EZH2.md
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@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
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csl: 'NLM.csl'
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link-citations: true
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---
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-# EZH2
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+[[_TOC_]]
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## Overview
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EZH2 encodes a histone methyltransferase that is a component of the polycomb repressive complex 2 (PRC2).
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A number of small molecule/pharmacologic inhibitors of EZH2 activity have been described.[@garapaty-raoIdentificationEZH2EZH12013; @knutsonSelectiveInhibitionEZH22014] At least one of these, tazemetostat, has shown benefit in FL.[@morinTreatingLymphomaNow2021]
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Combination therapies including EZH2 inhibitors are also under exploration for DLBCL patients with mutant EZH2.[@scholzeCombinedEZH2Bcl22020]
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-## History
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-```mermaid
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-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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-timeline
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- title Publication timing
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- 2010-02-02 : Morin : DLBCL
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- 2012-03-06 : Lohr : DLBCL
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- 2012-12-01 : Love : BL
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-2013-01-01 : Zhang : DLBCL
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-2013-08-15 : Morin : DLBCL
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- 2019-09-05 : Mottok : PMBL
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-```
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## Relevance tier by entity
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<!-- PMBL: mottokIntegrativeGenomicAnalysis2019b -->
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+[[include:mermaid_EZH2.md]]
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+
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## References
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mermaid_EZH2.md
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+## History
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+```mermaid
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+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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+timeline
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+ title Publication timing
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+ 2010-02-02 : Morin : DLBCL
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+ 2012-03-06 : Lohr : DLBCL
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+ 2012-12-01 : Love : BL
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+2013-01-01 : Zhang : DLBCL
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+2013-08-15 : Morin : DLBCL
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+ 2019-09-05 : Mottok : PMBL
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+```