
22
+|DLBCL |No |No |2.598 |0 |
23
+|FL |No |No |1.997 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
MYO18A.md
... ...
@@ -0,0 +1,27 @@
1
+# [MYO18A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.248 |0 |
22
+|DLBCL |No |No |0.412 |0 |
23
+|FL |No |No |2.227 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
MYO1E.md
... ...
@@ -0,0 +1,29 @@
1
+# [MYO1E]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort |1.30 |
15
+|BL |Panea cohort |4.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |Yes |No |0.516 |12.845 |
22
+|DLBCL |Yes |No |0.913 |14.181 |
23
+|FL |Yes |No |3.818 |29.467 |
24
+
25
+## aSHM regions
26
+
27
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
28
+|--------|----------|--------|------|------------------|
29
+|chr15 |59658991 |59671152|TSS |NA |
MYOM2.md
... ...
@@ -0,0 +1,25 @@
1
+# [MYOM2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.6 |
14
+|DLBCL |Schmitz cohort|8.1 |
15
+|DLBCL |Reddy cohort |3.2 |
16
+|DLBCL |Chapuy cohort |4.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.021 | 0.000 |
23
+|DLBCL |No |No |0.893 | 2.648 |
24
+|FL |No |No |0.649 |12.057 |
25
+
NANOG.md
... ...
@@ -0,0 +1,28 @@
1
+# [NANOG]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | NA |
14
+|DLBCL |Schmitz cohort|0.2 |
15
+|DLBCL |Reddy cohort |0.4 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0 |0 |
23
+|DLBCL |No |No |0 |0 |
24
+|FL |No |No |0 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
NAV1.md
... ...
@@ -0,0 +1,28 @@
1
+# [NAV1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort|2.8 |
15
+|DLBCL |Reddy cohort |2.0 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.719 |0 |
23
+|DLBCL |No |No |0.532 |0 |
24
+|FL |No |No |1.343 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
NBEAL1.md
... ...
@@ -0,0 +1,27 @@
1
+# [NBEAL1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.46 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.484 |0.000 |
22
+|DLBCL |No |No |0.765 |2.824 |
23
+|FL |No |No |0.863 |0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
NCOR1.md
... ...
@@ -0,0 +1,28 @@
1
+# [NCOR1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|4.5 |
15
+|DLBCL |Reddy cohort |2.7 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.496 |2.331 |
23
+|DLBCL |No |No |0.935 |4.098 |
24
+|FL |No |No |1.147 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
NCOR2.md
... ...
@@ -0,0 +1,32 @@
1
+# [NCOR2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|6.24 |
15
+|BL |Thomas cohort | NA |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes |2.00 |
18
+|DLBCL |Schmitz cohort |5.70 |
19
+|DLBCL |Reddy cohort |3.60 |
20
+|DLBCL |Chapuy cohort |4.30 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |0.551 |0.000 |
27
+|DLBCL |No |No |1.376 |4.613 |
28
+|FL |No |No |0.985 |0.000 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
NF1.md
... ...
@@ -0,0 +1,28 @@
1
+# [NF1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.5 |
14
+|DLBCL |Schmitz cohort|4.0 |
15
+|DLBCL |Reddy cohort |2.5 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.485 |0.000 |
23
+|DLBCL |No |No |1.135 |2.469 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
NFKB1.md
... ...
@@ -0,0 +1,25 @@
1
+# [NFKB1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort|1.3 |
15
+|DLBCL |Reddy cohort |1.6 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.644 |0 |
23
+|DLBCL |No |No |1.613 |0 |
24
+|FL |No |No |4.561 |0 |
25
+
NFKB2.md
... ...
@@ -0,0 +1,28 @@
1
+# [NFKB2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|1.5 |
15
+|DLBCL |Reddy cohort |1.4 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.937 |0.00 |
23
+|DLBCL |No |No |0.861 |8.02 |
24
+|FL |No |No |2.873 |0.00 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
NFKBIA.md
... ...
@@ -0,0 +1,31 @@
1
+# [NFKBIA]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|1.39 |
16
+|BL |Thomas cohort |1.70 |
17
+|BL |Panea cohort |2.00 |
18
+|DLBCL |GAMBL genomes |4.10 |
19
+|DLBCL |Schmitz cohort |3.80 |
20
+|DLBCL |Reddy cohort |3.60 |
21
+|DLBCL |Chapuy cohort |4.70 |
22
+|FL |GAMBL genomes |0.69 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No |3.358 |17.442 |
29
+|DLBCL |No |Yes |9.385 |40.878 |
30
+|FL |No |No |0.000 |28.519 |
31
+
NFKBIE.md
... ...
@@ -0,0 +1,28 @@
1
+# [NFKBIE]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.3 |
14
+|DLBCL |Schmitz cohort|5.7 |
15
+|DLBCL |Reddy cohort |2.9 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.702 | 0.000 |
23
+|DLBCL |No |Yes |8.732 |58.269 |
24
+|FL |No |No |0.000 |46.628 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2016 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/26647218)
... ...
\ No newline at end of file
NFKBIZ.md
... ...
@@ -0,0 +1,31 @@
1
+# [NFKBIZ]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|1.3 |
15
+|DLBCL |Reddy cohort |1.5 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |3.346 |0 |
23
+|DLBCL |Yes |No |2.091 |0 |
24
+|FL |Yes |No |0.000 |0 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
29
+|--------|----------|---------|------|------------------|
30
+|chr3 |101546669 |101547704|TSS-1 |active_promoter |
31
+|chr3 |101568239 |101569274|TSS-2 |active_promoter |
NLRC5.md
... ...
@@ -0,0 +1,25 @@
1
+# [NLRC5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.9 |
14
+|DLBCL |Schmitz cohort|8.3 |
15
+|DLBCL |Reddy cohort |3.7 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.602 | 0.000 |
23
+|DLBCL |No |No |0.529 |20.155 |
24
+|FL |No |No |0.000 | 7.677 |
25
+
NLRP8.md
... ...
@@ -0,0 +1,28 @@
1
+# [NLRP8]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|3.4 |
15
+|DLBCL |Reddy cohort |2.1 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.456 |7.316 |
23
+|DLBCL |No |No |2.731 |0.000 |
24
+|FL |No |No |0.000 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
NOA1.md
... ...
@@ -0,0 +1,27 @@
1
+# [NOA1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.31 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.647 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
NOL9.md
... ...
@@ -0,0 +1,25 @@
1
+# [NOL9]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.7 |
14
+|DLBCL |Schmitz cohort|6.8 |
15
+|DLBCL |Reddy cohort |1.3 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.514 |0 |
23
+|DLBCL |No |No |4.012 |0 |
24
+|FL |No |No |2.619 |0 |
25
+
NOTCH1.md
... ...
@@ -0,0 +1,32 @@
1
+# [NOTCH1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|4.16 |
15
+|BL |Thomas cohort | NA |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes |2.50 |
18
+|DLBCL |Schmitz cohort |8.90 |
19
+|DLBCL |Reddy cohort |3.40 |
20
+|DLBCL |Chapuy cohort |3.00 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |1.031 |0 |
27
+|DLBCL |No |No |0.792 |0 |
28
+|FL |No |No |2.864 |0 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2012 by [Lohr JG](https://pubmed.ncbi.nlm.nih.gov/22343534)
... ...
\ No newline at end of file
NOTCH2.md
... ...
@@ -0,0 +1,29 @@
1
+# [NOTCH2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 1.15 |
15
+|BL |Thomas cohort | 0.00 |
16
+|BL |Panea cohort | 5.00 |
17
+|DLBCL |GAMBL genomes | 6.80 |
18
+|DLBCL |Schmitz cohort |11.30 |
19
+|DLBCL |Reddy cohort | 3.70 |
20
+|DLBCL |Chapuy cohort | 7.30 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |0.000 | 0.000 |
27
+|DLBCL |No |Yes |0.527 |60.245 |
28
+|FL |No |No |0.000 | 0.000 |
29
+
NRXN2.md
... ...
@@ -0,0 +1,27 @@
1
+# [NRXN2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.77 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.039 |0 |
22
+|DLBCL |No |No |1.624 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
OR8H2.md
... ...
@@ -0,0 +1,25 @@
1
+# [OR8H2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|1.15 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |1.795 |0 |
20
+|DLBCL |No |No |0.000 |0 |
21
+|FL |No |No |7.647 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
OSBPL10.md
... ...
@@ -0,0 +1,34 @@
1
+# [OSBPL10]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 2.08 |
15
+|BL |Thomas cohort | 2.10 |
16
+|BL |Panea cohort | 3.00 |
17
+|DLBCL |GAMBL genomes | 8.80 |
18
+|DLBCL |Schmitz cohort |14.30 |
19
+|DLBCL |Reddy cohort | 2.30 |
20
+|DLBCL |Chapuy cohort | 2.60 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |No | 4.102 |11.721 |
27
+|DLBCL |Yes |Yes |12.983 | 0.000 |
28
+|FL |Yes |Yes | 5.877 | 8.779 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
33
+|--------|----------|--------|------|------------------|
34
+|chr3 |32020518 |32024930|TSS-1 |active_promoter |
P2RY2.md
... ...
