3f277375c955e42f270dcc18e39cee30868ae6d2
PMBL_genes.md
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| 9 | 9 | |
| 10 | 10 |  |
| 11 | 11 | |
| 12 | -## Tier 1 PMBL genes |
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| 12 | +## Tier 1, high-confidence PMBL genes |
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| 13 | 13 | |
| 14 | 14 | ### *76 total* |
| 15 | 15 | |
| 16 | -|Gene|Tier| First PMBL evidence | Other entities | |
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| 17 | -|:-:|:-:|:--|:-| |
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| 18 | -|[ACTB](ACTB)|1|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019b)[@wienandGenomicAnalysesFlowsorted2019b]|[@lohrDiscoveryPrioritizationSomatic2012a]| |
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| 19 | -|[ARID1A](ARID1A)|1|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019b)[@wienandGenomicAnalysesFlowsorted2019b]|[@rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013; @loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b]| |
|
| 20 | -|[ARID5B](ARID5B)|1|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)[@gomezUltraDeepSequencingReveals2023]|[@reddyGeneticFunctionalDrivers2017]| |
|
| 21 | -|[B2M](B2M)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@pararajalingamCodingNoncodingDrivers2020; @morinFrequentMutationHistonemodifying2011]| |
|
| 22 | -|[BIRC6](BIRC6)|1|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@reddyGeneticFunctionalDrivers2017]| |
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| 23 | -|[BTG1](BTG1)|1|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011]| |
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| 24 | -|[CD58](CD58)|1|[Schneider et al](papers/schneiderAlterationsCD58Gene2015a)[@schneiderAlterationsCD58Gene2015a]|[@morinFrequentMutationHistonemodifying2011]| |
|
| 25 | -|[CD83](CD83)|1|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b; @morinMutationalStructuralAnalysis2013]| |
|
| 26 | -|[CDKN2A](CDKN2A)|1||[@spinaGeneticsNodalMarginal2016b; @morinMutationalStructuralAnalysis2013; @grandeGenomewideDiscoverySomatic2019]| |
|
| 27 | -|[CHD8](CHD8)|1||[@grandeGenomewideDiscoverySomatic2019]| |
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| 28 | -|[CIITA](CIITA)|1|[Mottok et al](papers/mottokGenomicAlterationsCIITA2015b)[@mottokGenomicAlterationsCIITA2015b]|[@morinFrequentMutationHistonemodifying2011]| |
|
| 29 | -|[CISH](CISH)|1|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 30 | -|[CREBBP](CREBBP)|1|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011a; @loveGeneticLandscapeMutations2012]| |
|
| 31 | -|[CSF2RB](CSF2RB)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 32 | -|[DDX3X](DDX3X)|1|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@schmitzBurkittLymphomaPathogenesis2012; @reddyGeneticFunctionalDrivers2017]| |
|
| 33 | -|[DTX1](DTX1)|1|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)[@gomezUltraDeepSequencingReveals2023]|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013]| |
|
| 34 | -|[DUSP2](DUSP2)|1|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@lohrDiscoveryPrioritizationSomatic2012a]| |
|
| 35 | -|[EBF1](EBF1)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@thomasGeneticSubgroupsInform2023; @bohleRoleEarlyBcell2013]| |
|
| 36 | -|[EEF1A1](EEF1A1)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@hubschmannMutationalMechanismsShaping2021b]| |
|
| 37 | -|[ETS1](ETS1)|1||[@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]| |
|
| 38 | -|[EWSR1](EWSR1)|1||[@pararajalingamCodingNoncodingDrivers2020]| |
|
| 39 | -|[EZH2](EZH2)|1|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@morinSomaticMutationsAltering2010a; @loveGeneticLandscapeMutations2012]| |
|
| 40 | -|[FAS](FAS)|1||[@spinaGeneticsNodalMarginal2016b; @schollMutationsRegionFAS2007]| |
|
| 41 | -|[FAT1](FAT1)|1||[@spinaGeneticsNodalMarginal2016b]| |
|
| 42 | -|[FAT4](FAT4)|1||[@morinMutationalStructuralAnalysis2013; @zhangGenomicLandscapeMantle2014; @parryWholeExomeSequencing2013]| |
|
| 43 | -|[GNA13](GNA13)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@morinFrequentMutationHistonemodifying2011; @loveGeneticLandscapeMutations2012]| |
|
| 44 | -|[HIST1H1B](HIST1H1B)|1|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@chapuyMolecularSubtypesDiffuse2018b; @krysiakRecurrentSomaticMutations2017b]| |
|
| 45 | -|[HIST1H1C](HIST1H1C)|1||[@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]| |
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| 46 | -|[HIST1H1D](HIST1H1D)|1||[@morinMutationalStructuralAnalysis2013; @jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017b]| |
|
| 47 | -|[HIST1H1E](HIST1H1E)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @lohrDiscoveryPrioritizationSomatic2012a]| |
|
