CARD11.md
... ...
@@ -10,7 +10,6 @@ timeline
10 10
2011-07-27 : Morin : FL
11 11
2012-04-01 : Yan : MZL
12 12
2016-06-21 : Wu : MCL
13
- 2019-09-26 : Panea : BL
14 13
```
15 14
16 15
## Relevance tier by entity
... ...
@@ -18,7 +17,6 @@ timeline
18 17
|Entity|Tier|Description |
19 18
|:------:|:----:|--------------------------------------|
20 19
|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
21
-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
22 20
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
23 21
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
24 22
|![MCL](images/icons/MCL_tier1.png) |1 |high-confidence MCL gene |
... ...
@@ -90,5 +88,5 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
90 88
2. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJM, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298–303. PMCID: PMC3210554
91 89
3. Yan Q, Huang Y, Watkins AJ, Kocialkowski S, Zeng N, Hamoudi RA, Isaacson PG, de Leval L, Wotherspoon A, Du MQ. BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas. Haematologica. 2012 Apr;97(4):595–598. PMCID: PMC3347666
92 90
4. Wu C, de Miranda NF, Chen L, Wasik AM, Mansouri L, Jurczak W, Galazka K, Dlugosz-Danecka M, Machaczka M, Zhang H, Peng R, Morin RD, Rosenquist R, Sander B, Pan-Hammarström Q. Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations. Oncotarget. 2016 Jun 21;7(25):38180–38190. PMCID: PMC5122381
93
-5. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;
94
-<!-- BL: paneaWholeGenomeLandscape2019 -->
91
+
92
+
papers/paneaWholeGenomeLandscape2019.md
... ...
@@ -44,19 +44,18 @@ All other BL studies, BL Tier 2, 111
44 44
|New gene|BL tier|Rating of reviewed variants|
45 45
|:-|:-:|:-:|
46 46
|[ALPK2](../ALPK2)|2 | &starf; &star; &star; &star; &star;|
47
-|[CARD11](../CARD11)|2 | &starf; &star; &star; &star; &star;|
48
-|[CD79B](../CD79B)|2 | &starf; &star; &star; &star; &star;|
49
-|[CD83](../CD83)|2 | &starf; &star; &star; &star; &star;|
50
-|[CTCF](../CTCF)|2 | &starf; &star; &star; &star; &star;|
51
-|[CXCR4](../CXCR4)|2 | &starf; &star; &star; &star; &star;|
52
-|[DNMT1](../DNMT1)|2 | &starf; &star; &star; &star; &star;|
53
-|[DTX1](../DTX1)|2 | &starf; &star; &star; &star; &star;|
54
-|[EP300](../EP300)|2 | &starf; &star; &star; &star; &star;|
55
-|[ETS1](../ETS1)|2 | &starf; &star; &star; &star; &star;|
56
-|[FZD3](../FZD3)|2 | &starf; &star; &star; &star; &star;|
57
-|[GRB2](../GRB2)|2 | &starf; &star; &star; &star; &star;|
58
-|[HIST1H1C](../HIST1H1C)|2 | &starf; &star; &star; &star; &star;|
59
-|[HIST1H2AG](../HIST1H2AG)|2 | &starf; &star; &star; &star; &star;|
47
+|[CD79B](../CD79B)|2 | &starf; &starf; &star; &star; &star;|
48
+|[CD83](../CD83)|2 | &star; &star; &star; &star; &star;|
49
+|[CTCF](../CTCF)|2 | &star; &star; &star; &star; &star;|
50
+|[CXCR4](../CXCR4)|2 | &star; &star; &star; &star; &star;|
51
+|[DNMT1](../DNMT1)|2 | &star; &star; &star; &star; &star;|
52
+|[DTX1](../DTX1)|2 | &star; &star; &star; &star; &star;|
53
+|[EP300](../EP300)|2 | &star; &star; &star; &star; &star;|
54
+|[ETS1](../ETS1)|2 | &star; &star; &star; &star; &star;|
55
+|[FZD3](../FZD3)|2 | &star; &star; &star; &star; &star;|
56
+|[GRB2](../GRB2)|2 | &star; &star; &star; &star; &star;|
57
+|[HIST1H1C](../HIST1H1C)|2 | &star; &star; &star; &star; &star;|
58
+|[HIST1H2AG](../HIST1H2AG)|2 | &star; &star; &star; &star; &star;|
60 59
|[HIST1H2AM](../HIST1H2AM)|2 | &star; &star; &star; &star; &star;|
61 60
|[HIST1H2BK](../HIST1H2BK)|2 | &star; &star; &star; &star; &star;|
62 61
|[HIST1H3D](../HIST1H3D)|2 |&star; &star; &star; &star; &star;|
papers/paneaWholeGenomeLandscape2019.pdf
papers/paneaWholeGenomeLandscape2019_tmp.html
... ...