@@ -0,0 +1,27 @@
1
+# [P2RY2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.15 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.862 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
P2RY8.md
... ...
@@ -0,0 +1,34 @@
1
+# [P2RY8]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 6.93 |
16
+|BL |Thomas cohort |11.00 |
17
+|BL |Panea cohort | NA |
18
+|DLBCL |GAMBL genomes | 7.20 |
19
+|DLBCL |Schmitz cohort | 7.20 |
20
+|DLBCL |Reddy cohort | NA |
21
+|DLBCL |Chapuy cohort | 6.00 |
22
+|FL |GAMBL genomes | 2.31 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes |58.153 |189.145 |
29
+|DLBCL |No |Yes |31.041 | 0.000 |
30
+|FL |No |No |23.117 | 0.000 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2014 by [Muppidi JR](https://pubmed.ncbi.nlm.nih.gov/25274307). First described in DLBCL in 2012 by [Lohr JG](https://pubmed.ncbi.nlm.nih.gov/22343534)
... ...
\ No newline at end of file
PABPC4L.md
... ...
@@ -0,0 +1,27 @@
1
+# [PABPC4L]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort |1.30 |
15
+|BL |Panea cohort |3.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.776 |0 |
22
+|DLBCL |No |No |2.948 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
PAPOLG.md
... ...
@@ -0,0 +1,28 @@
1
+# [PAPOLG]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.2 |
14
+|DLBCL |Schmitz cohort|0.9 |
15
+|DLBCL |Reddy cohort |1.2 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |1.554 |0 |
24
+|FL |No |No |4.497 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
PAX5.md
... ...
@@ -0,0 +1,37 @@
1
+# [PAX5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.5 |
14
+|DLBCL |Schmitz cohort|3.2 |
15
+|DLBCL |Reddy cohort |1.9 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No | 6.750 |0 |
23
+|DLBCL |Yes |Yes |14.089 |0 |
24
+|FL |Yes |No |10.963 |0 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region |regulatory_comment|
29
+|--------|----------|--------|-----------------|------------------|
30
+|chr9 |37023396 |37027663|intron-1 |intron |
31
+|chr9 |37029849 |37037154|TSS-1 |active_promoter |
32
+|chr9 |37369209 |37372160|distal-enhancer-1|enhancer |
33
+|chr9 |37382267 |37385854|distal-enhancer-2|enhancer |
34
+|chr9 |37395932 |37409239|distal-enhancer-3|enhancer |
35
+
36
+> [!NOTE]
37
+> First described in DLBCL in 2001 by [Pasqualucci L](https://pubmed.ncbi.nlm.nih.gov/11460166)
... ...
\ No newline at end of file
PC.md
... ...
@@ -0,0 +1,27 @@
1
+# [PC]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.54 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.187 | 0.000 |
22
+|DLBCL |No |No |0.000 |10.914 |
23
+|FL |No |No |0.000 |27.654 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
PCBP1.md
... ...
@@ -0,0 +1,32 @@
1
+# [PCBP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|12.24 |
15
+|BL |Thomas cohort |12.30 |
16
+|BL |Panea cohort |11.90 |
17
+|DLBCL |GAMBL genomes | 1.60 |
18
+|DLBCL |Schmitz cohort | 2.30 |
19
+|DLBCL |Reddy cohort | 2.40 |
20
+|DLBCL |Chapuy cohort | 1.70 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |16.780 |424.685 |
27
+|DLBCL |No |No | 0.000 | 0.000 |
28
+|FL |No |No | 1.401 | 0.000 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2015 by [Wagener R](https://pubmed.ncbi.nlm.nih.gov/26173642)
... ...
\ No newline at end of file
PCDHA11.md
... ...
@@ -0,0 +1,27 @@
1
+# [PCDHA11]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort |1.30 |
15
+|BL |Panea cohort |3.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.171 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.784 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
PCLO.md
... ...
@@ -0,0 +1,30 @@
1
+# [PCLO]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |15.30 |
15
+|DLBCL |Schmitz cohort|21.30 |
16
+|DLBCL |Reddy cohort |15.10 |
17
+|DLBCL |Chapuy cohort |23.10 |
18
+|FL |GAMBL genomes | 9.24 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No |0.000 |0.000 |
25
+|DLBCL |No |No |1.223 |0.389 |
26
+|FL |No |No |0.000 |0.000 |
27
+
28
+
29
+> [!NOTE]
30
+> First described in DLBCL in 2012 by [Lohr JG](https://pubmed.ncbi.nlm.nih.gov/22343534)
... ...
\ No newline at end of file
PDCD11.md
... ...
@@ -0,0 +1,27 @@
1
+# [PDCD11]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.46 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |4.985 |0 |
22
+|DLBCL |No |No |2.400 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
PDE4DIP.md
... ...
@@ -0,0 +1,28 @@
1
+# [PDE4DIP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort|2.3 |
15
+|DLBCL |Reddy cohort |5.3 |
16
+|DLBCL |Chapuy cohort |8.5 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.344 |1.032 |
23
+|DLBCL |No |No |1.467 |5.897 |
24
+|FL |No |No |2.010 |7.866 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
PDZRN3.md
... ...
@@ -0,0 +1,27 @@
1
+# [PDZRN3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.46 |
14
+|BL |Thomas cohort |2.10 |
15
+|BL |Panea cohort |9.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.623 |0 |
22
+|DLBCL |No |No |0.461 |0 |
23
+|FL |No |No |0.935 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
PHF6.md
... ...
@@ -0,0 +1,32 @@
1
+# [PHF6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|7.16 |
15
+|BL |Thomas cohort |5.50 |
16
+|BL |Panea cohort |5.90 |
17
+|DLBCL |GAMBL genomes |2.30 |
18
+|DLBCL |Schmitz cohort |1.50 |
19
+|DLBCL |Reddy cohort |1.40 |
20
+|DLBCL |Chapuy cohort |0.90 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |10.853 |196.689 |
27
+|DLBCL |No |No | 6.130 | 36.559 |
28
+|FL |No |No |31.614 | 0.000 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2023 by [Thomas N](https://pubmed.ncbi.nlm.nih.gov/36201743). First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
PIK3CD.md
... ...
@@ -0,0 +1,25 @@
1
+# [PIK3CD]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.1 |
14
+|DLBCL |Schmitz cohort|4.9 |
15
+|DLBCL |Reddy cohort |2.5 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |4.941 |0 |
23
+|DLBCL |No |No |4.970 |0 |
24
+|FL |No |No |5.721 |0 |
25
+
PIK3R1.md
... ...
@@ -0,0 +1,32 @@
1
+# [PIK3R1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|3.0 |
15
+|BL |Thomas cohort |2.5 |
16
+|BL |Panea cohort |4.0 |
17
+|DLBCL |GAMBL genomes |2.0 |
18
+|DLBCL |Schmitz cohort |2.1 |
19
+|DLBCL |Reddy cohort |2.0 |
20
+|DLBCL |Chapuy cohort |4.7 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |3.917 | 0.000 |
27
+|DLBCL |No |No |2.158 |16.154 |
28
+|FL |No |No |0.000 |14.389 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468). First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
PIM1.md
... ...
@@ -0,0 +1,39 @@
1
+# [PIM1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 2.31 |
16
+|BL |Thomas cohort | NA |
17
+|BL |Panea cohort | NA |
18
+|DLBCL |GAMBL genomes |18.50 |
19
+|DLBCL |Schmitz cohort |27.70 |
20
+|DLBCL |Reddy cohort |19.10 |
21
+|DLBCL |Chapuy cohort |23.90 |
22
+|FL |GAMBL genomes | 9.24 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No |6.021 |0.000 |
29
+|DLBCL |Yes |Yes |2.096 |2.418 |
30
+|FL |Yes |No |4.214 |0.000 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chr6 |37138104 |37139804|TSS |active_promoter |
37
+
38
+> [!NOTE]
39
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096). First described in DLBCL in 2001 by [Pasqualucci L](https://pubmed.ncbi.nlm.nih.gov/11460166)
... ...
\ No newline at end of file
PIM2.md
... ...
@@ -0,0 +1,30 @@
1
+# [PIM2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.9 |
14
+|DLBCL |Schmitz cohort|6.4 |
15
+|DLBCL |Reddy cohort |4.0 |
16
+|DLBCL |Chapuy cohort |3.8 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |0.000 | 0.000 |
23
+|DLBCL |Yes |No |1.908 |14.378 |
24
+|FL |Yes |No |0.000 |62.405 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
29
+|--------|----------|--------|------|------------------|
30
+|chrX |48774756 |48776255|TSS |active_promoter |
PLCG2.md
... ...
