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@@ -282,15 +282,15 @@ PMBL panel, Desch 2020, 10
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|[@paneaWholeGenomeLandscape2019](papers/paneaWholeGenomeLandscape2019)|BL|4|22 (55%)|
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|[@hubschmannMutationalMechanismsShaping2021b](papers/hubschmannMutationalMechanismsShaping2021b)|DLBCL,FL|4|3 (9%)|
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-## Categorization
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+## Categorization of genes
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-### Gene Tiers
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+### Tiers
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**Tier 2** - Any gene described as significantly or recurrently mutated in one or more types of B-cell lymphoma is initially assigned to Tier 2 for that entity. The study describing the mutation of that gene in a particular entity is considered the originating study.
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**Tier 1** - Genes can transition to Tier 1 only after additional studies have demonstrated the recurrence of mutations in the same entity.
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-### Gene Designations
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+### Additional Designations
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**aSHM** - Denotes genes as affected by aberrant somatic hypermutation (aSHM). Tier 1 and Tier 2 genes can have this designation, respectively abbreviated as *1-a* and *2-a*. For example, see [BCL7A](BCL7A).
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