| 48 | -|[HLA-B](HLA-B)|1|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019b)[@wienandGenomicAnalysesFlowsorted2019b]|[@lohrDiscoveryPrioritizationSomatic2012a]| |
|
| 49 | -|[IL4R](IL4R)|1|[Vigano et al](papers/viganoSomaticIL4RMutations2018b)[@viganoSomaticIL4RMutations2018b]|[@dunsCharacterizationDLBCLPMBL2021b]| |
|
| 50 | -|[IRF8](IRF8)|1|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]| |
|
| 51 | -|[ITPKB](ITPKB)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@schmitzGeneticsPathogenesisDiffuse2018a]| |
|
| 52 | -|[JAK1](JAK1)|1|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 53 | -|[KMT2C](KMT2C)|1|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019; @zhangGeneticHeterogeneityDiffuse2013]| |
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| 54 | -|[LTB](LTB)|1|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|[@chapuyMolecularSubtypesDiffuse2018b]| |
|
| 55 | -|[MAP3K14](MAP3K14)|1|[Otto et al](papers/ottoGeneticLesionsTRAF32012a)[@ottoGeneticLesionsTRAF32012a]|[@rossiAlterationBIRC3Multiple2011a]| |
|
| 56 | -|[MS4A1](MS4A1)|1|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@rushtonGeneticEvolutionaryPatterns2020]| |
|
| 57 | -|[NFKBIA](NFKBIA)|1|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019b)[@wienandGenomicAnalysesFlowsorted2019b]|[@lakeMutationsNFKBIAEncoding2009; @russler-germainMutationsAssociatedProgression2023b]| |
|
| 58 | -|[NFKBIE](NFKBIE)|1|[Mansouri et al](papers/mansouriFrequentNFKBIEDeletions2016)[@mansouriFrequentNFKBIEDeletions2016]|[@morinGeneticLandscapesRelapsed2016; @pararajalingamCodingNoncodingDrivers2020]| |
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| 59 | -|[OSBPL10](OSBPL10)|1||[@zhangGeneticHeterogeneityDiffuse2013]| |
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| 60 | -|[P2RY8](P2RY8)|1||[@muppidiLossSignalingGa132014b; @lohrDiscoveryPrioritizationSomatic2012a]| |
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| 61 | -|[PCLO](PCLO)|1||[@lohrDiscoveryPrioritizationSomatic2012a]| |
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| 62 | -|[PHIP](PHIP)|1||| |
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| 63 | -|[PIM1](PIM1)|1|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@burkhardtClinicalRelevanceMolecular2022b; @pasqualucciHypermutationMultipleProtooncogenes2001a]| |
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| 64 | -|[PIM2](PIM2)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@arthurGenomewideDiscoverySomatic2018]| |
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| 65 | -|[PRKDC](PRKDC)|1||[@hubschmannMutationalMechanismsShaping2021b; @schmitzGeneticsPathogenesisDiffuse2018a]| |
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| 66 | -|[PTPN1](PTPN1)|1|[Gunawardana et al](papers/gunawardanaRecurrentSomaticMutations2014c)[@gunawardanaRecurrentSomaticMutations2014c]|| |
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| 67 | -|[PTPRD](PTPRD)|1||[@spinaGeneticsNodalMarginal2016b]| |
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| 68 | -|[RHOA](RHOA)|1||[@richterRecurrentMutationID32012a; @zhangGeneticHeterogeneityDiffuse2013]| |
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| 69 | -|[S1PR2](S1PR2)|1||[@muppidiLossSignalingGa132014b; @morinFrequentMutationHistonemodifying2011]| |
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| 70 | -|[SGK1](SGK1)|1|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@morinFrequentMutationHistonemodifying2011]| |
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| 71 | -|[SIN3A](SIN3A)|1||[@chapuyMolecularSubtypesDiffuse2018b; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]| |
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| 72 | -|[SMARCA2](SMARCA2)|1||| |
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| 73 | -|[SMARCA4](SMARCA4)|1||[@lohrDiscoveryPrioritizationSomatic2012a; @nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b; @richterRecurrentMutationID32012a]| |
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| 74 | -|[SOCS1](SOCS1)|1|[Weniger et al](papers/wenigerMutationsTumorSuppressor2006a)[@wenigerMutationsTumorSuppressor2006a]|[@morinFrequentMutationHistonemodifying2011]| |
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| 75 | -|[SPEN](SPEN)|1|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@albuquerqueEnhancingKnowledgeDiscovery2017a; @rossiCodingGenomeSplenic2012c]| |
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| 76 | -|[STAT3](STAT3)|1||[@lohrDiscoveryPrioritizationSomatic2012a]| |
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| 77 | -|[STAT6](STAT6)|1|[Ritz et al](papers/ritzRecurrentMutationsSTAT62009a)[@ritzRecurrentMutationsSTAT62009a]|[@yildizActivatingSTAT6Mutations2015c]| |
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| 78 | -|[TAP1](TAP1)|1||[@schmitzGeneticsPathogenesisDiffuse2018a]| |