@@ -0,0 +1,27 @@
1
+# [PLCG2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture| 3.0 |
14
+|BL |Thomas cohort | 0.8 |
15
+|BL |Panea cohort |10.9 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.800 | 0.000 |
22
+|DLBCL |No |No |2.213 |14.094 |
23
+|FL |No |No |1.491 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
PMAIP1.md
... ...
@@ -0,0 +1,24 @@
1
+# [PMAIP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.23 |
14
+|BL |Thomas cohort |3.00 |
15
+|BL |Panea cohort |5.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |Yes |15.382 |90.742 |
22
+|DLBCL |No |No | 0.000 | 0.000 |
23
+|FL |No |No | 0.000 | 0.000 |
24
+
POLRMT.md
... ...
@@ -0,0 +1,27 @@
1
+# [POLRMT]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.969 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
POR.md
... ...
@@ -0,0 +1,27 @@
1
+# [POR]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.54 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.005 |0 |
22
+|DLBCL |No |No |1.464 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
POU2AF1.md
... ...
@@ -0,0 +1,32 @@
1
+# [POU2AF1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes | 5.00 |
15
+|DLBCL |Schmitz cohort| 2.30 |
16
+|DLBCL |Reddy cohort | 3.30 |
17
+|DLBCL |Chapuy cohort | 5.60 |
18
+|FL |GAMBL genomes |12.24 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |Yes |No |0.000 | 0.000 |
25
+|DLBCL |Yes |No |6.798 | 74.689 |
26
+|FL |Yes |Yes |0.000 |659.924 |
27
+
28
+## aSHM regions
29
+
30
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
31
+|--------|----------|---------|------|------------------|
32
+|chr11 |111248078 |111250224|TSS |active_promoter |
POU2F2.md
... ...
@@ -0,0 +1,27 @@
1
+# [POU2F2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |5.20 |
15
+|DLBCL |Schmitz cohort|6.40 |
16
+|DLBCL |Reddy cohort |3.40 |
17
+|DLBCL |Chapuy cohort |6.40 |
18
+|FL |GAMBL genomes |6.24 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No | 3.431 | 0.000 |
25
+|DLBCL |No |Yes |12.445 |51.943 |
26
+|FL |No |No |17.646 | 0.000 |
27
+
PPP1R9B.md
... ...
@@ -0,0 +1,25 @@
1
+# [PPP1R9B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|3.4 |
15
+|DLBCL |Reddy cohort |0.7 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.267 |10.265 |
23
+|DLBCL |No |No |0.632 | 0.000 |
24
+|FL |No |No |0.000 |34.824 |
25
+
PPP6R2.md
... ...
@@ -0,0 +1,27 @@
1
+# [PPP6R2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.193 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
PRDM1.md
... ...
@@ -0,0 +1,29 @@
1
+# [PRDM1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 2.31 |
15
+|BL |Thomas cohort | 0.80 |
16
+|BL |Panea cohort | 5.90 |
17
+|DLBCL |GAMBL genomes | 8.10 |
18
+|DLBCL |Schmitz cohort |10.20 |
19
+|DLBCL |Reddy cohort | 5.40 |
20
+|DLBCL |Chapuy cohort | 8.50 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |0.746 | 0.000 |
27
+|DLBCL |No |Yes |4.912 |23.497 |
28
+|FL |No |No |0.000 | 0.000 |
29
+
PREX1.md
... ...
@@ -0,0 +1,27 @@
1
+# [PREX1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.633 | 4.023 |
22
+|DLBCL |No |No |0.722 | 4.039 |
23
+|FL |No |No |1.695 |10.067 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
PRKCB.md
... ...
@@ -0,0 +1,25 @@
1
+# [PRKCB]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.3 |
14
+|DLBCL |Schmitz cohort|5.1 |
15
+|DLBCL |Reddy cohort |1.6 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |3.889 |0 |
24
+|FL |No |No |1.828 |0 |
25
+
PRKCD.md
... ...
@@ -0,0 +1,24 @@
1
+# [PRKCD]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.31 |
14
+|BL |Thomas cohort |1.30 |
15
+|BL |Panea cohort |5.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No | 2.225 | 0.000 |
22
+|DLBCL |No |Yes |11.290 |71.966 |
23
+|FL |No |No |25.696 | 0.000 |
24
+
PRKDC.md
... ...
@@ -0,0 +1,25 @@
1
+# [PRKDC]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.9 |
14
+|DLBCL |Schmitz cohort|7.7 |
15
+|DLBCL |Reddy cohort |6.6 |
16
+|DLBCL |Chapuy cohort |6.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.571 |0.939 |
23
+|DLBCL |No |No |1.076 |0.000 |
24
+|FL |No |No |0.000 |7.794 |
25
+
PRPS1.md
... ...
@@ -0,0 +1,28 @@
1
+# [PRPS1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|0.6 |
15
+|DLBCL |Reddy cohort |0.2 |
16
+|DLBCL |Chapuy cohort |0.9 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |3.078 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
PRSS22.md
... ...
@@ -0,0 +1,27 @@
1
+# [PRSS22]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.023 |0 |
22
+|DLBCL |No |No |2.370 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
PTEN.md
... ...
@@ -0,0 +1,29 @@
1
+# [PTEN]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|4.16 |
15
+|BL |Thomas cohort |4.70 |
16
+|BL |Panea cohort |4.00 |
17
+|DLBCL |GAMBL genomes |3.20 |
18
+|DLBCL |Schmitz cohort |4.30 |
19
+|DLBCL |Reddy cohort |3.10 |
20
+|DLBCL |Chapuy cohort |4.70 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |22.104 |81.225 |
27
+|DLBCL |No |No | 4.548 |76.677 |
28
+|FL |No |No | 4.634 | 0.000 |
29
+
PTPN6.md
... ...
@@ -0,0 +1,28 @@
1
+# [PTPN6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.7 |
14
+|DLBCL |Schmitz cohort|4.5 |
15
+|DLBCL |Reddy cohort |2.9 |
16
+|DLBCL |Chapuy cohort |5.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 | 0.000 |
23
+|DLBCL |No |No |5.433 |14.931 |
24
+|FL |No |No |0.000 | 0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
PTPRD.md
... ...
@@ -0,0 +1,27 @@
1
+# [PTPRD]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |4.7 |
15
+|DLBCL |Schmitz cohort|7.7 |
16
+|DLBCL |Reddy cohort |5.2 |
17
+|DLBCL |Chapuy cohort |5.6 |
18
+|FL |GAMBL genomes |3.7 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No |1.905 |0.000 |
25
+|DLBCL |No |No |0.969 |0.000 |
26
+|FL |No |No |1.549 |3.769 |
27
+
PTPRK.md
... ...
@@ -0,0 +1,28 @@
1
+# [PTPRK]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.1 |
14
+|DLBCL |Schmitz cohort|3.6 |
15
+|DLBCL |Reddy cohort |3.3 |
16
+|DLBCL |Chapuy cohort |6.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.146 |0.000 |
23
+|DLBCL |No |No |1.555 |1.797 |
24
+|FL |No |No |1.875 |5.021 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
PTPRN.md
... ...
@@ -0,0 +1,27 @@
1
+# [PTPRN]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.69 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0 |0 |
22
+|DLBCL |No |No |0 |0 |
23
+|FL |No |No |0 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
PXDNL.md
... ...
@@ -0,0 +1,27 @@
1
+# [PXDNL]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.62 |
14
+|BL |Thomas cohort |3.00 |
15
+|BL |Panea cohort |9.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.255 |0 |
22
+|DLBCL |No |No |1.924 |0 |
23
+|FL |No |No |1.165 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
PZP.md
... ...
@@ -0,0 +1,25 @@
1
+# [PZP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0.92 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |0.936 |0 |
20
+|DLBCL |No |No |0.273 |0 |
21
+|FL |No |No |1.723 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
RAC2.md
... ...
@@ -0,0 +1,27 @@
1
+# [RAC2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.69 |
14
+|BL |Thomas cohort |0.40 |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |9.926 |0 |
22
+|DLBCL |No |No |6.256 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
RAD9A.md
... ...
@@ -0,0 +1,28 @@
1
+# [RAD9A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | NA |
14
+|DLBCL |Schmitz cohort|0.4 |
15
+|DLBCL |Reddy cohort |0.5 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0 |0 |
23
+|DLBCL |No |No |0 |0 |
24
+|FL |No |No |0 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
RANBP6.md
... ...
@@ -0,0 +1,27 @@
1
+# [RANBP6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |3.815 |0 |
22
+|DLBCL |No |No |0.306 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
RARA.md
... ...
@@ -0,0 +1,28 @@
1
+# [RARA]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|4.0 |
15
+|DLBCL |Reddy cohort |0.7 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |6.208 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
RB1.md
... ...
