gene_md_tables/MEF2B_Hotspots.md
... ...
@@ -1,24 +0,0 @@
1
-# MEF2B_Hotspots
2
-
3
-| Hugo_Symbol | Chromosome | Coordinate | DLBCL | FL | BL | HGVS |
4
-| ------ | ------ | ------ | ------ | ------ | ------ | ------ |
5
-| MEF2B | 19 | 19260044,19260045 | 43 | 35 | 0 | p.D83V |
6
-| MEF2B | 19 | 19260044,19260045 | 43 | 35 | 0 | p.D83A |
7
-| MEF2B | 19 | 19260044,19260045 | 43 | 35 | 0 | p.D83G |
8
-| MEF2B | 19 | 19260044,19260045 | 43 | 35 | 0 | p.D83E |
9
-| MEF2B | 19 | 19260064,19260063 | 9 | 1 | 0 | p.E77K |
10
-| MEF2B | 19 | 19260064,19260063 | 9 | 1 | 0 | p.E77G |
11
-| MEF2B | nan | nan | 4 | 0 | 0 | p.X86_splice |
12
-| MEF2B | 19 | 19260066 | 2 | 2 | 0 | p.H76R |
13
-| MEF2B | 19 | 19260050,19260052 | 4 | 0 | 0 | p.N81K |
14
-| MEF2B | 19 | 19260066 | 2 | 2 | 0 | p.H76P |
15
-| MEF2B | 19 | 19260050,19260052 | 4 | 0 | 0 | p.N81Y |
16
-| MEF2B | 19 | 19260050,19260052 | 4 | 0 | 0 | p.N81_T82del |
17
-| MEF2B | 19 | 19260055 | 3 | 0 | 0 | p.T80A |
18
-| MEF2B | 19 | 19260055 | 3 | 0 | 0 | p.T80P |
19
-| MEF2B | 19 | 19258640 | 1 | 1 | 0 | p.T87M |
20
-| MEF2B | 19 | 19260061 | 2 | 0 | 0 | p.S78G |
21
-| MEF2B | 19 | 19260061 | 2 | 0 | 0 | p.S78R |
22
-| MEF2B | 19 | 19260042 | 1 | 0 | 0 | p.I84T |
23
-| MEF2B | 19 | 19258638 | 1 | 0 | 0 | p.L88M |
24
-| MEF2B | 19 | 19260049 | 1 | 0 | 0 | p.T82A |
scripts/manuela_hotspots/Test_Script
... ...
@@ -1,67 +0,0 @@
1
-import pandas as pd
2
-import os
3
-
4
-# Config
5
-input_file = "hotspot_amino_acids_full_chrpos.tsv"
6
-output_dir = "per_gene_markdown"
7
-
8
-# Create output directory
9
-os.makedirs(output_dir, exist_ok=True)
10
-
11
-# Read TSV file
12
-df = pd.read_csv(input_file, sep="\t")
13
-
14
-# Lymphopedia format: select and rename columns
15
-df = df.rename(columns={
16
- "Start_Position": "Coordinate",
17
- "HGVSp_Short": "HGVS"
18
-})[["Hugo_Symbol", "Chromosome", "Coordinate", "DLBCL", "FL", "BL", "HGVS"]]
19
-
20
-# Containers for index and combined file
21
-gene_files = []
22
-toc_entries = []
23
-all_md_content = "# All Gene Mutation Tables\n\n## Table of Contents\n\n"
24
-
25
-# TOC entries
26
-
27
-for gene in sorted(df["Hugo_Symbol"].unique()):
28
- all_md_content += f"- [{gene}](#{gene.lower()})\n"
29
-
30
-#divider
31
-all_md_content += "\n---\n\n"
32
-
33
-# group by Hugo_Symbol --> per gene
34
-for gene, group in df.groupby("Hugo_Symbol"):
35
- # md table header
36
- md_table = "| " + " | ".join(group.columns) + " |\n"
37
- md_table += "| " + " | ".join(["------"] * len(group.columns)) + " |\n"
38
- for _, row in group.iterrows():
39
- md_table += "| " + " | ".join(map(str, row.values)) + " |\n"
40
-
41
- # per gene md file
42
- file_name = f"{gene}.md"
43
- output_path = os.path.join(output_dir, file_name)
44
- with open(output_path, "w", encoding="utf-8") as f:
45
- f.write(f"# {gene}\n\n")
46
- f.write(md_table)
47
-
48
-
49
-# add section divider for all tables in ALL_GENES.md
50
-all_md_content += "\n---\n\n"
51
-
52
-# add each gene's section to combined file
53
-for gene, group in df.groupby("Hugo_Symbol"):
54
- md_table = "| " + " | ".join(group.columns) + " |\n"
55
- md_table += "| " + " | ".join(["------"] * len(group.columns)) + " |\n"
56
- for _, row in group.iterrows():
57
- md_table += "| " + " | ".join(map(str, row.values)) + " |\n"
58
- all_md_content += f"## {gene}\n\n{md_table}\n\n"
59
-
60
-
61
-# create ALL_GENES.md (with TOC)
62
-all_path = os.path.join(output_dir, "ALL_GENES.md")
63
-with open(all_path, "w", encoding="utf-8") as f:
64
- f.write(all_md_content)
65
-
66
-
67
-
tables/hotspots/hotspot_ACTB.md
... ...
@@ -0,0 +1,53 @@
1
+## ACTB Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 7 | 5569230 | 10 | 7 | 1 | G20A |
6
+| 7 | 5569230 | 10 | 7 | 1 | G20D |
7
+| 7 | 5569230 | 10 | 7 | 1 | G20V |
8
+| 7 | 5569251 | 8 | 2 | 1 | G13A |
9
+| 7 | 5569251 | 8 | 2 | 1 | G13V |
10
+| 7 | 5569251 | 8 | 2 | 1 | G13D |
11
+| 7 | 5568876,5568878 | 8 | 1 | 0 | E93D |
12
+| 7 | 5568975,5568976 | 8 | 0 | 1 | S60N |
13
+| 7 | 5568975,5568976 | 8 | 0 | 1 | S60R |
14
+| 7 | 5568876,5568878 | 8 | 1 | 0 | E93K |
15
+| 7 | 5568975,5568976 | 8 | 0 | 1 | S60T |
16
+| 7 | 5568948,5568949,5568950 | 6 | 2 | 1 | Y69* |
17
+| 7 | 5568948,5568949,5568950 | 6 | 2 | 1 | Y69D |
18
+| 7 | 5568948,5568949,5568950 | 6 | 2 | 1 | Y69N |
19
+| 7 | 5568876,5568878 | 8 | 1 | 0 | E93Q |
20
+| 7 | 5568948,5568949,5568950 | 6 | 2 | 1 | Y69C |
21
+| 7 | 5568948,5568949,5568950 | 6 | 2 | 1 | Y69F |
22
+| 7 | 5568948,5568949,5568950 | 6 | 2 | 1 | Y69S |
23
+| 7 | 5569212 | 7 | 1 | 0 | A26D |
24
+| 7 | 5569212 | 7 | 1 | 0 | A26V |
25
+| 7 | 5569245,5569246 | 5 | 2 | 1 | G15D |
26
+| 7 | 5569245,5569246 | 5 | 2 | 1 | G15A |
27
+| 7 | 5569245,5569246 | 5 | 2 | 1 | G15R |
28
+| 7 | 5569243 | 1 | 3 | 0 | M16V |
29
+| 7 | 5569243 | 1 | 3 | 0 | M16L |
30
+| 7 | 5568982,5568983 | 1 | 2 | 0 | A58D |
31
+| 7 | 5568982,5568983 | 1 | 2 | 0 | A58Efs*33 |
32
+| 7 | 5568982,5568983 | 1 | 2 | 0 | A58S |
33
+| 7 | 5569249 | 1 | 2 | 0 | S14A |
34
+| 7 | 5569249 | 1 | 2 | 0 | S14P |
35
+| 7 | 5569249 | 1 | 2 | 0 | S14Pfs*30 |
36
+| 7 | 5569267 | 1 | 1 | 0 | L8F |
37
+| 7 | 5568978 | 2 | 0 | 0 | Q59H |
38
+| 7 | 5569238,5569239 | 2 | 0 | 0 | C17* |
39
+| 7 | 5569238,5569239 | 2 | 0 | 0 | C17S |
40
+| 7 | 5568248,5568247 | 1 | 1 | 0 | G156S |
41
+| 7 | 5568248,5568247 | 1 | 1 | 0 | G156V |
42
+| 7 | 5569194,5569195 | 2 | 0 | 0 | P32H |
43
+| 7 | 5569194,5569195 | 2 | 0 | 0 | P32S |
44
+| 7 | 5567496,5567497 | 2 | 0 | 0 | Y337* |
45
+| 7 | 5567496,5567497 | 2 | 0 | 0 | Y337S |
46
+| 7 | 5568323 | 1 | 0 | 0 | A131P |
47
+| 7 | 5569224 | 1 | 0 | 0 | A22V |
48
+| 7 | 5569270 | 0 | 1 | 0 | A7T |
49
+| 7 | 5569227 | 1 | 0 | 0 | F21C |
50
+| nan | nan | 1 | 0 | 0 | L67Tfs*37 |
51
+| 7 | 5568862 | 1 | 0 | 0 | P98H |
52
+| 7 | 5568958 | 1 | 0 | 0 | T66I |
53
+| 7 | 5569261 | 0 | 0 | 1 | V10I |
tables/hotspots/hotspot_ACTG1.md
... ...
@@ -0,0 +1,38 @@
1
+## ACTG1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 17 | 79479104,79479105 | 18 | 1 | 0 | G63D |
6
+| 17 | 79479104,79479105 | 18 | 1 | 0 | G63V |
7
+| 17 | 79479104,79479105 | 18 | 1 | 0 | G63A |
8
+| 17 | 79479104,79479105 | 18 | 1 | 0 | G63C |
9
+| 17 | 79479107,79479108 | 9 | 1 | 1 | R62C |
10
+| 17 | 79479107,79479108 | 9 | 1 | 1 | R62H |
11
+| 17 | 79479107,79479108 | 9 | 1 | 1 | R62G |
12
+| 17 | 79479343 | 5 | 4 | 0 | G13D |
13
+| 17 | 79479112,79479113 | 7 | 0 | 0 | S60N |
14
+| 17 | 79479112,79479113 | 7 | 0 | 0 | S60R |
15
+| 17 | 79479112,79479113 | 7 | 0 | 0 | S60T |
16
+| 17 | 79479322,79479323 | 6 | 0 | 0 | G20A |
17
+| 17 | 79479295 | 5 | 0 | 1 | A29V |
18
+| 17 | 79479295 | 5 | 0 | 1 | A29G |
19
+| 17 | 79479295 | 5 | 0 | 1 | A29Pfs*37 |
20
+| 17 | 79479322,79479323 | 6 | 0 | 0 | G20C |
21
+| 17 | 79479013 | 4 | 0 | 0 | E93D |
22
+| 17 | 79478397 | 2 | 0 | 1 | E207K |
23
+| 17 | 79479330,79479331 | 2 | 0 | 1 | C17Y |
24
+| 17 | 79479330,79479331 | 2 | 0 | 1 | C17W |
25
+| 17 | 79479337 | 1 | 1 | 0 | G15D |
26
+| 17 | 79479350 | 1 | 1 | 0 | D11H |
27
+| 17 | 79479350 | 1 | 1 | 0 | D11Y |
28
+| 17 | 79478989,79478991 | 2 | 0 | 0 | H101Q |
29
+| 17 | 79478989,79478991 | 2 | 0 | 0 | H101Y |
30
+| 17 | 79479088,79479090 | 1 | 1 | 0 | K68N |
31
+| 17 | 79479088,79479090 | 1 | 1 | 0 | K68Q |
32
+| 17 | 79479099,79479098 | 2 | 0 | 0 | L65M |
33
+| 17 | 79479099,79479098 | 2 | 0 | 0 | L65P |
34
+| 17 | 79479286 | 1 | 1 | 0 | P32L |
35
+| 17 | 79479286 | 1 | 1 | 0 | P32R |
36
+| 17 | 79479313 | 1 | 0 | 0 | G23M |
37
+| nan | nan | 1 | 0 | 0 | K61_R62del |
38
+| 17 | 79478975 | 1 | 0 | 0 | T106I |
tables/hotspots/hotspot_ARID1A.md
... ...
@@ -0,0 +1,5 @@
1
+## ARID1A Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 27100207 | 2 | 0 | 4 | R1335* |
tables/hotspots/hotspot_ATP6V1B2.md
... ...
@@ -0,0 +1,11 @@
1
+## ATP6V1B2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 8 | 20074768 | 3 | 22 | 1 | R400Q |
6
+| 8 | 20073956,20073957 | 3 | 12 | 0 | Y371C |
7
+| 8 | 20073956,20073957 | 3 | 12 | 0 | Y371D |
8
+| 8 | 20073956,20073957 | 3 | 12 | 0 | Y371S |
9
+| 8 | 20073956,20073957 | 3 | 12 | 0 | Y371H |
10
+| 8 | 20073944 | 1 | 2 | 0 | D367N |
11
+| 8 | 20073944 | 1 | 2 | 0 | D367H |
tables/hotspots/hotspot_B2M.md
... ...
@@ -0,0 +1,71 @@
1
+## B2M Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 15 | 45003745,45003746,45003747 | 87 | 11 | 4 | M1? |
6
+| 15 | 45003778,45003779 | 33 | 5 | 0 | L12P |
7
+| 15 | 45003778,45003779 | 33 | 5 | 0 | L12Q |
8
+| 15 | 45003778,45003779 | 33 | 5 | 0 | L12R |
9
+| 15 | 45003778,45003779 | 33 | 5 | 0 | L12* |
10
+| 15 | 45003763,45003764 | 35 | 3 | 0 | L7* |
11
+| 15 | 45003763,45003764 | 35 | 3 | 0 | L7S |
12
+| 15 | 45003763,45003764 | 35 | 3 | 0 | L7V |
13
+| nan | nan | 21 | 3 | 2 | L15Ffs*41 |
14
+| 15 | 45003768,45003770 | 7 | 2 | 1 | V9E |
15
+| 15 | 45007809,45007810,45007811 | 9 | 1 | 0 | Y86H |
16
+| 15 | 45007809,45007810,45007811 | 9 | 1 | 0 | Y86N |
17
+| 15 | 45003768,45003770 | 7 | 2 | 1 | V9G |
18
+| 15 | 45007809,45007810,45007811 | 9 | 1 | 0 | Y86* |
19
+| 15 | 45003768,45003770 | 7 | 2 | 1 | V9L |
20
+| 15 | 45003768,45003770 | 7 | 2 | 1 | V9_A20del |
21
+| 15 | 45007809,45007810,45007811 | 9 | 1 | 0 | Y86D |
22
+| 15 | 45007809,45007810,45007811 | 9 | 1 | 0 | Y86F |
23
+| 15 | 45007691,45007690 | 5 | 1 | 0 | Y46Cfs*10 |
24
+| 15 | 45003782,45003781 | 6 | 0 | 0 | L13R |
25
+| 15 | 45003766,45003767 | 6 | 0 | 0 | A8Lfs*36 |
26
+| 15 | 45003766,45003767 | 6 | 0 | 0 | A8P |
27
+| 15 | 45007686,45007687,45007688 | 4 | 2 | 0 | C45G |
28
+| 15 | 45007686,45007687,45007688 | 4 | 2 | 0 | C45Y |
29
+| 15 | 45003782,45003781 | 6 | 0 | 0 | L13P |
30
+| 15 | 45003766,45003767 | 6 | 0 | 0 | A8D |
31
+| 15 | 45003766,45003767 | 6 | 0 | 0 | A8T |
32
+| 15 | 45007686,45007687,45007688 | 4 | 2 | 0 | C45R |
33
+| 15 | 45007686,45007687,45007688 | 4 | 2 | 0 | C45W |
34
+| 15 | 45003782,45003781 | 6 | 0 | 0 | L13F |
35
+| 15 | 45007691,45007690 | 5 | 1 | 0 | Y46* |
36
+| 15 | 45007691,45007690 | 5 | 1 | 0 | Y46S |
37
+| 15 | 45003773 | 4 | 0 | 0 | L10R |
38
+| 15 | 45007845,45007846 | 4 | 0 | 0 | Y98N |
39
+| 15 | 45003773 | 4 | 0 | 0 | L10H |
40
+| 15 | 45007845,45007846 | 4 | 0 | 0 | Y98D |
41
+| 15 | 45007845,45007846 | 4 | 0 | 0 | Y98S |
42
+| 15 | 45003761 | 3 | 0 | 0 | A6D |
43
+| 15 | 45007676,45007674 | 3 | 0 | 0 | N41K |
44
+| 15 | 45003748 | 3 | 0 | 0 | S2P |
45
+| 15 | 45007768,45007767 | 2 | 1 | 0 | S72* |
46
+| 15 | 45007897,45007898,45007896 | 2 | 0 | 1 | W115* |
47
+| 15 | 45007676,45007674 | 3 | 0 | 0 | N41H |
48
+| 15 | 45003748 | 3 | 0 | 0 | S2_?4 |
49
+| 15 | 45007768,45007767 | 2 | 1 | 0 | S72A |
50
+| 15 | 45007897,45007898,45007896 | 2 | 0 | 1 | W115R |
51
+| nan | nan | 2 | 0 | 0 | A11Sfs*42 |
52
+| 15 | 45007727 | 2 | 0 | 0 | D58E |
53
+| 15 | 45007681 | 2 | 0 | 0 | L43P |
54
+| nan | nan | 2 | 0 | 0 | S14Ffs*29 |
55
+| nan | nan | 2 | 0 | 0 | Q28Sfs*29 |
56
+| nan | nan | 2 | 0 | 0 | Q28_V29del |
57
+| 15 | 45007639 | 0 | 1 | 1 | V29G |
58
+| 15 | 45007639 | 0 | 1 | 1 | V29Hfs*13 |
59
+| 15 | 45003758 | 2 | 0 | 0 | V5Afs*27 |
60
+| 15 | 45003758 | 2 | 0 | 0 | V5E |
61
+| 15 | 45007641 | 2 | 0 | 0 | Y30D |
62
+| 15 | 45007641 | 2 | 0 | 0 | Y30H |
63
+| 15 | 45007770 | 1 | 0 | 0 | D73H |
64
+| nan | nan | 1 | 0 | 0 | G17Ffs*41 |
65
+| 15 | 45007888 | 1 | 0 | 0 | I112K |
66
+| 15 | 45007633 | 1 | 0 | 0 | I27N |
67
+| nan | nan | 1 | 0 | 0 | L74Ffs*14 |
68
+| nan | nan | 1 | 0 | 0 | R101Lfs*15 |
69
+| 15 | 45003751 | 1 | 0 | 0 | R3C |
70
+| nan | nan | 0 | 1 | 0 | S31Vfs*12 |
71
+| nan | nan | 1 | 0 | 0 | S48Wfs*8 |
tables/hotspots/hotspot_BCL2.md
... ...
@@ -0,0 +1,266 @@
1
+## BCL2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 18 | 60985724,60985725 | 38 | 42 | 0 | P59A |
6
+| 18 | 60985724,60985725 | 38 | 42 | 0 | P59S |
7
+| 18 | 60985724,60985725 | 38 | 42 | 0 | P59L |
8
+| 18 | 60985724,60985725 | 38 | 42 | 0 | P59Q |
9
+| 18 | 60985724,60985725 | 38 | 42 | 0 | P59T |
10
+| 18 | 60985724,60985725 | 38 | 42 | 0 | P59V |
11
+| 18 | 60985507,60985508,60985509 | 50 | 25 | 0 | A131V |
12
+| 18 | 60985507,60985508,60985509 | 50 | 25 | 0 | A131D |
13
+| 18 | 60985507,60985508,60985509 | 50 | 25 | 0 | A131G |
14
+| 18 | 60985507,60985508,60985509 | 50 | 25 | 0 | A131T |
15
+| 18 | 60985721,60985722 | 23 | 22 | 0 | A60V |
16
+| 18 | 60985721,60985722 | 23 | 22 | 0 | A60G |
17
+| 18 | 60985721,60985722 | 23 | 22 | 0 | A60T |
18
+| 18 | 60985721,60985722 | 23 | 22 | 0 | A60D |
19
+| 18 | 60985721,60985722 | 23 | 22 | 0 | A60P |
20
+| 18 | 60985721,60985722 | 23 | 22 | 0 | A60I |
21
+| 18 | 60985721,60985722 | 23 | 22 | 0 | A60_A61insH |
22
+| 18 | 60985883,60985884,60985882 | 24 | 19 | 0 | R6T |
23
+| 18 | 60985883,60985884,60985882 | 24 | 19 | 0 | R6K |
24
+| 18 | 60985883,60985884,60985882 | 24 | 19 | 0 | R6G |
25
+| 18 | 60985883,60985884,60985882 | 24 | 19 | 0 | R6E |
26
+| 18 | 60985883,60985884,60985882 | 24 | 19 | 0 | R6I |
27
+| 18 | 60985883,60985884,60985882 | 24 | 19 | 0 | R6S |
28
+| 18 | 60985802,60985803 | 25 | 12 | 0 | G33R |
29
+| 18 | 60985802,60985803 | 25 | 12 | 0 | G33A |
30
+| 18 | 60985802,60985803 | 25 | 12 | 0 | G33E |
31
+| 18 | 60985802,60985803 | 25 | 12 | 0 | G33K |
32
+| 18 | 60985802,60985803 | 25 | 12 | 0 | G33Q |
33
+| 18 | 60985760,60985761 | 21 | 12 | 0 | G47D |
34
+| 18 | 60985760,60985761 | 21 | 12 | 0 | G47A |
35
+| 18 | 60985760,60985761 | 21 | 12 | 0 | G47V |
36
+| 18 | 60985760,60985761 | 21 | 12 | 0 | G47R |
37
+| 18 | 60985760,60985761 | 21 | 12 | 0 | G47S |
38
+| 18 | 60985513,60985514,60985515 | 23 | 9 | 0 | R129H |
39
+| 18 | 60985513,60985514,60985515 | 23 | 9 | 0 | R129L |
40
+| 18 | 60985513,60985514,60985515 | 23 | 9 | 0 | R129C |
41
+| 18 | 60985513,60985514,60985515 | 23 | 9 | 0 | R129S |
42
+| 18 | 60985513,60985514,60985515 | 23 | 9 | 0 | R129Y |
43
+| 18 | 60985889,60985890 | 14 | 24 | 0 | A4T |
44
+| 18 | 60985880,60985881 | 20 | 8 | 0 | T7I |
45
+| 18 | 60985880,60985881 | 20 | 8 | 0 | T7A |
46
+| 18 | 60985880,60985881 | 20 | 8 | 0 | T7P |
47
+| 18 | 60985889,60985890 | 14 | 24 | 0 | A4S |
48
+| 18 | 60985889,60985890 | 14 | 24 | 0 | A4V |
49
+| 18 | 60985880,60985881 | 20 | 8 | 0 | T7R |
50
+| 18 | 60985880,60985881 | 20 | 8 | 0 | T7S |
51
+| 18 | 60985889,60985890 | 14 | 24 | 0 | A4G |
52
+| 18 | 60985889,60985890 | 14 | 24 | 0 | A4P |
53
+| 18 | 60985889,60985890 | 14 | 24 | 0 | A4D |
54
+| 18 | 60985807,60985808,60985809 | 16 | 10 | 0 | D31N |
55
+| 18 | 60985877,60985878,60985876 | 18 | 8 | 0 | G8E |
56
+| 18 | 60985877,60985878,60985876 | 18 | 8 | 0 | G8R |
57
+| 18 | 60985807,60985808,60985809 | 16 | 10 | 0 | D31G |
58
+| 18 | 60985807,60985808,60985809 | 16 | 10 | 0 | D31H |
59
+| 18 | 60985807,60985808,60985809 | 16 | 10 | 0 | D31A |
60
+| 18 | 60985807,60985808,60985809 | 16 | 10 | 0 | D31E |
61
+| 18 | 60985877,60985878,60985876 | 18 | 8 | 0 | G8A |
62
+| 18 | 60985877,60985878,60985876 | 18 | 8 | 0 | G8D |
63
+| 18 | 60985877,60985878,60985876 | 18 | 8 | 0 | G8Q |
64
+| 18 | 60985877,60985878,60985876 | 18 | 8 | 0 | G8V |
65
+| 18 | 60985807,60985808,60985809 | 16 | 10 | 0 | D31S |
66
+| 18 | 60985807,60985808,60985809 | 16 | 10 | 0 | D31Y |
67
+| 18 | 60985742,60985743 | 15 | 8 | 0 | P53S |
68
+| 18 | 60985742,60985743 | 15 | 8 | 0 | P53T |
69
+| 18 | 60985742,60985743 | 15 | 8 | 0 | P53A |
70
+| 18 | 60985742,60985743 | 15 | 8 | 0 | P53L |
71
+| 18 | 60985861 | 17 | 12 | 0 | E13D |
72
+| 18 | 60985549,60985550,60985551 | 12 | 7 | 0 | S117R |
73
+| 18 | 60985549,60985550,60985551 | 12 | 7 | 0 | S117T |
74
+| 18 | 60985549,60985550,60985551 | 12 | 7 | 0 | S117N |
75
+| 18 | 60985840,60985841,60985842 | 12 | 6 | 0 | H20Q |
76
+| 18 | 60985644 | 13 | 5 | 0 | L86F |
77
+| 18 | 60985644 | 13 | 5 | 0 | L86V |
78
+| 18 | 60985840,60985841,60985842 | 12 | 6 | 0 | H20R |
79
+| 18 | 60985840,60985841,60985842 | 12 | 6 | 0 | H20Y |
80
+| 18 | 60985753,60985755 | 5 | 12 | 0 | F49L |
81
+| 18 | 60985793 | 8 | 9 | 0 | G36D |
82
+| 18 | 60985562,60985563 | 11 | 6 | 0 | A113G |
83
+| 18 | 60985562,60985563 | 11 | 6 | 0 | A113V |
84
+| 18 | 60985793 | 8 | 9 | 0 | G36A |
85
+| 18 | 60985753,60985755 | 5 | 12 | 0 | F49I |
86
+| 18 | 60985562,60985563 | 11 | 6 | 0 | A113T |
87
+| 18 | 60985753,60985755 | 5 | 12 | 0 | F49V |
88
+| 18 | 60985793 | 8 | 9 | 0 | G36V |
89
+| 18 | 60985849,60985850 | 9 | 6 | 1 | K17N |
90
+| 18 | 60985849,60985850 | 9 | 6 | 1 | K17R |
91
+| 18 | 60985764,60985763 | 10 | 5 | 0 | P46A |
92
+| 18 | 60985764,60985763 | 10 | 5 | 0 | P46S |
93
+| 18 | 60985764,60985763 | 10 | 5 | 0 | P46R |
94
+| 18 | 60985541,60985542 | 10 | 4 | 0 | H120Y |
95
+| 18 | 60985852,60985853,60985854 | 9 | 4 | 1 | M16V |
96
+| 18 | 60985852,60985853,60985854 | 9 | 4 | 1 | M16L |
97
+| 18 | 60985852,60985853,60985854 | 9 | 4 | 1 | M16I |
98
+| 18 | 60985541,60985542 | 10 | 4 | 0 | H120N |
99
+| 18 | 60985541,60985542 | 10 | 4 | 0 | H120R |
100
+| 18 | 60985852,60985853,60985854 | 9 | 4 | 1 | M16K |
101
+| 18 | 60985541,60985542 | 10 | 4 | 0 | H120L |
102
+| 18 | 60985541,60985542 | 10 | 4 | 0 | H120S |
103
+| 18 | 60985639,60985640,60985641 | 7 | 5 | 0 | S87R |
104
+| 18 | 60985798,60985800 | 7 | 5 | 0 | D34H |
105
+| 18 | 60985798,60985800 | 7 | 5 | 0 | D34N |
106
+| 18 | 60985874,60985875 | 8 | 4 | 0 | Y9N |
107
+| 18 | 60985798,60985800 | 7 | 5 | 0 | D34E |
108
+| 18 | 60985639,60985640,60985641 | 7 | 5 | 0 | S87N |
109
+| 18 | 60985639,60985640,60985641 | 7 | 5 | 0 | S87T |
110
+| 18 | 60985874,60985875 | 8 | 4 | 0 | Y9F |
111
+| 18 | 60985874,60985875 | 8 | 4 | 0 | Y9H |
112
+| 18 | 60985874,60985875 | 8 | 4 | 0 | Y9C |
113
+| 18 | 60985874,60985875 | 8 | 4 | 0 | Y9S |
114
+| 18 | 60985868,60985869 | 8 | 3 | 0 | N11H |
115
+| 18 | 60985342,60985344 | 5 | 6 | 0 | H186Q |
116
+| 18 | 60985813,60985814,60985815 | 7 | 4 | 0 | E29D |
117
+| 18 | 60985813,60985814,60985815 | 7 | 4 | 0 | E29A |
118
+| 18 | 60985813,60985814,60985815 | 7 | 4 | 0 | E29Q |
119
+| 18 | 60985342,60985344 | 5 | 6 | 0 | H186Y |
120
+| 18 | 60985756,60985757,60985758 | 6 | 5 | 0 | I48F |
121
+| 18 | 60985756,60985757,60985758 | 6 | 5 | 0 | I48M |
122
+| 18 | 60985342,60985344 | 5 | 6 | 0 | H186D |
123
+| 18 | 60985868,60985869 | 8 | 3 | 0 | N11S |
124
+| 18 | 60985868,60985869 | 8 | 3 | 0 | N11Y |
125
+| 18 | 60985813,60985814,60985815 | 7 | 4 | 0 | E29V |
126
+| 18 | 60985342,60985344 | 5 | 6 | 0 | H186N |
127
+| 18 | 60985756,60985757,60985758 | 6 | 5 | 0 | I48L |
128
