ETS1.md
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# ETS1
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-<<Warn("The variants reported in this gene in BL failed QC")>>
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-**[See below ](#representative-mutations) or [the study page ](papers/paneaWholeGenomeLandscape2019.md#tier-2) for more information**
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## Overview
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ETS1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
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This gene has some recurrent sites of mutations (hot spots).
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The mutation pattern in DLBCL implies the preferential accumulation of *inactivating mutations*.
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|:------:|:----:|--------------------------------------|
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|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
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|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
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-|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
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+|![BL](images/icons/BL_tier2.png) |2-F | Failed QC|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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