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+ </script>
368
+<h1 id="paneawholegenomelandscape2019">@paneaWholeGenomeLandscape2019</h1>
369
+<h2 id="summary-of-novel-genes">Summary of novel genes</h2>
370
+<table>
371
+<thead>
372
+<tr>
373
+<th style="text-align:center">Entity</th>
374
+<th style="text-align:center">Tier 1 genes</th>
375
+<th style="text-align:center">Tier 2 genes</th>
376
+</tr>
377
+</thead>
378
+<tbody>
379
+<tr>
380
+<td style="text-align:center">BL</td>
381
+<td style="text-align:center">4</td>
382
+<td style="text-align:center">46</td>
383
+</tr>
384
+</tbody>
385
+</table>
386
+<pre><code class="language-mermaid"><div class="mermaid">---
387
+config:
388
+ sankey:
389
+ showValues: true
390
+ linkColor: target
391
+ width: 600
392
+ height: 300
393
+ nodeAlignment: right
394
+ prefix: '('
395
+ suffix: ' genes)'
396
+---
397
+sankey-beta
398
+This study, New Tier 1, 4
399
+New Tier 1, BL Tier 1, 4
400
+This study, New Tier 2, 46
401
+New Tier 2, BL Tier 2, 46
402
+All other BL studies, BL Tier 1, 25
403
+All other BL studies, BL Tier 2, 111
404
+</div></code></pre>
405
+<h2 id="novel-genes-reported-in-this-study">Novel genes reported in this study</h2>
406
+<h3 id="tier-1">Tier 1</h3>
407
+<table>
408
+<thead>
409
+<tr>
410
+<th style="text-align:left">New gene</th>
411
+<th style="text-align:center">BL tier</th>
412
+</tr>
413
+</thead>
414
+<tbody>
415
+<tr>
416
+<td style="text-align:left"><a href="../BMP7">BMP7</a></td>
417
+<td style="text-align:center">1</td>
418
+</tr>
419
+<tr>
420
+<td style="text-align:left"><a href="../EIF4A1">EIF4A1</a></td>
421
+<td style="text-align:center">1</td>
422
+</tr>
423
+<tr>
424
+<td style="text-align:left"><a href="../EPPK1">EPPK1</a></td>
425
+<td style="text-align:center">1</td>
426
+</tr>
427
+<tr>
428
+<td style="text-align:left"><a href="../HNRNPU">HNRNPU</a></td>
429
+<td style="text-align:center">1</td>
430
+</tr>
431
+</tbody>
432
+</table>
433
+<h3 id="tier-2">Tier 2</h3>
434
+<table>
435
+<thead>
436
+<tr>
437
+<th style="text-align:left">New gene</th>
438
+<th style="text-align:center">BL tier</th>
439
+<th style="text-align:center">Rating of reviewed variants</th>
440
+</tr>
441
+</thead>
442
+<tbody>
443
+<tr>
444
+<td style="text-align:left"><a href="../ALPK2">ALPK2</a></td>
445
+<td style="text-align:center">2</td>
446
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
447
+</tr>
448
+<tr>
449
+<td style="text-align:left"><a href="../CD79B">CD79B</a></td>
450
+<td style="text-align:center">2</td>
451
+<td style="text-align:center">★ ★ ☆ ☆ ☆</td>
452
+</tr>
453
+<tr>
454
+<td style="text-align:left"><a href="../CD83">CD83</a></td>
455
+<td style="text-align:center">2</td>
456
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
457
+</tr>
458
+<tr>
459
+<td style="text-align:left"><a href="../CTCF">CTCF</a></td>
460
+<td style="text-align:center">2</td>
461
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
462
+</tr>
463
+<tr>
464
+<td style="text-align:left"><a href="../CXCR4">CXCR4</a></td>
465
+<td style="text-align:center">2</td>
466
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
467
+</tr>
468
+<tr>
469
+<td style="text-align:left"><a href="../DNMT1">DNMT1</a></td>
470
+<td style="text-align:center">2</td>
471
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
472
+</tr>
473
+<tr>
474
+<td style="text-align:left"><a href="../DTX1">DTX1</a></td>
475
+<td style="text-align:center">2</td>
476
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
477
+</tr>
478
+<tr>
479
+<td style="text-align:left"><a href="../EP300">EP300</a></td>
480