+| 18 | 60985756,60985757,60985758 | 6 | 5 | 0 | I48N |
129
+| 18 | 60985756,60985757,60985758 | 6 | 5 | 0 | I48S |
130
+| 18 | 60985756,60985757,60985758 | 6 | 5 | 0 | I48T |
131
+| 18 | 60985756,60985757,60985758 | 6 | 5 | 0 | I48V |
132
+| 18 | 60985868,60985869 | 8 | 3 | 0 | N11T |
133
+| 18 | 60985767,60985766 | 5 | 5 | 0 | A45T |
134
+| 18 | 60985361,60985362 | 7 | 3 | 0 | Y180F |
135
+| 18 | 60985694,60985695 | 5 | 5 | 0 | T69A |
136
+| 18 | 60985767,60985766 | 5 | 5 | 0 | A45V |
137
+| 18 | 60985694,60985695 | 5 | 5 | 0 | T69P |
138
+| 18 | 60985361,60985362 | 7 | 3 | 0 | Y180H |
139
+| 18 | 60985767,60985766 | 5 | 5 | 0 | A45P |
140
+| 18 | 60985694,60985695 | 5 | 5 | 0 | T69I |
141
+| 18 | 60985694,60985695 | 5 | 5 | 0 | T69S |
142
+| 18 | 60985361,60985362 | 7 | 3 | 0 | Y180D |
143
+| 18 | 60985718,60985719 | 5 | 4 | 0 | A61T |
144
+| 18 | 60985718,60985719 | 5 | 4 | 0 | A61E |
145
+| 18 | 60985718,60985719 | 5 | 4 | 0 | A61G |
146
+| 18 | 60985718,60985719 | 5 | 4 | 0 | A61P |
147
+| 18 | 60985718,60985719 | 5 | 4 | 0 | A61S |
148
+| 18 | 60985718,60985719 | 5 | 4 | 0 | A61_S62insP |
149
+| 18 | 60985363 | 4 | 4 | 0 | E179D |
150
+| 18 | 60985632 | 7 | 1 | 0 | P90S |
151
+| 18 | 60985546,60985547 | 7 | 1 | 0 | Q118H |
152
+| 18 | 60985499,60985500 | 8 | 0 | 0 | V134M |
153
+| 18 | 60985433,60985434 | 6 | 2 | 0 | V156A |
154
+| 18 | 60985632 | 7 | 1 | 0 | P90A |
155
+| 18 | 60985546,60985547 | 7 | 1 | 0 | Q118R |
156
+| 18 | 60985499,60985500 | 8 | 0 | 0 | V134L |
157
+| 18 | 60985433,60985434 | 6 | 2 | 0 | V156I |
158
+| 18 | 60985632 | 7 | 1 | 0 | P90T |
159
+| 18 | 60985546,60985547 | 7 | 1 | 0 | Q118L |
160
+| 18 | 60985499,60985500 | 8 | 0 | 0 | V134A |
161
+| 18 | 60985433,60985434 | 6 | 2 | 0 | V156D |
162
+| 18 | 60985433,60985434 | 6 | 2 | 0 | V156L |
163
+| 18 | 60985805,60985806 | 4 | 3 | 0 | A32V |
164
+| 18 | 60985616,60985617 | 4 | 3 | 0 | L95V |
165
+| 18 | 60985805,60985806 | 4 | 3 | 0 | A32T |
166
+| 18 | 60985616,60985617 | 4 | 3 | 0 | L95R |
167
+| 18 | 60985616,60985617 | 4 | 3 | 0 | L95M |
168
+| 18 | 60985495 | 5 | 1 | 0 | E135D |
169
+| 18 | 60985566 | 2 | 4 | 0 | F112L |
170
+| 18 | 60985629,60985628 | 5 | 1 | 0 | P91S |
171
+| 18 | 60985751,60985752,60985750 | 3 | 3 | 0 | S50P |
172
+| 18 | 60985629,60985628 | 5 | 1 | 0 | P91L |
173
+| 18 | 60985751,60985752,60985750 | 3 | 3 | 0 | S50F |
174
+| 18 | 60985796,60985797 | 2 | 4 | 0 | V35M |
175
+| 18 | 60985566 | 2 | 4 | 0 | F112V |
176
+| 18 | 60985629,60985628 | 5 | 1 | 0 | P91A |
177
+| 18 | 60985751,60985752,60985750 | 3 | 3 | 0 | S50L |
178
+| 18 | 60985796,60985797 | 2 | 4 | 0 | V35A |
179
+| 18 | 60985796,60985797 | 2 | 4 | 0 | V35E |
180
+| 18 | 60985796,60985797 | 2 | 4 | 0 | V35G |
181
+| 18 | 60985796,60985797 | 2 | 4 | 0 | V35L |
182
+| 18 | 60985870 | 3 | 2 | 0 | D10E |
183
+| 18 | 60985847 | 12 | 3 | 0 | Y18F |
184
+| 18 | 60985545 | 3 | 2 | 0 | L119V |
185
+| 18 | 60985834,60985835 | 2 | 3 | 0 | K22R |
186
+| 18 | 60985866 | 27 | 10 | 0 | R12W |
187
+| 18 | 60985834,60985835 | 2 | 3 | 0 | K22N |
188
+| 18 | 60985866 | 27 | 10 | 0 | R12G |
189
+| 18 | 60985822,60985823,60985824 | 4 | 1 | 0 | R26S |
190
+| 18 | 60985505,60985506 | 3 | 2 | 0 | T132A |
191
+| 18 | 60985505,60985506 | 3 | 2 | 0 | T132M |
192
+| 18 | 60985703,60985704 | 1 | 4 | 0 | V66G |
193
+| 18 | 60985703,60985704 | 1 | 4 | 0 | V66I |
194
+| 18 | 60985545 | 3 | 2 | 0 | L119M |
195
+| 18 | 60985822,60985823,60985824 | 4 | 1 | 0 | R26G |
196
+| 18 | 60985822,60985823,60985824 | 4 | 1 | 0 | R26K |
197
+| 18 | 60985822,60985823,60985824 | 4 | 1 | 0 | R26T |
198
+| 18 | 60985505,60985506 | 3 | 2 | 0 | T132P |
199
+| 18 | 60985703,60985704 | 1 | 4 | 0 | V66A |
200
+| 18 | 60985492 | 1 | 3 | 0 | E136D |
201
+| 18 | 60985833 | 4 | 0 | 0 | L23V |
202
+| 18 | 60985383 | 3 | 1 | 0 | I173V |
203
+| 18 | 60985491 | 2 | 2 | 0 | L137I |
204
+| 18 | 60985712 | 2 | 2 | 0 | R63P |
205
+| 18 | 60985748,60985749 | 2 | 2 | 0 | S51P |
206
+| 18 | 60985646,60985647 | 1 | 3 | 0 | A85V |
207
+| 18 | 60985886 | 2 | 2 | 0 | G5E |
208
+| 18 | 60985843,60985845 | 3 | 1 | 0 | I19L |
209
+| 18 | 60985730,60985731 | 2 | 2 | 0 | P57L |
210
+| 18 | 60985730,60985731 | 2 | 2 | 0 | P57S |
211
+| 18 | 60985838,60985839 | 3 | 1 | 0 | Y21C |
212
+| 18 | 60985817,60985818 | 2 | 2 | 0 | Y28F |
213
+| 18 | 60985646,60985647 | 1 | 3 | 0 | A85E |
214
+| 18 | 60985646,60985647 | 1 | 3 | 0 | A85P |
215
+| 18 | 60985886 | 2 | 2 | 0 | G5A |
216
+| 18 | 60985886 | 2 | 2 | 0 | G5V |
217
+| 18 | 60985383 | 3 | 1 | 0 | I173F |
218
+| 18 | 60985843,60985845 | 3 | 1 | 0 | I19M |
219
+| 18 | 60985843,60985845 | 3 | 1 | 0 | I19V |
220
+| 18 | 60985491 | 2 | 2 | 0 | L137V |
221
+| 18 | 60985712 | 2 | 2 | 0 | R63L |
222
+| 18 | 60985748,60985749 | 2 | 2 | 0 | S51F |
223
+| 18 | 60985715,60985716 | 1 | 3 | 0 | S62A |
224
+| 18 | 60985715,60985716 | 1 | 3 | 0 | S62C |
225
+| 18 | 60985715,60985716 | 1 | 3 | 0 | S62P |
226
+| 18 | 60985715,60985716 | 1 | 3 | 0 | S62T |
227
+| 18 | 60985838,60985839 | 3 | 1 | 0 | Y21H |
228
+| 18 | 60985838,60985839 | 3 | 1 | 0 | Y21S |
229
+| 18 | 60985817,60985818 | 2 | 2 | 0 | Y28C |
230
+| 18 | 60985817,60985818 | 2 | 2 | 0 | Y28N |
231
+| 18 | 60985707 | 1 | 2 | 0 | P65S |
232
+| 18 | 60985463 | 3 | 0 | 0 | R146K |
233
+| 18 | 60985330,60985332 | 3 | 0 | 0 | Q190H |
234
+| 18 | 60985744,60985745 | 1 | 2 | 0 | Q52H |
235
+| 18 | 60985353 | 1 | 2 | 0 | R183W |
236
+| 18 | 60985830 | 1 | 2 | 0 | S24A |
237
+| 18 | 60985625,60985626 | 3 | 0 | 0 | V92A |
238
+| 18 | 60985330,60985332 | 3 | 0 | 0 | Q190E |
239
+| 18 | 60985744,60985745 | 1 | 2 | 0 | Q52R |
240
+| 18 | 60985353 | 1 | 2 | 0 | R183G |
241
+| 18 | 60985830 | 1 | 2 | 0 | S24T |
242
+| 18 | 60985625,60985626 | 3 | 0 | 0 | V92M |
243
+| 18 | 60985452,60985450 | 1 | 1 | 0 | F150L |
244
+| 18 | 60985820 | 1 | 1 | 0 | G27D |
245
+| 18 | 60985826 | 2 | 0 | 0 | Q25L |
246
+| 18 | 60985623 | 2 | 0 | 0 | V93L |
247
+| 18 | 60985791,60985790 | 0 | 2 | 0 | A37T |
248
+| 18 | 60985791,60985790 | 0 | 2 | 0 | A37V |
249
+| 18 | 60985700 | 1 | 1 | 0 | A67G |
250
+| 18 | 60985700 | 1 | 1 | 0 | A67V |
251
+| 18 | 60985341,60985340 | 1 | 1 | 0 | T187A |
252
+| 18 | 60985341,60985340 | 1 | 1 | 0 | T187I |
253
+| 18 | 60985502 | 1 | 1 | 0 | V133A |
254
+| 18 | 60985502 | 1 | 1 | 0 | V133E |
255
+| 18 | 60985812,60985810 | 0 | 2 | 0 | W30C |
256
+| 18 | 60985812,60985810 | 0 | 2 | 0 | W30R |
257
+| 18 | 60985788 | 1 | 0 | 0 | A38S |
258
+| 18 | 60985428 | 1 | 0 | 0 | C158S |
259
+| 18 | 60985710 | 0 | 1 | 0 | D64Y |
260
+| nan | nan | 0 | 1 | 0 | DF111EL |
261
+| 18 | 60985444 | 1 | 0 | 0 | E152G |
262
+| 18 | 60985443 | 1 | 0 | 0 | F153L |
263
+| 18 | 60985478 | 1 | 0 | 0 | G141E |
264
+| 18 | 60985860 | 0 | 1 | 0 | I14L |
265
+| 18 | 60985359 | 1 | 0 | 0 | L181M |
266
+| 18 | 60985785 | 0 | 1 | 0 | P39S |
tables/hotspots/hotspot_BCL7A.md
... ...
@@ -0,0 +1,15 @@
1
+## BCL7A Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 12 | 122460082,122460083 | 12 | 1 | 1 | R29C |
6
+| 12 | 122460082,122460083 | 12 | 1 | 1 | R29H |
7
+| 12 | 122460082,122460083 | 12 | 1 | 1 | R29P |
8
+| 12 | 122460088,122460089 | 8 | 2 | 2 | W31R |
9
+| 12 | 122460088,122460089 | 8 | 2 | 2 | W31G |
10
+| 12 | 122460088,122460089 | 8 | 2 | 2 | W31* |
11
+| 12 | 122460088,122460089 | 8 | 2 | 2 | W31S |
12
+| 12 | 122460086,122460087 | 6 | 0 | 2 | K30= |
13
+| 12 | 122460086,122460087 | 6 | 0 | 2 | K30R |
14
+| nan | nan | 3 | 1 | 0 | X31_splice |
15
+| nan | nan | 0 | 0 | 1 | X29_splice |
tables/hotspots/hotspot_BMP7.md
... ...
@@ -0,0 +1,10 @@
1
+## BMP7 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 20 | 55841156,55841157 | 4 | 5 | 7 | A8P |
6
+| 20 | 55841156,55841157 | 4 | 5 | 7 | A8T |
7
+| 20 | 55841156,55841157 | 4 | 5 | 7 | A8G |
8
+| 20 | 55841156,55841157 | 4 | 5 | 7 | A8V |
9
+| 20 | 55841162 | 1 | 0 | 0 | L6P |
10
+| 20 | 55841165 | 1 | 0 | 0 | S5L |
tables/hotspots/hotspot_BRAF.md
... ...
@@ -0,0 +1,21 @@
1
+## BRAF Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 7 | 140453153,140453154,140453155 | 10 | 2 | 3 | D594G |
6
+| 7 | 140453153,140453154,140453155 | 10 | 2 | 3 | D594N |
7
+| 7 | 140453153,140453154,140453155 | 10 | 2 | 3 | D594A |
8
+| 7 | 140453153,140453154,140453155 | 10 | 2 | 3 | D594E |
9
+| 7 | 140481402,140481403 | 7 | 2 | 1 | G469A |
10
+| 7 | 140481402,140481403 | 7 | 2 | 1 | G469E |
11
+| 7 | 140481402,140481403 | 7 | 2 | 1 | G469R |
12
+| 7 | 140481402,140481403 | 7 | 2 | 1 | G469V |
13
+| 7 | 140453132,140453134 | 6 | 1 | 0 | K601E |
14
+| 7 | 140453132,140453134 | 6 | 1 | 0 | K601N |
15
+| 7 | 140453136 | 4 | 2 | 0 | V600E |
16
+| 7 | 140453145 | 4 | 0 | 1 | L597R |
17
+| 7 | 140453145 | 4 | 0 | 1 | L597Q |
18
+| 7 | 140453150 | 2 | 0 | 1 | F595L |
19
+| 7 | 140481417 | 1 | 0 | 1 | G464V |
20
+| 7 | 140477806 | 0 | 0 | 1 | E501A |
21
+| nan | nan | 1 | 0 | 0 | T599dup |
tables/hotspots/hotspot_BTG1.md
... ...
@@ -0,0 +1,42 @@
1
+## BTG1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 12 | 92539202,92539203 | 19 | 3 | 0 | L37V |
6
+| 12 | 92539202,92539203 | 19 | 3 | 0 | L37M |
7
+| 12 | 92539202,92539203 | 19 | 3 | 0 | L37E |
8
+| 12 | 92539202,92539203 | 19 | 3 | 0 | L37K |
9
+| 12 | 92539204,92539206 | 15 | 3 | 0 | Q36H |
10
+| 12 | 92539204,92539206 | 15 | 3 | 0 | Q36* |
11
+| 12 | 92539204,92539206 | 15 | 3 | 0 | Q36Hfs*44 |
12
+| 12 | 92539204,92539206 | 15 | 3 | 0 | Q36L |
13
+| 12 | 92539204,92539206 | 15 | 3 | 0 | Q36Rfs*38 |
14
+| 12 | 92539204,92539206 | 15 | 3 | 0 | Q36_S41delinsR |
15
+| 12 | 92539204,92539206 | 15 | 3 | 0 | Q36_T39delinsH |
16
+| 12 | 92539184,92539185 | 9 | 2 | 2 | S43N |
17
+| 12 | 92539184,92539185 | 9 | 2 | 2 | S43T |
18
+| 12 | 92539184,92539185 | 9 | 2 | 2 | S43C |
19
+| 12 | 92539184,92539185 | 9 | 2 | 2 | S43R |
20
+| 12 | 92539184,92539185 | 9 | 2 | 2 | S43Tfs*37 |
21
+| 12 | 92539195,92539196 | 8 | 0 | 0 | T39S |
22
+| 12 | 92539195,92539196 | 8 | 0 | 0 | T39I |
23
+| 12 | 92539195,92539196 | 8 | 0 | 0 | T39M |
24
+| 12 | 92539195,92539196 | 8 | 0 | 0 | T39Ifs*14 |
25
+| 12 | 92539200,92539198 | 6 | 1 | 0 | Q38* |
26
+| 12 | 92539200,92539198 | 6 | 1 | 0 | Q38H |
27
+| 12 | 92539200,92539198 | 6 | 1 | 0 | Q38Pfs*41 |
28
+| 12 | 92539221 | 6 | 0 | 0 | L31F |
29
+| 12 | 92539209 | 6 | 0 | 0 | R35* |
30
+| 12 | 92539209 | 6 | 0 | 0 | R35G |
31
+| 12 | 92539223,92539224 | 4 | 1 | 0 | G30R |
32
+| 12 | 92539189,92539190 | 5 | 0 | 0 | S41R |
33
+| 12 | 92539223,92539224 | 4 | 1 | 0 | G30E |
34
+| 12 | 92539189,92539190 | 5 | 0 | 0 | S41N |
35
+| 12 | 92539186,92539188 | 3 | 0 | 0 | Q42H |
36
+| 12 | 92539214 | 1 | 2 | 0 | S33N |
37
+| 12 | 92539193 | 3 | 0 | 0 | F40C |
38
+| 12 | 92539193 | 3 | 0 | 0 | F40Qfs*13 |
39
+| 12 | 92539193 | 3 | 0 | 0 | F40Rfs*38 |
40
+| 12 | 92539186,92539188 | 3 | 0 | 0 | Q42* |
41
+| 12 | 92539214 | 1 | 2 | 0 | S33T |
42
+| 12 | 92539218 | 1 | 0 | 0 | T32A |
tables/hotspots/hotspot_BTG2.md
... ...
@@ -0,0 +1,62 @@
1
+## BTG2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 203274876,203276233 | 24 | 4 | 3 | E48K |
6
+| 1 | 203274876,203276233 | 24 | 4 | 3 | E48* |
7
+| 1 | 203274876,203276233 | 24 | 4 | 3 | E48Q |
8
+| 1 | 203274876,203276233 | 24 | 4 | 3 | E48= |
9
+| 1 | 203274876,203276233 | 24 | 4 | 3 | E48D |
10
+| 1 | 203274867,203274868 | 18 | 1 | 0 | A45T |
11
+| 1 | 203274867,203274868 | 18 | 1 | 0 | A45E |
12
+| 1 | 203274867,203274868 | 18 | 1 | 0 | A45G |
13
+| 1 | 203274867,203274868 | 18 | 1 | 0 | A45P |
14
+| 1 | 203274867,203274868 | 18 | 1 | 0 | A45S |
15
+| 1 | 203274867,203274868 | 18 | 1 | 0 | A45V |
16
+| 1 | 203274762 | 13 | 3 | 1 | L10F |
17
+| 1 | 203274762 | 13 | 3 | 1 | L10V |
18
+| 1 | 203274759,203274761 | 11 | 0 | 0 | M9I |
19
+| 1 | 203274759,203274761 | 11 | 0 | 0 | M9V |
20
+| 1 | 203276249,203276251 | 9 | 0 | 0 | W54* |
21
+| 1 | 203276249,203276251 | 9 | 0 | 0 | W54C |
22
+| 1 | 203276237,203276238,203276239 | 6 | 2 | 1 | Y50H |
23
+| 1 | 203276237,203276238,203276239 | 6 | 2 | 1 | Y50S |
24
+| 1 | 203276237,203276238,203276239 | 6 | 2 | 1 | Y50D |
25
+| 1 | 203276249,203276251 | 9 | 0 | 0 | W54R |
26
+| 1 | 203276237,203276238,203276239 | 6 | 2 | 1 | Y50* |
27
+| 1 | 203274870 | 7 | 1 | 0 | L46F |
28
+| 1 | 203274870 | 7 | 1 | 0 | L46V |
29
+| 1 | 203276274 | 6 | 0 | 0 | G62D |
30
+| 1 | 203276274 | 6 | 0 | 0 | G62V |
31
+| 1 | 203276289 | 5 | 0 | 0 | C67Y |
32
+| 1 | 203274858 | 4 | 0 | 1 | L42F |
33
+| 1 | 203274768,203274769,203274770 | 5 | 0 | 0 | E12V |
34
+| 1 | 203274768,203274769,203274770 | 5 | 0 | 0 | E12A |
35
+| 1 | 203274768,203274769,203274770 | 5 | 0 | 0 | E12D |
36
+| 1 | 203274768,203274769,203274770 | 5 | 0 | 0 | E12K |
37
+| 1 | 203274858 | 4 | 0 | 1 | L42V |
38
+| 1 | 203276280 | 4 | 0 | 0 | G64D |
39
+| 1 | 203276280 | 4 | 0 | 0 | G64A |
40
+| 1 | 203276280 | 4 | 0 | 0 | G64V |
41
+| 1 | 203276246,203276247 | 3 | 0 | 0 | H53Y |
42
+| 1 | 203274774,203274775 | 2 | 1 | 0 | A14G |
43
+| 1 | 203274774,203274775 | 2 | 1 | 0 | A14P |
44
+| 1 | 203274774,203274775 | 2 | 1 | 0 | A14V |
45
+| 1 | 203276246,203276247 | 3 | 0 | 0 | H53R |
46
+| 1 | 203274875,203274873 | 2 | 1 | 0 | T47= |
47
+| 1 | 203274875,203274873 | 2 | 1 | 0 | T47A |
48
+| 1 | 203274875,203274873 | 2 | 1 | 0 | T47P |
49
+| 1 | 203276282,203276284 | 3 | 0 | 0 | Y65* |
50
+| 1 | 203276282,203276284 | 3 | 0 | 0 | Y65H |
51
+| 1 | 203276282,203276284 | 3 | 0 | 0 | Y65N |
52
+| 1 | 203274855 | 1 | 0 | 1 | A41T |
53
+| 1 | 203276312 | 2 | 0 | 0 | D75H |
54
+| nan | nan | 2 | 0 | 0 | X48_splice |
55
+| 1 | 203276403,203276402 | 1 | 1 | 0 | D105A |
56
+| 1 | 203276403,203276402 | 1 | 1 | 0 | D105N |
57
+| 1 | 203276276 | 2 | 0 | 0 | S63A |
58
+| 1 | 203276276 | 2 | 0 | 0 | S63P |
59
+| 1 | 203276292 | 1 | 0 | 0 | I68S |
60
+| 1 | 203276318 | 1 | 0 | 0 | I77F |
61
+| 1 | 203276321 | 1 | 0 | 0 | I78V |
62
+| 1 | 203276328 | 1 | 0 | 0 | R80T |
tables/hotspots/hotspot_CARD11.md
... ...
@@ -0,0 +1,35 @@
1
+## CARD11 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 7 | 2977613,2977614 | 13 | 18 | 0 | D357V |
6
+| 7 | 2977613,2977614 | 13 | 18 | 0 | D357E |
7
+| 7 | 2977613,2977614 | 13 | 18 | 0 | D357G |
8
+| 7 | 2979559,2979558 | 19 | 2 | 2 | D230N |
9
+| 7 | 2979559,2979558 | 19 | 2 | 2 | D230A |
10
+| 7 | 2979495 | 10 | 8 | 0 | L251P |
11
+| 7 | 2979501 | 4 | 5 | 1 | Q249P |
12
+| 7 | 2979499 | 8 | 2 | 0 | S250P |
13
+| 7 | 2979513 | 2 | 4 | 0 | L245P |
14
+| 7 | 2977605,2977606,2977604 | 6 | 0 | 0 | M360V |
15
+| 7 | 2977605,2977606,2977604 | 6 | 0 | 0 | M360I |
16
+| 7 | 2977602,2977603 | 6 | 0 | 0 | Y361H |
17
+| 7 | 2977602,2977603 | 6 | 0 | 0 | Y361S |
18
+| 7 | 2977605,2977606,2977604 | 6 | 0 | 0 | M360K |
19
+| 7 | 2977602,2977603 | 6 | 0 | 0 | Y361C |
20
+| 7 | 2977602,2977603 | 6 | 0 | 0 | Y361D |
21
+| 7 | 2979489 | 3 | 2 | 0 | L253P |
22
+| 7 | 2979508 | 3 | 0 | 0 | R247G |
23
+| 7 | 2979521,2979522 | 1 | 2 | 0 | E242D |
24
+| 7 | 2979521,2979522 | 1 | 2 | 0 | E242G |
25
+| 7 | 2979521,2979522 | 1 | 2 | 0 | E242del |
26
+| 7 | 2979493 | 1 | 2 | 0 | K252* |
27
+| 7 | 2979493 | 1 | 2 | 0 | K252E |
28
+| 7 | 2979493 | 1 | 2 | 0 | K252_L253delinsM |
29
+| 7 | 2979485,2979486 | 1 | 2 | 0 | K254N |
30
+| 7 | 2979485,2979486 | 1 | 2 | 0 | K254R |
31
+| 7 | 2979485,2979486 | 1 | 2 | 0 | K254_N255del |
32
+| 7 | 2979481 | 0 | 1 | 0 | D256N |
33
+| 7 | 2979483 | 0 | 1 | 0 | N255S |
34
+| nan | nan | 1 | 0 | 0 | Q231_H234del |
35
+| 7 | 2979543 | 0 | 1 | 0 | R235P |
tables/hotspots/hotspot_CD79B.md
... ...
@@ -0,0 +1,24 @@
1
+## CD79B Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197H |
6
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197S |
7
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197N |
8
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197D |
9
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197C |
10
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197F |
11
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197* |
12
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197del |
13
+| 17 | 62006797,62006798,62006799 | 151 | 1 | 1 | Y197_E198del |
14
+| 17 | 62006680 | 9 | 0 | 0 | L200P |
15
+| 17 | 62006680 | 9 | 0 | 0 | L200Q |
16
+| 17 | 62006680 | 9 | 0 | 0 | L200R |
17
+| 17 | 62006680 | 9 | 0 | 0 | L200S |
18
+| 17 | 62006795 | 4 | 0 | 0 | E198G |
19
+| 17 | 62006795 | 4 | 0 | 0 | E198A |
20
+| 17 | 62006809 | 2 | 0 | 0 | E193D |
21
+| 17 | 62006809 | 2 | 0 | 0 | E193Rfs*6 |
22
+| 17 | 62006807 | 1 | 0 | 0 | D194G |
23
+| nan | nan | 1 | 0 | 0 | H195_E198delinsQ |
24
+| 17 | 62006802 | 1 | 0 | 0 | T196A |
tables/hotspots/hotspot_CD83.md
... ...
@@ -0,0 +1,37 @@
1
+## CD83 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 14118192,14118193 | 19 | 2 | 0 | A17T |
6
+| 6 | 14118192,14118193 | 19 | 2 | 0 | A17P |
7
+| 6 | 14118192,14118193 | 19 | 2 | 0 | A17G |
8
+| 6 | 14118192,14118193 | 19 | 2 | 0 | A17Rfs*4 |
9
+| 6 | 14118181,14118182 | 10 | 0 | 0 | A13V |
10
+| 6 | 14118181,14118182 | 10 | 0 | 0 | A13D |
11
+| 6 | 14118181,14118182 | 10 | 0 | 0 | A13= |
12
+| 6 | 14118181,14118182 | 10 | 0 | 0 | A13G |
13
+| 6 | 14118219,14118220 | 8 | 1 | 0 | A26P |
14
+| 6 | 14118219,14118220 | 8 | 1 | 0 | A26T |
15
+| 6 | 14118219,14118220 | 8 | 1 | 0 | A26S |
16
+| 6 | 14118219,14118220 | 8 | 1 | 0 | A26G |
17
+| 6 | 14118222,14118223,14118224 | 8 | 0 | 0 | C27Y |
18
+| 6 | 14118222,14118223,14118224 | 8 | 0 | 0 | C27* |
19
+| 6 | 14118222,14118223,14118224 | 8 | 0 | 0 | C27G |
20
+| 6 | 14118222,14118223,14118224 | 8 | 0 | 0 | C27R |
21
+| 6 | 14118222,14118223,14118224 | 8 | 0 | 0 | C27W |
22
+| 6 | 14118207,14118209 | 2 | 0 | 1 | E22D |
23
+| 6 | 14118204 | 3 | 0 | 0 | P21S |
24
+| 6 | 14118207,14118209 | 2 | 0 | 1 | E22K |
25
+| 6 | 14118204 | 3 | 0 | 0 | P21T |
26
+| 6 | 14118186,14118187 | 3 | 0 | 0 | S15G |
27
+| 6 | 14118186,14118187 | 3 | 0 | 0 | S15N |
28
+| 6 | 14118186,14118187 | 3 | 0 | 0 | S15T |
29
+| 6 | 14118243 | 2 | 0 | 0 | P34S |
30
+| 6 | 14118226 | 2 | 0 | 0 | S28C |
31
+| 6 | 14118215,14118213 | 2 | 0 | 0 | K24L |
32
+| 6 | 14118215,14118213 | 2 | 0 | 0 | K24N |
33
+| 6 | 14118231 | 1 | 0 | 0 | D30N |
34
+| 6 | 14118237 | 1 | 0 | 0 | D32H |
35
+| 6 | 14118195 | 1 | 0 | 0 | P18S |
36
+| 6 | 14118216 | 1 | 0 | 0 | V25L |
37
+| 6 | 14118183 | 0 | 0 | 1 | Y14N |
tables/hotspots/hotspot_CDKN2A.md
... ...
@@ -0,0 +1,5 @@
1
+## CDKN2A Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 9 | 21971120 | 29 | 2 | 2 | R80* |
tables/hotspots/hotspot_CREBBP.md
... ...