@@ -0,0 +1,25 @@
1
+# [RB1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.6 |
14
+|DLBCL |Schmitz cohort|3.2 |
15
+|DLBCL |Reddy cohort |1.6 |
16
+|DLBCL |Chapuy cohort |3.8 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.029 | 6.855 |
23
+|DLBCL |No |Yes |0.933 |17.514 |
24
+|FL |No |No |1.890 | 0.000 |
25
+
RBP3.md
... ...
@@ -0,0 +1,27 @@
1
+# [RBP3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.69 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.00 |0 |
22
+|DLBCL |No |No |0.38 |0 |
23
+|FL |No |No |0.00 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
RET.md
... ...
@@ -0,0 +1,27 @@
1
+# [RET]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.31 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.901 |0 |
22
+|DLBCL |No |No |2.518 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
REV3L.md
... ...
@@ -0,0 +1,27 @@
1
+# [REV3L]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.067 |0 |
22
+|DLBCL |No |No |0.915 |0 |
23
+|FL |No |No |0.731 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
RFX7.md
... ...
@@ -0,0 +1,29 @@
1
+# [RFX7]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|9.47 |
15
+|BL |Thomas cohort |9.30 |
16
+|BL |Panea cohort |4.00 |
17
+|DLBCL |GAMBL genomes |3.20 |
18
+|DLBCL |Schmitz cohort |1.90 |
19
+|DLBCL |Reddy cohort |3.40 |
20
+|DLBCL |Chapuy cohort |4.70 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |2.347 |98.419 |
27
+|DLBCL |No |No |1.219 |17.441 |
28
+|FL |No |No |0.000 | 0.000 |
29
+
RFXAP.md
... ...
@@ -0,0 +1,25 @@
1
+# [RFXAP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.1 |
14
+|DLBCL |Schmitz cohort|1.3 |
15
+|DLBCL |Reddy cohort |0.6 |
16
+|DLBCL |Chapuy cohort | NA |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.222 |91.553 |
23
+|DLBCL |No |No |3.462 |29.787 |
24
+|FL |No |No |4.119 | 0.000 |
25
+
RHOA.md
... ...
@@ -0,0 +1,29 @@
1
+# [RHOA]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 9.47 |
15
+|BL |Thomas cohort | 8.10 |
16
+|BL |Panea cohort |12.90 |
17
+|DLBCL |GAMBL genomes | 3.20 |
18
+|DLBCL |Schmitz cohort | 3.60 |
19
+|DLBCL |Reddy cohort | 3.30 |
20
+|DLBCL |Chapuy cohort | 5.10 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |88.993 |0 |
27
+|DLBCL |No |Yes |52.294 |0 |
28
+|FL |No |No |31.528 |0 |
29
+
RNF144B.md
... ...
@@ -0,0 +1,32 @@
1
+# [RNF144B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.23 |
14
+|BL |Thomas cohort |0.40 |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |Yes |No |0 |0 |
22
+|DLBCL |Yes |No |0 |0 |
23
+|FL |Yes |No |0 |0 |
24
+
25
+## aSHM regions
26
+
27
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
28
+|--------|----------|--------|------|------------------|
29
+|chr6 |25861094 |25868788|TSS |NA |
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
RPL10.md
... ...
@@ -0,0 +1,27 @@
1
+# [RPL10]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|13.63 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.00 |0 |
22
+|DLBCL |No |No |1.03 |0 |
23
+|FL |No |No |0.00 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
RPL22.md
... ...
@@ -0,0 +1,24 @@
1
+# [RPL22]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.31 |
14
+|BL |Thomas cohort |3.00 |
15
+|BL |Panea cohort |2.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |Yes |16.054 |60.122 |
22
+|DLBCL |No |No | 0.000 | 0.000 |
23
+|FL |No |No |21.073 | 0.000 |
24
+
RRAGC.md
... ...
@@ -0,0 +1,30 @@
1
+# [RRAGC]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes | 1.80 |
15
+|DLBCL |Schmitz cohort| 3.00 |
16
+|DLBCL |Reddy cohort | 2.00 |
17
+|DLBCL |Chapuy cohort | 0.40 |
18
+|FL |GAMBL genomes |10.85 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No | 0.000 |0 |
25
+|DLBCL |No |No | 2.679 |0 |
26
+|FL |No |Yes |163.715 |0 |
27
+
28
+
29
+> [!NOTE]
30
+> First described in DLBCL in 2016 by [Okosun J](https://pubmed.ncbi.nlm.nih.gov/26691987)
... ...
\ No newline at end of file
RUNX1.md
... ...
@@ -0,0 +1,28 @@
1
+# [RUNX1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|0.9 |
15
+|DLBCL |Reddy cohort |0.5 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0 |0 |
23
+|DLBCL |No |No |0 |0 |
24
+|FL |No |No |0 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
S1PR2.md
... ...
@@ -0,0 +1,39 @@
1
+# [S1PR2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|1.15 |
16
+|BL |Thomas cohort |0.00 |
17
+|BL |Panea cohort |4.00 |
18
+|DLBCL |GAMBL genomes |4.10 |
19
+|DLBCL |Schmitz cohort |2.10 |
20
+|DLBCL |Reddy cohort |2.20 |
21
+|DLBCL |Chapuy cohort |2.60 |
22
+|FL |GAMBL genomes |6.24 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 0.000 | 0.000 |
29
+|DLBCL |Yes |Yes |34.147 | 0.000 |
30
+|FL |Yes |Yes |36.780 |339.679 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chr19 |10340142 |10341764|TSS |active_promoter |
37
+
38
+> [!NOTE]
39
+> First described in BL in 2014 by [Muppidi JR](https://pubmed.ncbi.nlm.nih.gov/25274307)
... ...
\ No newline at end of file
SAL3.md
... ...
@@ -0,0 +1,24 @@
1
+# [SAL3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|NA |
14
+|BL |Thomas cohort |NA |
15
+|BL |Panea cohort |NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+
22
+
23
+> [!NOTE]
24
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
SALL3.md
... ...
@@ -0,0 +1,27 @@
1
+# [SALL3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.16 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.641 | 0.000 |
22
+|DLBCL |No |No |1.052 |13.148 |
23
+|FL |No |No |1.660 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
SAPS2.md
... ...
@@ -0,0 +1,24 @@
1
+# [SAPS2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|NA |
14
+|BL |Thomas cohort |NA |
15
+|BL |Panea cohort |NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+
22
+
23
+> [!NOTE]
24
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
SBF1.md
... ...
@@ -0,0 +1,27 @@
1
+# [SBF1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|4.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.613 | 0.000 |
22
+|DLBCL |No |No |2.003 |12.038 |
23
+|FL |No |No |1.554 |19.971 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
SEPT10.md
... ...
@@ -0,0 +1,24 @@
1
+# [SEPT10]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.92 |
14
+|BL |Thomas cohort |2.10 |
15
+|BL |Panea cohort |2.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |7.224 |13.447 |
22
+|DLBCL |No |No |0.000 | 0.000 |
23
+|FL |No |No |2.834 | 0.000 |
24
+
SESN1.md
... ...
@@ -0,0 +1,25 @@
1
+# [SESN1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|0.23 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |4.805 |0 |
20
+|DLBCL |No |No |1.629 |0 |
21
+|FL |No |No |0.000 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2017 by [Oricchio E](https://pubmed.ncbi.nlm.nih.gov/28659443)
... ...
\ No newline at end of file
SETD1B.md
... ...
@@ -0,0 +1,25 @@
1
+# [SETD1B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | 3.6 |
14
+|DLBCL |Schmitz cohort|12.8 |
15
+|DLBCL |Reddy cohort | 5.8 |
16
+|DLBCL |Chapuy cohort | NA |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 | 0.000 |
23
+|DLBCL |No |No |2.645 | 24.278 |
24
+|FL |No |Yes |4.979 |128.132 |
25
+
SETD2.md
... ...
@@ -0,0 +1,25 @@
1
+# [SETD2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.7 |
14
+|DLBCL |Schmitz cohort|6.4 |
15
+|DLBCL |Reddy cohort |4.6 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.730 |0 |
23
+|DLBCL |No |No |2.572 |0 |
24
+|FL |No |No |2.306 |0 |
25
+
SETD5.md
... ...
@@ -0,0 +1,28 @@
1
+# [SETD5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.5 |
14
+|DLBCL |Schmitz cohort|5.3 |
15
+|DLBCL |Reddy cohort |3.2 |
16
+|DLBCL |Chapuy cohort |2.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 | 0.000 |
23
+|DLBCL |No |No |0.841 |32.108 |
24
+|FL |No |No |2.236 | 0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
SF3B1.md
... ...
