2fe96feaa8fc2985ed7140b7d408d19225bbe546
NFKBIZ.md
| ... | ... | @@ -28,11 +28,7 @@ timeline |
| 28 | 28 | |
| 29 | 29 | ## Mutation pattern and selective pressure estimates |
| 30 | 30 | |
| 31 | -|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)| |
|
| 32 | -|:------:|:----:|:---------------------:|:----------------:|:----------------:| |
|
| 33 | -|BL |Yes |No |3.346 |0 | |
|
| 34 | -|DLBCL |Yes |No |2.091 |0 | |
|
| 35 | -|FL |Yes |No |0.000 |0 | |
|
| 31 | +[[include:dnds_NFKBIZ.md]] |
|
| 36 | 32 | |
| 37 | 33 | ## aSHM regions |
| 38 | 34 |
NOL9.md
| ... | ... | @@ -27,14 +27,7 @@ timeline |
| 27 | 27 | |
| 28 | 28 | ## Mutation pattern and selective pressure estimates |
| 29 | 29 | |
| 30 | -|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)| |
|
| 31 | -|:------:|:----:|:---------------------:|:----------------:|:----------------:| |
|
| 32 | -|BL |No |No |1.514 |0 | |
|
| 33 | -|DLBCL |No |No |4.012 |0 | |
|
| 34 | -|FL |No |No |2.619 |0 | |
|
| 35 | - |
|
| 36 | - |
|
| 37 | - |
|
| 30 | +[[include:dnds_NOL9.md]] |
|
| 38 | 31 | |
| 39 | 32 | ## NOL9 Hotspots |
| 40 | 33 |
NOTCH1.md
| ... | ... | @@ -37,11 +37,7 @@ timeline |
| 37 | 37 | |
| 38 | 38 | ## Mutation pattern and selective pressure estimates |
| 39 | 39 | |
| 40 | -|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)| |
|
| 41 | -|:------:|:----:|:---------------------:|:----------------:|:----------------:| |
|
| 42 | -|BL |No |No |1.031 |0 | |
|
| 43 | -|DLBCL |No |No |0.792 |0 | |
|
| 44 | -|FL |No |No |2.864 |0 | |
|
| 40 | +[[include:dnds_NOTCH1.md]] |
|
| 45 | 41 | |
| 46 | 42 | |
| 47 | 43 | ## NOTCH1 Hotspots |
NOTCH2.md
| ... | ... | @@ -6,6 +6,7 @@ link-citations: true |
| 6 | 6 | # NOTCH2 |
| 7 | 7 | |
| 8 | 8 | ## History |
| 9 | + |
|
| 9 | 10 | ```mermaid |
| 10 | 11 | %%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% |
| 11 | 12 | timeline |
| ... | ... | @@ -34,13 +35,7 @@ timeline |
| 34 | 35 | |
| 35 | 36 | ## Mutation pattern and selective pressure estimates |
| 36 | 37 | |
| 37 | -|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)| |
|
| 38 | -|:------:|:----:|:---------------------:|:----------------:|:----------------:| |
|
| 39 | -|BL |No |No |0.000 | 0.000 | |
|
| 40 | -|DLBCL |No |Yes |0.527 |60.245 | |
|
| 41 | -|FL |No |No |0.000 | 0.000 | |
|
| 42 | - |
|
| 43 | - |
|
| 38 | +[[include:dnds_NOTCH2.md]] |
|
| 44 | 39 | |
| 45 | 40 | ## NOTCH2 Hotspots |
| 46 | 41 |
OSBPL10.md
| ... | ... | @@ -22,7 +22,7 @@ timeline |
| 22 | 22 | |
| 23 | 23 | |Entity|Tier|Description | |
| 24 | 24 | |:------:|:----:|--------------------------------------| |
| 25 | -| |1-a | aSHM target and high-confidence DLBCL gene [@zhangGeneticHeterogeneityDiffuse2013; @arthurGenomewideDiscoverySomatic2018; @schmitzGeneticsPathogenesisDiffuse2018a]| |
|
| 25 | +| |1 | aSHM target and high-confidence DLBCL gene [@zhangGeneticHeterogeneityDiffuse2013; @arthurGenomewideDiscoverySomatic2018; @schmitzGeneticsPathogenesisDiffuse2018a]| |
|
| 26 | 26 | |
| 27 | 27 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 28 | 28 | |
| ... | ... | @@ -30,11 +30,7 @@ timeline |
| 30 | 30 | |
| 31 | 31 | ## Mutation pattern and selective pressure estimates |
| 32 | 32 | |
| 33 | -|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)| |
|
| 34 | -|:------:|:----:|:---------------------:|:----------------:|:----------------:| |
|
| 35 | -|BL |Yes |No | 4.102 |11.721 | |
|
| 36 | -|DLBCL |Yes |Yes |12.983 | 0.000 | |
|
| 37 | -|FL |Yes |Yes | 5.877 | 8.779 | |
|
| 33 | +[[include:dnds_OSBPL10.md]] |
|
| 38 | 34 | |
| 39 | 35 | ## aSHM regions |
| 40 | 36 |