@@ -0,0 +1,42 @@
1
+## CREBBP Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 16 | 3788617,3788618 | 27 | 58 | 1 | R1446C |
6
+| 16 | 3788617,3788618 | 27 | 58 | 1 | R1446H |
7
+| 16 | 3788617,3788618 | 27 | 58 | 1 | R1446L |
8
+| 16 | 3788617,3788618 | 27 | 58 | 1 | R1446S |
9
+| 16 | 3786703,3786704 | 19 | 36 | 0 | Y1503H |
10
+| 16 | 3786703,3786704 | 19 | 36 | 0 | Y1503N |
11
+| 16 | 3786703,3786704 | 19 | 36 | 0 | Y1503D |
12
+| 16 | 3786703,3786704 | 19 | 36 | 0 | Y1503F |
13
+| 16 | 3786703,3786704 | 19 | 36 | 0 | Y1503C |
14
+| 16 | 3786703,3786704 | 19 | 36 | 0 | Y1503S |
15
+| 16 | 3788604,3788605,3788606 | 7 | 15 | 1 | Y1450C |
16
+| 16 | 3788604,3788605,3788606 | 7 | 15 | 1 | Y1450D |
17
+| 16 | 3788604,3788605,3788606 | 7 | 15 | 1 | Y1450N |
18
+| 16 | 3788604,3788605,3788606 | 7 | 15 | 1 | Y1450S |
19
+| 16 | 3788604,3788605,3788606 | 7 | 15 | 1 | Y1450* |
20
+| 16 | 3786705,3786706,3786707 | 7 | 12 | 0 | W1502C |
21
+| 16 | 3786705,3786706,3786707 | 7 | 12 | 0 | W1502R |
22
+| 16 | 3786705,3786706,3786707 | 7 | 12 | 0 | W1502* |
23
+| 16 | 3786705,3786706,3786707 | 7 | 12 | 0 | W1502G |
24
+| 16 | 3786705,3786706,3786707 | 7 | 12 | 0 | W1502L |
25
+| 16 | 3786715 | 6 | 5 | 0 | L1499P |
26
+| 16 | 3786715 | 6 | 5 | 0 | L1499R |
27
+| 16 | 3786715 | 6 | 5 | 0 | L1499Q |
28
+| 16 | 3786739,3786740 | 6 | 4 | 0 | Q1491E |
29
+| 16 | 3786739,3786740 | 6 | 4 | 0 | Q1491K |
30
+| 16 | 3786739,3786740 | 6 | 4 | 0 | Q1491P |
31
+| 16 | 3786739,3786740 | 6 | 4 | 0 | Q1491_K1495del |
32
+| 16 | 3788593,3788594 | 2 | 4 | 0 | L1454R |
33
+| 16 | 3788593,3788594 | 2 | 4 | 0 | L1454H |
34
+| 16 | 3788593,3788594 | 2 | 4 | 0 | L1454I |
35
+| 16 | 3786691 | 2 | 1 | 0 | L1507P |
36
+| 16 | 3786730 | 0 | 3 | 0 | P1494R |
37
+| 16 | 3786710 | 1 | 0 | 0 | E1501* |
38
+| nan | nan | 0 | 1 | 0 | H1451del |
39
+| 16 | 3788596 | 1 | 0 | 0 | I1453T |
40
+| 16 | 3786733 | 1 | 0 | 0 | I1493K |
41
+| 16 | 3786727 | 0 | 1 | 0 | K1495T |
42
+| nan | nan | 1 | 0 | 0 | Q1500del |
tables/hotspots/hotspot_CTSS.md
... ...
@@ -0,0 +1,6 @@
1
+## CTSS Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 150727482 | 11 | 17 | 0 | Y132D |
6
+| 1 | 150727482 | 11 | 17 | 0 | Y132N |
tables/hotspots/hotspot_DAZAP1.md
... ...
@@ -0,0 +1,6 @@
1
+## DAZAP1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 19 | 1434903 | 13 | 2 | 0 | R406* |
6
+| 19 | 1434903 | 13 | 2 | 0 | R406G |
tables/hotspots/hotspot_DDX3X.md
... ...
@@ -0,0 +1,49 @@
1
+## DDX3X Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| X | 41205625,41205627 | 4 | 1 | 5 | F487L |
6
+| X | 41205589,41205590 | 3 | 0 | 7 | R475C |
7
+| X | 41205589,41205590 | 3 | 0 | 7 | R475H |
8
+| X | 41205625,41205627 | 4 | 1 | 5 | F487I |
9
+| X | 41205589,41205590 | 3 | 0 | 7 | R475S |
10
+| X | 41205860,41205861 | 4 | 1 | 1 | R534C |
11
+| X | 41205860,41205861 | 4 | 1 | 1 | R534H |
12
+| X | 41205854,41205855 | 3 | 1 | 2 | T532M |
13
+| X | 41205854,41205855 | 3 | 1 | 2 | T532A |
14
+| X | 41205854,41205855 | 3 | 1 | 2 | T532P |
15
+| X | 41206117,41206118 | 2 | 2 | 1 | A541T |
16
+| X | 41206117,41206118 | 2 | 2 | 1 | A541E |
17
+| nan | nan | 2 | 0 | 1 | Q417Efs*16 |
18
+| X | 41205640 | 0 | 0 | 3 | S492G |
19
+| X | 41205581,41205580 | 1 | 0 | 2 | H472Y |
20
+| X | 41205842,41205843 | 2 | 0 | 1 | R528C |
21
+| X | 41205581,41205580 | 1 | 0 | 2 | H472L |
22
+| X | 41205845,41205846 | 2 | 0 | 1 | I529F |
23
+| X | 41205845,41205846 | 2 | 0 | 1 | I529L |
24
+| X | 41205845,41205846 | 2 | 0 | 1 | I529N |
25
+| X | 41205842,41205843 | 2 | 0 | 1 | R528H |
26
+| X | 41205656 | 0 | 0 | 2 | A497V |
27
+| X | 41205583 | 0 | 0 | 2 | G473R |
28
+| X | 41205658 | 2 | 0 | 0 | T498S |
29
+| X | 41204742 | 0 | 0 | 2 | V419G |
30
+| X | 41204730,41204729 | 1 | 0 | 1 | I415T |
31
+| X | 41204730,41204729 | 1 | 0 | 1 | I415V |
32
+| X | 41205767,41205768 | 1 | 0 | 1 | R503G |
33
+| X | 41205767,41205768 | 1 | 0 | 1 | R503K |
34
+| X | 41206124 | 0 | 0 | 2 | S543L |
35
+| X | 41206124 | 0 | 0 | 2 | S543Rfs*4 |
36
+| X | 41205502,41205503 | 1 | 0 | 1 | V446E |
37
+| X | 41205502,41205503 | 1 | 0 | 1 | V446L |
38
+| X | 41205837 | 0 | 0 | 2 | V526A |
39
+| X | 41205837 | 0 | 0 | 2 | V526E |
40
+| X | 41205761 | 0 | 0 | 1 | A501T |
41
+| X | 41205771 | 0 | 0 | 1 | G504E |
42
+| X | 41205617 | 1 | 0 | 0 | L484P |
43
+| X | 41205774 | 1 | 0 | 0 | L505R |
44
+| X | 41206175 | 1 | 0 | 0 | L560P |
45
+| X | 41204727 | 1 | 0 | 0 | N414I |
46
+| X | 41204769 | 0 | 1 | 0 | R428Q |
47
+| X | 41202601 | 0 | 0 | 1 | T226P |
48
+| X | 41205571 | 0 | 0 | 1 | T469P |
49
+| X | 41205864 | 0 | 0 | 1 | V535E |
tables/hotspots/hotspot_DTX1.md
... ...
@@ -0,0 +1,106 @@
1
+## DTX1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 12 | 113496211,113496212,113496213,113496210 | 11 | 2 | 0 | Y72Tfs*74 |
6
+| 12 | 113496211,113496212,113496213,113496210 | 11 | 2 | 0 | Y72C |
7
+| 12 | 113496211,113496212,113496213,113496210 | 11 | 2 | 0 | Y72D |
8
+| 12 | 113496211,113496212,113496213,113496210 | 11 | 2 | 0 | Y72H |
9
+| 12 | 113496211,113496212,113496213,113496210 | 11 | 2 | 0 | Y72N |
10
+| 12 | 113496211,113496212,113496213,113496210 | 11 | 2 | 0 | Y72* |
11
+| 12 | 113496211,113496212,113496213,113496210 | 11 | 2 | 0 | Y72S |
12
+| 12 | 113496202,113496203 | 10 | 2 | 0 | L69F |
13
+| 12 | 113496202,113496203 | 10 | 2 | 0 | L69V |
14
+| 12 | 113496130,113496131,113496132 | 12 | 0 | 0 | C45* |
15
+| 12 | 113496130,113496131,113496132 | 12 | 0 | 0 | C45W |
16
+| 12 | 113496130,113496131,113496132 | 12 | 0 | 0 | C45R |
17
+| 12 | 113496202,113496203 | 10 | 2 | 0 | L69P |
18
+| 12 | 113496130,113496131,113496132 | 12 | 0 | 0 | C45F |
19
+| 12 | 113496130,113496131,113496132 | 12 | 0 | 0 | C45S |
20
+| 12 | 113496130,113496131,113496132 | 12 | 0 | 0 | C45Sfs*4 |
21
+| 12 | 113496130,113496131,113496132 | 12 | 0 | 0 | C45Y |
22
+| 12 | 113496096 | 10 | 1 | 0 | E33D |
23
+| 12 | 113496087,113496085 | 9 | 2 | 0 | W30* |
24
+| 12 | 113496087,113496085 | 9 | 2 | 0 | W30C |
25
+| 12 | 113496087,113496085 | 9 | 2 | 0 | W30G |
26
+| 12 | 113496115,113496116,113496117 | 6 | 2 | 1 | Y40C |
27
+| 12 | 113496115,113496116,113496117 | 6 | 2 | 1 | Y40N |
28
+| 12 | 113496115,113496116,113496117 | 6 | 2 | 1 | Y40* |
29
+| 12 | 113496115,113496116,113496117 | 6 | 2 | 1 | Y40H |
30
+| 12 | 113496115,113496116,113496117 | 6 | 2 | 1 | Y40S |
31
+| 12 | 113496159 | 6 | 0 | 2 | E54D |
32
+| 12 | 113496238,113496239,113496240 | 5 | 3 | 0 | Q81H |
33
+| 12 | 113496238,113496239,113496240 | 5 | 3 | 0 | Q81* |
34
+| 12 | 113496238,113496239,113496240 | 5 | 3 | 0 | Q81E |
35
+| 12 | 113496238,113496239,113496240 | 5 | 3 | 0 | Q81L |
36
+| 12 | 113496238,113496239,113496240 | 5 | 3 | 0 | Q81R |
37
+| 12 | 113496173 | 4 | 1 | 2 | S59F |
38
+| 12 | 113496082,113496083 | 5 | 2 | 0 | E29G |
39
+| 12 | 113496082,113496083 | 5 | 2 | 0 | E29K |
40
+| 12 | 113496169,113496170 | 6 | 1 | 0 | G58D |
41
+| 12 | 113496241,113496242,113496243 | 4 | 3 | 0 | F82L |
42
+| 12 | 113496241,113496242,113496243 | 4 | 3 | 0 | F82S |
43
+| 12 | 113496169,113496170 | 6 | 1 | 0 | G58V |
44
+| 12 | 113496139,113496140,113496141 | 5 | 1 | 1 | I48S |
45
+| 12 | 113496173 | 4 | 1 | 2 | S59Y |
46
+| 12 | 113496082,113496083 | 5 | 2 | 0 | E29V |
47
+| 12 | 113496241,113496242,113496243 | 4 | 3 | 0 | F82C |
48
+| 12 | 113496241,113496242,113496243 | 4 | 3 | 0 | F82I |
49
+| 12 | 113496241,113496242,113496243 | 4 | 3 | 0 | F82Y |
50
+| 12 | 113496169,113496170 | 6 | 1 | 0 | G58A |
51
+| 12 | 113496169,113496170 | 6 | 1 | 0 | G58R |
52
+| 12 | 113496139,113496140,113496141 | 5 | 1 | 1 | I48F |
53
+| 12 | 113496139,113496140,113496141 | 5 | 1 | 1 | I48L |
54
+| 12 | 113496139,113496140,113496141 | 5 | 1 | 1 | I48M |
55
+| 12 | 113496139,113496140,113496141 | 5 | 1 | 1 | I48N |
56
+| 12 | 113496139,113496140,113496141 | 5 | 1 | 1 | I48V |
57
+| 12 | 113496173 | 4 | 1 | 2 | S59L |
58
+| 12 | 113496256,113515229 | 5 | 1 | 0 | G87S |
59
+| 12 | 113496155,113496156 | 5 | 0 | 1 | K53N |
60
+| 12 | 113496155,113496156 | 5 | 0 | 1 | K53M |
61
+| 12 | 113496088,113496089 | 5 | 0 | 1 | L31Q |
62
+| 12 | 113496088,113496089 | 5 | 0 | 1 | L31V |
63
+| 12 | 113496256,113515229 | 5 | 1 | 0 | G87R |
64
+| 12 | 113496256,113515229 | 5 | 1 | 0 | G87V |
65
+| 12 | 113496155,113496156 | 5 | 0 | 1 | K53R |
66
+| 12 | 113496088,113496089 | 5 | 0 | 1 | L31P |
67
+| 12 | 113496088,113496089 | 5 | 0 | 1 | L31Pfs*14 |
68
+| 12 | 113496201 | 4 | 0 | 1 | Q68H |
69
+| 12 | 113496133,113496135 | 4 | 1 | 0 | H46Q |
70
+| 12 | 113496163,113496164 | 5 | 0 | 0 | A56G |
71
+| 12 | 113496163,113496164 | 5 | 0 | 0 | A56S |
72
+| 12 | 113496163,113496164 | 5 | 0 | 0 | A56V |
73
+| 12 | 113496133,113496135 | 4 | 1 | 0 | H46N |
74
+| 12 | 113496133,113496135 | 4 | 1 | 0 | H46Y |
75
+| 12 | 113496144 | 4 | 0 | 0 | E49D |
76
+| 12 | 113496176,113496175 | 2 | 1 | 1 | V60E |
77
+| 12 | 113496144 | 4 | 0 | 0 | E49Dfs*90 |
78
+| 12 | 113496176,113496175 | 2 | 1 | 1 | V60G |
79
+| 12 | 113496176,113496175 | 2 | 1 | 1 | V60M |
80
+| 12 | 113496233,113496234 | 3 | 0 | 0 | M79I |
81
+| 12 | 113496208 | 3 | 0 | 0 | P71S |
82
+| 12 | 113496076 | 3 | 0 | 0 | V27L |
83
+| 12 | 113496191 | 2 | 1 | 0 | V65A |
84
+| 12 | 113496205,113496206 | 2 | 0 | 1 | V70L |
85
+| 12 | 113496197,113496196 | 3 | 0 | 0 | A67G |
86
+| 12 | 113496197,113496196 | 3 | 0 | 0 | A67T |
87
+| 12 | 113496197,113496196 | 3 | 0 | 0 | A67V |
88
+| 12 | 113496233,113496234 | 3 | 0 | 0 | M79T |
89
+| 12 | 113496208 | 3 | 0 | 0 | P71A |
90
+| 12 | 113496248,113496249 | 2 | 0 | 1 | Q84H |
91
+| 12 | 113496248,113496249 | 2 | 0 | 1 | Q84P |
92
+| 12 | 113496248,113496249 | 2 | 0 | 1 | Q84R |
93
+| 12 | 113496076 | 3 | 0 | 0 | V27M |
94
+| 12 | 113496191 | 2 | 1 | 0 | V65G |
95
+| 12 | 113496205,113496206 | 2 | 0 | 1 | V70A |
96
+| 12 | 113496148 | 2 | 0 | 0 | V51M |
97
+| 12 | 113496217,113496218 | 2 | 0 | 0 | I74T |
98
+| 12 | 113496217,113496218 | 2 | 0 | 0 | I74V |
99
+| 12 | 113496178 | 2 | 0 | 0 | V61F |
100
+| 12 | 113496178 | 2 | 0 | 0 | V61I |
101
+| 12 | 113496121 | 1 | 0 | 0 | A42P |
102
+| nan | nan | 1 | 0 | 0 | CH45WD |
103
+| nan | nan | 1 | 0 | 0 | DA55ET |
104
+| nan | nan | 1 | 0 | 0 | EN49DY |
105
+| nan | nan | 1 | 0 | 0 | H34_W37del |
106
+| nan | nan | 0 | 0 | 1 | V44Lfs*5 |
tables/hotspots/hotspot_DUSP2.md
... ...
@@ -0,0 +1,8 @@
1
+## DUSP2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 2 | 96810842 | 2 | 0 | 1 | E84D |
6
+| 2 | 96810841 | 2 | 0 | 0 | L85V |
7
+| 2 | 96810859 | 1 | 0 | 0 | R79G |
8
+| 2 | 96810853 | 1 | 0 | 0 | V81I |
tables/hotspots/hotspot_EBF1.md
... ...
@@ -0,0 +1,36 @@
1
+## EBF1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 5 | 158524075,158524076,158524077 | 11 | 1 | 0 | N66K |
6
+| 5 | 158524075,158524076,158524077 | 11 | 1 | 0 | N66D |
7
+| 5 | 158524075,158524076,158524077 | 11 | 1 | 0 | N66I |
8
+| 5 | 158524075,158524076,158524077 | 11 | 1 | 0 | N66S |
9
+| 5 | 158267083,158267084,158267082 | 7 | 1 | 0 | N197I |
10
+| 5 | 158267083,158267084,158267082 | 7 | 1 | 0 | N197T |
11
+| 5 | 158267083,158267084,158267082 | 7 | 1 | 0 | N197D |
12
+| 5 | 158267083,158267084,158267082 | 7 | 1 | 0 | N197K |
13
+| 5 | 158524085,158524086 | 2 | 3 | 0 | R63Q |
14
+| 5 | 158524085,158524086 | 2 | 3 | 0 | R63W |
15
+| 5 | 158250257,158250258,158250259 | 3 | 1 | 0 | H235Q |
16
+| 5 | 158267047,158267048 | 3 | 1 | 0 | R209Q |
17
+| 5 | 158267047,158267048 | 3 | 1 | 0 | R209W |
18
+| 5 | 158250257,158250258,158250259 | 3 | 1 | 0 | H235L |
19
+| 5 | 158250257,158250258,158250259 | 3 | 1 | 0 | H235Y |
20
+| 5 | 158267092 | 3 | 0 | 0 | C194Y |
21
+| 5 | 158511705 | 2 | 1 | 0 | R152G |
22
+| 5 | 158524079,158524080 | 1 | 1 | 1 | S65F |
23
+| 5 | 158250261,158250262 | 3 | 0 | 0 | V234G |
24
+| 5 | 158267092 | 3 | 0 | 0 | C194F |
25
+| 5 | 158511705 | 2 | 1 | 0 | R152* |
26
+| 5 | 158524079,158524080 | 1 | 1 | 1 | S65T |
27
+| 5 | 158250261,158250262 | 3 | 0 | 0 | V234F |
28
+| 5 | 158511737,158511736 | 2 | 1 | 0 | Y141* |
29
+| 5 | 158511737,158511736 | 2 | 1 | 0 | Y141C |
30
+| 5 | 158511737,158511736 | 2 | 1 | 0 | Y141F |
31
+| 5 | 158511714 | 2 | 0 | 0 | E149K |
32
+| 5 | 158511718,158511720 | 1 | 1 | 0 | N147D |
33
+| 5 | 158511718,158511720 | 1 | 1 | 0 | N147K |
34
+| 5 | 158511698 | 0 | 1 | 0 | L154W |
35
+| nan | nan | 0 | 1 | 0 | Q144Rfs*16 |
36
+| 5 | 158511701 | 1 | 0 | 0 | V153D |
tables/hotspots/hotspot_EEF1A1.md
... ...
@@ -0,0 +1,9 @@
1
+## EEF1A1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 74229094,74229095 | 10 | 17 | 0 | D97N |
6
+| 6 | 74229094,74229095 | 10 | 17 | 0 | D97V |
7
+| 6 | 74229094,74229095 | 10 | 17 | 0 | D97H |
8
+| 6 | 74229110 | 2 | 0 | 0 | A92T |
9
+| 6 | 74227628 | 0 | 0 | 1 | T432A |
tables/hotspots/hotspot_EIF2AK3.md
... ...
@@ -0,0 +1,6 @@
1
+## EIF2AK3 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 2 | 88926540 | 2 | 0 | 2 | Q85* |
6
+| 2 | 88926535 | 0 | 0 | 1 | E86D |
tables/hotspots/hotspot_EIF4A1.md
... ...
@@ -0,0 +1,11 @@
1
+## EIF4A1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 17 | 7479902 | 0 | 0 | 3 | G136R |
6
+| 17 | 7481161 | 1 | 0 | 1 | Q308R |
7
+| 17 | 7479896 | 1 | 0 | 0 | C134G |
8
+| 17 | 7479906 | 0 | 0 | 1 | G137A |
9
+| 17 | 7481170 | 0 | 0 | 1 | R311Q |
10
+| 17 | 7479968 | 0 | 0 | 1 | T158A |
11
+| 17 | 7479915 | 1 | 0 | 0 | V140A |
tables/hotspots/hotspot_EP300.md
... ...
@@ -0,0 +1,28 @@
1
+## EP300 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 22 | 41566522,41566523 | 18 | 16 | 0 | Y1467D |
6
+| 22 | 41566522,41566523 | 18 | 16 | 0 | Y1467N |
7
+| 22 | 41566522,41566523 | 18 | 16 | 0 | Y1467H |
8
+| 22 | 41566522,41566523 | 18 | 16 | 0 | Y1467F |
9
+| 22 | 41566522,41566523 | 18 | 16 | 0 | Y1467C |
10
+| 22 | 41525969 | 9 | 6 | 1 | L415P |
11
+| 22 | 41566519,41566520,41566521 | 6 | 3 | 0 | W1466R |
12
+| 22 | 41566519,41566520,41566521 | 6 | 3 | 0 | W1466C |
13
+| 22 | 41566519,41566520,41566521 | 6 | 3 | 0 | W1466L |
14
+| 22 | 41566459,41566460 | 3 | 2 | 0 | Y1446H |
15
+| 22 | 41566459,41566460 | 3 | 2 | 0 | Y1446C |
16
+| 22 | 41566459,41566460 | 3 | 2 | 0 | Y1446S |
17
+| 22 | 41566474,41566476 | 3 | 0 | 0 | H1451Y |
18
+| 22 | 41566511 | 3 | 0 | 0 | L1463P |
19
+| 22 | 41566486,41566487 | 2 | 1 | 0 | Q1455E |
20
+| 22 | 41566474,41566476 | 3 | 0 | 0 | H1451Q |
21
+| 22 | 41566511 | 3 | 0 | 0 | L1463R |
22
+| 22 | 41566486,41566487 | 2 | 1 | 0 | Q1455R |
23
+| 22 | 41566493 | 2 | 0 | 0 | I1457K |
24
+| 22 | 41566478 | 2 | 0 | 0 | P1452L |
25
+| 22 | 41566496,41566495 | 0 | 2 | 0 | P1458L |
26
+| 22 | 41566496,41566495 | 0 | 2 | 0 | P1458T |
27
+| 22 | 41566462 | 0 | 1 | 0 | I1447F |
28
+| 22 | 41566507 | 1 | 0 | 0 | R1462* |
tables/hotspots/hotspot_EZH2.md
... ...
@@ -0,0 +1,19 @@
1
+## EZH2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 7 | 148508727,148508728 | 204 | 119 | 8 | Y646N |
6
+| 7 | 148508727,148508728 | 204 | 119 | 8 | Y646F |
7
+| 7 | 148508727,148508728 | 204 | 119 | 8 | Y646S |
8
+| 7 | 148508727,148508728 | 204 | 119 | 8 | Y646H |
9
+| 7 | 148508727,148508728 | 204 | 119 | 8 | Y646C |
10
+| 7 | 148506466,148506467 | 8 | 11 | 0 | A682G |
11
+| 7 | 148506437 | 7 | 11 | 0 | A692V |
12
+| 7 | 148506437 | 7 | 11 | 0 | A692L |
13
+| 7 | 148508741 | 1 | 0 | 1 | E641D |
14
+| 7 | 148508745,148508746 | 1 | 1 | 0 | N640D |
15
+| 7 | 148508745,148508746 | 1 | 1 | 0 | N640S |
16
+| 7 | 148508725 | 1 | 0 | 0 | C647S |
17
+| 7 | 148507446 | 0 | 1 | 0 | F670L |
18
+| 7 | 148508772 | 1 | 0 | 0 | I631T |
19
+| 7 | 148506215 | 0 | 1 | 0 | I715F |
tables/hotspots/hotspot_FBXO11.md
... ...
@@ -0,0 +1,25 @@
1
+## FBXO11 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 2 | 48040427,48040426 | 0 | 0 | 7 | N725H |
6
+| 2 | 48040427,48040426 | 0 | 0 | 7 | N725D |
7
+| 2 | 48040427,48040426 | 0 | 0 | 7 | N725I |
8
+| 2 | 48040427,48040426 | 0 | 0 | 7 | N725Y |
9
+| 2 | 48040495,48040496 | 0 | 0 | 5 | N702S |
10
+| 2 | 48040495,48040496 | 0 | 0 | 5 | N702D |
11
+| 2 | 48040495,48040496 | 0 | 0 | 5 | N702I |
12
+| 2 | 48040495,48040496 | 0 | 0 | 5 | N702Y |
13
+| 2 | 48040488,48040489 | 1 | 0 | 3 | I704M |
14
+| 2 | 48040488,48040489 | 1 | 0 | 3 | I704Mfs*21 |
15
+| 2 | 48040488,48040489 | 1 | 0 | 3 | I704R |
16
+| 2 | 48040488,48040489 | 1 | 0 | 3 | I704S |
17
+| 2 | 48040500,48040501 | 1 | 0 | 2 | E700D |
18
+| 2 | 48040500,48040501 | 1 | 0 | 2 | E700Kfs*23 |
19
+| 2 | 48040500,48040501 | 1 | 0 | 2 | E700V |
20
+| nan | nan | 0 | 0 | 1 | G695_I699dup |
21
+| 2 | 48040947 | 0 | 0 | 1 | I689T |
22
+| 2 | 48040504 | 0 | 0 | 1 | I699T |
23
+| 2 | 48040973 | 0 | 0 | 1 | K680N |
24
+| 2 | 48045966 | 0 | 0 | 1 | L653P |
25
+| 2 | 48045928 | 0 | 0 | 1 | V666F |
tables/hotspots/hotspot_FBXW7.md
... ...
@@ -0,0 +1,10 @@
1
+## FBXW7 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 4 | 153247366 | 4 | 0 | 1 | R479Q |
6
+| 4 | 153249384,153249385 | 5 | 0 | 0 | R465H |
7
+| 4 | 153249384,153249385 | 5 | 0 | 0 | R465C |
8
+| 4 | 153250906,153250907 | 3 | 1 | 0 | T385P |
9
+| 4 | 153250906,153250907 | 3 | 1 | 0 | T385I |
10
+| 4 | 153247289 | 2 | 0 | 0 | R505C |
tables/hotspots/hotspot_FOXO1.md
... ...
@@ -0,0 +1,45 @@
1
+## FOXO1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 13 | 41240288,41240289 | 14 | 16 | 25 | R21H |
6
+| 13 | 41240288,41240289 | 14 | 16 | 25 | R21C |
7
+| 13 | 41240288,41240289 | 14 | 16 | 25 | R21P |
8
+| 13 | 41240288,41240289 | 14 | 16 | 25 | R21L |
9
+| 13 | 41240288,41240289 | 14 | 16 | 25 | R21G |
10
+| 13 | 41240279,41240280 | 14 | 7 | 27 | T24I |
11
+| 13 | 41240279,41240280 | 14 | 7 | 27 | T24A |
12
+| 13 | 41240279,41240280 | 14 | 7 | 27 | T24N |
13
+| 13 | 41240285,41240286 | 12 | 8 | 20 | S22P |
14
+| 13 | 41240285,41240286 | 12 | 8 | 20 | S22W |
15
+| 13 | 41240285,41240286 | 12 | 8 | 20 | S22A |
16
+| 13 | 41240273,41240274 | 10 | 4 | 8 | P26L |
17
+| 13 | 41240273,41240274 | 10 | 4 | 8 | P26S |
18
+| 13 | 41240273,41240274 | 10 | 4 | 8 | P26A |
19
+| 13 | 41240273,41240274 | 10 | 4 | 8 | P26R |
20
+| 13 | 41239735,41239736,41239737 | 12 | 1 | 1 | S205N |
21
+| 13 | 41239735,41239736,41239737 | 12 | 1 | 1 | S205T |
22
+| 13 | 41239735,41239736,41239737 | 12 | 1 | 1 | S205G |
23
+| 13 | 41239735,41239736,41239737 | 12 | 1 | 1 | S205R |
24
+| 13 | 41240294,41240295 | 3 | 5 | 4 | R19Q |
25
+| 13 | 41240294,41240295 | 3 | 5 | 4 | R19P |
26
+| 13 | 41240294,41240295 | 3 | 5 | 4 | R19W |
27
+| 13 | 41240294,41240295 | 3 | 5 | 4 | R19L |
28
+| 13 | 41240281 | 2 | 2 | 3 | C23W |
29
+| 13 | 41240281 | 2 | 2 | 3 | C23* |
30
+| 13 | 41239742 | 3 | 1 | 0 | S203N |
31
+| 13 | 41240275,41240277 | 1 | 1 | 2 | W25R |
32
+| 13 | 41239742 | 3 | 1 | 0 | S203T |
33
+| 13 | 41239742 | 3 | 1 | 0 | S203Y |
34
+| 13 | 41240275,41240277 | 1 | 1 | 2 | W25* |
35
+| 13 | 41240275,41240277 | 1 | 1 | 2 | W25G |
36
+| 13 | 41239727 | 2 | 1 | 0 | G208A |
37
+| 13 | 41239727 | 2 | 1 | 0 | G208D |
38
+| 13 | 41239727 | 2 | 1 | 0 | G208V |
39
+| 13 | 41239755 | 2 | 0 | 0 | D199N |
40
+| 13 | 41239745 | 0 | 1 | 0 | D202A |
41
+| 13 | 41239752 | 1 | 0 | 0 | K200E |
42
+| 13 | 41240300 | 0 | 0 | 1 | L17P |
43
+| 13 | 41240271 | 1 | 0 | 0 | L27V |
44
+| 13 | 41240298 | 0 | 1 | 0 | P18S |
45
+| nan | nan | 0 | 0 | 1 | P5_P20del |
tables/hotspots/hotspot_GNA13.md
... ...