+<td style="text-align:center">2</td>
481
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
482
+</tr>
483
+<tr>
484
+<td style="text-align:left"><a href="../ETS1">ETS1</a></td>
485
+<td style="text-align:center">2</td>
486
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
487
+</tr>
488
+<tr>
489
+<td style="text-align:left"><a href="../FZD3">FZD3</a></td>
490
+<td style="text-align:center">2</td>
491
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
492
+</tr>
493
+<tr>
494
+<td style="text-align:left"><a href="../GRB2">GRB2</a></td>
495
+<td style="text-align:center">2</td>
496
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
497
+</tr>
498
+<tr>
499
+<td style="text-align:left"><a href="../HIST1H1C">HIST1H1C</a></td>
500
+<td style="text-align:center">2</td>
501
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
502
+</tr>
503
+<tr>
504
+<td style="text-align:left"><a href="../HIST1H2AG">HIST1H2AG</a></td>
505
+<td style="text-align:center">2</td>
506
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
507
+</tr>
508
+<tr>
509
+<td style="text-align:left"><a href="../HIST1H2AM">HIST1H2AM</a></td>
510
+<td style="text-align:center">2</td>
511
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
512
+</tr>
513
+<tr>
514
+<td style="text-align:left"><a href="../HIST1H2BK">HIST1H2BK</a></td>
515
+<td style="text-align:center">2</td>
516
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
517
+</tr>
518
+<tr>
519
+<td style="text-align:left"><a href="../HIST1H3D">HIST1H3D</a></td>
520
+<td style="text-align:center">2</td>
521
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
522
+</tr>
523
+<tr>
524
+<td style="text-align:left"><a href="../HIST1H3H">HIST1H3H</a></td>
525
+<td style="text-align:center">2</td>
526
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
527
+</tr>
528
+<tr>
529
+<td style="text-align:left"><a href="../HIST1H3I">HIST1H3I</a></td>
530
+<td style="text-align:center">2</td>
531
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
532
+</tr>
533
+<tr>
534
+<td style="text-align:left"><a href="../HIST1H3J">HIST1H3J</a></td>
535
+<td style="text-align:center">2</td>
536
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
537
+</tr>
538
+<tr>
539
+<td style="text-align:left"><a href="../HIST1H4J">HIST1H4J</a></td>
540
+<td style="text-align:center">2</td>
541
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
542
+</tr>
543
+<tr>
544
+<td style="text-align:left"><a href="../IGLL5">IGLL5</a></td>
545
+<td style="text-align:center">2</td>
546
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
547
+</tr>
548
+<tr>
549
+<td style="text-align:left"><a href="../IKZF3">IKZF3</a></td>
550
+<td style="text-align:center">2</td>
551
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
552
+</tr>
553
+<tr>
554
+<td style="text-align:left"><a href="../IRF8">IRF8</a></td>
555
+<td style="text-align:center">2</td>
556
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
557
+</tr>
558
+<tr>
559
+<td style="text-align:left"><a href="../KCNK10">KCNK10</a></td>
560
+<td style="text-align:center">2</td>
561
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
562
+</tr>
563
+<tr>
564
+<td style="text-align:left"><a href="../KLHL6">KLHL6</a></td>
565
+<td style="text-align:center">2</td>
566
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
567
+</tr>
568
+<tr>
569
+<td style="text-align:left"><a href="../LTB">LTB</a></td>
570
+<td style="text-align:center">2</td>
571
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
572
+</tr>
573
+<tr>
574
+<td style="text-align:left"><a href="../MCL1">MCL1</a></td>
575
