ARID1A.md
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-# [ARID1A]
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+# ARID1A
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+## Overview
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ARID1A (AT-rich interactive domain-containing protein 1A) is a gene that encodes a subunit of the SWI/SNF chromatin remodeling complex, which is involved in regulating DNA accessibility. Mutations in ARID1A are implicated in various cancers, including B-cell lymphomas. They are the most abundant in Burkitt lymphoma but also occur in FL and, to a lesser extent, DLBCL.
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-## Mutation tier
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+## Relevance tier by entity
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------|
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|BL |1 |high-confidence BL gene |
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|DLBCL |1 |high-confidence DLBCL gene|
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|FL |1 |high-confidence FL gene |
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-## Mutation incidence
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+## Mutation incidence in large cohorts
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|Entity|source |frequency (%)|
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|:------:|:---------------------:|:-------------:|
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|DLBCL |Chapuy cohort | 4.27 |
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|FL |GAMBL genomes |12.47 |
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-## Mutation pattern
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+## Mutation pattern and selective pressure estimates
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|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
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|:------:|:----:|:---------------------:|:----------------:|:----------------:|