@@ -0,0 +1,87 @@
1
+## GNA13 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 17 | 63052631,63052632,63052633 | 20 | 1 | 14 | Q27* |
6
+| 17 | 63052631,63052632,63052633 | 20 | 1 | 14 | Q27H |
7
+| 17 | 63052631,63052632,63052633 | 20 | 1 | 14 | Q27E |
8
+| 17 | 63052631,63052632,63052633 | 20 | 1 | 14 | Q27K |
9
+| 17 | 63052631,63052632,63052633 | 20 | 1 | 14 | Q27L |
10
+| 17 | 63052631,63052632,63052633 | 20 | 1 | 14 | Q27P |
11
+| 17 | 63052631,63052632,63052633 | 20 | 1 | 14 | Q27Wfs*79 |
12
+| 17 | 63052630 | 13 | 0 | 4 | Q28* |
13
+| 17 | 63010844,63010845 | 12 | 2 | 1 | D222G |
14
+| 17 | 63010844,63010845 | 12 | 2 | 1 | D222N |
15
+| 17 | 63010844,63010845 | 12 | 2 | 1 | D222A |
16
+| 17 | 63052533 | 8 | 0 | 3 | G60D |
17
+| 17 | 63052529,63052530,63052531 | 8 | 0 | 3 | K61* |
18
+| 17 | 63052529,63052530,63052531 | 8 | 0 | 3 | K61N |
19
+| 17 | 63052533 | 8 | 0 | 3 | G60V |
20
+| 17 | 63052529,63052530,63052531 | 8 | 0 | 3 | K61E |
21
+| 17 | 63052529,63052530,63052531 | 8 | 0 | 3 | K61M |
22
+| 17 | 63052533 | 8 | 0 | 3 | G60A |
23
+| 17 | 63010718,63010719 | 5 | 4 | 0 | R264H |
24
+| 17 | 63010718,63010719 | 5 | 4 | 0 | R264C |
25
+| 17 | 63010775 | 4 | 0 | 2 | F245S |
26
+| 17 | 63010736,63010737 | 3 | 3 | 0 | E258G |
27
+| 17 | 63052527,63052528 | 4 | 1 | 1 | S62P |
28
+| 17 | 63010810,63010812 | 3 | 2 | 1 | W233R |
29
+| 17 | 63052524,63052525 | 4 | 2 | 0 | T63A |
30
+| 17 | 63052527,63052528 | 4 | 1 | 1 | S62F |
31
+| 17 | 63052524,63052525 | 4 | 2 | 0 | T63I |
32
+| 17 | 63010810,63010812 | 3 | 2 | 1 | W233* |
33
+| 17 | 63010736,63010737 | 3 | 3 | 0 | E258K |
34
+| 17 | 63010736,63010737 | 3 | 3 | 0 | E258V |
35
+| 17 | 63010775 | 4 | 0 | 2 | F245C |
36
+| 17 | 63052524,63052525 | 4 | 2 | 0 | T63S |
37
+| 17 | 63010708,63010709,63010710 | 2 | 3 | 0 | E267D |
38
+| 17 | 63010708,63010709,63010710 | 2 | 3 | 0 | E267A |
39
+| 17 | 63010708,63010709,63010710 | 2 | 3 | 0 | E267G |
40
+| 17 | 63010708,63010709,63010710 | 2 | 3 | 0 | E267K |
41
+| 17 | 63010755,63010754 | 4 | 0 | 0 | F252L |
42
+| 17 | 63052521 | 3 | 1 | 0 | F64S |
43
+| 17 | 63010697,63010698 | 3 | 1 | 0 | I271F |
44
+| 17 | 63010778,63010779 | 3 | 0 | 1 | L244P |
45
+| 17 | 63010637,63010638,63010636 | 3 | 0 | 1 | N291H |
46
+| 17 | 63010829,63010830 | 4 | 0 | 0 | R227G |
47
+| 17 | 63010829,63010830 | 4 | 0 | 0 | R227K |
48
+| 17 | 63010755,63010754 | 4 | 0 | 0 | F252C |
49
+| 17 | 63052521 | 3 | 1 | 0 | F64C |
50
+| 17 | 63010697,63010698 | 3 | 1 | 0 | I271N |
51
+| 17 | 63010697,63010698 | 3 | 1 | 0 | I271T |
52
+| 17 | 63010778,63010779 | 3 | 0 | 1 | L244F |
53
+| 17 | 63010778,63010779 | 3 | 0 | 1 | L244R |
54
+| 17 | 63010637,63010638,63010636 | 3 | 0 | 1 | N291K |
55
+| 17 | 63010637,63010638,63010636 | 3 | 0 | 1 | N291S |
56
+| 17 | 63010899 | 2 | 1 | 0 | K204E |
57
+| 17 | 63010693,63010694 | 3 | 0 | 0 | F272L |
58
+| 17 | 63052549,63052548 | 2 | 0 | 1 | G55D |
59
+| 17 | 63010721 | 0 | 3 | 0 | N263_T266del |
60
+| 17 | 63010693,63010694 | 3 | 0 | 0 | F272S |
61
+| 17 | 63010838,63010839 | 3 | 0 | 0 | G224D |
62
+| 17 | 63010838,63010839 | 3 | 0 | 0 | G224R |
63
+| 17 | 63010838,63010839 | 3 | 0 | 0 | G224S |
64
+| 17 | 63052549,63052548 | 2 | 0 | 1 | G55C |
65
+| 17 | 63010781,63010782 | 1 | 0 | 2 | I243L |
66
+| 17 | 63010781,63010782 | 1 | 0 | 2 | I243R |
67
+| 17 | 63010781,63010782 | 1 | 0 | 2 | I243Tfs*8 |
68
+| 17 | 63052500,63052501 | 3 | 0 | 0 | I71F |
69
+| 17 | 63052500,63052501 | 3 | 0 | 0 | I71N |
70
+| 17 | 63052500,63052501 | 3 | 0 | 0 | I71S |
71
+| 17 | 63010721 | 0 | 3 | 0 | N263S |
72
+| 17 | 63052535,63052536 | 2 | 0 | 1 | S59K |
73
+| 17 | 63052535,63052536 | 2 | 0 | 1 | S59N |
74
+| 17 | 63052535,63052536 | 2 | 0 | 1 | S59R |
75
+| 17 | 63052543 | 1 | 1 | 0 | G57S |
76
+| 17 | 63010725 | 2 | 0 | 0 | T262A |
77
+| 17 | 63010742,63010743 | 1 | 1 | 0 | L256F |
78
+| 17 | 63010742,63010743 | 1 | 1 | 0 | L256P |
79
+| 17 | 63049623,63049625 | 2 | 0 | 0 | Q169* |
80
+| 17 | 63049623,63049625 | 2 | 0 | 0 | Q169H |
81
+| nan | nan | 0 | 0 | 1 | E24Sfs*19 |
82
+| 17 | 63010445 | 0 | 1 | 0 | I355N |
83
+| nan | nan | 0 | 0 | 1 | L246Sfs*17 |
84
+| nan | nan | 1 | 0 | 0 | L54dup |
85
+| 17 | 63010739 | 0 | 1 | 0 | M257T |
86
+| nan | nan | 0 | 0 | 1 | N277Qfs*2 |
87
+| 17 | 63052626 | 1 | 0 | 0 | R29P |
tables/hotspots/hotspot_GNAI2.md
... ...
@@ -0,0 +1,33 @@
1
+## GNAI2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| nan | nan | 23 | 1 | 23 | K272del |
6
+| 3 | 50293694,50293695 | 9 | 1 | 7 | R179H |
7
+| 3 | 50293694,50293695 | 9 | 1 | 7 | R179C |
8
+| 3 | 50289546,50289547 | 6 | 3 | 7 | G45E |
9
+| 3 | 50289546,50289547 | 6 | 3 | 7 | G45W |
10
+| 3 | 50293703,50293704 | 3 | 7 | 1 | T182A |
11
+| 3 | 50293703,50293704 | 3 | 7 | 1 | T182P |
12
+| 3 | 50293703,50293704 | 3 | 7 | 1 | T182I |
13
+| 3 | 50289553,50289554 | 5 | 1 | 2 | S47N |
14
+| 3 | 50289553,50289554 | 5 | 1 | 2 | S47R |
15
+| 3 | 50294456 | 3 | 1 | 3 | K271E |
16
+| 3 | 50293686 | 5 | 0 | 1 | L176R |
17
+| 3 | 50293686 | 5 | 0 | 1 | L176Q |
18
+| 3 | 50294177,50294178 | 1 | 4 | 0 | R206W |
19
+| 3 | 50294177,50294178 | 1 | 4 | 0 | R206L |
20
+| 3 | 50294169,50294168 | 1 | 3 | 0 | G203D |
21
+| 3 | 50294169,50294168 | 1 | 3 | 0 | G203R |
22
+| 3 | 50289532 | 1 | 1 | 1 | G40D |
23
+| 3 | 50295034,50295033 | 2 | 0 | 1 | A327D |
24
+| 3 | 50295034,50295033 | 2 | 0 | 1 | A327G |
25
+| 3 | 50295034,50295033 | 2 | 0 | 1 | A327P |
26
+| nan | nan | 1 | 0 | 0 | A41dup |
27
+| 3 | 50294396 | 1 | 0 | 0 | F251L |
28
+| 3 | 50294190 | 1 | 0 | 0 | K210T |
29
+| 3 | 50294175 | 1 | 0 | 0 | Q205R |
30
+| 3 | 50293689 | 1 | 0 | 0 | R177P |
31
+| 3 | 50293691 | 1 | 0 | 0 | T178P |
32
+| 3 | 50289555 | 0 | 0 | 1 | T48P |
33
+| 3 | 50293698 | 1 | 0 | 0 | V180E |
tables/hotspots/hotspot_GRHPR.md
... ...
@@ -0,0 +1,24 @@
1
+## GRHPR Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 9 | 37424900 | 8 | 0 | 0 | G48R |
6
+| 9 | 37424900 | 8 | 0 | 0 | G48S |
7
+| 9 | 37424900 | 8 | 0 | 0 | G48N |
8
+| 9 | 37424890 | 4 | 0 | 0 | E44D |
9
+| 9 | 37424969,37424970 | 4 | 0 | 0 | A71V |
10
+| 9 | 37424882,37424883 | 4 | 0 | 0 | A42D |
11
+| 9 | 37424882,37424883 | 4 | 0 | 0 | A42P |
12
+| 9 | 37424882,37424883 | 4 | 0 | 0 | A42T |
13
+| 9 | 37424882,37424883 | 4 | 0 | 0 | A42V |
14
+| 9 | 37424969,37424970 | 4 | 0 | 0 | A71T |
15
+| 9 | 37424967 | 3 | 0 | 0 | A70V |
16
+| 9 | 37424879 | 3 | 0 | 0 | P41S |
17
+| 9 | 37424967 | 3 | 0 | 0 | A70D |
18
+| 9 | 37424879 | 3 | 0 | 0 | P41T |
19
+| 9 | 37424955 | 2 | 0 | 0 | R66K |
20
+| 9 | 37424955 | 2 | 0 | 0 | R66M |
21
+| 9 | 37424906 | 1 | 0 | 0 | A50T |
22
+| nan | nan | 1 | 0 | 0 | L45Pfs*4 |
23
+| 9 | 37424873 | 1 | 0 | 0 | P39S |
24
+| 9 | 37424897 | 1 | 0 | 0 | R47G |
tables/hotspots/hotspot_HIST1H1E.md
... ...
@@ -0,0 +1,34 @@
1
+## HIST1H1E Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 26157108,26157109 | 41 | 6 | 4 | A164V |
6
+| 6 | 26157108,26157109 | 41 | 6 | 4 | A164G |
7
+| 6 | 26157108,26157109 | 41 | 6 | 4 | A164T |
8
+| 6 | 26157108,26157109 | 41 | 6 | 4 | A164P |
9
+| 6 | 26157108,26157109 | 41 | 6 | 4 | A164D |
10
+| 6 | 26157118 | 11 | 0 | 2 | A167V |
11
+| 6 | 26157118 | 11 | 0 | 2 | A167G |
12
+| 6 | 26157099,26157100 | 5 | 1 | 3 | P161S |
13
+| 6 | 26157099,26157100 | 5 | 1 | 3 | P161A |
14
+| 6 | 26157099,26157100 | 5 | 1 | 3 | P161L |
15
+| 6 | 26157090,26157091 | 6 | 1 | 1 | A158T |
16
+| 6 | 26157111,26157112 | 6 | 1 | 1 | A165V |
17
+| 6 | 26157111,26157112 | 6 | 1 | 1 | A165T |
18
+| 6 | 26157090,26157091 | 6 | 1 | 1 | A158P |
19
+| 6 | 26157090,26157091 | 6 | 1 | 1 | A158S |
20
+| 6 | 26157090,26157091 | 6 | 1 | 1 | A158V |
21
+| 6 | 26157111,26157112 | 6 | 1 | 1 | A165G |
22
+| 6 | 26157106,26157105 | 2 | 1 | 0 | A163V |
23
+| 6 | 26157126,26157127 | 3 | 0 | 0 | A170G |
24
+| 6 | 26157106,26157105 | 2 | 1 | 0 | A163T |
25
+| 6 | 26157126,26157127 | 3 | 0 | 0 | A170P |
26
+| 6 | 26157114 | 2 | 0 | 0 | G166R |
27
+| 6 | 26157121 | 1 | 1 | 0 | K168I |
28
+| 6 | 26157121 | 1 | 1 | 0 | K168R |
29
+| 6 | 26157123 | 2 | 0 | 0 | K169* |
30
+| 6 | 26157123 | 2 | 0 | 0 | K169E |
31
+| 6 | 26157129,26157130 | 2 | 0 | 0 | K171E |
32
+| 6 | 26157129,26157130 | 2 | 0 | 0 | K171R |
33
+| 6 | 26157102 | 1 | 0 | 0 | A162T |
34
+| 6 | 26157096 | 1 | 0 | 0 | K160Q |
tables/hotspots/hotspot_HIST1H2AG.md
... ...
@@ -0,0 +1,9 @@
1
+## HIST1H2AG Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 27101130 | 5 | 1 | 0 | L94V |
6
+| 6 | 27101130 | 5 | 1 | 0 | L94F |
7
+| 6 | 27101130 | 5 | 1 | 0 | L94Qfs*28 |
8
+| 6 | 27101129 | 3 | 0 | 1 | E93D |
9
+| 6 | 27101138 | 0 | 3 | 0 | K96N |
tables/hotspots/hotspot_HIST1H2AM.md
... ...
@@ -0,0 +1,47 @@
1
+## HIST1H2AM Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 27860548,27860549 | 37 | 7 | 3 | A127V |
6
+| 6 | 27860548,27860549 | 37 | 7 | 3 | A127P |
7
+| 6 | 27860548,27860549 | 37 | 7 | 3 | A127T |
8
+| 6 | 27860548,27860549 | 37 | 7 | 3 | A127G |
9
+| 6 | 27860627 | 11 | 1 | 0 | V101L |
10
+| 6 | 27860627 | 11 | 1 | 0 | V101I |
11
+| 6 | 27860627 | 11 | 1 | 0 | V101F |
12
+| 6 | 27860627 | 11 | 1 | 0 | V101Pfs*32 |
13
+| 6 | 27860622,27860623,27860624 | 6 | 2 | 0 | T102I |
14
+| 6 | 27860622,27860623,27860624 | 6 | 2 | 0 | T102S |
15
+| 6 | 27860640 | 6 | 0 | 0 | K96N |
16
+| 6 | 27860636 | 4 | 1 | 0 | L98V |
17
+| 6 | 27860636 | 4 | 1 | 0 | L98F |
18
+| 6 | 27860649 | 3 | 1 | 0 | E93D |
19
+| 6 | 27860639 | 3 | 0 | 0 | L97V |
20
+| 6 | 27860652,27860654 | 3 | 0 | 0 | E92D |
21
+| 6 | 27860633,27860632 | 2 | 1 | 0 | G99R |
22
+| 6 | 27860673,27860675 | 3 | 0 | 0 | Q85* |
23
+| 6 | 27860652,27860654 | 3 | 0 | 0 | E92K |
24
+| 6 | 27860633,27860632 | 2 | 1 | 0 | G99A |
25
+| 6 | 27860673,27860675 | 3 | 0 | 0 | Q85H |
26
+| 6 | 27860542 | 2 | 0 | 0 | G129D |
27
+| 6 | 27860538 | 2 | 0 | 0 | K130N |
28
+| 6 | 27860648 | 1 | 1 | 0 | L94F |
29
+| 6 | 27860648 | 1 | 1 | 0 | L94V |
30
+| 6 | 27860658,27860660 | 2 | 0 | 0 | N90D |
31
+| 6 | 27860658,27860660 | 2 | 0 | 0 | N90K |
32
+| 6 | 27860643,27860644 | 1 | 1 | 0 | N95K |
33
+| 6 | 27860643,27860644 | 1 | 1 | 0 | N95S |
34
+| 6 | 27860695 | 2 | 0 | 0 | R78H |
35
+| 6 | 27860695 | 2 | 0 | 0 | R78L |
36
+| 6 | 27860617 | 1 | 0 | 0 | A104V |
37
+| 6 | 27860668 | 1 | 0 | 0 | A87V |
38
+| 6 | 27860562 | 0 | 1 | 0 | E122D |
39
+| 6 | 27860608 | 1 | 0 | 0 | G107D |
40
+| 6 | 27860554 | 1 | 0 | 0 | H125P |
41
+| 6 | 27860679 | 1 | 0 | 0 | H83Q |
42
+| 6 | 27860630 | 1 | 0 | 0 | K100* |
43
+| nan | nan | 1 | 0 | 0 | K126dup |
44
+| 6 | 27860672 | 1 | 0 | 0 | L86V |
45
+| 6 | 27860687 | 1 | 0 | 0 | P81S |
46
+| 6 | 27860615 | 1 | 0 | 0 | Q105* |
47
+| 6 | 27860559 | 1 | 0 | 0 | S123R |
tables/hotspots/hotspot_HIST1H2BK.md
... ...
@@ -0,0 +1,45 @@
1
+## HIST1H2BK Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 27114467,27114468 | 16 | 4 | 2 | S37N |
6
+| 6 | 27114467,27114468 | 16 | 4 | 2 | S37R |
7
+| 6 | 27114467,27114468 | 16 | 4 | 2 | S37T |
8
+| 6 | 27114467,27114468 | 16 | 4 | 2 | S37I |
9
+| 6 | 27114434,27114436 | 8 | 0 | 2 | Q48E |
10
+| 6 | 27114434,27114436 | 8 | 0 | 2 | Q48* |
11
+| 6 | 27114434,27114436 | 8 | 0 | 2 | Q48H |
12
+| 6 | 27114434,27114436 | 8 | 0 | 2 | Q48K |
13
+| 6 | 27114455,27114456,27114457 | 6 | 1 | 0 | Y41* |
14
+| 6 | 27114455,27114456,27114457 | 6 | 1 | 0 | Y41D |
15
+| 6 | 27114455,27114456,27114457 | 6 | 1 | 0 | Y41N |
16
+| 6 | 27114455,27114456,27114457 | 6 | 1 | 0 | Y41F |
17
+| 6 | 27114498 | 3 | 0 | 1 | G27D |
18
+| 6 | 27114460,27114459 | 3 | 1 | 0 | V40L |
19
+| 6 | 27114498 | 3 | 0 | 1 | G27A |
20
+| 6 | 27114460,27114459 | 3 | 1 | 0 | V40A |
21
+| 6 | 27114460,27114459 | 3 | 1 | 0 | V40I |
22
+| 6 | 27114503,27114504 | 2 | 1 | 0 | K25N |
23
+| 6 | 27114503,27114504 | 2 | 1 | 0 | K25R |
24
+| 6 | 27114503,27114504 | 2 | 1 | 0 | K25Tfs*20 |
25
+| 6 | 27114444,27114445 | 3 | 0 | 0 | V45A |
26
+| 6 | 27114444,27114445 | 3 | 0 | 0 | V45M |
27
+| 6 | 27114444,27114445 | 3 | 0 | 0 | V45_K47del |
28
+| 6 | 27114484 | 0 | 2 | 0 | R32G |
29
+| 6 | 27114454 | 1 | 0 | 1 | V42M |
30
+| 6 | 27114464,27114430 | 2 | 0 | 0 | Y38* |
31
+| 6 | 27114446,27114448 | 2 | 0 | 0 | K44N |
32
+| 6 | 27114446,27114448 | 2 | 0 | 0 | K44Q |
33
+| 6 | 27114514 | 1 | 0 | 0 | A22T |
34
+| 6 | 27114362 | 1 | 0 | 0 | E72D |
35
+| 6 | 27114365 | 1 | 0 | 0 | F71L |
36
+| 6 | 27114430 | 1 | 0 | 0 | H50N |
37
+| 6 | 27114516 | 1 | 0 | 0 | K21T |
38
+| nan | nan | 1 | 0 | 0 | K24Efs*34 |
39
+| 6 | 27114492 | 1 | 0 | 0 | K29M |
40
+| 6 | 27114485 | 0 | 1 | 0 | K31N |
41
+| 6 | 27114437 | 0 | 0 | 1 | K47N |
42
+| 6 | 27114387 | 1 | 0 | 0 | N64S |
43
+| nan | nan | 1 | 0 | 0 | S39Rfs*19 |
44
+| 6 | 27114519 | 1 | 0 | 0 | T20S |
45
+| 6 | 27114379 | 1 | 0 | 0 | V67L |
tables/hotspots/hotspot_HLA-A.md
... ...
@@ -0,0 +1,15 @@
1
+## HLA-A Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 29910609 | 9 | 0 | 0 | G50D |
6
+| 6 | 29910609 | 9 | 0 | 0 | G50V |
7
+| 6 | 29910551,29910552 | 2 | 1 | 0 | Y31N |
8
+| 6 | 29910551,29910552 | 2 | 1 | 0 | Y31C |
9
+| 6 | 29910611,29910613 | 2 | 1 | 0 | Y51* |
10
+| 6 | 29910611,29910613 | 2 | 1 | 0 | Y51D |
11
+| 6 | 29910611,29910613 | 2 | 1 | 0 | Y51H |
12
+| 6 | 29910668 | 2 | 0 | 0 | E70* |
13
+| 6 | 29910668 | 2 | 0 | 0 | E70Q |
14
+| 6 | 29910596 | 1 | 0 | 0 | F46I |
15
+| 6 | 29910546 | 1 | 0 | 0 | M29K |
tables/hotspots/hotspot_HLA-B.md
... ...
@@ -0,0 +1,24 @@
1
+## HLA-B Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 31324576 | 18 | 2 | 2 | Q78* |
6
+| 6 | 31324659 | 16 | 0 | 2 | G50D |
7
+| 6 | 31324659 | 16 | 0 | 2 | G50V |
8
+| 6 | 31324584,31324583 | 4 | 2 | 0 | W75* |
9
+| 6 | 31324122,31324124 | 3 | 1 | 2 | Y147* |
10
+| 6 | 31324122,31324124 | 3 | 1 | 2 | Y147N |
11
+| 6 | 31324584,31324583 | 4 | 2 | 0 | W75C |
12
+| 6 | 31324122,31324124 | 3 | 1 | 2 | Y147D |
13
+| 6 | 31324122,31324124 | 3 | 1 | 2 | Y147Hfs*29 |
14
+| 6 | 31324141 | 5 | 0 | 0 | A141D |
15
+| 6 | 31324141 | 5 | 0 | 0 | A141V |
16
+| 6 | 31324073 | 3 | 0 | 1 | A164T |
17
+| 6 | 31324050 | 4 | 0 | 0 | W171* |
18
+| 6 | 31324050 | 4 | 0 | 0 | W171C |
19
+| 6 | 31324139,31324138 | 3 | 0 | 0 | Y142D |
20
+| 6 | 31324139,31324138 | 3 | 0 | 0 | Y142F |
21
+| 6 | 31324139,31324138 | 3 | 0 | 0 | Y142N |
22
+| 6 | 31324642 | 2 | 0 | 0 | Q56* |
23
+| 6 | 31324642 | 2 | 0 | 0 | Q56E |
24
+| 6 | 31324630 | 1 | 0 | 0 | F60I |
tables/hotspots/hotspot_HNRNPU.md
... ...
@@ -0,0 +1,9 @@
1
+## HNRNPU Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 245027100,245027102 | 5 | 5 | 2 | Q170* |
6
+| 1 | 245027100,245027102 | 5 | 5 | 2 | Q170H |
7
+| 1 | 245027099 | 1 | 0 | 3 | Q171* |
8
+| 1 | 245027099 | 1 | 0 | 3 | Q171E |
9
+| 1 | 245027095 | 1 | 0 | 0 | Q172P |
tables/hotspots/hotspot_HVCN1.md
... ...
@@ -0,0 +1,8 @@
1
+## HVCN1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 12 | 111089051,111089052 | 6 | 4 | 0 | R205Q |
6
+| 12 | 111089051,111089052 | 6 | 4 | 0 | R205W |
7
+| 12 | 111089061,111089060 | 3 | 0 | 0 | I202F |
8
+| 12 | 111089061,111089060 | 3 | 0 | 0 | I202N |
tables/hotspots/hotspot_ID3.md
... ...
@@ -0,0 +1,94 @@
1
+## ID3 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 23885727,23885728 | 16 | 1 | 59 | L64F |
6
+| 1 | 23885727,23885728 | 16 | 1 | 59 | L64V |
7
+| 1 | 23885727,23885728 | 16 | 1 | 59 | L64Pfs*28 |
8
+| 1 | 23885727,23885728 | 16 | 1 | 59 | L64H |
9
+| 1 | 23885727,23885728 | 16 | 1 | 59 | L64I |
10
+| 1 | 23885727,23885728 | 16 | 1 | 59 | L64P |
11
+| 1 | 23885751,23885752 | 7 | 0 | 33 | P56S |
12
+| 1 | 23885751,23885752 | 7 | 0 | 33 | P56L |
13
+| 1 | 23885751,23885752 | 7 | 0 | 33 | P56A |
14
+| 1 | 23885751,23885752 | 7 | 0 | 33 | P56T |
15
+| 1 | 23885751,23885752 | 7 | 0 | 33 | P56Gfs*11 |
16
+| 1 | 23885751,23885752 | 7 | 0 | 33 | P56H |
17
+| 1 | 23885774,23885775,23885776 | 3 | 0 | 23 | Y48* |
18
+| 1 | 23885774,23885775,23885776 | 3 | 0 | 23 | Y48H |
19
+| 1 | 23885774,23885775,23885776 | 3 | 0 | 23 | Y48S |
20
+| 1 | 23885714,23885716,23885715 | 4 | 0 | 16 | E68* |
21
+| 1 | 23885714,23885716,23885715 | 4 | 0 | 16 | E68K |
22
+| 1 | 23885709,23885710 | 4 | 0 | 16 | L70P |
23
+| 1 | 23885709,23885710 | 4 | 0 | 16 | L70V |
24
+| 1 | 23885709,23885710 | 4 | 0 | 16 | L70Q |
25
+| 1 | 23885714,23885716,23885715 | 4 | 0 | 16 | E68Kfs*15 |
26
+| 1 | 23885709,23885710 | 4 | 0 | 16 | L70R |
27
+| 1 | 23885714,23885716,23885715 | 4 | 0 | 16 | E68D |
28
+| 1 | 23885714,23885716,23885715 | 4 | 0 | 16 | E68V |
29
+| 1 | 23885758,23885757 | 3 | 0 | 11 | L54V |
30
+| 1 | 23885758,23885757 | 3 | 0 | 11 | L54Efs*23 |
31
+| 1 | 23885758,23885757 | 3 | 0 | 11 | L54P |
32
+| 1 | 23885758,23885757 | 3 | 0 | 11 | L54R |
33
+| 1 | 23885729,23885730,23885731 | 4 | 1 | 5 | Q63H |
34
+| 1 | 23885777,23885778 | 5 | 0 | 5 | C47* |
35
+| 1 | 23885777,23885778 | 5 | 0 | 5 | C47Y |
36
+| 1 | 23885729,23885730,23885731 | 4 | 1 | 5 | Q63* |
37
+| 1 | 23885777,23885778 | 5 | 0 | 5 | C47Gfs*31 |
38
+| 1 | 23885777,23885778 | 5 | 0 | 5 | C47Sfs*20 |
39
+| 1 | 23885729,23885730,23885731 | 4 | 1 | 5 | Q63Hfs*20 |
40
+| 1 | 23885729,23885730,23885731 | 4 | 1 | 5 | Q63L |
41
+| 1 | 23885707,23885706 | 0 | 0 | 8 | Q71* |
42
+| 1 | 23885707,23885706 | 0 | 0 | 8 | Q71R |
43
+| 1 | 23885761,23885760 | 2 | 0 | 5 | E53* |
44
+| 1 | 23885761,23885760 | 2 | 0 | 5 | E53Q |
45
+| 1 | 23885761,23885760 | 2 | 0 | 5 | E53Sfs*8 |
46
+| 1 | 23885761,23885760 | 2 | 0 | 5 | E53V |
47
+| 1 | 23885754 | 2 | 0 | 4 | V55E |
48
+| 1 | 23885723,23885724 | 0 | 0 | 6 | S65R |
49
+| 1 | 23885723,23885724 | 0 | 0 | 6 | S65Afs*18 |
50
+| 1 | 23885723,23885724 | 0 | 0 | 6 | S65I |
51
+| 1 | 23885723,23885724 | 0 | 0 | 6 | S65Rfs*17 |
52
+| 1 | 23885723,23885724 | 0 | 0 | 6 | S65_Q66insH |
53
+| 1 | 23885754 | 2 | 0 | 4 | V55A |
54
+| 1 | 23885754 | 2 | 0 | 4 | V55G |
55
+| 1 | 23885713,23885711,23885712 | 1 | 0 | 4 | I69M |
56
+| 1 | 23885713,23885711,23885712 | 1 | 0 | 4 | I69S |
57
+| 1 | 23885713,23885711,23885712 | 1 | 0 | 4 | I69Sfs*14 |
58
+| 1 | 23885713,23885711,23885712 | 1 | 0 | 4 | I69T |
59
+| 1 | 23885713,23885711,23885712 | 1 | 0 | 4 | I69V |
60
+| 1 | 23885736,23885737 | 2 | 0 | 2 | G61C |
61
+| 1 | 23885748 | 1 | 0 | 3 | G57A |
62
+| 1 | 23885748 | 1 | 0 | 3 | G57Efs*6 |
63
+| 1 | 23885748 | 1 | 0 | 3 | G57V |
64
+| 1 | 23885748 | 1 | 0 | 3 | G57_L70delinsV |
65
+| 1 | 23885736,23885737 | 2 | 0 | 2 | G61Afs*22 |
66
+| 1 | 23885736,23885737 | 2 | 0 | 2 | G61D |
67
+| 1 | 23885798 | 0 | 0 | 3 | L40* |
68
+| 1 | 23885798 | 0 | 0 | 3 | L40F |
69
+| 1 | 23885798 | 0 | 0 | 3 | L40Ffs*26 |
70
+| 1 | 23885767 | 0 | 0 | 3 | L51M |
71
+| 1 | 23885767 | 0 | 0 | 3 | L51Rfs*31 |
72
+| 1 | 23885767 | 0 | 0 | 3 | L51Tfs*12 |
73
+| 1 | 23885769,23885770 | 0 | 1 | 2 | R50G |
74
+| 1 | 23885769,23885770 | 0 | 1 | 2 | R50H |
75
+| 1 | 23885769,23885770 | 0 | 1 | 2 | R50_L51insG |
76
+| 1 | 23885740 | 0 | 0 | 3 | R60* |
77
+| 1 | 23885740 | 0 | 0 | 3 | R60G |
78
+| 1 | 23885740 | 0 | 0 | 3 | R60Sfs*27 |
79
+| 1 | 23885718 | 1 | 0 | 2 | V67A |
80
+| 1 | 23885718 | 1 | 0 | 2 | V67E |
81
+| 1 | 23885718 | 1 | 0 | 2 | V67_E68del |
82
+| 1 | 23885782 | 0 | 0 | 2 | H46* |
83
+| 1 | 23885782 | 0 | 0 | 2 | H46Y |
84
+| 1 | 23885787,23885788 | 0 | 0 | 2 | M44K |
85
+| 1 | 23885787,23885788 | 0 | 0 | 2 | M44V |
86
+| 1 | 23885784 | 1 | 0 | 1 | N45S |
87
+| 1 | 23885784 | 1 | 0 | 1 | N45Tfs*37 |
88
+| 1 | 23885772,23885773 | 1 | 0 | 1 | S49T |
89
+| 1 | 23885772,23885773 | 1 | 0 | 1 | S49Y |
90
+| 1 | 23885791 | 0 | 0 | 1 | D43N |
91
+| 1 | 23885743 | 0 | 0 | 1 | P59T |
92
+| 1 | 23885720 | 1 | 0 | 0 | Q66H |
93
+| 1 | 23885733 | 0 | 0 | 1 | T62I |
94
+| nan | nan | 0 | 0 | 1 | V58Rfs*9 |
tables/hotspots/hotspot_IGLL5.md
... ...