@@ -0,0 +1,32 @@
1
+# [SF3B1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|3.0 |
15
+|BL |Thomas cohort | NA |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes |2.0 |
18
+|DLBCL |Schmitz cohort |2.1 |
19
+|DLBCL |Reddy cohort |2.0 |
20
+|DLBCL |Chapuy cohort |3.0 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |2.277 |0.000 |
27
+|DLBCL |No |No |3.245 |7.004 |
28
+|FL |No |No |2.408 |0.000 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
SGK1.md
... ...
@@ -0,0 +1,36 @@
1
+# [SGK1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 2.08 |
16
+|BL |Thomas cohort | 2.50 |
17
+|BL |Panea cohort | 4.00 |
18
+|DLBCL |GAMBL genomes |11.70 |
19
+|DLBCL |Schmitz cohort |10.60 |
20
+|DLBCL |Reddy cohort |11.20 |
21
+|DLBCL |Chapuy cohort |12.80 |
22
+|FL |GAMBL genomes | 6.00 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 5.451 | 7.487 |
29
+|DLBCL |Yes |Yes | 6.056 | 13.755 |
30
+|FL |Yes |Yes |23.198 |134.356 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end |region|regulatory_comment|
35
+|--------|----------|---------|------|------------------|
36
+|chr6 |134487960 |134499859|TSS-1 |active_promoter |
SHANK1.md
... ...
@@ -0,0 +1,27 @@
1
+# [SHANK1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.77 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.869 |0 |
22
+|DLBCL |No |No |0.895 |0 |
23
+|FL |No |No |2.138 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
SHROOM3.md
... ...
@@ -0,0 +1,25 @@
1
+# [SHROOM3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|1.15 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |0.333 |0 |
20
+|DLBCL |No |No |1.125 |0 |
21
+|FL |No |No |0.774 |0 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
SIN3A.md
... ...
@@ -0,0 +1,32 @@
1
+# [SIN3A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|11.09 |
15
+|BL |Thomas cohort |10.60 |
16
+|BL |Panea cohort |14.90 |
17
+|DLBCL |GAMBL genomes | 2.90 |
18
+|DLBCL |Schmitz cohort | 2.80 |
19
+|DLBCL |Reddy cohort | 3.00 |
20
+|DLBCL |Chapuy cohort | 3.80 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |3.871 |55.210 |
27
+|DLBCL |No |No |2.483 |15.818 |
28
+|FL |No |No |0.000 |20.676 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Grande BM](https://pubmed.ncbi.nlm.nih.gov/30617194)
... ...
\ No newline at end of file
SLC29A2.md
... ...
@@ -0,0 +1,27 @@
1
+# [SLC29A2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.46 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0 |0 |
22
+|DLBCL |No |No |0 |0 |
23
+|FL |No |No |0 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
SMARCA4.md
... ...
@@ -0,0 +1,34 @@
1
+# [SMARCA4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|22.63 |
16
+|BL |Thomas cohort |17.80 |
17
+|BL |Panea cohort |18.80 |
18
+|DLBCL |GAMBL genomes | 2.70 |
19
+|DLBCL |Schmitz cohort | 3.00 |
20
+|DLBCL |Reddy cohort | 3.30 |
21
+|DLBCL |Chapuy cohort | 2.10 |
22
+|FL |GAMBL genomes | 4.16 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes |13.014 |7.632 |
29
+|DLBCL |No |No | 3.876 |0.000 |
30
+|FL |No |No |11.081 |0.000 |
31
+
32
+
33
+> [!NOTE]
34
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937). First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
SMEK1.md
... ...
@@ -0,0 +1,28 @@
1
+# [SMEK1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.0 |
14
+|DLBCL |Schmitz cohort| NA |
15
+|DLBCL |Reddy cohort |0.9 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 | 5.691 |
23
+|DLBCL |No |No |1.264 | 0.000 |
24
+|FL |No |No |9.566 |58.730 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
SNTB2.md
... ...
@@ -0,0 +1,27 @@
1
+# [SNTB2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.69 |
14
+|BL |Thomas cohort |0.00 |
15
+|BL |Panea cohort |2.00 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.000 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |3.904 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
SOCS1.md
... ...
@@ -0,0 +1,36 @@
1
+# [SOCS1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 1.85 |
16
+|BL |Thomas cohort | 1.70 |
17
+|BL |Panea cohort | 3.00 |
18
+|DLBCL |GAMBL genomes |16.50 |
19
+|DLBCL |Schmitz cohort |12.80 |
20
+|DLBCL |Reddy cohort |10.40 |
21
+|DLBCL |Chapuy cohort | 4.70 |
22
+|FL |GAMBL genomes | 9.70 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 4.476 | 0.000 |
29
+|DLBCL |Yes |Yes | 5.023 | 17.509 |
30
+|FL |Yes |Yes |21.460 |123.344 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region |regulatory_comment|
35
+|--------|----------|--------|--------|------------------|
36
+|chr16 |11347512 |11350007|intron-1|enhancer |
SP3.md
... ...
@@ -0,0 +1,27 @@
1
+# [SP3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.0 |
14
+|BL |Thomas cohort |2.5 |
15
+|BL |Panea cohort |5.0 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.249 |16.244 |
22
+|DLBCL |No |No |1.085 |25.775 |
23
+|FL |No |No |2.231 |27.201 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
SPEN.md
... ...
@@ -0,0 +1,25 @@
1
+# [SPEN]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | 3.4 |
14
+|DLBCL |Schmitz cohort|10.0 |
15
+|DLBCL |Reddy cohort | 7.4 |
16
+|DLBCL |Chapuy cohort | 9.8 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.456 | 0.000 |
23
+|DLBCL |No |No |0.900 |13.083 |
24
+|FL |No |No |1.765 |25.228 |
25
+
SRRM2.md
... ...
@@ -0,0 +1,25 @@
1
+# [SRRM2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|1.39 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |1.604 |1.723 |
20
+|DLBCL |No |No |1.835 |0.000 |
21
+|FL |No |No |1.461 |0.000 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
STAB2.md
... ...
@@ -0,0 +1,25 @@
1
+# [STAB2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|2.54 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |0.371 |1.052 |
20
+|DLBCL |No |No |0.781 |0.000 |
21
+|FL |No |No |1.912 |0.000 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
STAT3.md
... ...
@@ -0,0 +1,29 @@
1
+# [STAT3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|0.92 |
15
+|BL |Thomas cohort |0.00 |
16
+|BL |Panea cohort |1.00 |
17
+|DLBCL |GAMBL genomes |7.40 |
18
+|DLBCL |Schmitz cohort |9.40 |
19
+|DLBCL |Reddy cohort |3.60 |
20
+|DLBCL |Chapuy cohort |7.30 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No | 0.000 | 0.000 |
27
+|DLBCL |No |Yes |27.471 |12.427 |
28
+|FL |No |No |34.737 | 0.000 |
29
+
STAT5B.md
... ...
@@ -0,0 +1,28 @@
1
+# [STAT5B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|0.4 |
15
+|DLBCL |Reddy cohort |1.6 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.137 |0 |
23
+|DLBCL |No |No |1.568 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
STAT6.md
... ...
@@ -0,0 +1,31 @@
1
+# [STAT6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 1.62 |
16
+|BL |Thomas cohort | 1.70 |
17
+|BL |Panea cohort | 2.00 |
18
+|DLBCL |GAMBL genomes | 4.50 |
19
+|DLBCL |Schmitz cohort | 2.60 |
20
+|DLBCL |Reddy cohort | 3.80 |
21
+|DLBCL |Chapuy cohort | 4.70 |
22
+|FL |GAMBL genomes |15.94 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 3.301 |0 |
29
+|DLBCL |No |No | 11.582 |0 |
30
+|FL |No |Yes |116.612 |0 |
31
+
SYK.md
... ...
@@ -0,0 +1,28 @@
1
+# [SYK]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|2.3 |
15
+|DLBCL |Reddy cohort |0.8 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |2.281 | 0.00 |
23
+|DLBCL |No |No |3.818 |12.94 |
24
+|FL |No |No |0.000 | 0.00 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
SYNCRIP.md
... ...
@@ -0,0 +1,27 @@
1
+# [SYNCRIP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|3.0 |
14
+|BL |Thomas cohort |2.5 |
15
+|BL |Panea cohort |5.0 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No | 4.806 |35.301 |
22
+|DLBCL |No |No | 2.325 |47.239 |
23
+|FL |No |No |16.820 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
SYNGAP1.md
... ...
@@ -0,0 +1,27 @@
1
+# [SYNGAP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.39 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.464 |0 |
22
+|DLBCL |No |No |0.650 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
TAF1.md
... ...
@@ -0,0 +1,28 @@
1
+# [TAF1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |5.4 |
14
+|DLBCL |Schmitz cohort|4.9 |
15
+|DLBCL |Reddy cohort |4.0 |
16
+|DLBCL |Chapuy cohort |3.8 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.410 |0 |
23
+|DLBCL |No |No |5.884 |0 |
24
+|FL |No |No |8.661 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
TAP1.md
... ...