+<td style="text-align:center">2</td>
576
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
577
+</tr>
578
+<tr>
579
+<td style="text-align:left"><a href="../MME">MME</a></td>
580
+<td style="text-align:center">2</td>
581
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
582
+</tr>
583
+<tr>
584
+<td style="text-align:left"><a href="../MTOR">MTOR</a></td>
585
+<td style="text-align:center">2</td>
586
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
587
+</tr>
588
+<tr>
589
+<td style="text-align:left"><a href="../NOTCH2">NOTCH2</a></td>
590
+<td style="text-align:center">2</td>
591
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
592
+</tr>
593
+<tr>
594
+<td style="text-align:left"><a href="../PABPC4L">PABPC4L</a></td>
595
+<td style="text-align:center">2</td>
596
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
597
+</tr>
598
+<tr>
599
+<td style="text-align:left"><a href="../PCDHA11">PCDHA11</a></td>
600
+<td style="text-align:center">2</td>
601
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
602
+</tr>
603
+<tr>
604
+<td style="text-align:left"><a href="../PDZRN3">PDZRN3</a></td>
605
+<td style="text-align:center">2</td>
606
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
607
+</tr>
608
+<tr>
609
+<td style="text-align:left"><a href="../PIK3R1">PIK3R1</a></td>
610
+<td style="text-align:center">2</td>
611
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
612
+</tr>
613
+<tr>
614
+<td style="text-align:left"><a href="../PLCG2">PLCG2</a></td>
615
+<td style="text-align:center">2</td>
616
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
617
+</tr>
618
+<tr>
619
+<td style="text-align:left"><a href="../PXDNL">PXDNL</a></td>
620
+<td style="text-align:center">2</td>
621
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
622
+</tr>
623
+<tr>
624
+<td style="text-align:left"><a href="../RAC2">RAC2</a></td>
625
+<td style="text-align:center">2</td>
626
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
627
+</tr>
628
+<tr>
629
+<td style="text-align:left"><a href="../RNF144B">RNF144B</a></td>
630
+<td style="text-align:center">2</td>
631
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
632
+</tr>
633
+<tr>
634
+<td style="text-align:left"><a href="../SNTB2">SNTB2</a></td>
635
+<td style="text-align:center">2</td>
636
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
637
+</tr>
638
+<tr>
639
+<td style="text-align:left"><a href="../SP3">SP3</a></td>
640
+<td style="text-align:center">2</td>
641
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
642
+</tr>
643
+<tr>
644
+<td style="text-align:left"><a href="../SYNCRIP">SYNCRIP</a></td>
645
+<td style="text-align:center">2</td>
646
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
647
+</tr>
648
+<tr>
649
+<td style="text-align:left"><a href="../TET2">TET2</a></td>
650
+<td style="text-align:center">2</td>
651
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
652
+</tr>
653
+<tr>
654
+<td style="text-align:left"><a href="../WDR7">WDR7</a></td>
655
+<td style="text-align:center">2</td>
656
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
657
+</tr>
658
+<tr>
659
+<td style="text-align:left"><a href="../WNK2">WNK2</a></td>
660
+<td style="text-align:center">2</td>
661
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
662
+</tr>
663
+<tr>
664
+<td style="text-align:left"><a href="../ZFP36L1">ZFP36L1</a></td>
665
+<td style="text-align:center">2</td>
666
+<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td>
667
+</tr>
668
+</tbody>
669
+</table>
670
+<h1 id="details">Details</h1>
671
+
672
+</body>
673
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