@@ -0,0 +1,210 @@
1
+## IGLL5 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 22 | 23230360,23230361 | 38 | 12 | 7 | V43I |
6
+| 22 | 23230360,23230361 | 38 | 12 | 7 | V43L |
7
+| 22 | 23230360,23230361 | 38 | 12 | 7 | V43A |
8
+| 22 | 23230360,23230361 | 38 | 12 | 7 | V43F |
9
+| 22 | 23230360,23230361 | 38 | 12 | 7 | V43G |
10
+| 22 | 23230360,23230361 | 38 | 12 | 7 | V43D |
11
+| 22 | 23230360,23230361 | 38 | 12 | 7 | V43E |
12
+| 22 | 23230393,23230394 | 29 | 15 | 10 | A54V |
13
+| 22 | 23230393,23230394 | 29 | 15 | 10 | A54D |
14
+| 22 | 23230393,23230394 | 29 | 15 | 10 | A54T |
15
+| 22 | 23230393,23230394 | 29 | 15 | 10 | A54G |
16
+| 22 | 23230393,23230394 | 29 | 15 | 10 | A54P |
17
+| 22 | 23230393,23230394 | 29 | 15 | 10 | A54S |
18
+| 22 | 23230356,23230357,23230358,23230359 | 25 | 19 | 8 | M42L |
19
+| 22 | 23230356,23230357,23230358,23230359 | 25 | 19 | 8 | M42I |
20
+| 22 | 23230356,23230357,23230358,23230359 | 25 | 19 | 8 | M42V |
21
+| 22 | 23230356,23230357,23230358,23230359 | 25 | 19 | 8 | M42K |
22
+| 22 | 23230356,23230357,23230358,23230359 | 25 | 19 | 8 | M42R |
23
+| 22 | 23230356,23230357,23230358,23230359 | 25 | 19 | 8 | M42T |
24
+| 22 | 23230356,23230357,23230358,23230359 | 25 | 19 | 8 | M42_G48del |
25
+| 22 | 23230363,23230364 | 27 | 14 | 6 | A44V |
26
+| 22 | 23230363,23230364 | 27 | 14 | 6 | A44T |
27
+| 22 | 23230363,23230364 | 27 | 14 | 6 | A44E |
28
+| 22 | 23230363,23230364 | 27 | 14 | 6 | A44G |
29
+| 22 | 23230363,23230364 | 27 | 14 | 6 | A44S |
30
+| 22 | 23230363,23230364 | 27 | 14 | 6 | A44I |
31
+| 22 | 23230363,23230364 | 27 | 14 | 6 | A44L |
32
+| 22 | 23230363,23230364 | 27 | 14 | 6 | A44P |
33
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56I |
34
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56L |
35
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56A |
36
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56F |
37
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56D |
38
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56G |
39
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56Lfs*53 |
40
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56P |
41
+| 22 | 23230399,23230400 | 21 | 17 | 4 | V56T |
42
+| 22 | 23230366,23230367,23230365 | 28 | 10 | 3 | P45S |
43
+| 22 | 23230372,23230373,23230374 | 21 | 12 | 8 | S47N |
44
+| 22 | 23230372,23230373,23230374 | 21 | 12 | 8 | S47T |
45
+| 22 | 23230366,23230367,23230365 | 28 | 10 | 3 | P45A |
46
+| 22 | 23230372,23230373,23230374 | 21 | 12 | 8 | S47R |
47
+| 22 | 23230366,23230367,23230365 | 28 | 10 | 3 | P45L |
48
+| 22 | 23230372,23230373,23230374 | 21 | 12 | 8 | S47G |
49
+| 22 | 23230366,23230367,23230365 | 28 | 10 | 3 | P45T |
50
+| 22 | 23230366,23230367,23230365 | 28 | 10 | 3 | P45R |
51
+| 22 | 23230372,23230373,23230374 | 21 | 12 | 8 | S47C |
52
+| 22 | 23230372,23230373,23230374 | 21 | 12 | 8 | S47I |
53
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58G |
54
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58N |
55
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58R |
56
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58C |
57
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58I |
58
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58D |
59
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58T |
60
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58A |
61
+| 22 | 23230405,23230406,23230407 | 23 | 11 | 6 | S58Afs*51 |
62
+| 22 | 23230438,23230439,23235880 | 18 | 6 | 5 | R69K |
63
+| 22 | 23230438,23230439,23235880 | 18 | 6 | 5 | R69T |
64
+| 22 | 23230438,23230439,23235880 | 18 | 6 | 5 | R69= |
65
+| 22 | 23230438,23230439,23235880 | 18 | 6 | 5 | R69G |
66
+| 22 | 23235947,23235948 | 26 | 0 | 0 | P92S |
67
+| 22 | 23230435,23230436,23230437 | 16 | 4 | 6 | G68D |
68
+| 22 | 23230435,23230436,23230437 | 16 | 4 | 6 | G68= |
69
+| 22 | 23230435,23230436,23230437 | 16 | 4 | 6 | G68A |
70
+| 22 | 23230435,23230436,23230437 | 16 | 4 | 6 | G68N |
71
+| 22 | 23235947,23235948 | 26 | 0 | 0 | P92T |
72
+| 22 | 23230435,23230436,23230437 | 16 | 4 | 6 | G68H |
73
+| 22 | 23230435,23230436,23230437 | 16 | 4 | 6 | G68V |
74
+| 22 | 23235947,23235948 | 26 | 0 | 0 | P92L |
75
+| 22 | 23235971,23235972 | 23 | 2 | 0 | G100E |
76
+| 22 | 23235971,23235972 | 23 | 2 | 0 | G100A |
77
+| 22 | 23235971,23235972 | 23 | 2 | 0 | G100R |
78
+| 22 | 23235971,23235972 | 23 | 2 | 0 | G100V |
79
+| 22 | 23230402,23230403 | 13 | 3 | 5 | G57A |
80
+| 22 | 23230402,23230403 | 13 | 3 | 5 | G57E |
81
+| 22 | 23230402,23230403 | 13 | 3 | 5 | G57R |
82
+| 22 | 23230402,23230403 | 13 | 3 | 5 | G57* |
83
+| 22 | 23230402,23230403 | 13 | 3 | 5 | G57V |
84
+| 22 | 23230408,23230409,23230410 | 14 | 3 | 3 | S59R |
85
+| 22 | 23230417,23230418,23230419 | 7 | 8 | 5 | S62R |
86
+| 22 | 23230415,23230414 | 9 | 6 | 5 | S61C |
87
+| 22 | 23230415,23230414 | 9 | 6 | 5 | S61F |
88
+| 22 | 23230417,23230418,23230419 | 7 | 8 | 5 | S62N |
89
+| 22 | 23230408,23230409,23230410 | 14 | 3 | 3 | S59G |
90
+| 22 | 23230417,23230418,23230419 | 7 | 8 | 5 | S62T |
91
+| 22 | 23230408,23230409,23230410 | 14 | 3 | 3 | S59N |
92
+| 22 | 23230415,23230414 | 9 | 6 | 5 | S61A |
93
+| 22 | 23230408,23230409,23230410 | 14 | 3 | 3 | S59T |
94
+| 22 | 23230408,23230409,23230410 | 14 | 3 | 3 | S59I |
95
+| 22 | 23230415,23230414 | 9 | 6 | 5 | S61P |
96
+| 22 | 23230415,23230414 | 9 | 6 | 5 | S61Y |
97
+| 22 | 23230417,23230418,23230419 | 7 | 8 | 5 | S62C |
98
+| 22 | 23230417,23230418,23230419 | 7 | 8 | 5 | S62I |
99
+| 22 | 23230381,23230382 | 10 | 5 | 4 | P50S |
100
+| 22 | 23230381,23230382 | 10 | 5 | 4 | P50A |
101
+| 22 | 23230381,23230382 | 10 | 5 | 4 | P50L |
102
+| 22 | 23230381,23230382 | 10 | 5 | 4 | P50R |
103
+| 22 | 23230381,23230382 | 10 | 5 | 4 | P50* |
104
+| 22 | 23230381,23230382 | 10 | 5 | 4 | P50T |
105
+| 22 | 23230369,23230370,23230371 | 11 | 5 | 2 | Q46L |
106
+| 22 | 23230369,23230370,23230371 | 11 | 5 | 2 | Q46R |
107
+| 22 | 23230369,23230370,23230371 | 11 | 5 | 2 | Q46* |
108
+| 22 | 23230369,23230370,23230371 | 11 | 5 | 2 | Q46E |
109
+| 22 | 23230369,23230370,23230371 | 11 | 5 | 2 | Q46H |
110
+| 22 | 23230369,23230370,23230371 | 11 | 5 | 2 | Q46Afs*46 |
111
+| 22 | 23230369,23230370,23230371 | 11 | 5 | 2 | Q46Rfs*41 |
112
+| 22 | 23230427,23230428,23230426 | 12 | 2 | 1 | S65R |
113
+| 22 | 23235974,23235975 | 12 | 0 | 3 | T101I |
114
+| 22 | 23235974,23235975 | 12 | 0 | 3 | T101S |
115
+| 22 | 23230427,23230428,23230426 | 12 | 2 | 1 | S65G |
116
+| 22 | 23230427,23230428,23230426 | 12 | 2 | 1 | S65N |
117
+| 22 | 23230427,23230428,23230426 | 12 | 2 | 1 | S65T |
118
+| 22 | 23235974,23235975 | 12 | 0 | 3 | T101A |
119
+| 22 | 23235974,23235975 | 12 | 0 | 3 | T101Mfs*8 |
120
+| 22 | 23235974,23235975 | 12 | 0 | 3 | T101N |
121
+| 22 | 23237662,23237663 | 11 | 0 | 0 | A145V |
122
+| 22 | 23230390,23230391 | 7 | 3 | 1 | G53R |
123
+| 22 | 23230387,23230388,23230386 | 7 | 2 | 2 | P52S |
124
+| 22 | 23230390,23230391 | 7 | 3 | 1 | G53E |
125
+| 22 | 23237662,23237663 | 11 | 0 | 0 | A145T |
126
+| 22 | 23230387,23230388,23230386 | 7 | 2 | 2 | P52L |
127
+| 22 | 23237662,23237663 | 11 | 0 | 0 | A145G |
128
+| 22 | 23237662,23237663 | 11 | 0 | 0 | A145I |
129
+| 22 | 23230390,23230391 | 7 | 3 | 1 | G53A |
130
+| 22 | 23230390,23230391 | 7 | 3 | 1 | G53V |
131
+| 22 | 23230387,23230388,23230386 | 7 | 2 | 2 | P52F |
132
+| 22 | 23230387,23230388,23230386 | 7 | 2 | 2 | P52R |
133
+| 22 | 23230387,23230388,23230386 | 7 | 2 | 2 | P52T |
134
+| nan | nan | 4 | 6 | 0 | X69_splice |
135
+| 22 | 23235998,23237555 | 8 | 0 | 2 | G109R |
136
+| 22 | 23235998,23237555 | 8 | 0 | 2 | G109S |
137
+| 22 | 23235998,23237555 | 8 | 0 | 2 | G109D |
138
+| 22 | 23237629,23237630 | 8 | 1 | 0 | L134V |
139
+| 22 | 23235989,23235990 | 7 | 0 | 2 | T106S |
140
+| 22 | 23235989,23235990 | 7 | 0 | 2 | T106I |
141
+| 22 | 23237629,23237630 | 8 | 1 | 0 | L134P |
142
+| 22 | 23235978 | 8 | 0 | 0 | G102E |
143
+| 22 | 23235932,23235933 | 7 | 0 | 1 | G87E |
144
+| 22 | 23230428,23230430 | 4 | 1 | 3 | L66Q |
145
+| 22 | 23230378,23230379 | 6 | 1 | 1 | D49G |
146
+| 22 | 23230385,23230386,23230384 | 3 | 2 | 3 | D51E |
147
+| 22 | 23230378,23230379 | 6 | 1 | 1 | D49A |
148
+| 22 | 23230385,23230386,23230384 | 3 | 2 | 3 | D51G |
149
+| 22 | 23235932,23235933 | 7 | 0 | 1 | G87R |
150
+| 22 | 23230428,23230430 | 4 | 1 | 3 | L66M |
151
+| 22 | 23230378,23230379 | 6 | 1 | 1 | D49R |
152
+| 22 | 23230378,23230379 | 6 | 1 | 1 | D49_G53del |
153
+| 22 | 23230385,23230386,23230384 | 3 | 2 | 3 | D51A |
154
+| 22 | 23230385,23230386,23230384 | 3 | 2 | 3 | D51N |
155
+| 22 | 23230385,23230386,23230384 | 3 | 2 | 3 | D51_S55del |
156
+| 22 | 23235978 | 8 | 0 | 0 | G102V |
157
+| 22 | 23230428,23230430 | 4 | 1 | 3 | L66R |
158
+| 22 | 23230432,23230434 | 2 | 3 | 2 | W67R |
159
+| 22 | 23237804,23237805,23237803 | 6 | 1 | 0 | S192R |
160
+| 22 | 23237804,23237805,23237803 | 6 | 1 | 0 | S192G |
161
+| 22 | 23237804,23237805,23237803 | 6 | 1 | 0 | S192N |
162
+| 22 | 23237804,23237805,23237803 | 6 | 1 | 0 | S192T |
163
+| 22 | 23237804,23237805,23237803 | 6 | 1 | 0 | S192Tfs*59 |
164
+| 22 | 23230432,23230434 | 2 | 3 | 2 | W67C |
165
+| 22 | 23230432,23230434 | 2 | 3 | 2 | W67G |
166
+| 22 | 23235887 | 5 | 1 | 0 | L72F |
167
+| 22 | 23235921 | 4 | 1 | 0 | C83Y |
168
+| 22 | 23237810 | 5 | 0 | 0 | S194N |
169
+| 22 | 23237725 | 5 | 0 | 0 | P166A |
170
+| 22 | 23237632,23237631 | 5 | 0 | 0 | V135L |
171
+| 22 | 23237725 | 5 | 0 | 0 | P166S |
172
+| 22 | 23237632,23237631 | 5 | 0 | 0 | V135M |
173
+| 22 | 23235921 | 4 | 1 | 0 | C83F |
174
+| 22 | 23237810 | 5 | 0 | 0 | S194I |
175
+| 22 | 23230376 | 3 | 1 | 0 | G48E |
176
+| nan | nan | 1 | 3 | 0 | MV42II |
177
+| 22 | 23235983,23235984,23235985 | 1 | 0 | 3 | K104R |
178
+| 22 | 23237569,23237570 | 4 | 0 | 0 | N114D |
179
+| 22 | 23235983,23235984,23235985 | 1 | 0 | 3 | K104E |
180
+| 22 | 23235983,23235984,23235985 | 1 | 0 | 3 | K104N |
181
+| 22 | 23237569,23237570 | 4 | 0 | 0 | N114S |
182
+| 22 | 23237569,23237570 | 4 | 0 | 0 | N114Y |
183
+| 22 | 23230420,23230421 | 1 | 0 | 2 | L63Q |
184
+| 22 | 23237644,23237645 | 2 | 1 | 0 | S139N |
185
+| 22 | 23230397,23230396 | 2 | 0 | 1 | S55* |
186
+| 22 | 23230420,23230421 | 1 | 0 | 2 | L63V |
187
+| 22 | 23237644,23237645 | 2 | 1 | 0 | S139G |
188
+| 22 | 23237834,23237833 | 2 | 1 | 0 | S202C |
189
+| 22 | 23237834,23237833 | 2 | 1 | 0 | S202N |
190
+| 22 | 23237834,23237833 | 2 | 1 | 0 | S202T |
191
+| 22 | 23230397,23230396 | 2 | 0 | 1 | S55P |
192
+| 22 | 23237767 | 2 | 0 | 0 | L180V |
193
+| 22 | 23237590 | 2 | 0 | 0 | P121T |
194
+| 22 | 23237567 | 2 | 0 | 0 | A113G |
195
+| 22 | 23237567 | 2 | 0 | 0 | A113V |
196
+| 22 | 23237572,23237573 | 2 | 0 | 0 | P115L |
197
+| 22 | 23237572,23237573 | 2 | 0 | 0 | P115T |
198
+| 22 | 23230354,23230355 | 2 | 0 | 0 | P41L |
199
+| 22 | 23230354,23230355 | 2 | 0 | 0 | P41S |
200
+| 22 | 23235939 | 2 | 0 | 0 | W89S |
201
+| 22 | 23235939 | 2 | 0 | 0 | W89_S90delinsC |
202
+| 22 | 23237855 | 0 | 0 | 1 | A209G |
203
+| nan | nan | 0 | 0 | 1 | DP51ET |
204
+| nan | nan | 0 | 0 | 1 | MV42IL |
205
+| nan | nan | 1 | 0 | 0 | P74_Q77del |
206
+| nan | nan | 1 | 0 | 0 | T103Pfs*6 |
207
+| 22 | 23237668 | 1 | 0 | 0 | T147S |
208
+| 22 | 23237836 | 1 | 0 | 0 | T203A |
209
+| 22 | 23235992 | 1 | 0 | 0 | V107I |
210
+| 22 | 23237840 | 1 | 0 | 0 | V204G |
tables/hotspots/hotspot_IKZF3.md
... ...
@@ -0,0 +1,16 @@
1
+## IKZF3 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 17 | 37947776 | 21 | 5 | 0 | L162R |
6
+| 17 | 37944575,37944577 | 8 | 3 | 2 | S215R |
7
+| 17 | 37944568 | 6 | 0 | 0 | E218K |
8
+| 17 | 37948958 | 3 | 0 | 0 | N131S |
9
+| 17 | 37948968 | 2 | 0 | 0 | I128V |
10
+| 17 | 37948949,37948950 | 2 | 0 | 0 | M134K |
11
+| 17 | 37948949,37948950 | 2 | 0 | 0 | M134V |
12
+| 17 | 37944583,37944582 | 2 | 0 | 0 | Q213K |
13
+| 17 | 37944583,37944582 | 2 | 0 | 0 | Q213R |
14
+| 17 | 37944556 | 0 | 1 | 0 | E222K |
15
+| 17 | 37948996 | 1 | 0 | 0 | M118I |
16
+| 17 | 37944529 | 1 | 0 | 0 | T231P |
tables/hotspots/hotspot_IL4R.md
... ...
@@ -0,0 +1,12 @@
1
+## IL4R Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 16 | 27367183 | 13 | 0 | 2 | I242N |
6
+| 16 | 27356201,27356200 | 2 | 1 | 0 | C74G |
7
+| 16 | 27353471,27353472 | 3 | 0 | 0 | C34F |
8
+| 16 | 27353471,27353472 | 3 | 0 | 0 | C34R |
9
+| 16 | 27353471,27353472 | 3 | 0 | 0 | C34S |
10
+| 16 | 27356201,27356200 | 2 | 1 | 0 | C74S |
11
+| 16 | 27353501 | 1 | 0 | 0 | C44R |
12
+| 16 | 27356325 | 1 | 0 | 0 | F115L |
tables/hotspots/hotspot_IRF8.md
... ...
@@ -0,0 +1,15 @@
1
+## IRF8 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 16 | 85936784 | 21 | 5 | 0 | S55A |
6
+| 16 | 85936688 | 16 | 1 | 1 | Y23H |
7
+| 16 | 85942618 | 5 | 2 | 0 | K66R |
8
+| 16 | 85942665,85942666,85942667 | 1 | 3 | 0 | L82S |
9
+| 16 | 85942665,85942666,85942667 | 1 | 3 | 0 | L82F |
10
+| 16 | 85942665,85942666,85942667 | 1 | 3 | 0 | L82V |
11
+| 16 | 85942602 | 2 | 1 | 0 | A61S |
12
+| 16 | 85942602 | 2 | 1 | 0 | A61T |
13
+| 16 | 85942605,85942606 | 1 | 0 | 1 | V62A |
14
+| 16 | 85942605,85942606 | 1 | 0 | 1 | V62I |
15
+| 16 | 85936788 | 1 | 0 | 0 | I56T |
tables/hotspots/hotspot_ITPKB.md
... ...
@@ -0,0 +1,11 @@
1
+## ITPKB Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 226925148 | 6 | 1 | 0 | Y4* |
6
+| 1 | 226925140,226925141 | 4 | 0 | 0 | A7V |
7
+| 1 | 226925140,226925141 | 4 | 0 | 0 | A7T |
8
+| 1 | 226925143 | 3 | 0 | 0 | Y6C |
9
+| 1 | 226925143 | 3 | 0 | 0 | Y6F |
10
+| 1 | 226925143 | 3 | 0 | 0 | Y6S |
11
+| 1 | 226925146 | 1 | 1 | 0 | C5Y |
tables/hotspots/hotspot_KLF2.md
... ...
@@ -0,0 +1,16 @@
1
+## KLF2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 19 | 16436775,16436776 | 16 | 1 | 0 | S275N |
6
+| 19 | 16436775,16436776 | 16 | 1 | 0 | S275T |
7
+| 19 | 16436775,16436776 | 16 | 1 | 0 | S275R |
8
+| 19 | 16436784 | 2 | 0 | 0 | G278D |
9
+| 19 | 16436784 | 2 | 0 | 0 | G278V |
10
+| 19 | 16436763 | 1 | 1 | 0 | T271I |
11
+| 19 | 16436763 | 1 | 1 | 0 | T271S |
12
+| 19 | 16436781 | 1 | 0 | 0 | A277E |
13
+| 19 | 16436787 | 1 | 0 | 0 | C279Y |
14
+| 19 | 16436790 | 1 | 0 | 0 | G280V |
15
+| 19 | 16436769 | 1 | 0 | 0 | T273I |
16
+| 19 | 16436796 | 1 | 0 | 0 | T282S |
tables/hotspots/hotspot_KLHL6.md
... ...
@@ -0,0 +1,63 @@
1
+## KLHL6 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 3 | 183273248,183273249 | 25 | 2 | 2 | L65P |
6
+| 3 | 183273248,183273249 | 25 | 2 | 2 | L65Q |
7
+| 3 | 183273248,183273249 | 25 | 2 | 2 | L65V |
8
+| 3 | 183273248,183273249 | 25 | 2 | 2 | L65del |
9
+| 3 | 183273173,183273174 | 15 | 4 | 0 | L90F |
10
+| 3 | 183273173,183273174 | 15 | 4 | 0 | L90V |
11
+| 3 | 183273173,183273174 | 15 | 4 | 0 | L90P |
12
+| 3 | 183273173,183273174 | 15 | 4 | 0 | L90Qfs*17 |
13
+| 3 | 183273173,183273174 | 15 | 4 | 0 | L90R |
14
+| 3 | 183273173,183273174 | 15 | 4 | 0 | L90S |
15
+| 3 | 183273161,183273162 | 8 | 3 | 0 | S94N |
16
+| 3 | 183273223,183273225,183273224 | 8 | 3 | 0 | D73E |
17
+| 3 | 183273223,183273225,183273224 | 8 | 3 | 0 | D73N |
18
+| 3 | 183273223,183273225,183273224 | 8 | 3 | 0 | D73H |
19
+| 3 | 183273161,183273162 | 8 | 3 | 0 | S94G |
20
+| 3 | 183273223,183273225,183273224 | 8 | 3 | 0 | D73A |
21
+| 3 | 183273161,183273162 | 8 | 3 | 0 | S94C |
22
+| 3 | 183273161,183273162 | 8 | 3 | 0 | S94I |
23
+| 3 | 183273161,183273162 | 8 | 3 | 0 | S94T |
24
+| 3 | 183273154,183273155,183273156 | 7 | 3 | 0 | Y96D |
25
+| 3 | 183273154,183273155,183273156 | 7 | 3 | 0 | Y96F |
26
+| 3 | 183273154,183273155,183273156 | 7 | 3 | 0 | Y96S |
27
+| 3 | 183273154,183273155,183273156 | 7 | 3 | 0 | Y96* |
28
+| 3 | 183273154,183273155,183273156 | 7 | 3 | 0 | Y96H |
29
+| 3 | 183273152,183273153 | 6 | 1 | 0 | F97L |
30
+| 3 | 183273193,183273194,183273195 | 5 | 2 | 0 | F83L |
31
+| 3 | 183273193,183273194,183273195 | 5 | 2 | 0 | F83I |
32
+| 3 | 183273193,183273194,183273195 | 5 | 2 | 0 | F83S |
33
+| 3 | 183273193,183273194,183273195 | 5 | 2 | 0 | F83V |
34
+| 3 | 183273152,183273153 | 6 | 1 | 0 | F97S |
35
+| 3 | 183273231 | 5 | 0 | 0 | L71V |
36
+| 3 | 183273269 | 3 | 1 | 0 | L58P |
37
+| 3 | 183273164 | 4 | 0 | 0 | A93G |
38
+| 3 | 183273164 | 4 | 0 | 0 | A93Qfs*14 |
39
+| 3 | 183273164 | 4 | 0 | 0 | A93V |
40
+| 3 | 183273164 | 4 | 0 | 0 | A93del |
41
+| 3 | 183273170 | 3 | 0 | 0 | A91V |
42
+| 3 | 183273201 | 3 | 0 | 0 | Q81* |
43
+| 3 | 183273196,183273198 | 2 | 1 | 0 | E82D |
44
+| 3 | 183273186,183273185 | 2 | 0 | 1 | H86Y |
45
+| 3 | 183273187,183273188,183273189 | 3 | 0 | 0 | C85R |
46
+| 3 | 183273187,183273188,183273189 | 3 | 0 | 0 | C85W |
47
+| 3 | 183273187,183273188,183273189 | 3 | 0 | 0 | C85Y |
48
+| 3 | 183273196,183273198 | 2 | 1 | 0 | E82Q |
49
+| 3 | 183273186,183273185 | 2 | 0 | 1 | H86L |
50
+| 3 | 183273176,183273177 | 1 | 2 | 0 | V89E |
51
+| 3 | 183273176,183273177 | 1 | 2 | 0 | V89G |
52
+| 3 | 183273176,183273177 | 1 | 2 | 0 | V89M |
53
+| 3 | 183273206 | 2 | 0 | 0 | D79V |
54
+| 3 | 183273203,183273204 | 1 | 1 | 0 | I80N |
55
+| 3 | 183273203,183273204 | 1 | 1 | 0 | I80V |
56
+| 3 | 183273237,183273235 | 2 | 0 | 0 | N69D |
57
+| 3 | 183273237,183273235 | 2 | 0 | 0 | N69K |
58
+| 3 | 183273209,183273210 | 2 | 0 | 0 | V78E |
59
+| 3 | 183273209,183273210 | 2 | 0 | 0 | V78L |
60
+| 3 | 183273211 | 1 | 0 | 0 | C77W |
61
+| 3 | 183273158 | 1 | 0 | 0 | N95S |
62
+| 3 | 183273192 | 1 | 0 | 0 | S84T |
63
+| 3 | 183273179 | 1 | 0 | 0 | V88E |
tables/hotspots/hotspot_KMT2D.md
... ...