@@ -0,0 +1,28 @@
1
+# [TAP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|3.6 |
15
+|DLBCL |Reddy cohort | NA |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.986 | 0.000 |
23
+|DLBCL |No |No |0.632 | 0.000 |
24
+|FL |No |No |3.142 |39.164 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/29641966)
... ...
\ No newline at end of file
TBC1D9B.md
... ...
@@ -0,0 +1,27 @@
1
+# [TBC1D9B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |2.926 |0.000 |
22
+|DLBCL |No |No |0.871 |9.918 |
23
+|FL |No |No |0.000 |0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
TBL1XR1.md
... ...
@@ -0,0 +1,31 @@
1
+# [TBL1XR1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 6.00 |
16
+|BL |Thomas cohort | 4.70 |
17
+|BL |Panea cohort | 7.90 |
18
+|DLBCL |GAMBL genomes | 8.80 |
19
+|DLBCL |Schmitz cohort |12.80 |
20
+|DLBCL |Reddy cohort | 5.70 |
21
+|DLBCL |Chapuy cohort | 8.10 |
22
+|FL |GAMBL genomes | 3.93 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes |17.892 |29.577 |
29
+|DLBCL |No |Yes |24.811 |24.179 |
30
+|FL |No |No |12.400 |18.940 |
31
+
TCF3.md
... ...
@@ -0,0 +1,27 @@
1
+# [TCF3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|11.55 |
14
+|BL |Thomas cohort |11.00 |
15
+|BL |Panea cohort | 9.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |4.463 |34.108 |
22
+|DLBCL |No |No |1.567 | 0.000 |
23
+|FL |No |No |0.000 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Schmitz R](https://pubmed.ncbi.nlm.nih.gov/22885699)
... ...
\ No newline at end of file
TCL1A.md
... ...
@@ -0,0 +1,37 @@
1
+# [TCL1A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|4.16 |
15
+|BL |Thomas cohort |5.90 |
16
+|BL |Panea cohort |4.00 |
17
+|DLBCL |GAMBL genomes |2.00 |
18
+|DLBCL |Schmitz cohort |3.80 |
19
+|DLBCL |Reddy cohort |2.80 |
20
+|DLBCL |Chapuy cohort |3.00 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |Yes |13.813 | 49.800 |
27
+|DLBCL |Yes |Yes |25.501 |112.487 |
28
+|FL |Yes |No |30.159 | 88.355 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
33
+|--------|----------|--------|------|------------------|
34
+|chr14 |96179535 |96180366|TSS |active_promoter |
35
+
36
+> [!NOTE]
37
+> First described in BL in 2019 by [Grande BM](https://pubmed.ncbi.nlm.nih.gov/30617194)
... ...
\ No newline at end of file
TET2.md
... ...
@@ -0,0 +1,32 @@
1
+# [TET2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture| 5.31 |
15
+|BL |Thomas cohort | 5.10 |
16
+|BL |Panea cohort |10.90 |
17
+|DLBCL |GAMBL genomes | 6.30 |
18
+|DLBCL |Schmitz cohort |11.70 |
19
+|DLBCL |Reddy cohort | 7.40 |
20
+|DLBCL |Chapuy cohort | 6.00 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |1.516 |25.932 |
27
+|DLBCL |No |Yes |0.663 |12.181 |
28
+|FL |No |No |0.892 |10.949 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
TFAP4.md
... ...
@@ -0,0 +1,27 @@
1
+# [TFAP4]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|10.16 |
14
+|BL |Thomas cohort |10.60 |
15
+|BL |Panea cohort | 9.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |Yes |16.997 |47.948 |
22
+|DLBCL |No |No | 5.215 | 0.000 |
23
+|FL |No |No | 0.000 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Grande BM](https://pubmed.ncbi.nlm.nih.gov/30617194)
... ...
\ No newline at end of file
TGFBR2.md
... ...
@@ -0,0 +1,28 @@
1
+# [TGFBR2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.3 |
14
+|DLBCL |Schmitz cohort|1.9 |
15
+|DLBCL |Reddy cohort |1.9 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.941 |0.000 |
23
+|DLBCL |No |No |0.599 |8.085 |
24
+|FL |No |No |2.530 |0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
TIGD6.md
... ...
@@ -0,0 +1,27 @@
1
+# [TIGD6]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.15 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |4.838 |0 |
22
+|DLBCL |No |No |0.000 |0 |
23
+|FL |No |No |4.007 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
TIPARP.md
... ...
@@ -0,0 +1,28 @@
1
+# [TIPARP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes | NA |
14
+|DLBCL |Schmitz cohort|1.3 |
15
+|DLBCL |Reddy cohort |0.9 |
16
+|DLBCL |Chapuy cohort | NA |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.495 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
TLR2.md
... ...
@@ -0,0 +1,28 @@
1
+# [TLR2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |2.7 |
14
+|DLBCL |Schmitz cohort|2.8 |
15
+|DLBCL |Reddy cohort |1.5 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.141 |0 |
23
+|DLBCL |No |No |3.705 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
TMEM30A.md
... ...
@@ -0,0 +1,31 @@
1
+# [TMEM30A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |2 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|1.85 |
16
+|BL |Thomas cohort |1.30 |
17
+|BL |Panea cohort |5.00 |
18
+|DLBCL |GAMBL genomes |5.00 |
19
+|DLBCL |Schmitz cohort |7.70 |
20
+|DLBCL |Reddy cohort |2.80 |
21
+|DLBCL |Chapuy cohort |5.60 |
22
+|FL |GAMBL genomes |0.92 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No |4.270 | 46.360 |
29
+|DLBCL |No |Yes |0.000 |221.848 |
30
+|FL |No |No |5.098 | 0.000 |
31
+
TMSB4X.md
... ...
@@ -0,0 +1,36 @@
1
+# [TMSB4X]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 0.69 |
16
+|BL |Thomas cohort | 0.00 |
17
+|BL |Panea cohort | 2.00 |
18
+|DLBCL |GAMBL genomes |14.40 |
19
+|DLBCL |Schmitz cohort |18.10 |
20
+|DLBCL |Reddy cohort |13.10 |
21
+|DLBCL |Chapuy cohort |18.40 |
22
+|FL |GAMBL genomes | 4.39 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |Yes |No | 0.000 | 0.000 |
29
+|DLBCL |Yes |Yes |23.522 |254.537 |
30
+|FL |Yes |Yes |60.545 |310.498 |
31
+
32
+## aSHM regions
33
+
34
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
35
+|--------|----------|--------|------|------------------|
36
+|chrX |12993308 |12994511|intron|active_promoter |
TNFAIP3.md
... ...
@@ -0,0 +1,31 @@
1
+# [TNFAIP3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 1.39 |
16
+|BL |Thomas cohort | 0.80 |
17
+|BL |Panea cohort | 2.00 |
18
+|DLBCL |GAMBL genomes | 6.10 |
19
+|DLBCL |Schmitz cohort |16.60 |
20
+|DLBCL |Reddy cohort | 8.10 |
21
+|DLBCL |Chapuy cohort |12.40 |
22
+|FL |GAMBL genomes | 4.85 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No |1.168 |16.846 |
29
+|DLBCL |No |Yes |1.550 |30.319 |
30
+|FL |No |No |5.686 |75.953 |
31
+
TNFRSF14.md
... ...
@@ -0,0 +1,31 @@
1
+# [TNFRSF14]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture| 1.39 |
16
+|BL |Thomas cohort | 0.80 |
17
+|BL |Panea cohort | 3.00 |
18
+|DLBCL |GAMBL genomes |14.20 |
19
+|DLBCL |Schmitz cohort |16.80 |
20
+|DLBCL |Reddy cohort | 9.70 |
21
+|DLBCL |Chapuy cohort |12.80 |
22
+|FL |GAMBL genomes |40.42 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |No | 1.388 | 34.410 |
29
+|DLBCL |No |Yes |32.541 | 207.456 |
30
+|FL |No |Yes |96.380 |1034.281 |
31
+
TOP2A.md
... ...
@@ -0,0 +1,27 @@
1
+# [TOP2A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |3.194 |0 |
22
+|DLBCL |No |No |0.774 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
TOX.md
... ...
@@ -0,0 +1,29 @@
1
+# [TOX]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|2.08 |
15
+|BL |Thomas cohort |0.80 |
16
+|BL |Panea cohort |5.90 |
17
+|DLBCL |GAMBL genomes |4.50 |
18
+|DLBCL |Schmitz cohort |5.50 |
19
+|DLBCL |Reddy cohort |4.00 |
20
+|DLBCL |Chapuy cohort |5.10 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |1.503 |17.955 |
27
+|DLBCL |No |No |3.481 |12.292 |
28
+|FL |No |No |1.975 |21.081 |
29
+
TP53.md
... ...
