morinlab.bib
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+@article{nieGenomewideCRISPRScreens2021b,
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+ title = {Genome-Wide {{CRISPR}} Screens Reveal Synthetic Lethal Interaction between {{CREBBP}} and {{EP300}} in Diffuse Large {{B-cell}} Lymphoma},
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+ author = {Nie, Man and Du, Likun and Ren, Weicheng and Joung, Julia and Ye, Xiaofei and Shi, Xi and Ciftci, Sibel and Liu, Dongbing and Wu, Kui and Zhang, Feng and Pan-Hammarström, Qiang},
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+ date = {2021-04-28},
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+ journaltitle = {Cell Death \& Disease},
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+ shortjournal = {Cell Death Dis},
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+ volume = {12},
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+ number = {5},
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+ eprint = {33911074},
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+ eprinttype = {pmid},
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+ pages = {419},
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+ issn = {2041-4889},
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+ doi = {10.1038/s41419-021-03695-8},
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+ abstract = {Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoid malignancy and a highly heterogeneous disease. In this study, we performed whole-genome and transcriptome sequencing, and a genome-wide CRISPR-Cas9-knockout screen to study an activated B-cell-like DLBCL cell line (RC-K8). We identified a distinct pattern of genetic essentialities in RC-K8, including a dependency on CREBBP and MDM2. The dependency on CREBBP is associated with a balanced translocation involving EP300, which results in a truncated form of the protein that lacks the critical histone acetyltransferase (HAT) domain. The synthetic lethal interaction between CREBBP and EP300 genes, two frequently mutated epigenetic modulators in B-cell lymphoma, was further validated in the previously published CRISPR-Cas9 screens and inhibitor assays. Our study suggests that integration of the unbiased functional screen results with genomic and transcriptomic data can identify both common and unique druggable vulnerabilities in DLBCL and histone acetyltransferases inhibition could be a therapeutic option for CREBBP or EP300 mutated cases.},
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+ langid = {english},
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+ pmcid = {PMC8080727},
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+ keywords = {Cell Line Tumor,Clustered Regularly Interspaced Short Palindromic Repeats,CREB-Binding Protein,E1A-Associated p300 Protein,Gene Knockdown Techniques,Humans,Lymphoma Large B-Cell Diffuse},
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+ file = {/Users/rmorin/Zotero/storage/4WPLXAZC/Nie et al. - 2021 - Genome-wide CRISPR screens reveal synthetic lethal.pdf}
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+}
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@article{veazeyCARM1InhibitionReduces2020b,
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title = {{{CARM1}} Inhibition Reduces Histone Acetyltransferase Activity Causing Synthetic Lethality in {{CREBBP}}/{{EP300-mutated}} Lymphomas},