@@ -0,0 +1,7 @@
1
+## KMT2D Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 12 | 49420606,49420607 | 6 | 2 | 0 | R5048C |
6
+| 12 | 49420606,49420607 | 6 | 2 | 0 | R5048H |
7
+| 12 | 49420609 | 1 | 0 | 0 | A5047V |
tables/hotspots/hotspot_KRAS.md
... ...
@@ -0,0 +1,13 @@
1
+## KRAS Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 12 | 25398281,25398282 | 15 | 0 | 0 | G13D |
6
+| 12 | 25398281,25398282 | 15 | 0 | 0 | G13C |
7
+| 12 | 25398284,25398285 | 8 | 0 | 4 | G12A |
8
+| 12 | 25398284,25398285 | 8 | 0 | 4 | G12D |
9
+| 12 | 25398284,25398285 | 8 | 0 | 4 | G12R |
10
+| 12 | 25398284,25398285 | 8 | 0 | 4 | G12V |
11
+| 12 | 25398284,25398285 | 8 | 0 | 4 | G12C |
12
+| 12 | 25398284,25398285 | 8 | 0 | 4 | G12S |
13
+| 12 | 25378647 | 4 | 0 | 0 | K117N |
tables/hotspots/hotspot_LAPTM5.md
... ...
@@ -0,0 +1,8 @@
1
+## LAPTM5 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 31230591,31230592 | 9 | 8 | 0 | M1? |
6
+| 1 | 31230579 | 1 | 0 | 0 | L5* |
7
+| 1 | 31230582 | 1 | 0 | 0 | R4H |
8
+| 1 | 31230577 | 1 | 0 | 0 | S6P |
tables/hotspots/hotspot_LRRN3.md
... ...
@@ -0,0 +1,12 @@
1
+## LRRN3 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 7 | 110764071,110764073 | 3 | 0 | 0 | M415I |
6
+| 7 | 110764071,110764073 | 3 | 0 | 0 | M415V |
7
+| 7 | 110764069 | 2 | 0 | 0 | D414G |
8
+| 7 | 110764060,110764059 | 1 | 1 | 0 | H411L |
9
+| 7 | 110764060,110764059 | 1 | 1 | 0 | H411N |
10
+| 7 | 110764082 | 1 | 0 | 0 | I418M |
11
+| 7 | 110764086 | 1 | 0 | 0 | L420I |
12
+| 7 | 110764056 | 1 | 0 | 0 | V410L |
tables/hotspots/hotspot_MAP2K1.md
... ...
@@ -0,0 +1,14 @@
1
+## MAP2K1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 15 | 66727441,66727442,66727443 | 15 | 3 | 1 | F53L |
6
+| 15 | 66727441,66727442,66727443 | 15 | 3 | 1 | F53V |
7
+| 15 | 66727441,66727442,66727443 | 15 | 3 | 1 | F53S |
8
+| 15 | 66727441,66727442,66727443 | 15 | 3 | 1 | F53Y |
9
+| 15 | 66727441,66727442,66727443 | 15 | 3 | 1 | F53C |
10
+| 15 | 66727453,66727454,66727455 | 9 | 1 | 0 | K57E |
11
+| 15 | 66727453,66727454,66727455 | 9 | 1 | 0 | K57T |
12
+| 15 | 66727453,66727454,66727455 | 9 | 1 | 0 | K57N |
13
+| 15 | 66729180,66729181 | 4 | 1 | 0 | Y130H |
14
+| 15 | 66729180,66729181 | 4 | 1 | 0 | Y130C |
tables/hotspots/hotspot_MEF2B.md
... ...
@@ -0,0 +1,24 @@
1
+## MEF2B Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 19 | 19260044,19260045 | 43 | 35 | 0 | D83V |
6
+| 19 | 19260044,19260045 | 43 | 35 | 0 | D83A |
7
+| 19 | 19260044,19260045 | 43 | 35 | 0 | D83G |
8
+| 19 | 19260044,19260045 | 43 | 35 | 0 | D83E |
9
+| 19 | 19260064,19260063 | 9 | 1 | 0 | E77K |
10
+| 19 | 19260064,19260063 | 9 | 1 | 0 | E77G |
11
+| nan | nan | 4 | 0 | 0 | X86_splice |
12
+| 19 | 19260066 | 2 | 2 | 0 | H76R |
13
+| 19 | 19260050,19260052 | 4 | 0 | 0 | N81K |
14
+| 19 | 19260066 | 2 | 2 | 0 | H76P |
15
+| 19 | 19260050,19260052 | 4 | 0 | 0 | N81Y |
16
+| 19 | 19260050,19260052 | 4 | 0 | 0 | N81_T82del |
17
+| 19 | 19260055 | 3 | 0 | 0 | T80A |
18
+| 19 | 19260055 | 3 | 0 | 0 | T80P |
19
+| 19 | 19258640 | 1 | 1 | 0 | T87M |
20
+| 19 | 19260061 | 2 | 0 | 0 | S78G |
21
+| 19 | 19260061 | 2 | 0 | 0 | S78R |
22
+| 19 | 19260042 | 1 | 0 | 0 | I84T |
23
+| 19 | 19258638 | 1 | 0 | 0 | L88M |
24
+| 19 | 19260049 | 1 | 0 | 0 | T82A |
tables/hotspots/hotspot_MYC.md
... ...
@@ -0,0 +1,67 @@
1
+## MYC Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 8 | 128750677,128750678 | 18 | 0 | 41 | P72S |
6
+| 8 | 128750677,128750678 | 18 | 0 | 41 | P72T |
7
+| 8 | 128750677,128750678 | 18 | 0 | 41 | P72F |
8
+| 8 | 128750677,128750678 | 18 | 0 | 41 | P72A |
9
+| 8 | 128750677,128750678 | 18 | 0 | 41 | P72R |
10
+| 8 | 128750677,128750678 | 18 | 0 | 41 | P72C |
11
+| 8 | 128750677,128750678 | 18 | 0 | 41 | P72L |
12
+| 8 | 128750677,128750678 | 18 | 0 | 41 | P72_L84del |
13
+| 8 | 128750680,128750681 | 16 | 1 | 29 | T73I |
14
+| 8 | 128750680,128750681 | 16 | 1 | 29 | T73N |
15
+| 8 | 128750680,128750681 | 16 | 1 | 29 | T73A |
16
+| 8 | 128750680,128750681 | 16 | 1 | 29 | T73M |
17
+| 8 | 128750680,128750681 | 16 | 1 | 29 | T73S |
18
+| 8 | 128750686,128750687 | 10 | 0 | 10 | P75S |
19
+| 8 | 128750686,128750687 | 10 | 0 | 10 | P75A |
20
+| 8 | 128750686,128750687 | 10 | 0 | 10 | P75F |
21
+| 8 | 128750686,128750687 | 10 | 0 | 10 | P75H |
22
+| 8 | 128750686,128750687 | 10 | 0 | 10 | P75R |
23
+| 8 | 128750686,128750687 | 10 | 0 | 10 | P75T |
24
+| 8 | 128751253,128751254 | 4 | 0 | 11 | S264N |
25
+| 8 | 128751253,128751254 | 4 | 0 | 11 | S264I |
26
+| 8 | 128751253,128751254 | 4 | 0 | 11 | S264R |
27
+| 8 | 128751253,128751254 | 4 | 0 | 11 | S264G |
28
+| 8 | 128751253,128751254 | 4 | 0 | 11 | S264T |
29
+| 8 | 128750682,128750683,128750684 | 4 | 0 | 8 | P74A |
30
+| 8 | 128750682,128750683,128750684 | 4 | 0 | 8 | P74S |
31
+| 8 | 128750682,128750683,128750684 | 4 | 0 | 8 | P74T |
32
+| 8 | 128750682,128750683,128750684 | 4 | 0 | 8 | P74L |
33
+| 8 | 128750682,128750683,128750684 | 4 | 0 | 8 | P74Q |
34
+| 8 | 128750695,128750696,128750694 | 2 | 0 | 8 | P78S |
35
+| 8 | 128750695,128750696,128750694 | 2 | 0 | 8 | P78R |
36
+| 8 | 128750695,128750696,128750694 | 2 | 0 | 8 | P78A |
37
+| 8 | 128750695,128750696,128750694 | 2 | 0 | 8 | P78L |
38
+| 8 | 128750695,128750696,128750694 | 2 | 0 | 8 | P78T |
39
+| 8 | 128751241,128751242 | 5 | 0 | 4 | P260Q |
40
+| 8 | 128751241,128751242 | 5 | 0 | 4 | P260S |
41
+| 8 | 128751241,128751242 | 5 | 0 | 4 | P260A |
42
+| 8 | 128751241,128751242 | 5 | 0 | 4 | P260L |
43
+| 8 | 128751241,128751242 | 5 | 0 | 4 | P260R |
44
+| 8 | 128750692,128750693 | 1 | 0 | 6 | S77P |
45
+| 8 | 128750692,128750693 | 1 | 0 | 6 | S77A |
46
+| 8 | 128750692,128750693 | 1 | 0 | 6 | S77C |
47
+| 8 | 128751244 | 3 | 0 | 3 | P261S |
48
+| 8 | 128751244 | 3 | 0 | 3 | P261A |
49
+| 8 | 128751244 | 3 | 0 | 3 | P261T |
50
+| 8 | 128751250,128751251 | 4 | 0 | 1 | T263I |
51
+| 8 | 128751250,128751251 | 4 | 0 | 1 | T263S |
52
+| 8 | 128751250,128751251 | 4 | 0 | 1 | T263A |
53
+| 8 | 128751226 | 0 | 0 | 3 | L255F |
54
+| 8 | 128751226 | 0 | 0 | 3 | L255V |
55
+| 8 | 128751263,128751264 | 2 | 0 | 1 | S267= |
56
+| 8 | 128751263,128751264 | 2 | 0 | 1 | S267C |
57
+| 8 | 128751263,128751264 | 2 | 0 | 1 | S267F |
58
+| 8 | 128750674 | 0 | 0 | 2 | L71M |
59
+| 8 | 128751257 | 0 | 0 | 2 | S265T |
60
+| nan | nan | 2 | 0 | 0 | TP73NS |
61
+| 8 | 128751259,128751261 | 0 | 0 | 2 | D266E |
62
+| 8 | 128751259,128751261 | 0 | 0 | 2 | D266N |
63
+| 8 | 128750699,128750700 | 0 | 0 | 2 | S79N |
64
+| 8 | 128750699,128750700 | 0 | 0 | 2 | S79R |
65
+| nan | nan | 0 | 0 | 1 | DS266ET |
66
+| 8 | 128750670 | 0 | 0 | 1 | E69D |
67
+| 8 | 128752702 | 1 | 0 | 0 | P288H |
tables/hotspots/hotspot_MYD88.md
... ...
@@ -0,0 +1,8 @@
1
+## MYD88 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 3 | 38182641 | 271 | 1 | 0 | L265P |
6
+| 3 | 38182259 | 17 | 3 | 0 | M232T |
7
+| 3 | 38181908 | 3 | 0 | 0 | I178V |
8
+| 3 | 38182641 | 1 | 0 | 0 | L273P |
tables/hotspots/hotspot_NFKBIA.md
... ...
@@ -0,0 +1,11 @@
1
+## NFKBIA Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 14 | 35872506,35872505 | 6 | 0 | 0 | A133T |
6
+| 14 | 35872506,35872505 | 6 | 0 | 0 | A133V |
7
+| 14 | 35872506,35872505 | 6 | 0 | 0 | A133P |
8
+| 14 | 35872995,35872996 | 2 | 0 | 0 | H79P |
9
+| 14 | 35872995,35872996 | 2 | 0 | 0 | H79Q |
10
+| 14 | 35872925 | 1 | 0 | 0 | F103V |
11
+| 14 | 35872918 | 1 | 0 | 0 | N105T |
tables/hotspots/hotspot_NOL9.md
... ...
@@ -0,0 +1,11 @@
1
+## NOL9 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 6614186,6614187 | 8 | 1 | 0 | L126V |
6
+| 1 | 6614186,6614187 | 8 | 1 | 0 | L126P |
7
+| 1 | 6614167 | 1 | 2 | 0 | Q132H |
8
+| 1 | 6614167 | 1 | 2 | 0 | Q132= |
9
+| 1 | 6614184 | 1 | 1 | 0 | L127V |
10
+| 1 | 6614170 | 1 | 0 | 0 | E131D |
11
+| 1 | 6614181 | 0 | 1 | 0 | L128M |
tables/hotspots/hotspot_NOTCH2.md
... ...
@@ -0,0 +1,5 @@
1
+## NOTCH2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 120458147 | 35 | 1 | 0 | R2400* |
tables/hotspots/hotspot_OSBPL10.md
... ...
@@ -0,0 +1,27 @@
1
+## OSBPL10 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 3 | 32022391 | 16 | 0 | 1 | R94K |
6
+| 3 | 32022391 | 16 | 0 | 1 | R94M |
7
+| 3 | 32022391 | 16 | 0 | 1 | R94T |
8
+| 3 | 32022431 | 8 | 1 | 0 | L81F |
9
+| 3 | 32022431 | 8 | 1 | 0 | L81V |
10
+| 3 | 32022413 | 6 | 1 | 0 | L87F |
11
+| 3 | 32022433,32022434 | 7 | 0 | 0 | V80M |
12
+| 3 | 32022433,32022434 | 7 | 0 | 0 | V80L |
13
+| 3 | 32022413 | 6 | 1 | 0 | L87V |
14
+| 3 | 32022433,32022434 | 7 | 0 | 0 | V80A |
15
+| 3 | 32022420,32022422 | 5 | 1 | 0 | Y84* |
16
+| 3 | 32022420,32022422 | 5 | 1 | 0 | Y84D |
17
+| 3 | 32022420,32022422 | 5 | 1 | 0 | Y84N |
18
+| 3 | 32022426,32022427 | 5 | 0 | 0 | S82R |
19
+| 3 | 32022426,32022427 | 5 | 0 | 0 | S82N |
20
+| 3 | 32022426,32022427 | 5 | 0 | 0 | S82T |
21
+| nan | nan | 1 | 3 | 0 | X94_splice |
22
+| 3 | 32022393 | 1 | 1 | 0 | N93K |
23
+| 3 | 32022393 | 1 | 1 | 0 | N93R |
24
+| 3 | 32022418 | 2 | 0 | 0 | T85I |
25
+| 3 | 32022418 | 2 | 0 | 0 | T85S |
26
+| 3 | 32022424 | 1 | 0 | 0 | K83I |
27
+| 3 | 32022415 | 1 | 0 | 0 | N86T |
tables/hotspots/hotspot_P2RY8.md
... ...
@@ -0,0 +1,19 @@
1
+## P2RY8 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| X | 1585414,1585415 | 3 | 1 | 2 | T13M |
6
+| X | 1585414,1585415 | 3 | 1 | 2 | T13A |
7
+| X | 1585414,1585415 | 3 | 1 | 2 | T13S |
8
+| X | 1585423,1585424 | 0 | 0 | 3 | D10A |
9
+| X | 1585423,1585424 | 0 | 0 | 3 | D10H |
10
+| X | 1585423,1585424 | 0 | 0 | 3 | D10N |
11
+| X | 1585402,1585403 | 2 | 0 | 1 | L17Q |
12
+| X | 1585402,1585403 | 2 | 0 | 1 | L17R |
13
+| X | 1585402,1585403 | 2 | 0 | 1 | L17V |
14
+| X | 1585405 | 1 | 0 | 0 | M16K |
15
+| X | 1585420 | 1 | 0 | 0 | N11T |
16
+| X | 1585396 | 1 | 0 | 0 | N19I |
17
+| X | 1585394 | 1 | 0 | 0 | P20S |
18
+| X | 1585426 | 1 | 0 | 0 | P9Q |
19
+| X | 1585433 | 0 | 1 | 0 | T7P |
tables/hotspots/hotspot_PIK3CD.md
... ...
@@ -0,0 +1,7 @@
1
+## PIK3CD Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 9787030 | 20 | 3 | 3 | E1021K |
6
+| 1 | 9787043 | 3 | 0 | 0 | E1025G |
7
+| 1 | 9787040 | 0 | 0 | 1 | R1024H |
tables/hotspots/hotspot_PIM1.md
... ...
@@ -0,0 +1,118 @@
1
+## PIM1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 37139063 | 72 | 5 | 0 | E135K |
6
+| 6 | 37139063 | 72 | 5 | 0 | E135* |
7
+| 6 | 37139063 | 72 | 5 | 0 | E135Q |
8
+| 6 | 37138950,37138951 | 52 | 3 | 1 | S97N |
9
+| 6 | 37138950,37138951 | 52 | 3 | 1 | S97T |
10
+| 6 | 37138950,37138951 | 52 | 3 | 1 | S97R |
11
+| 6 | 37138950,37138951 | 52 | 3 | 1 | S97Rfs*21 |
12
+| 6 | 37138950,37138951 | 52 | 3 | 1 | S97I |
13
+| 6 | 37139210 | 47 | 1 | 0 | L184F |
14
+| 6 | 37139210 | 47 | 1 | 0 | L184V |
15
+| 6 | 37138901,37138902 | 40 | 4 | 0 | P81S |
16
+| 6 | 37138901,37138902 | 40 | 4 | 0 | P81T |
17
+| 6 | 37138901,37138902 | 40 | 4 | 0 | P81A |
18
+| 6 | 37138901,37138902 | 40 | 4 | 0 | P81F |
19
+| 6 | 37138901,37138902 | 40 | 4 | 0 | P81I |
20
+| 6 | 37138901,37138902 | 40 | 4 | 0 | P81L |
21
+| 6 | 37138549,37138550 | 39 | 3 | 0 | G28D |
22
+| 6 | 37138549,37138550 | 39 | 3 | 0 | G28A |
23
+| 6 | 37138549,37138550 | 39 | 3 | 0 | G28V |
24
+| 6 | 37138549,37138550 | 39 | 3 | 0 | G28= |
25
+| 6 | 37139038,37139039,37139040 | 34 | 2 | 0 | Q127* |
26
+| 6 | 37139038,37139039,37139040 | 34 | 2 | 0 | Q127E |
27
+| 6 | 37139038,37139039,37139040 | 34 | 2 | 0 | Q127K |
28
+| 6 | 37139038,37139039,37139040 | 34 | 2 | 0 | Q127L |
29
+| 6 | 37139038,37139039,37139040 | 34 | 2 | 0 | Q127R |
30
+| 6 | 37139097,37139098 | 24 | 3 | 0 | S146N |
31
+| 6 | 37139097,37139098 | 24 | 3 | 0 | S146R |
32
+| 6 | 37139097,37139098 | 24 | 3 | 0 | S146T |
33
+| 6 | 37138423 | 21 | 3 | 1 | K24N |
34
+| 6 | 37138946 | 21 | 4 | 0 | V96M |
35
+| 6 | 37138946 | 21 | 4 | 0 | V96L |
36
+| 6 | 37138563 | 21 | 3 | 0 | P33S |
37
+| 6 | 37138563 | 21 | 3 | 0 | P33T |
38
+| 6 | 37138563 | 21 | 3 | 0 | P33A |
39
+| 6 | 37139033 | 22 | 0 | 0 | P125S |
40
+| 6 | 37139033 | 22 | 0 | 0 | P125A |
41
+| 6 | 37139033 | 22 | 0 | 0 | P125T |
42
+| 6 | 37139033 | 22 | 0 | 0 | P125V |
43
+| 6 | 37139204 | 16 | 0 | 0 | L182F |
44
+| 6 | 37139204 | 16 | 0 | 0 | L182V |
45
+| 6 | 37139204 | 16 | 0 | 0 | L182D |
46
+| 6 | 37138554 | 14 | 0 | 0 | E30K |
47
+| 6 | 37138554 | 14 | 0 | 0 | E30Q |
48
+| 6 | 37138554 | 14 | 0 | 0 | E30Wfs*60 |
49
+| 6 | 37138961,37138962 | 10 | 1 | 0 | S101F |
50
+| 6 | 37138961,37138962 | 10 | 1 | 0 | S101P |
51
+| 6 | 37138961,37138962 | 10 | 1 | 0 | S101Y |
52
+| 6 | 37138961,37138962 | 10 | 1 | 0 | S101A |
53
+| 6 | 37139035,37139036 | 9 | 1 | 0 | V126L |
54
+| 6 | 37139035,37139036 | 9 | 1 | 0 | V126M |
55
+| 6 | 37139203 | 9 | 0 | 0 | E181D |
56
+| 6 | 37138560,37138561 | 9 | 0 | 0 | E32K |
57
+| 6 | 37138976,37138977 | 8 | 1 | 0 | L106F |
58
+| 6 | 37138987 | 8 | 1 | 0 | W109* |
59
+| 6 | 37138419 | 9 | 0 | 0 | T23I |
60
+| 6 | 37139111 | 8 | 0 | 1 | V151M |
61
+| 6 | 37138419 | 9 | 0 | 0 | T23S |
62
+| 6 | 37138987 | 8 | 1 | 0 | W109C |
63
+| 6 | 37139111 | 8 | 0 | 1 | V151I |
64
+| 6 | 37139111 | 8 | 0 | 1 | V151L |
65
+| 6 | 37138560,37138561 | 9 | 0 | 0 | E32A |
66
+| 6 | 37138560,37138561 | 9 | 0 | 0 | E32Q |
67
+| 6 | 37138976,37138977 | 8 | 1 | 0 | L106P |
68
+| 6 | 37138976,37138977 | 8 | 1 | 0 | L106Sfs*13 |
69
+| 6 | 37138424 | 8 | 0 | 0 | L25V |
70
+| 6 | 37138919,37138920 | 8 | 0 | 0 | P87S |
71
+| 6 | 37139045 | 7 | 1 | 0 | L129V |
72
+| 6 | 37139045 | 7 | 1 | 0 | L129F |
73
+| 6 | 37138424 | 8 | 0 | 0 | L25M |
74
+| 6 | 37138919,37138920 | 8 | 0 | 0 | P87L |
75
+| 6 | 37138919,37138920 | 8 | 0 | 0 | P87T |
76
+| 6 | 37138955,37138956 | 7 | 0 | 0 | G99D |
77
+| 6 | 37138955,37138956 | 7 | 0 | 0 | G99N |
78
+| 6 | 37138955,37138956 | 7 | 0 | 0 | G99V |
79
+| 6 | 37138800 | 5 | 0 | 0 | G78E |
80
+| 6 | 37138412 | 3 | 2 | 0 | H21Y |
81
+| 6 | 37139199 | 5 | 0 | 0 | G180A |
82
+| 6 | 37139199 | 5 | 0 | 0 | G180D |
83
+| 6 | 37139199 | 5 | 0 | 0 | G180V |
84
+| 6 | 37138800 | 5 | 0 | 0 | G78A |
85
+| 6 | 37138412 | 3 | 2 | 0 | H21D |
86
+| 6 | 37138412 | 3 | 2 | 0 | H21N |
87
+| 6 | 37138942,37138941 | 4 | 0 | 0 | K94N |
88
+| 6 | 37138973,37138975 | 4 | 0 | 0 | R105S |
89
+| 6 | 37138942,37138941 | 4 | 0 | 0 | K94Nfs*10 |
90
+| 6 | 37138942,37138941 | 4 | 0 | 0 | K94R |
91
+| 6 | 37138973,37138975 | 4 | 0 | 0 | R105G |
92
+| 6 | 37138973,37138975 | 4 | 0 | 0 | R105Sfs*103 |
93
+| 6 | 37139223 | 3 | 0 | 0 | G188E |
94
+| 6 | 37139180 | 2 | 1 | 0 | L174V |
95
+| 6 | 37138928,37138929 | 3 | 0 | 0 | V90L |
96
+| 6 | 37139223 | 3 | 0 | 0 | G188A |
97
+| 6 | 37139180 | 2 | 1 | 0 | L174F |
98
+| 6 | 37138928,37138929 | 3 | 0 | 0 | V90G |
99
+| 6 | 37138406 | 2 | 0 | 0 | D19N |
100
+| 6 | 37138559 | 1 | 1 | 0 | K31N |
101
+| 6 | 37138953 | 2 | 0 | 0 | S98L |
102
+| 6 | 37138427 | 2 | 0 | 0 | A26P |
103
+| 6 | 37138427 | 2 | 0 | 0 | A26T |
104
+| 6 | 37139042,37139043 | 1 | 1 | 0 | D128G |
105
+| 6 | 37139042,37139043 | 1 | 1 | 0 | D128H |
106
+| 6 | 37139021 | 2 | 0 | 0 | E121K |
107
+| 6 | 37139021 | 2 | 0 | 0 | E121Q |
108
+| 6 | 37138430 | 2 | 0 | 0 | P27S |
109
+| 6 | 37138430 | 2 | 0 | 0 | P27T |
110
+| 6 | 37139068,37139067 | 2 | 0 | 0 | R136K |
111
+| 6 | 37139068,37139067 | 2 | 0 | 0 | R136S |
112
+| 6 | 37138761 | 1 | 0 | 0 | A65V |
113
+| nan | nan | 1 | 0 | 0 | DL128EV |
114
+| 6 | 37138409 | 1 | 0 | 0 | L20V |
115
+| 6 | 37138968 | 0 | 1 | 0 | V103A |
116
+| nan | nan | 1 | 0 | 0 | X24_splice |
117
+| nan | nan | 1 | 0 | 0 | X26_splice |
118
+| nan | nan | 1 | 0 | 0 | X28_splice |
tables/hotspots/hotspot_PIM2.md
... ...
@@ -0,0 +1,17 @@
1
+## PIM2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| X | 48775868,48775869 | 9 | 0 | 0 | G39D |
6
+| X | 48775868,48775869 | 9 | 0 | 0 | G39S |
7
+| X | 48775868,48775869 | 9 | 0 | 0 | G39R |
8
+| X | 48775868,48775869 | 9 | 0 | 0 | G39V |
9
+| X | 48775868,48775869 | 9 | 0 | 0 | G39_G42del |
10
+| X | 48775872 | 5 | 0 | 0 | L38M |
11
+| X | 48775872 | 5 | 0 | 0 | L38V |
12
+| X | 48775842,48775841 | 2 | 0 | 0 | A48T |
13
+| X | 48775842,48775841 | 2 | 0 | 0 | A48V |
14
+| X | 48775859 | 2 | 0 | 0 | G42D |
15
+| X | 48775859 | 2 | 0 | 0 | G42V |
16
+| X | 48775855 | 1 | 0 | 0 | F43L |
17
+| X | 48775878 | 1 | 0 | 0 | P36S |
tables/hotspots/hotspot_POU2AF1.md
... ...
@@ -0,0 +1,9 @@
1
+## POU2AF1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 11 | 111249899 | 10 | 1 | 1 | L2F |
6
+| 11 | 111249900,111249901 | 3 | 2 | 0 | M1? |
7
+| 11 | 111249894,111249896 | 2 | 1 | 0 | W3* |
8
+| 11 | 111249894,111249896 | 2 | 1 | 0 | W3R |
9
+| 11 | 111275352 | 1 | 0 | 0 | R6G |
tables/hotspots/hotspot_POU2F2.md
... ...
@@ -0,0 +1,18 @@
1
+## POU2F2 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 19 | 42600029,42600030 | 45 | 25 | 2 | T239A |
6
+| 19 | 42600029,42600030 | 45 | 25 | 2 | T239S |
7
+| 19 | 42600029,42600030 | 45 | 25 | 2 | T239K |
8
+| 19 | 42599541 | 4 | 1 | 0 | V343A |
9
+| 19 | 42600031,42600032 | 1 | 0 | 2 | Q238H |
10
+| 19 | 42600031,42600032 | 1 | 0 | 2 | Q238P |
11
+| 19 | 42600012 | 2 | 0 | 0 | E245K |
12
+| 19 | 42599509 | 1 | 1 | 0 | R354C |
13
+| 19 | 42599528,42599530 | 1 | 1 | 0 | N347H |
14
+| 19 | 42599528,42599530 | 1 | 1 | 0 | N347K |
15
+| 19 | 42599531 | 1 | 0 | 0 | C346W |
16
+| 19 | 42599553 | 1 | 0 | 0 | E339G |
17
+| 19 | 42599749 | 1 | 0 | 0 | R301K |
18
+| 19 | 42599523 | 1 | 0 | 0 | R349H |
tables/hotspots/hotspot_PRDM1.md
... ...
@@ -0,0 +1,10 @@
1
+## PRDM1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 6 | 106536324 | 23 | 0 | 0 | E97= |
6
+| 6 | 106536324 | 23 | 0 | 0 | E97D |
7
+| nan | nan | 5 | 0 | 0 | X97_splice |
8
+| 6 | 106536308 | 1 | 0 | 0 | A92V |
9
+| nan | nan | 1 | 0 | 0 | X95_splice |
10
+| nan | nan | 0 | 0 | 0 | |
tables/hotspots/hotspot_PTPN6.md
... ...
@@ -0,0 +1,10 @@
1
+## PTPN6 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 12 | 7069113 | 3 | 0 | 0 | T462I |
6
+| 12 | 7069101,7069100 | 3 | 0 | 0 | G458S |
7
+| 12 | 7069101,7069100 | 3 | 0 | 0 | G458D |
8
+| 12 | 7069104,7069103 | 2 | 0 | 0 | R459C |
9
+| 12 | 7069104,7069103 | 2 | 0 | 0 | R459H |
10
+| 12 | 7067142 | 1 | 0 | 0 | P423T |
tables/hotspots/hotspot_RHOA.md
... ...