@@ -0,0 +1,31 @@
1
+# [TP53]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+|FL |1 |
10
+
11
+## Mutation incidence
12
+
13
+|Entity|study |frequency (%)|
14
+|------|---------------------|-------------|
15
+|BL |GAMBL genomes+capture|45.50 |
16
+|BL |Thomas cohort |41.90 |
17
+|BL |Panea cohort |43.60 |
18
+|DLBCL |GAMBL genomes |21.90 |
19
+|DLBCL |Schmitz cohort |22.30 |
20
+|DLBCL |Reddy cohort |10.90 |
21
+|DLBCL |Chapuy cohort |21.40 |
22
+|FL |GAMBL genomes | 6.93 |
23
+
24
+## Mutation pattern
25
+
26
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
27
+|------|----|---------------------|----------------|----------------|
28
+|BL |No |Yes | 83.783 | 58.309 |
29
+|DLBCL |No |Yes |127.531 |143.760 |
30
+|FL |No |Yes | 63.211 |142.226 |
31
+
TPST2.md
... ...
@@ -0,0 +1,27 @@
1
+# [TPST2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.92 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.788 |0 |
22
+|DLBCL |No |No |2.633 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
TRAF3.md
... ...
@@ -0,0 +1,25 @@
1
+# [TRAF3]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|1.5 |
15
+|DLBCL |Reddy cohort |0.9 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.795 |0 |
23
+|DLBCL |No |No |1.440 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
TRIP12.md
... ...
@@ -0,0 +1,25 @@
1
+# [TRIP12]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.2 |
14
+|DLBCL |Schmitz cohort|6.0 |
15
+|DLBCL |Reddy cohort |3.2 |
16
+|DLBCL |Chapuy cohort |3.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.620 |0 |
23
+|DLBCL |No |No |1.161 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
TRRAP.md
... ...
@@ -0,0 +1,25 @@
1
+# [TRRAP]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.2 |
14
+|DLBCL |Schmitz cohort|8.9 |
15
+|DLBCL |Reddy cohort |3.5 |
16
+|DLBCL |Chapuy cohort |6.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.571 |0 |
23
+|DLBCL |No |No |1.296 |0 |
24
+|FL |No |No |2.757 |0 |
25
+
TTN.md
... ...
@@ -0,0 +1,27 @@
1
+# [TTN]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|28.64 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.000 |0.000 |
22
+|DLBCL |No |No |0.921 |1.537 |
23
+|FL |No |No |0.000 |0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
UBE2A.md
... ...
@@ -0,0 +1,29 @@
1
+# [UBE2A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|0.92 |
15
+|BL |Thomas cohort |0.00 |
16
+|BL |Panea cohort |3.00 |
17
+|DLBCL |GAMBL genomes |3.40 |
18
+|DLBCL |Schmitz cohort |7.00 |
19
+|DLBCL |Reddy cohort |3.90 |
20
+|DLBCL |Chapuy cohort |4.70 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No | 0.000 |0 |
27
+|DLBCL |No |Yes |26.609 |0 |
28
+|FL |No |No |51.360 |0 |
29
+
UBR5.md
... ...
@@ -0,0 +1,28 @@
1
+# [UBR5]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.4 |
14
+|DLBCL |Schmitz cohort|5.5 |
15
+|DLBCL |Reddy cohort |3.2 |
16
+|DLBCL |Chapuy cohort |5.1 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.678 |1.875 |
23
+|DLBCL |No |No |1.342 |5.285 |
24
+|FL |No |No |0.918 |6.988 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
UNC5C.md
... ...
@@ -0,0 +1,25 @@
1
+# [UNC5C]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.6 |
14
+|DLBCL |Schmitz cohort|5.1 |
15
+|DLBCL |Reddy cohort |2.2 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |3.406 |0 |
23
+|DLBCL |No |No |1.948 |0 |
24
+|FL |No |No |1.266 |0 |
25
+
UNC5D.md
... ...
@@ -0,0 +1,25 @@
1
+# [UNC5D]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.4 |
14
+|DLBCL |Schmitz cohort|1.9 |
15
+|DLBCL |Reddy cohort |1.8 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.954 |5.751 |
23
+|DLBCL |No |No |1.655 |2.419 |
24
+|FL |No |No |1.545 |0.000 |
25
+
USP7.md
... ...
@@ -0,0 +1,29 @@
1
+# [USP7]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|6.47 |
15
+|BL |Thomas cohort |6.80 |
16
+|BL |Panea cohort |5.90 |
17
+|DLBCL |GAMBL genomes |1.60 |
18
+|DLBCL |Schmitz cohort |3.20 |
19
+|DLBCL |Reddy cohort |1.10 |
20
+|DLBCL |Chapuy cohort |3.80 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |Yes |3.462 |21.705 |
27
+|DLBCL |No |No |0.938 | 0.000 |
28
+|FL |No |No |0.000 |15.446 |
29
+
VMA21.md
... ...
@@ -0,0 +1,22 @@
1
+# [VMA21]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|5.08 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No | 0.000 | 0.000 |
20
+|DLBCL |No |No | 3.430 | 81.281 |
21
+|FL |No |Yes |25.632 |598.612 |
22
+
VPS13B.md
... ...
@@ -0,0 +1,25 @@
1
+# [VPS13B]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |4.1 |
14
+|DLBCL |Schmitz cohort|8.3 |
15
+|DLBCL |Reddy cohort |5.7 |
16
+|DLBCL |Chapuy cohort |4.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.768 |0.000 |
23
+|DLBCL |No |No |1.730 |0.000 |
24
+|FL |No |No |0.000 |4.014 |
25
+
VWA7.md
... ...
@@ -0,0 +1,27 @@
1
+# [VWA7]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.954 |0 |
22
+|DLBCL |No |No |1.059 |0 |
23
+|FL |No |No |1.950 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
WAC.md
... ...
@@ -0,0 +1,28 @@
1
+# [WAC]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.8 |
14
+|DLBCL |Schmitz cohort|3.4 |
15
+|DLBCL |Reddy cohort |1.2 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.957 |0 |
23
+|DLBCL |No |No |1.590 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
WDR7.md
... ...
@@ -0,0 +1,27 @@
1
+# [WDR7]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|2.08 |
14
+|BL |Thomas cohort |0.40 |
15
+|BL |Panea cohort |6.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.257 |0.000 |
22
+|DLBCL |No |No |0.454 |0.000 |
23
+|FL |No |No |1.904 |8.746 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
WDR90.md
... ...
@@ -0,0 +1,27 @@
1
+# [WDR90]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.62 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.227 |0 |
22
+|DLBCL |No |No |1.118 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
WEE1.md
... ...
@@ -0,0 +1,30 @@
1
+# [WEE1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.8 |
14
+|DLBCL |Schmitz cohort|2.8 |
15
+|DLBCL |Reddy cohort |1.6 |
16
+|DLBCL |Chapuy cohort |1.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |4.336 | 0.000 |
23
+|DLBCL |Yes |Yes |8.073 |15.059 |
24
+|FL |Yes |No |4.041 | 0.000 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
29
+|--------|----------|--------|------|------------------|
30
+|chr11 |9595246 |9599502 |intron|NA |
WHAMM.md
... ...
@@ -0,0 +1,27 @@
1
+# [WHAMM]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.15 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.909 | 0.000 |
22
+|DLBCL |No |No |0.000 |12.559 |
23
+|FL |No |No |0.000 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
WNK1.md
... ...
@@ -0,0 +1,27 @@
1
+# [WNK1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture| 6.7 |
14
+|BL |Thomas cohort | 6.8 |
15
+|BL |Panea cohort |11.9 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |3.429 |0 |
22
+|DLBCL |No |No |1.812 |0 |
23
+|FL |No |No |3.487 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2023 by [Thomas N](https://pubmed.ncbi.nlm.nih.gov/36201743)
... ...
\ No newline at end of file
WNK2.md
... ...
@@ -0,0 +1,27 @@
1
+# [WNK2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture| 3.23 |
14
+|BL |Thomas cohort | 0.80 |
15
+|BL |Panea cohort |10.90 |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.309 |0 |
22
+|DLBCL |No |No |0.637 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
... ...
\ No newline at end of file
XBP1.md
... ...
@@ -0,0 +1,30 @@
1
+# [XBP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.1 |
14
+|DLBCL |Schmitz cohort|1.3 |
15
+|DLBCL |Reddy cohort |1.6 |
16
+|DLBCL |Chapuy cohort | NA |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |Yes |No |1.624 |39.881 |
23
+|DLBCL |Yes |No |1.835 | 0.000 |
24
+|FL |Yes |No |2.607 | 0.000 |
25
+
26
+## aSHM regions
27
+
28
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
29
+|--------|----------|--------|------|------------------|
30
+|chr22 |29194943 |29197461|TSS |NA |
XIRP2.md
... ...