@@ -0,0 +1,24 @@
1
+## RHOA Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 3 | 49413009,49413010 | 16 | 5 | 15 | R5Q |
6
+| 3 | 49413009,49413010 | 16 | 5 | 15 | R5W |
7
+| 3 | 49412898,49412899 | 10 | 1 | 8 | Y42C |
8
+| 3 | 49412898,49412899 | 10 | 1 | 8 | Y42S |
9
+| 3 | 49412898,49412899 | 10 | 1 | 8 | Y42F |
10
+| 3 | 49412898,49412899 | 10 | 1 | 8 | Y42H |
11
+| 3 | 49412898,49412899 | 10 | 1 | 8 | Y42del |
12
+| 3 | 49412922,49412923 | 7 | 1 | 2 | Y34D |
13
+| 3 | 49412922,49412923 | 7 | 1 | 2 | Y34F |
14
+| 3 | 49412922,49412923 | 7 | 1 | 2 | Y34C |
15
+| 3 | 49412922,49412923 | 7 | 1 | 2 | Y34N |
16
+| 3 | 49412922,49412923 | 7 | 1 | 2 | Y34S |
17
+| 3 | 49397742,49397743 | 3 | 0 | 0 | A161T |
18
+| 3 | 49412965 | 2 | 1 | 0 | C20R |
19
+| 3 | 49397742,49397743 | 3 | 0 | 0 | A161V |
20
+| 3 | 49412965 | 2 | 1 | 0 | C20G |
21
+| 3 | 49405962 | 2 | 0 | 0 | D59V |
22
+| 3 | 49412955 | 2 | 0 | 0 | I23R |
23
+| 3 | 49412955 | 2 | 0 | 0 | I23T |
24
+| 3 | 49405971 | 1 | 0 | 0 | A56D |
tables/hotspots/hotspot_RRAGC.md
... ...
@@ -0,0 +1,39 @@
1
+## RRAGC Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 39322723,39322724 | 8 | 9 | 0 | T90N |
6
+| 1 | 39322723,39322724 | 8 | 9 | 0 | T90P |
7
+| 1 | 39322723,39322724 | 8 | 9 | 0 | T90I |
8
+| 1 | 39322647,39322649 | 1 | 10 | 0 | W115R |
9
+| 1 | 39322647,39322649 | 1 | 10 | 0 | W115C |
10
+| 1 | 39325095,39325096 | 2 | 5 | 0 | S75F |
11
+| 1 | 39325095,39325096 | 2 | 5 | 0 | S75A |
12
+| 1 | 39325095,39325096 | 2 | 5 | 0 | S75C |
13
+| 1 | 39322732,39322733 | 3 | 3 | 0 | P87L |
14
+| 1 | 39322636,39322637 | 4 | 2 | 0 | G119R |
15
+| 1 | 39322645,39322646 | 2 | 3 | 1 | D116G |
16
+| 1 | 39322645,39322646 | 2 | 3 | 1 | D116N |
17
+| 1 | 39322636,39322637 | 4 | 2 | 0 | G119E |
18
+| 1 | 39322645,39322646 | 2 | 3 | 1 | D116V |
19
+| 1 | 39322645,39322646 | 2 | 3 | 1 | D116Y |
20
+| 1 | 39322636,39322637 | 4 | 2 | 0 | G119W |
21
+| 1 | 39322732,39322733 | 3 | 3 | 0 | P87S |
22
+| 1 | 39322732,39322733 | 3 | 3 | 0 | P87T |
23
+| 1 | 39322753 | 4 | 1 | 0 | V80A |
24
+| 1 | 39325098 | 1 | 4 | 0 | K74R |
25
+| 1 | 39325098 | 1 | 4 | 0 | K74T |
26
+| 1 | 39325098 | 1 | 4 | 0 | K74W |
27
+| 1 | 39325092 | 1 | 3 | 0 | S76F |
28
+| 1 | 39322639 | 1 | 3 | 0 | P118L |
29
+| 1 | 39322639 | 1 | 3 | 0 | P118H |
30
+| 1 | 39322639 | 1 | 3 | 0 | P118R |
31
+| 1 | 39325092 | 1 | 3 | 0 | S76N |
32
+| 1 | 39325101 | 0 | 3 | 0 | G73D |
33
+| 1 | 39322744 | 1 | 1 | 0 | H83P |
34
+| 1 | 39322696 | 1 | 1 | 0 | I99N |
35
+| 1 | 39322642 | 2 | 0 | 0 | F117S |
36
+| 1 | 39322642 | 2 | 0 | 0 | F117Y |
37
+| 1 | 39322651 | 0 | 2 | 0 | I114K |
38
+| 1 | 39322651 | 0 | 2 | 0 | I114R |
39
+| 1 | 39325120 | 0 | 1 | 0 | M67V |
tables/hotspots/hotspot_SF3B1.md
... ...
@@ -0,0 +1,14 @@
1
+## SF3B1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 2 | 198266833,198266832,198266834 | 4 | 0 | 3 | K700E |
6
+| 2 | 198266833,198266832,198266834 | 4 | 0 | 3 | K700T |
7
+| 2 | 198266833,198266832,198266834 | 4 | 0 | 3 | K700N |
8
+| 2 | 198266821,198266822 | 3 | 0 | 1 | I704S |
9
+| 2 | 198266821,198266822 | 3 | 0 | 1 | I704F |
10
+| 2 | 198266821,198266822 | 3 | 0 | 1 | I704T |
11
+| 2 | 198267379 | 0 | 0 | 1 | A660T |
12
+| 2 | 198267484 | 1 | 0 | 0 | R625C |
13
+| 2 | 198266825 | 1 | 0 | 0 | T703P |
14
+| 2 | 198266831 | 1 | 0 | 0 | V701F |
tables/hotspots/hotspot_SGK1.md
... ...
@@ -0,0 +1,118 @@
1
+## SGK1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| nan | nan | 41 | 2 | 0 | X121_splice |
6
+| 6 | 134495724 | 30 | 7 | 1 | A121G |
7
+| 6 | 134495724 | 30 | 7 | 1 | A121V |
8
+| nan | nan | 20 | 0 | 1 | X146_splice |
9
+| 6 | 134495724,134495727,134495728,134495730,134495729 | 0 | 0 | 0 | |
10
+| 6 | 134495658,134495659 | 17 | 1 | 1 | A143V |
11
+| 6 | 134495658,134495659 | 17 | 1 | 1 | A143E |
12
+| 6 | 134495658,134495659 | 17 | 1 | 1 | A143G |
13
+| 6 | 134495658,134495659 | 17 | 1 | 1 | A143T |
14
+| 6 | 134495658,134495659 | 17 | 1 | 1 | A143P |
15
+| 6 | 134495169 | 15 | 1 | 1 | L163F |
16
+| 6 | 134495169 | 15 | 1 | 1 | L163V |
17
+| 6 | 134495170,134495172,134495171 | 13 | 1 | 1 | E162D |
18
+| 6 | 134495649,134495650 | 10 | 5 | 0 | H146Y |
19
+| 6 | 134495649,134495650 | 10 | 5 | 0 | H146D |
20
+| 6 | 134495649,134495650 | 10 | 5 | 0 | H146N |
21
+| 6 | 134495170,134495172,134495171 | 13 | 1 | 1 | E162A |
22
+| 6 | 134495170,134495172,134495171 | 13 | 1 | 1 | E162G |
23
+| 6 | 134495170,134495172,134495171 | 13 | 1 | 1 | E162Q |
24
+| 6 | 134495649,134495650 | 10 | 5 | 0 | H146P |
25
+| 6 | 134495660,134495661,134495662 | 11 | 3 | 0 | Y142H |
26
+| 6 | 134495660,134495661,134495662 | 11 | 3 | 0 | Y142N |
27
+| 6 | 134495660,134495661,134495662 | 11 | 3 | 0 | Y142* |
28
+| 6 | 134495660,134495661,134495662 | 11 | 3 | 0 | Y142C |
29
+| 6 | 134495660,134495661,134495662 | 11 | 3 | 0 | Y142D |
30
+| 6 | 134495660,134495661,134495662 | 11 | 3 | 0 | Y142F |
31
+| 6 | 134495660,134495661,134495662 | 11 | 3 | 0 | Y142S |
32
+| 6 | 134495673 | 11 | 2 | 0 | A138V |
33
+| 6 | 134495673 | 11 | 2 | 0 | A138G |
34
+| 6 | 134495705,134495706,134495707 | 12 | 0 | 0 | R127T |
35
+| 6 | 134495705,134495706,134495707 | 12 | 0 | 0 | R127K |
36
+| 6 | 134495705,134495706,134495707 | 12 | 0 | 0 | R127M |
37
+| 6 | 134495705,134495706,134495707 | 12 | 0 | 0 | R127S |
38
+| 6 | 134495705,134495706,134495707 | 12 | 0 | 0 | R127W |
39
+| 6 | 134495666,134495667,134495668 | 8 | 2 | 0 | N140K |
40
+| 6 | 134495712,134495713,134495711 | 8 | 2 | 0 | Q125* |
41
+| 6 | 134492803,134492804 | 9 | 1 | 0 | A380G |
42
+| 6 | 134492803,134492804 | 9 | 1 | 0 | A380P |
43
+| 6 | 134492803,134492804 | 9 | 1 | 0 | A380V |
44
+| 6 | 134495666,134495667,134495668 | 8 | 2 | 0 | N140T |
45
+| 6 | 134495712,134495713,134495711 | 8 | 2 | 0 | Q125L |
46
+| 6 | 134492803,134492804 | 9 | 1 | 0 | A380T |
47
+| 6 | 134495666,134495667,134495668 | 8 | 2 | 0 | N140D |
48
+| 6 | 134495712,134495713,134495711 | 8 | 2 | 0 | Q125Dfs*13 |
49
+| 6 | 134495712,134495713,134495711 | 8 | 2 | 0 | Q125H |
50
+| 6 | 134495712,134495713,134495711 | 8 | 2 | 0 | Q125R |
51
+| 6 | 134495703,134495704 | 8 | 1 | 0 | M128K |
52
+| 6 | 134495703,134495704 | 8 | 1 | 0 | M128V |
53
+| 6 | 134495703,134495704 | 8 | 1 | 0 | M128T |
54
+| 6 | 134494484,134494485,134494486 | 7 | 0 | 1 | A210T |
55
+| 6 | 134495210,134495211 | 6 | 1 | 1 | V149I |
56
+| 6 | 134495210,134495211 | 6 | 1 | 1 | V149L |
57
+| 6 | 134494484,134494485,134494486 | 7 | 0 | 1 | A210P |
58
+| 6 | 134494484,134494485,134494486 | 7 | 0 | 1 | A210V |
59
+| 6 | 134495210,134495211 | 6 | 1 | 1 | V149G |
60
+| 6 | 134494484,134494485,134494486 | 7 | 0 | 1 | A210G |
61
+| 6 | 134495682,134495683 | 7 | 0 | 0 | Q135E |
62
+| 6 | 134495700,134495701 | 7 | 0 | 0 | G129S |
63
+| 6 | 134495700,134495701 | 7 | 0 | 0 | G129C |
64
+| 6 | 134495700,134495701 | 7 | 0 | 0 | G129D |
65
+| 6 | 134495700,134495701 | 7 | 0 | 0 | G129H |
66
+| 6 | 134495700,134495701 | 7 | 0 | 0 | G129R |
67
+| 6 | 134495700,134495701 | 7 | 0 | 0 | G129Y |
68
+| 6 | 134495682,134495683 | 7 | 0 | 0 | Q135P |
69
+| 6 | 134495682,134495683 | 7 | 0 | 0 | Q135R |
70
+| 6 | 134495687,134495688 | 4 | 1 | 1 | F133C |
71
+| 6 | 134495709 | 6 | 0 | 0 | R126T |
72
+| 6 | 134494455,134494456 | 6 | 0 | 0 | A220E |
73
+| 6 | 134494455,134494456 | 6 | 0 | 0 | A220T |
74
+| 6 | 134494455,134494456 | 6 | 0 | 0 | A220V |
75
+| 6 | 134495709 | 6 | 0 | 0 | R126K |
76
+| 6 | 134495687,134495688 | 4 | 1 | 1 | F133L |
77
+| 6 | 134495183,134495184 | 4 | 0 | 1 | P158A |
78
+| 6 | 134494650 | 3 | 2 | 0 | P190A |
79
+| 6 | 134495717,134495719 | 4 | 1 | 0 | M123I |
80
+| 6 | 134495717,134495719 | 4 | 1 | 0 | M123L |
81
+| 6 | 134494650 | 3 | 2 | 0 | P190S |
82
+| 6 | 134495717,134495719 | 4 | 1 | 0 | M123V |
83
+| 6 | 134495183,134495184 | 4 | 0 | 1 | P158R |
84
+| 6 | 134495183,134495184 | 4 | 0 | 1 | P158V |
85
+| 6 | 134495166 | 4 | 0 | 0 | M164L |
86
+| 6 | 134495721,134495722 | 2 | 1 | 1 | F122L |
87
+| 6 | 134495671,134495669,134495670 | 3 | 1 | 0 | N139S |
88
+| 6 | 134495721,134495722 | 2 | 1 | 1 | F122C |
89
+| 6 | 134495721,134495722 | 2 | 1 | 1 | F122V |
90
+| 6 | 134495166 | 4 | 0 | 0 | M164V |
91
+| 6 | 134495671,134495669,134495670 | 3 | 1 | 0 | N139K |
92
+| 6 | 134495671,134495669,134495670 | 3 | 1 | 0 | N139Y |
93
+| 6 | 134494462,134494460 | 3 | 0 | 0 | F218L |
94
+| 6 | 134494464,134494465 | 3 | 0 | 0 | V217E |
95
+| 6 | 134493854 | 3 | 0 | 0 | A298D |
96
+| 6 | 134493854 | 3 | 0 | 0 | A298G |
97
+| 6 | 134493854 | 3 | 0 | 0 | A298V |
98
+| 6 | 134494643,134494644,134494642 | 1 | 1 | 1 | D192E |
99
+| 6 | 134494643,134494644,134494642 | 1 | 1 | 1 | D192G |
100
+| 6 | 134494643,134494644,134494642 | 1 | 1 | 1 | D192Y |
101
+| 6 | 134494464,134494465 | 3 | 0 | 0 | V217M |
102
+| 6 | 134493884 | 2 | 0 | 0 | C288Y |
103
+| 6 | 134493873 | 2 | 0 | 0 | P292S |
104
+| 6 | 134495191,134495192 | 2 | 0 | 0 | I155M |
105
+| 6 | 134495191,134495192 | 2 | 0 | 0 | I155S |
106
+| 6 | 134495715 | 2 | 0 | 0 | K124M |
107
+| 6 | 134495715 | 2 | 0 | 0 | K124T |
108
+| 6 | 134495204 | 2 | 0 | 0 | S151C |
109
+| 6 | 134495204 | 2 | 0 | 0 | S151F |
110
+| nan | nan | 1 | 0 | 0 | C144Afs*10 |
111
+| 6 | 134495178 | 0 | 0 | 1 | E160K |
112
+| 6 | 134494639 | 1 | 0 | 0 | F193L |
113
+| 6 | 134494635 | 1 | 0 | 0 | F195L |
114
+| 6 | 134495686 | 1 | 0 | 0 | I134L |
115
+| 6 | 134493900 | 1 | 0 | 0 | L283F |
116
+| 6 | 134492800 | 1 | 0 | 0 | V381A |
117
+| 6 | 134492794 | 1 | 0 | 0 | Y383F |
118
+| 6 | 134492783 | 1 | 0 | 0 | Y387N |
tables/hotspots/hotspot_SMARCA4.md
... ...
@@ -0,0 +1,24 @@
1
+## SMARCA4 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 19 | 11143993,11143994 | 1 | 0 | 10 | R1192C |
6
+| 19 | 11143993,11143994 | 1 | 0 | 10 | R1192H |
7
+| 19 | 11134251,11134252 | 2 | 1 | 6 | R973Q |
8
+| 19 | 11134251,11134252 | 2 | 1 | 6 | R973W |
9
+| 19 | 11134251,11134252 | 2 | 1 | 6 | R973G |
10
+| 19 | 11141507,11141508 | 3 | 0 | 3 | G1162S |
11
+| 19 | 11141507,11141508 | 3 | 0 | 3 | G1162D |
12
+| 19 | 11141507,11141508 | 3 | 0 | 3 | G1162R |
13
+| 19 | 11141507,11141508 | 3 | 0 | 3 | G1162V |
14
+| 19 | 11143999 | 2 | 0 | 1 | G1194R |
15
+| 19 | 11134254,11134255 | 0 | 0 | 3 | P974S |
16
+| 19 | 11134254,11134255 | 0 | 0 | 3 | P974L |
17
+| 19 | 11143976 | 1 | 1 | 0 | A1186V |
18
+| 19 | 11143982 | 1 | 1 | 0 | D1188V |
19
+| 19 | 11123668 | 1 | 0 | 1 | L773P |
20
+| 19 | 11143985 | 0 | 1 | 1 | R1189Q |
21
+| 19 | 11143988 | 1 | 0 | 0 | A1190G |
22
+| 19 | 11141498 | 0 | 1 | 0 | G1159R |
23
+| 19 | 11134241 | 0 | 0 | 1 | H969Q |
24
+| 19 | 11143973 | 0 | 0 | 1 | Q1185L |
tables/hotspots/hotspot_SOCS1.md
... ...
@@ -0,0 +1,113 @@
1
+## SOCS1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 16 | 11348988,11348989 | 26 | 4 | 2 | S116N |
6
+| 16 | 11348988,11348989 | 26 | 4 | 2 | S116T |
7
+| 16 | 11348988,11348989 | 26 | 4 | 2 | S116R |
8
+| 16 | 11348988,11348989 | 26 | 4 | 2 | S116I |
9
+| 16 | 11348961,11348962 | 22 | 5 | 0 | S125T |
10
+| 16 | 11348961,11348962 | 22 | 5 | 0 | S125R |
11
+| 16 | 11348961,11348962 | 22 | 5 | 0 | S125N |
12
+| 16 | 11348961,11348962 | 22 | 5 | 0 | S125I |
13
+| 16 | 11348961,11348962 | 22 | 5 | 0 | S125Rfs*125 |
14
+| 16 | 11348949,11348950,11348951 | 14 | 3 | 0 | H129Q |
15
+| 16 | 11348949,11348950,11348951 | 14 | 3 | 0 | H129N |
16
+| 16 | 11348949,11348950,11348951 | 14 | 3 | 0 | H129Y |
17
+| 16 | 11348949,11348950,11348951 | 14 | 3 | 0 | H129L |
18
+| 16 | 11348949,11348950,11348951 | 14 | 3 | 0 | H129P |
19
+| 16 | 11348971,11348972 | 11 | 4 | 0 | G122R |
20
+| 16 | 11348971,11348972 | 11 | 4 | 0 | G122* |
21
+| 16 | 11348971,11348972 | 11 | 4 | 0 | G122A |
22
+| 16 | 11348943,11348944,11348945 | 11 | 2 | 0 | Q131* |
23
+| 16 | 11348943,11348944,11348945 | 11 | 2 | 0 | Q131H |
24
+| 16 | 11348943,11348944,11348945 | 11 | 2 | 0 | Q131L |
25
+| 16 | 11348943,11348944,11348945 | 11 | 2 | 0 | Q131P |
26
+| 16 | 11348943,11348944,11348945 | 11 | 2 | 0 | Q131R |
27
+| 16 | 11348943,11348944,11348945 | 11 | 2 | 0 | Q131Rfs*122 |
28
+| 16 | 11349093,11349095,11349094 | 9 | 1 | 0 | W81* |
29
+| 16 | 11349018,11349020,11349019 | 10 | 0 | 0 | S106R |
30
+| 16 | 11349018,11349020,11349019 | 10 | 0 | 0 | S106G |
31
+| 16 | 11349018,11349020,11349019 | 10 | 0 | 0 | S106Ifs*5 |
32
+| 16 | 11349018,11349020,11349019 | 10 | 0 | 0 | S106N |
33
+| 16 | 11349018,11349020,11349019 | 10 | 0 | 0 | S106Rfs*14 |
34
+| 16 | 11349093,11349095,11349094 | 9 | 1 | 0 | W81G |
35
+| 16 | 11349093,11349095,11349094 | 9 | 1 | 0 | W81L |
36
+| 16 | 11349093,11349095,11349094 | 9 | 1 | 0 | W81R |
37
+| 16 | 11349099,11349101 | 8 | 1 | 0 | F79L |
38
+| 16 | 11349099,11349101 | 8 | 1 | 0 | F79V |
39
+| 16 | 11349099,11349101 | 8 | 1 | 0 | F79I |
40
+| 16 | 11349099,11349101 | 8 | 1 | 0 | F79S |
41
+| 16 | 11348853,11348855 | 8 | 0 | 0 | M161I |
42
+| 16 | 11348853,11348855 | 8 | 0 | 0 | M161L |
43
+| 16 | 11349003,11349004 | 7 | 0 | 0 | C111W |
44
+| 16 | 11349003,11349004 | 7 | 0 | 0 | C111F |
45
+| 16 | 11349003,11349004 | 7 | 0 | 0 | C111S |
46
+| 16 | 11349003,11349004 | 7 | 0 | 0 | C111Y |
47
+| 16 | 11349006 | 5 | 1 | 0 | N110K |
48
+| 16 | 11348920 | 5 | 1 | 0 | G139V |
49
+| 16 | 11349040 | 4 | 2 | 0 | G99D |
50
+| 16 | 11349037,11349038 | 6 | 0 | 0 | T100I |
51
+| 16 | 11348977,11348978 | 6 | 0 | 0 | A120G |
52
+| 16 | 11348977,11348978 | 6 | 0 | 0 | A120V |
53
+| 16 | 11348920 | 5 | 1 | 0 | G139D |
54
+| 16 | 11349040 | 4 | 2 | 0 | G99A |
55
+| 16 | 11349037,11349038 | 6 | 0 | 0 | T100S |
56
+| 16 | 11348977,11348978 | 6 | 0 | 0 | A120T |
57
+| 16 | 11348977,11348978 | 6 | 0 | 0 | A120_S121dup |
58
+| 16 | 11349037,11349038 | 6 | 0 | 0 | T100P |
59
+| 16 | 11348932,11348933 | 4 | 1 | 0 | F135C |
60
+| 16 | 11348956 | 5 | 0 | 0 | R127H |
61
+| 16 | 11348923,11348924 | 3 | 2 | 0 | D138G |
62
+| 16 | 11348923,11348924 | 3 | 2 | 0 | D138H |
63
+| 16 | 11348959,11348960 | 5 | 0 | 0 | I126T |
64
+| 16 | 11348923,11348924 | 3 | 2 | 0 | D138A |
65
+| 16 | 11348932,11348933 | 4 | 1 | 0 | F135L |
66
+| 16 | 11348959,11348960 | 5 | 0 | 0 | I126F |
67
+| 16 | 11348959,11348960 | 5 | 0 | 0 | I126L |
68
+| 16 | 11348959,11348960 | 5 | 0 | 0 | I126Tfs*126 |
69
+| 16 | 11348956 | 5 | 0 | 0 | R127P |
70
+| 16 | 11349047 | 4 | 0 | 0 | P97A |
71
+| 16 | 11349047 | 4 | 0 | 0 | P97S |
72
+| 16 | 11349012 | 3 | 0 | 0 | Q108H |
73
+| 16 | 11348981,11348980 | 3 | 0 | 0 | M119V |
74
+| 16 | 11349011,11349010 | 2 | 1 | 0 | R109W |
75
+| 16 | 11349028 | 3 | 0 | 0 | V103dup |
76
+| 16 | 11348983,11348984 | 3 | 0 | 0 | K118E |
77
+| 16 | 11348983,11348984 | 3 | 0 | 0 | K118R |
78
+| 16 | 11348983,11348984 | 3 | 0 | 0 | K118Sfs*136 |
79
+| 16 | 11349032,11349031 | 3 | 0 | 0 | L102Pfs*15 |
80
+| 16 | 11349032,11349031 | 3 | 0 | 0 | L102Q |
81
+| 16 | 11349032,11349031 | 3 | 0 | 0 | L102V |
82
+| 16 | 11348981,11348980 | 3 | 0 | 0 | M119K |
83
+| 16 | 11348968,11348969 | 3 | 0 | 0 | P123L |
84
+| 16 | 11348968,11348969 | 3 | 0 | 0 | P123S |
85
+| 16 | 11348968,11348969 | 3 | 0 | 0 | P123Sfs*79 |
86
+| 16 | 11349011,11349010 | 2 | 1 | 0 | R109Q |
87
+| 16 | 11349028 | 3 | 0 | 0 | V103G |
88
+| 16 | 11348930 | 0 | 2 | 0 | H136Y |
89
+| 16 | 11348852 | 2 | 0 | 0 | L162V |
90
+| 16 | 11349022 | 1 | 1 | 0 | D105A |
91
+| 16 | 11349022 | 1 | 1 | 0 | D105G |
92
+| nan | nan | 2 | 0 | 0 | E91Afs*24 |
93
+| nan | nan | 2 | 0 | 0 | E91Gfs*22 |
94
+| 16 | 11349035 | 1 | 1 | 0 | F101I |
95
+| 16 | 11349035 | 1 | 1 | 0 | F101L |
96
+| 16 | 11349001 | 1 | 1 | 0 | F112S |
97
+| 16 | 11349001 | 1 | 1 | 0 | F112Y |
98
+| 16 | 11348935,11348936 | 1 | 1 | 0 | R134C |
99
+| 16 | 11348935,11348936 | 1 | 1 | 0 | R134L |
100
+| 16 | 11348987 | 1 | 1 | 0 | V117L |
101
+| 16 | 11348987 | 1 | 1 | 0 | V117M |
102
+| 16 | 11348995 | 1 | 0 | 0 | A114D |
103
+| nan | nan | 1 | 0 | 0 | A89_L93delinsV |
104
+| nan | nan | 1 | 0 | 0 | E96Rfs*19 |
105
+| 16 | 11348998 | 1 | 0 | 0 | F113S |
106
+| 16 | 11348948 | 0 | 1 | 0 | F130L |
107
+| 16 | 11348938 | 1 | 0 | 0 | G133A |
108
+| nan | nan | 1 | 0 | 0 | G88Cfs*25 |
109
+| 16 | 11349026 | 1 | 0 | 0 | R104C |
110
+| 16 | 11349017 | 1 | 0 | 0 | R107G |
111
+| nan | nan | 1 | 0 | 0 | T124Afs*71 |
112
+| 16 | 11348953 | 1 | 0 | 0 | V128G |
113
+| nan | nan | 1 | 0 | 0 | V98Rfs*19 |
tables/hotspots/hotspot_SPEN.md
... ...
@@ -0,0 +1,7 @@
1
+## SPEN Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 16256847,16256846 | 2 | 2 | 0 | R1371* |
6
+| 1 | 16256847,16256846 | 2 | 2 | 0 | R1371Q |
7
+| 1 | 16256831 | 2 | 0 | 0 | R1366* |
tables/hotspots/hotspot_STAT3.md
... ...
@@ -0,0 +1,39 @@
1
+## STAT3 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 17 | 40475325 | 14 | 0 | 0 | N567K |
6
+| 17 | 40475063,40475064 | 11 | 0 | 0 | E616G |
7
+| 17 | 40475063,40475064 | 11 | 0 | 0 | E616K |
8
+| 17 | 40475063,40475064 | 11 | 0 | 0 | E616Q |
9
+| 17 | 40475063,40475064 | 11 | 0 | 0 | E616Rfs*15 |
10
+| 17 | 40475068,40475070 | 9 | 1 | 0 | S614R |
11
+| 17 | 40475068,40475070 | 9 | 1 | 0 | S614K |
12
+| 17 | 40475329,40475330 | 9 | 0 | 0 | D566N |
13
+| 17 | 40475329,40475330 | 9 | 0 | 0 | D566A |
14
+| 17 | 40475329,40475330 | 9 | 0 | 0 | D566G |
15
+| 17 | 40475329,40475330 | 9 | 0 | 0 | D566H |
16
+| 17 | 40475329,40475330 | 9 | 0 | 0 | D566V |
17
+| 17 | 40475329,40475330 | 9 | 0 | 0 | D566Y |
18
+| 17 | 40474482 | 8 | 0 | 0 | Y640F |
19
+| 17 | 40474419,40474420 | 8 | 0 | 0 | D661Y |
20
+| 17 | 40475317,40475318 | 7 | 1 | 0 | D570G |
21
+| 17 | 40475317,40475318 | 7 | 1 | 0 | D570N |
22
+| 17 | 40475317,40475318 | 7 | 1 | 0 | D570A |
23
+| 17 | 40474419,40474420 | 8 | 0 | 0 | D661A |
24
+| 17 | 40474419,40474420 | 8 | 0 | 0 | D661H |
25
+| 17 | 40474419,40474420 | 8 | 0 | 0 | D661V |
26
+| 17 | 40469200 | 5 | 1 | 0 | P715L |
27
+| 17 | 40474428,40474427,40474429 | 4 | 0 | 0 | K658R |
28
+| 17 | 40474428,40474427,40474429 | 4 | 0 | 0 | K658* |
29
+| 17 | 40474428,40474427,40474429 | 4 | 0 | 0 | K658N |
30
+| 17 | 40474461 | 3 | 0 | 0 | N647I |
31
+| 17 | 40474444 | 1 | 1 | 0 | I653V |
32
+| 17 | 40474408 | 2 | 0 | 0 | I665L |
33
+| 17 | 40474408 | 2 | 0 | 0 | I665V |
34
+| 17 | 40474447 | 1 | 0 | 0 | E652K |
35
+| 17 | 40474354 | 0 | 1 | 0 | F683V |
36
+| 17 | 40475058 | 1 | 0 | 0 | G618R |
37
+| 17 | 40474458 | 1 | 0 | 0 | M648K |
38
+| 17 | 40469203 | 1 | 0 | 0 | T714I |
39
+| 17 | 40474402 | 1 | 0 | 0 | V667L |
tables/hotspots/hotspot_STAT6.md
... ...
@@ -0,0 +1,34 @@
1
+## STAT6 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 12 | 57496661,57496662 | 44 | 40 | 0 | D419G |
6
+| 12 | 57496661,57496662 | 44 | 40 | 0 | D419N |
7
+| 12 | 57496661,57496662 | 44 | 40 | 0 | D419H |
8
+| 12 | 57496661,57496662 | 44 | 40 | 0 | D419A |
9
+| 12 | 57496661,57496662 | 44 | 40 | 0 | D419V |
10
+| 12 | 57496661,57496662 | 44 | 40 | 0 | D419Y |
11
+| 12 | 57498344,57498345 | 5 | 14 | 0 | E372K |
12
+| 12 | 57498344,57498345 | 5 | 14 | 0 | E372A |
13
+| 12 | 57498329,57498330 | 5 | 12 | 1 | E377K |
14
+| 12 | 57498329,57498330 | 5 | 12 | 1 | E377A |
15
+| 12 | 57498329,57498330 | 5 | 12 | 1 | E377G |
16
+| 12 | 57493830,57493831 | 3 | 12 | 0 | D519N |
17
+| 12 | 57493830,57493831 | 3 | 12 | 0 | D519V |
18
+| 12 | 57493830,57493831 | 3 | 12 | 0 | D519H |
19
+| 12 | 57493830,57493831 | 3 | 12 | 0 | D519Y |
20
+| 12 | 57493830,57493831 | 3 | 12 | 0 | D519G |
21
+| 12 | 57496657,57496658 | 6 | 5 | 1 | N420S |
22
+| 12 | 57496657,57496658 | 6 | 5 | 1 | N420K |
23
+| 12 | 57496657,57496658 | 6 | 5 | 1 | N420T |
24
+| 12 | 57496667,57496668,57496666 | 9 | 2 | 0 | N417Y |
25
+| 12 | 57496667,57496668,57496666 | 9 | 2 | 0 | N417K |
26
+| 12 | 57496667,57496668,57496666 | 9 | 2 | 0 | N417S |
27
+| 12 | 57493818,57493819 | 1 | 8 | 0 | D523V |
28
+| 12 | 57493818,57493819 | 1 | 8 | 0 | D523N |
29
+| 12 | 57493818,57493819 | 1 | 8 | 0 | D523G |
30
+| 12 | 57493818,57493819 | 1 | 8 | 0 | D523H |
31
+| 12 | 57496654,57496655,57496656 | 4 | 3 | 1 | N421K |
32
+| 12 | 57496654,57496655,57496656 | 4 | 3 | 1 | N421D |
33
+| 12 | 57496654,57496655,57496656 | 4 | 3 | 1 | N421S |
34
+| 12 | 57496671 | 1 | 2 | 0 | G416R |
tables/hotspots/hotspot_TAF1.md
... ...
@@ -0,0 +1,13 @@
1
+## TAF1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| X | 70612788,70612789 | 2 | 2 | 0 | L1019F |
6
+| X | 70612788,70612789 | 2 | 2 | 0 | L1019P |
7
+| X | 70612788,70612789 | 2 | 2 | 0 | L1019R |
8
+| X | 70612795 | 2 | 0 | 0 | L1021P |
9
+| X | 70612795 | 2 | 0 | 0 | L1021R |
10
+| X | 70612783,70612782 | 2 | 0 | 0 | R1017C |
11
+| X | 70612783,70612782 | 2 | 0 | 0 | R1017H |
12
+| X | 70612764 | 0 | 1 | 0 | G1011R |
13
+| X | 70612779 | 1 | 0 | 0 | L1016I |
tables/hotspots/hotspot_TBL1XR1.md
... ...
@@ -0,0 +1,56 @@
1
+## TBL1XR1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 3 | 176750838,176750839 | 19 | 2 | 2 | Y446C |
6
+| 3 | 176750838,176750839 | 19 | 2 | 2 | Y446S |
7
+| 3 | 176750838,176750839 | 19 | 2 | 2 | Y446H |
8
+| 3 | 176750838,176750839 | 19 | 2 | 2 | Y446N |
9
+| 3 | 176752052,176752053 | 11 | 5 | 2 | Y395C |
10
+| 3 | 176752052,176752053 | 11 | 5 | 2 | Y395D |
11
+| 3 | 176752052,176752053 | 11 | 5 | 2 | Y395N |
12
+| 3 | 176752052,176752053 | 11 | 5 | 2 | Y395S |
13
+| 3 | 176752052,176752053 | 11 | 5 | 2 | Y395H |
14
+| 3 | 176750916,176750917 | 8 | 0 | 0 | F420S |
15
+| 3 | 176765152,176765153 | 6 | 2 | 0 | G267V |
16
+| 3 | 176765152,176765153 | 6 | 2 | 0 | G267S |
17
+| 3 | 176750916,176750917 | 8 | 0 | 0 | F420C |
18
+| 3 | 176750916,176750917 | 8 | 0 | 0 | F420L |
19
+| 3 | 176765152,176765153 | 6 | 2 | 0 | G267C |
20
+| 3 | 176765152,176765153 | 6 | 2 | 0 | G267D |
21
+| 3 | 176750835,176750836 | 4 | 1 | 1 | S447N |
22
+| 3 | 176750835,176750836 | 4 | 1 | 1 | S447R |
23
+| 3 | 176750835,176750836 | 4 | 1 | 1 | S447G |
24
+| 3 | 176750835,176750836 | 4 | 1 | 1 | S447I |
25
+| 3 | 176755901,176755902 | 4 | 1 | 0 | D369E |
26
+| 3 | 176765143 | 5 | 0 | 0 | F270C |
27
+| 3 | 176750853,176750854 | 5 | 0 | 0 | H441L |
28
+| 3 | 176765143 | 5 | 0 | 0 | F270S |
29
+| 3 | 176755901,176755902 | 4 | 1 | 0 | D369A |
30
+| 3 | 176755901,176755902 | 4 | 1 | 0 | D369G |
31
+| 3 | 176750853,176750854 | 5 | 0 | 0 | H441R |
32
+| 3 | 176750853,176750854 | 5 | 0 | 0 | H441Y |
33
+| 3 | 176755949 | 3 | 0 | 1 | N353K |
34
+| 3 | 176755911,176755912 | 3 | 0 | 1 | S366P |
35
+| 3 | 176755911,176755912 | 3 | 0 | 1 | S366C |
36
+| 3 | 176752066,176752067 | 3 | 0 | 0 | H390Q |
37
+| 3 | 176752066,176752067 | 3 | 0 | 0 | H390R |
38
+| 3 | 176767799 | 2 | 0 | 0 | S230P |
39
+| 3 | 176767805 | 2 | 0 | 0 | V228L |
40
+| 3 | 176765310,176765309 | 1 | 1 | 0 | S244F |
41
+| 3 | 176765310,176765309 | 1 | 1 | 0 | S244P |
42
+| 3 | 176750919,176750920 | 2 | 0 | 0 | S419F |
43
+| 3 | 176750919,176750920 | 2 | 0 | 0 | S419P |
44
+| 3 | 176750793 | 2 | 0 | 0 | S461F |
45
+| 3 | 176750793 | 2 | 0 | 0 | S461Y |
46
+| 3 | 176744211 | 0 | 1 | 0 | C490R |
47
+| 3 | 176767917 | 1 | 0 | 0 | D190E |
48
+| 3 | 176752059 | 0 | 1 | 0 | E393K |
49
+| 3 | 176768309 | 1 | 0 | 0 | F173V |
50
+| 3 | 176765312 | 0 | 0 | 1 | G243V |
51
+| 3 | 176752054 | 1 | 0 | 0 | I394M |
52
+| 3 | 176755886 | 0 | 0 | 1 | K374N |
53
+| nan | nan | 1 | 0 | 0 | K440_H441del |
54
+| 3 | 176756171 | 1 | 0 | 0 | S326T |
55
+| 3 | 176755905 | 0 | 1 | 0 | S368F |
56
+| 3 | 176767801 | 0 | 0 | 1 | T229K |
tables/hotspots/hotspot_TCF3.md
... ...
@@ -0,0 +1,12 @@
1
+## TCF3 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 19 | 1612336,1612337,1612338 | 1 | 0 | 14 | D561E |
6
+| 19 | 1612336,1612337,1612338 | 1 | 0 | 14 | D561A |
7
+| 19 | 1612336,1612337,1612338 | 1 | 0 | 14 | D561V |
8
+| 19 | 1612336,1612337,1612338 | 1 | 0 | 14 | D561Y |
9
+| 19 | 1612349 | 1 | 0 | 11 | V557E |
10
+| 19 | 1612349 | 1 | 0 | 11 | V557A |
11
+| 19 | 1612344 | 0 | 0 | 4 | V559M |
12
+| 19 | 1612329 | 1 | 0 | 0 | E564K |
tables/hotspots/hotspot_TCL1A.md
... ...
@@ -0,0 +1,18 @@
1
+## TCL1A Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 14 | 96180291 | 8 | 2 | 4 | T38I |
6
+| 14 | 96180291 | 8 | 2 | 4 | T38S |
7
+| 14 | 96180291 | 8 | 2 | 4 | T38N |
8
+| 14 | 96180327,96180328 | 6 | 1 | 2 | Y26C |
9
+| 14 | 96180327,96180328 | 6 | 1 | 2 | Y26F |
10
+| 14 | 96180327,96180328 | 6 | 1 | 2 | Y26D |
11
+| 14 | 96180327,96180328 | 6 | 1 | 2 | Y26S |
12
+| 14 | 96180302,96180304 | 2 | 0 | 2 | W34* |
13
+| 14 | 96180302,96180304 | 2 | 0 | 2 | W34C |
14
+| 14 | 96180302,96180304 | 2 | 0 | 2 | W34R |
15
+| 14 | 96180300 | 2 | 0 | 1 | L35P |
16
+| 14 | 96180300 | 2 | 0 | 1 | L35Q |
17
+| 14 | 96180307 | 1 | 0 | 0 | A33T |
18
+| 14 | 96180339 | 0 | 0 | 1 | E22G |
tables/hotspots/hotspot_TFAP4.md
... ...
@@ -0,0 +1,11 @@
1
+## TFAP4 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 16 | 4312613,4312614 | 2 | 0 | 12 | R60C |
6
+| 16 | 4312613,4312614 | 2 | 0 | 12 | R60H |
7
+| 16 | 4312619,4312620 | 1 | 0 | 5 | R58Q |
8
+| 16 | 4312619,4312620 | 1 | 0 | 5 | R58W |
9
+| 16 | 4312644 | 0 | 0 | 3 | R50W |
10
+| 16 | 4312623 | 1 | 0 | 1 | E57K |
11
+| 16 | 4312623 | 1 | 0 | 1 | E57Q |
tables/hotspots/hotspot_TNFRSF14.md
... ...
@@ -0,0 +1,26 @@
1
+## TNFRSF14 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 1 | 2488104,2488105,2488106 | 23 | 19 | 1 | M1? |
6
+| 1 | 2488138,2488139 | 16 | 24 | 0 | W12* |
7
+| 1 | 2488138,2488139 | 16 | 24 | 0 | W12Gfs*10 |
8
+| 1 | 2488123,2488124 | 5 | 9 | 0 | W7* |
9
+| 1 | 2488123,2488124 | 5 | 9 | 0 | W7S |
10
+| 1 | 2488123,2488124 | 5 | 9 | 0 | W7Cfs*13 |
11
+| 1 | 2488123,2488124 | 5 | 9 | 0 | W7Cfs*14 |
12
+| 1 | 2488152 | 1 | 4 | 0 | K17* |
13
+| 1 | 2488152 | 1 | 4 | 0 | K17Qfs*60 |
14
+| 1 | 2488109,2488107 | 3 | 1 | 0 | E2* |
15
+| nan | nan | 2 | 2 | 0 | D6Lfs*70 |
16
+| nan | nan | 2 | 2 | 0 | D6Afs*74 |
17
+| nan | nan | 2 | 2 | 0 | D6Sfs*66 |
18
+| 1 | 2488109,2488107 | 3 | 1 | 0 | E2D |
19
+| nan | nan | 2 | 0 | 0 | P9Lfs*13 |
20
+| 1 | 2488116,2488117 | 1 | 1 | 0 | G5* |
21
+| 1 | 2488116,2488117 | 1 | 1 | 0 | G5E |
22
+| 1 | 2488132 | 0 | 1 | 0 | P10H |
23
+| nan | nan | 1 | 0 | 0 | P4Qfs*5 |
24
+| 1 | 2488140 | 1 | 0 | 0 | R13* |
25
+| 1 | 2488144 | 1 | 0 | 0 | S14C |
26
+| 1 | 2488156 | 0 | 1 | 0 | T18N |
tables/hotspots/hotspot_TOX.md
... ...
@@ -0,0 +1,12 @@
1
+## TOX Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 8 | 60031445,60031446 | 17 | 1 | 0 | K34= |
6
+| 8 | 60031445,60031446 | 17 | 1 | 0 | K34R |
7
+| 8 | 60031445,60031446 | 17 | 1 | 0 | K34N |
8
+| 8 | 60031445,60031446 | 17 | 1 | 0 | K34T |
9
+| 8 | 60031454 | 2 | 0 | 0 | Y31* |
10
+| 8 | 60031454 | 2 | 0 | 0 | Y31del |
11
+| 8 | 60031451 | 0 | 1 | 0 | C32* |
12
+| nan | nan | 1 | 0 | 0 | N33Tfs*10 |
tables/hotspots/hotspot_TP53.md
... ...
@@ -0,0 +1,188 @@
1
+## TP53 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 17 | 7577538,7577539 | 44 | 5 | 26 | R248Q |
6
+| 17 | 7577538,7577539 | 44 | 5 | 26 | R248W |
7
+| 17 | 7577120,7577121 | 32 | 5 | 28 | R273C |
8
+| 17 | 7577120,7577121 | 32 | 5 | 28 | R273H |
9
+| 17 | 7577120,7577121 | 32 | 5 | 28 | R273L |
10
+| 17 | 7577120,7577121 | 32 | 5 | 28 | R273G |
11
+| 17 | 7577120,7577121 | 32 | 5 | 28 | R273S |
12
+| 17 | 7578406 | 32 | 3 | 11 | R175H |
13
+| 17 | 7577580,7577581,7577579 | 17 | 3 | 8 | Y234H |
14
+| 17 | 7577580,7577581,7577579 | 17 | 3 | 8 | Y234N |
15
+| 17 | 7577580,7577581,7577579 | 17 | 3 | 8 | Y234S |
16
+| 17 | 7577580,7577581,7577579 | 17 | 3 | 8 | Y234C |
17
+| 17 | 7577580,7577581,7577579 | 17 | 3 | 8 | Y234* |
18
+| 17 | 7577580,7577581,7577579 | 17 | 3 | 8 | Y234D |
19
+| 17 | 7577547,7577548 | 15 | 0 | 10 | G245S |
20
+| 17 | 7577547,7577548 | 15 | 0 | 10 | G245D |
21
+| 17 | 7577547,7577548 | 15 | 0 | 10 | G245C |
22
+| 17 | 7577547,7577548 | 15 | 0 | 10 | G245R |
23
+| 17 | 7577547,7577548 | 15 | 0 | 10 | G245V |
24
+| 17 | 7577093,7577094 | 17 | 0 | 5 | R282W |
25
+| 17 | 7577093,7577094 | 17 | 0 | 5 | R282P |
26
+| 17 | 7577093,7577094 | 17 | 0 | 5 | R282G |
27
+| 17 | 7577093,7577094 | 17 | 0 | 5 | R282Q |
28
+| 17 | 7578402,7578403,7578404 | 15 | 0 | 2 | C176F |
29
+| 17 | 7578402,7578403,7578404 | 15 | 0 | 2 | C176R |
30
+| 17 | 7578402,7578403,7578404 | 15 | 0 | 2 | C176S |
31
+| 17 | 7578402,7578403,7578404 | 15 | 0 | 2 | C176Y |
32
+| 17 | 7578402,7578403,7578404 | 15 | 0 | 2 | C176G |
33
+| 17 | 7578402,7578403,7578404 | 15 | 0 | 2 | C176W |
34
+| 17 | 7578211,7578212 | 10 | 0 | 5 | R213* |
35
+| 17 | 7578211,7578212 | 10 | 0 | 5 | R213Q |
36
+| 17 | 7578234,7578235,7578236 | 11 | 2 | 2 | Y205C |
37
+| 17 | 7578234,7578235,7578236 | 11 | 2 | 2 | Y205N |
38
+| 17 | 7578234,7578235,7578236 | 11 | 2 | 2 | Y205D |
39
+| 17 | 7578234,7578235,7578236 | 11 | 2 | 2 | Y205H |
40
+| 17 | 7578211,7578212 | 10 | 0 | 5 | R213G |
41
+| 17 | 7578211,7578212 | 10 | 0 | 5 | R213L |
42
+| 17 | 7578234,7578235,7578236 | 11 | 2 | 2 | Y205* |
43
+| 17 | 7578234,7578235,7578236 | 11 | 2 | 2 | Y205F |
44
+| 17 | 7578234,7578235,7578236 | 11 | 2 | 2 | Y205S |
45
+| 17 | 7577565,7577566,7577564 | 10 | 1 | 2 | N239D |
46
+| 17 | 7577565,7577566,7577564 | 10 | 1 | 2 | N239S |
47
+| 17 | 7577565,7577566,7577564 | 10 | 1 | 2 | N239T |
48
+| 17 | 7577565,7577566,7577564 | 10 | 1 | 2 | N239K |
49
+| 17 | 7578412,7578413 | 9 | 0 | 3 | V173M |
50
+| 17 | 7577574,7577575 | 10 | 0 | 2 | Y236C |
51
+| 17 | 7577574,7577575 | 10 | 0 | 2 | Y236D |
52
+| 17 | 7577574,7577575 | 10 | 0 | 2 | Y236H |
53
+| 17 | 7578412,7578413 | 9 | 0 | 3 | V173L |
54
+| 17 | 7577574,7577575 | 10 | 0 | 2 | Y236N |
55
+| 17 | 7578412,7578413 | 9 | 0 | 3 | V173A |
56
+| 17 | 7578412,7578413 | 9 | 0 | 3 | V173Efs*7 |
57
+| 17 | 7578412,7578413 | 9 | 0 | 3 | V173G |
58
+| 17 | 7577574,7577575 | 10 | 0 | 2 | Y236S |
59
+| 17 | 7578203,7578202 | 7 | 0 | 3 | V216M |
60
+| 17 | 7578393,7578394,7578395 | 7 | 0 | 3 | H179R |
61
+| 17 | 7578203,7578202 | 7 | 0 | 3 | V216L |
62
+| 17 | 7578393,7578394,7578395 | 7 | 0 | 3 | H179L |
63
+| 17 | 7578393,7578394,7578395 | 7 | 0 | 3 | H179Q |
64
+| 17 | 7578393,7578394,7578395 | 7 | 0 | 3 | H179Y |
65
+| 17 | 7578203,7578202 | 7 | 0 | 3 | V216G |
66
+| 17 | 7578262,7578263 | 8 | 0 | 1 | R196* |
67
+| 17 | 7578262,7578263 | 8 | 0 | 1 | R196P |
68
+| 17 | 7577550,7577551 | 4 | 2 | 2 | G244D |
69
+| 17 | 7577559,7577560 | 4 | 1 | 3 | S241P |
70
+| 17 | 7578525,7578526,7578527 | 4 | 1 | 3 | C135F |
71
+| 17 | 7578442,7578443 | 7 | 0 | 1 | Y163C |
72
+| 17 | 7578442,7578443 | 7 | 0 | 1 | Y163D |
73
+| 17 | 7578525,7578526,7578527 | 4 | 1 | 3 | C135Y |
74
+| 17 | 7577559,7577560 | 4 | 1 | 3 | S241A |
75
+| 17 | 7577559,7577560 | 4 | 1 | 3 | S241F |
76
+| 17 | 7578525,7578526,7578527 | 4 | 1 | 3 | C135G |
77
+| 17 | 7578525,7578526,7578527 | 4 | 1 | 3 | C135R |
78
+| 17 | 7578525,7578526,7578527 | 4 | 1 | 3 | C135W |
79
+| 17 | 7577550,7577551 | 4 | 2 | 2 | G244R |
80
+| 17 | 7577550,7577551 | 4 | 2 | 2 | G244S |
81
+| 17 | 7577550,7577551 | 4 | 2 | 2 | G244V |
82
+| 17 | 7578442,7578443 | 7 | 0 | 1 | Y163H |
83
+| 17 | 7578442,7578443 | 7 | 0 | 1 | Y163N |
84
+| 17 | 7578508,7578509 | 4 | 1 | 2 | C141Y |
85
+| 17 | 7578457 | 2 | 0 | 5 | R158H |
86
+| 17 | 7577556,7577557 | 5 | 1 | 1 | C242S |
87
+| 17 | 7577556,7577557 | 5 | 1 | 1 | C242R |
88
+| 17 | 7577556,7577557 | 5 | 1 | 1 | C242Y |
89
+| 17 | 7578508,7578509 | 4 | 1 | 2 | C141G |
90
+| 17 | 7578457 | 2 | 0 | 5 | R158L |
91
+| 17 | 7578553 | 3 | 0 | 3 | Y126C |
92
+| 17 | 7577535,7577536 | 3 | 0 | 3 | R249G |
93
+| 17 | 7578204,7578205,7578206 | 2 | 0 | 4 | S215R |
94
+| 17 | 7577567,7577568,7577569 | 4 | 0 | 2 | C238Y |
95
+| 17 | 7578460,7578461 | 3 | 2 | 1 | V157F |
96
+| 17 | 7578271,7578272 | 3 | 2 | 1 | H193L |
97
+| 17 | 7578271,7578272 | 3 | 2 | 1 | H193R |
98
+| 17 | 7577567,7577568,7577569 | 4 | 0 | 2 | C238G |
99
+| 17 | 7577567,7577568,7577569 | 4 | 0 | 2 | C238S |
100
+| 17 | 7577567,7577568,7577569 | 4 | 0 | 2 | C238W |
101
+| 17 | 7578271,7578272 | 3 | 2 | 1 | H193D |
102
+| 17 | 7578271,7578272 | 3 | 2 | 1 | H193Y |
103
+| 17 | 7577535,7577536 | 3 | 0 | 3 | R249T |
104
+| 17 | 7578204,7578205,7578206 | 2 | 0 | 4 | S215N |
105
+| 17 | 7578204,7578205,7578206 | 2 | 0 | 4 | S215T |
106
+| 17 | 7578460,7578461 | 3 | 2 | 1 | V157A |
107
+| 17 | 7578460,7578461 | 3 | 2 | 1 | V157D |
108
+| 17 | 7578460,7578461 | 3 | 2 | 1 | V157G |
109
+| 17 | 7578449 | 2 | 1 | 2 | A161T |
110
+| 17 | 7579312,7579313 | 2 | 0 | 3 | T125= |
111
+| 17 | 7578517,7578518 | 4 | 0 | 1 | A138P |
112
+| 17 | 7578517,7578518 | 4 | 0 | 1 | A138V |
113
+| 17 | 7578534,7578535,7578536 | 3 | 0 | 2 | K132Q |
114
+| 17 | 7577106,7577105 | 4 | 0 | 1 | P278T |
115
+| 17 | 7577099,7577100 | 2 | 0 | 3 | R280K |
116
+| 17 | 7579312,7579313 | 2 | 0 | 3 | T125M |
117
+| 17 | 7577117,7577118 | 5 | 0 | 0 | V274L |
118
+| 17 | 7578517,7578518 | 4 | 0 | 1 | A138Cfs*27 |
119
+| 17 | 7578449 | 2 | 1 | 2 | A161P |
120
+| 17 | 7578534,7578535,7578536 | 3 | 0 | 2 | K132E |
121
+| 17 | 7578534,7578535,7578536 | 3 | 0 | 2 | K132R |
122
+| 17 | 7578534,7578535,7578536 | 3 | 0 | 2 | K132T |
123
+| 17 | 7577106,7577105 | 4 | 0 | 1 | P278A |
124
+| 17 | 7577106,7577105 | 4 | 0 | 1 | P278L |
125
+| 17 | 7577106,7577105 | 4 | 0 | 1 | P278R |
126
+| 17 | 7577099,7577100 | 2 | 0 | 3 | R280G |
127
+| 17 | 7577099,7577100 | 2 | 0 | 3 | R280I |
128
+| 17 | 7577099,7577100 | 2 | 0 | 3 | R280T |
129
+| 17 | 7577117,7577118 | 5 | 0 | 0 | V274A |
130
+| 17 | 7577117,7577118 | 5 | 0 | 0 | V274F |
131
+| 17 | 7577117,7577118 | 5 | 0 | 0 | V274G |
132
+| 17 | 7578265 | 3 | 0 | 1 | I195T |
133
+| 17 | 7578389,7578388 | 3 | 0 | 1 | R181C |
134
+| 17 | 7577095,7577096,7577097 | 1 | 1 | 2 | D281G |
135
+| 17 | 7577586,7577587 | 3 | 0 | 1 | I232T |
136
+| 17 | 7578280,7578281 | 2 | 0 | 2 | P190L |
137
+| 17 | 7578415,7578416 | 2 | 0 | 2 | V172D |
138
+| 17 | 7577095,7577096,7577097 | 1 | 1 | 2 | D281E |
139
+| 17 | 7577095,7577096,7577097 | 1 | 1 | 2 | D281N |
140
+| 17 | 7578265 | 3 | 0 | 1 | I195N |
141
+| 17 | 7577586,7577587 | 3 | 0 | 1 | I232F |
142
+| 17 | 7577586,7577587 | 3 | 0 | 1 | I232N |
143
+| 17 | 7577543,7577544,7577545 | 2 | 0 | 2 | M246I |
144
+| 17 | 7577543,7577544,7577545 | 2 | 0 | 2 | M246K |
145
+| 17 | 7577543,7577544,7577545 | 2 | 0 | 2 | M246T |
146
+| 17 | 7577543,7577544,7577545 | 2 | 0 | 2 | M246V |
147
+| 17 | 7578280,7578281 | 2 | 0 | 2 | P190Lfs*57 |
148
+| 17 | 7578280,7578281 | 2 | 0 | 2 | P190T |
149
+| 17 | 7578389,7578388 | 3 | 0 | 1 | R181H |
150
+| 17 | 7578415,7578416 | 2 | 0 | 2 | V172A |
151
+| 17 | 7578415,7578416 | 2 | 0 | 2 | V172F |
152
+| 17 | 7577085 | 3 | 0 | 0 | E285K |
153
+| 17 | 7578538 | 3 | 0 | 0 | N131I |
154
+| 17 | 7577082,7577081 | 2 | 1 | 0 | E286G |
155
+| 17 | 7579328,7579329 | 2 | 0 | 1 | K120R |
156
+| 17 | 7577124,7577123 | 1 | 0 | 2 | V272M |
157
+| 17 | 7577082,7577081 | 2 | 1 | 0 | E286K |
158
+| 17 | 7577520 | 2 | 0 | 1 | I254D |
159
+| 17 | 7577520 | 2 | 0 | 1 | I254N |
160
+| 17 | 7577520 | 2 | 0 | 1 | I254S |
161
+| 17 | 7579328,7579329 | 2 | 0 | 1 | K120E |
162
+| 17 | 7578532 | 2 | 1 | 0 | M133Ifs*17 |
163
+| 17 | 7578532 | 2 | 1 | 0 | M133K |
164
+| 17 | 7578532 | 2 | 1 | 0 | M133T |
165
+| 17 | 7577124,7577123 | 1 | 0 | 2 | V272A |
166
+| 17 | 7578454 | 1 | 0 | 1 | A159V |
167
+| 17 | 7577113,7577114 | 1 | 0 | 1 | C275W |
168
+| 17 | 7577113,7577114 | 1 | 0 | 1 | C275Y |
169
+| 17 | 7577541 | 0 | 0 | 2 | N247I |
170
+| 17 | 7577541 | 0 | 0 | 2 | N247T |
171
+| 17 | 7577108 | 1 | 0 | 0 | C277Y |
172
+| nan | nan | 1 | 0 | 0 | E204_Y205insLE |
173
+| 17 | 7578427 | 1 | 0 | 0 | H168R |
174
+| nan | nan | 0 | 1 | 0 | HY233QH |
175
+| 17 | 7578513 | 0 | 0 | 1 | K139N |
176
+| 17 | 7578542 | 0 | 0 | 1 | L130F |
177
+| 17 | 7578268 | 1 | 0 | 0 | L194R |
178
+| nan | nan | 1 | 0 | 0 | L252_I254del |
179
+| nan | nan | 0 | 0 | 1 | P152Afs*14 |
180
+| 17 | 7577532 | 0 | 0 | 1 | P250L |
181
+| 17 | 7578463 | 0 | 0 | 1 | R156H |
182
+| nan | nan | 1 | 0 | 0 | R283Gfs*68 |
183
+| 17 | 7577563 | 1 | 0 | 0 | S240G |
184
+| nan | nan | 1 | 0 | 0 | T155_R156dup |
185
+| 17 | 7577524 | 1 | 0 | 0 | T253P |
186
+| 17 | 7578502 | 1 | 0 | 0 | V143A |
187
+| 17 | 7578241 | 0 | 1 | 0 | V203A |
188
+| nan | nan | 1 | 0 | 0 | X125_splice |
tables/hotspots/hotspot_VMA21.md
... ...
@@ -0,0 +1,7 @@
1
+## VMA21 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| X | 150573501 | 6 | 12 | 0 | R93* |
6
+| X | 150573519 | 0 | 1 | 0 | K99E |
7
+| X | 150573509 | 0 | 1 | 0 | W95C |
tables/hotspots/hotspot_WHSC1.md
... ...
@@ -0,0 +1,6 @@
1
+## WHSC1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 4 | 1962801 | 8 | 4 | 0 | E1099K |
6
+| 4 | 1962787 | 0 | 0 | 1 | G1094E |
tables/hotspots/hotspot_XPO1.md
... ...
@@ -0,0 +1,7 @@
1
+## XPO1 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 2 | 61719471,61719472 | 26 | 3 | 1 | E571K |
6
+| 2 | 61719471,61719472 | 26 | 3 | 1 | E571A |
7
+| 2 | 61719471,61719472 | 26 | 3 | 1 | E571G |
tables/hotspots/hotspot_ZNF608.md
... ...
@@ -0,0 +1,9 @@
1
+## ZNF608 Hotspots
2
+
3
+| Chromosome | Coordinate (hg19) | DLBCL | FL | BL | HGVSp |
4
+| ------ | ------ | ------ | ------ | ------ | ------ |
5
+| 5 | 124080445,124080444 | 5 | 0 | 1 | A80P |
6
+| 5 | 124080445,124080444 | 5 | 0 | 1 | A80T |
7
+| 5 | 124080445,124080444 | 5 | 0 | 1 | A80G |
8
+| 5 | 124080445,124080444 | 5 | 0 | 1 | A80V |
9
+| 5 | 124080459 | 1 | 0 | 0 | A75V |