@@ -0,0 +1,25 @@
1
+# [XIRP2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|FL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|-------------|-------------|
13
+|FL |GAMBL genomes|3.93 |
14
+
15
+## Mutation pattern
16
+
17
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
18
+|------|----|---------------------|----------------|----------------|
19
+|BL |No |No |0.000 |0.000 |
20
+|DLBCL |No |No |2.268 |2.044 |
21
+|FL |No |No |0.000 |0.000 |
22
+
23
+
24
+> [!NOTE]
25
+> First described in FL in 2023 by [Russler-Germain DA](https://pubmed.ncbi.nlm.nih.gov/37493986)
... ...
\ No newline at end of file
XPO1.md
... ...
@@ -0,0 +1,28 @@
1
+# [XPO1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.2 |
14
+|DLBCL |Schmitz cohort|2.3 |
15
+|DLBCL |Reddy cohort |1.4 |
16
+|DLBCL |Chapuy cohort |1.3 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.028 |0 |
23
+|DLBCL |No |No |9.927 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2016 by [Mareschal S](https://pubmed.ncbi.nlm.nih.gov/26608593)
... ...
\ No newline at end of file
YY1.md
... ...
@@ -0,0 +1,28 @@
1
+# [YY1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.1 |
14
+|DLBCL |Schmitz cohort|4.3 |
15
+|DLBCL |Reddy cohort |1.1 |
16
+|DLBCL |Chapuy cohort |3.8 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |6.553 | 0.000 |
23
+|DLBCL |No |No |3.473 |57.733 |
24
+|FL |No |No |3.554 |61.850 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
YY1AP1.md
... ...
@@ -0,0 +1,27 @@
1
+# [YY1AP1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|1.85 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |1.988 |14.209 |
22
+|DLBCL |No |No |0.000 | 0.000 |
23
+|FL |No |No |0.000 | 0.000 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
ZAN.md
... ...
@@ -0,0 +1,24 @@
1
+# [ZAN]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|5.77 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+
22
+
23
+> [!NOTE]
24
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file
ZBTB7A.md
... ...
@@ -0,0 +1,32 @@
1
+# [ZBTB7A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|3.0 |
15
+|BL |Thomas cohort | NA |
16
+|BL |Panea cohort | NA |
17
+|DLBCL |GAMBL genomes |1.8 |
18
+|DLBCL |Schmitz cohort |1.5 |
19
+|DLBCL |Reddy cohort |1.3 |
20
+|DLBCL |Chapuy cohort |1.7 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |No |No |4.693 |0 |
27
+|DLBCL |No |No |1.625 |0 |
28
+|FL |No |No |0.000 |0 |
29
+
30
+
31
+> [!NOTE]
32
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096). First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
ZC3H12A.md
... ...
@@ -0,0 +1,27 @@
1
+# [ZC3H12A]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+|FL |2 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|--------------|-------------|
14
+|DLBCL |GAMBL genomes |3.20 |
15
+|DLBCL |Schmitz cohort|6.00 |
16
+|DLBCL |Reddy cohort |3.10 |
17
+|DLBCL |Chapuy cohort |4.70 |
18
+|FL |GAMBL genomes |0.46 |
19
+
20
+## Mutation pattern
21
+
22
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
23
+|------|----|---------------------|----------------|----------------|
24
+|BL |No |No |0.000 | 0.000 |
25
+|DLBCL |No |No |2.488 |18.944 |
26
+|FL |No |No |0.000 | 0.000 |
27
+
ZEB2.md
... ...
@@ -0,0 +1,28 @@
1
+# [ZEB2]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |3.4 |
14
+|DLBCL |Schmitz cohort|6.8 |
15
+|DLBCL |Reddy cohort |3.7 |
16
+|DLBCL |Chapuy cohort |6.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 | 0.000 |
23
+|DLBCL |No |Yes |1.406 |33.261 |
24
+|FL |No |No |2.638 | 0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
ZFAT.md
... ...
@@ -0,0 +1,28 @@
1
+# [ZFAT]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.9 |
14
+|DLBCL |Schmitz cohort|2.8 |
15
+|DLBCL |Reddy cohort |2.7 |
16
+|DLBCL |Chapuy cohort |2.6 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.000 |0 |
23
+|DLBCL |No |No |1.873 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
ZFP36L1.md
... ...
@@ -0,0 +1,34 @@
1
+# [ZFP36L1]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+|DLBCL |1 |
9
+
10
+## Mutation incidence
11
+
12
+|Entity|study |frequency (%)|
13
+|------|---------------------|-------------|
14
+|BL |GAMBL genomes+capture|2.08 |
15
+|BL |Thomas cohort |2.10 |
16
+|BL |Panea cohort |3.00 |
17
+|DLBCL |GAMBL genomes |5.60 |
18
+|DLBCL |Schmitz cohort |8.50 |
19
+|DLBCL |Reddy cohort |5.60 |
20
+|DLBCL |Chapuy cohort |8.10 |
21
+
22
+## Mutation pattern
23
+
24
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
25
+|------|----|---------------------|----------------|----------------|
26
+|BL |Yes |Yes |2.453 |185.809 |
27
+|DLBCL |Yes |Yes |1.293 | 14.964 |
28
+|FL |Yes |Yes |7.622 |419.109 |
29
+
30
+## aSHM regions
31
+
32
+|chr_name|hg19_start|hg19_end|region|regulatory_comment|
33
+|--------|----------|--------|------|------------------|
34
+|chr14 |69257848 |69259739|TSS |active_promoter |
ZFX.md
... ...
@@ -0,0 +1,28 @@
1
+# [ZFX]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |0.5 |
14
+|DLBCL |Schmitz cohort|1.7 |
15
+|DLBCL |Reddy cohort |1.4 |
16
+|DLBCL |Chapuy cohort |0.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |3.677 |0 |
23
+|DLBCL |No |No |0.000 |0 |
24
+|FL |No |No |0.000 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2017 by [Reddy A](https://pubmed.ncbi.nlm.nih.gov/28985567)
... ...
\ No newline at end of file
ZNF229.md
... ...
@@ -0,0 +1,27 @@
1
+# [ZNF229]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.69 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.954 |0 |
22
+|DLBCL |No |No |1.346 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597)
... ...
\ No newline at end of file
ZNF292.md
... ...
@@ -0,0 +1,28 @@
1
+# [ZNF292]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |1 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |5.2 |
14
+|DLBCL |Schmitz cohort|6.4 |
15
+|DLBCL |Reddy cohort |4.3 |
16
+|DLBCL |Chapuy cohort |6.0 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |1.036 | 2.462 |
23
+|DLBCL |No |No |1.272 |11.022 |
24
+|FL |No |No |2.049 | 0.000 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
ZNF423.md
... ...
@@ -0,0 +1,28 @@
1
+# [ZNF423]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |1.8 |
14
+|DLBCL |Schmitz cohort|3.4 |
15
+|DLBCL |Reddy cohort |2.1 |
16
+|DLBCL |Chapuy cohort |3.4 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.594 |0 |
23
+|DLBCL |No |No |1.430 |0 |
24
+|FL |No |No |0.836 |0 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2018 by [Chapuy B](https://pubmed.ncbi.nlm.nih.gov/29713087)
... ...
\ No newline at end of file
ZNF608.md
... ...
@@ -0,0 +1,28 @@
1
+# [ZNF608]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|DLBCL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|--------------|-------------|
13
+|DLBCL |GAMBL genomes |6.3 |
14
+|DLBCL |Schmitz cohort|9.4 |
15
+|DLBCL |Reddy cohort |8.1 |
16
+|DLBCL |Chapuy cohort |7.7 |
17
+
18
+## Mutation pattern
19
+
20
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
21
+|------|----|---------------------|----------------|----------------|
22
+|BL |No |No |0.986 |0.000 |
23
+|DLBCL |No |No |1.714 |3.638 |
24
+|FL |No |No |1.867 |4.218 |
25
+
26
+
27
+> [!NOTE]
28
+> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
... ...
\ No newline at end of file
ZNF85.md
... ...
@@ -0,0 +1,27 @@
1
+# [ZNF85]
2
+
3
+## Mutation tier
4
+
5
+|Entity|Tier|
6
+|------|----|
7
+|BL |2 |
8
+
9
+## Mutation incidence
10
+
11
+|Entity|study |frequency (%)|
12
+|------|---------------------|-------------|
13
+|BL |GAMBL genomes+capture|0.69 |
14
+|BL |Thomas cohort | NA |
15
+|BL |Panea cohort | NA |
16
+
17
+## Mutation pattern
18
+
19
+|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
20
+|------|----|---------------------|----------------|----------------|
21
+|BL |No |No |0.000 |0 |
22
+|DLBCL |No |No |1.446 |0 |
23
+|FL |No |No |0.000 |0 |
24
+
25
+
26
+> [!NOTE]
27
+> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096)
... ...
\ No newline at end of file