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| 79 | -|[TBL1XR1](TBL1XR1)|1||[@rossiCodingGenomeSplenic2012c; @lohrDiscoveryPrioritizationSomatic2012a]| |
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| 80 | -|[TCF3](TCF3)|1||[@schmitzBurkittLymphomaPathogenesis2012]| |
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| 81 | -|[TET3](TET3)|1||| |
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| 82 | -|[TMSB4X](TMSB4X)|1||[@albuquerqueEnhancingKnowledgeDiscovery2017a]| |
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| 83 | -|[TNFAIP3](TNFAIP3)|1|[Schmitz et al](papers/schmitzTNFAIP3A20Tumor2009a)[@schmitzTNFAIP3A20Tumor2009a]|[@compagnoMutationsMultipleGenes2009a; @rossiAlterationBIRC3Multiple2011a]| |
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| 84 | -|[TNFRSF1B](TNFRSF1B)|1||| |
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| 85 | -|[TP53](TP53)|1|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|[@beaLandscapeSomaticMutations2013; @lohrDiscoveryPrioritizationSomatic2012a; @rossiCodingGenomeSplenic2012c; @wildaInactivationARFMDM2p53Pathway2004; @morinFrequentMutationHistonemodifying2011]| |
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| 86 | -|[TRAF3](TRAF3)|1|[Otto et al](papers/ottoGeneticLesionsTRAF32012a)[@ottoGeneticLesionsTRAF32012a]|[@pasqualucciAnalysisCodingGenome2011; @rossiAlterationBIRC3Multiple2011a]| |
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| 87 | -|[UBE2A](UBE2A)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@lohrDiscoveryPrioritizationSomatic2012a]| |
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| 88 | -|[UBR5](UBR5)|1||[@zhangGeneticHeterogeneityDiffuse2013; @pararajalingamCodingNoncodingDrivers2020]| |
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| 89 | -|[UNC5C](UNC5C)|1||[@lohrDiscoveryPrioritizationSomatic2012a]| |
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| 90 | -|[VPS13B](VPS13B)|1||[@lohrDiscoveryPrioritizationSomatic2012a]| |
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| 91 | -|[WEE1](WEE1)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@schmitzGeneticsPathogenesisDiffuse2018a]| |
|
| 92 | -|[XPO1](XPO1)|1|[Jardin et al](papers/jardinRecurrentMutationsExportin2016a)[@jardinRecurrentMutationsExportin2016a]|[@mareschalWholeExomeSequencing2016]| |
|
| 93 | -|[ZFP36L1](ZFP36L1)|1|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]| |
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| 16 | +|Gene|Summary| First PMBL study | Other entities | QC result | |
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| 17 | +|:-:|:--:|:-:|:-|:-| |
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| 18 | +|[ACTB](ACTB)|Tier 1 GE[@wienandGenomicAnalysesFlowsorted2019], aSHM|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019)|[@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 19 | +|[ARID1A](ARID1A)|Tier 1 GE[@wienandGenomicAnalysesFlowsorted2019], FE[@barisicARID1AOrchestratesSWI2024]|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019)|[@krysiakRecurrentSomaticMutations2017; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012; @zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 20 | +|[ARID5B](ARID5B)|Tier 1 GE[@gomezUltraDeepSequencingReveals2023]|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)|[@reddyGeneticFunctionalDrivers2017]|| |
|
| 21 | +|[B2M](B2M)|Tier 1 GE[@reichelFlowSortingExome2015], FE[@challa-malladiCombinedGeneticInactivation2011]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@morinFrequentMutationHistonemodifying2011; @pararajalingamCodingNoncodingDrivers2020]|| |
|
| 22 | +|[BIRC6](BIRC6)|Tier 1 GE[@sarkozyMutationalLandscapeGray2021]|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@reddyGeneticFunctionalDrivers2017]|| |
|
| 23 | +|[BTG1](BTG1)|Tier 1 GE[@sarkozyMutationalLandscapeGray2021], FE[@almasmoumFrequentLossBTG12021], aSHM|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@burkhardtClinicalRelevanceMolecular2022; @drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011]|| |
|
| 24 | +|[CD58](CD58)|Tier 1 GE[@schneiderAlterationsCD58Gene2015], FE[@challa-malladiCombinedGeneticInactivation2011]|[Schneider et al](papers/schneiderAlterationsCD58Gene2015)|[@morinFrequentMutationHistonemodifying2011]|| |
|
| 25 | +|[CD83](CD83)|Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], aSHM|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023]|| |
|
| 26 | +|[CDKN2A](CDKN2A)|Tier 1 GE[@], FE[@kannengiesserFunctionalStructuralGenetic2009]||[@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013; @spinaGeneticsNodalMarginal2016]|| |
|
| 27 | +|[CHD8](CHD8)|Tier 1 GE[@]||[@grandeGenomewideDiscoverySomatic2019]|| |
|
| 28 | +|[CIITA](CIITA)|Tier 1 GE[@mottokGenomicAlterationsCIITA2015], FE[@mottokGenomicAlterationsCIITA2015], aSHM|[Mottok et al](papers/mottokGenomicAlterationsCIITA2015)|[@morinFrequentMutationHistonemodifying2011]|| |
|
| 29 | +|[CISH](CISH)|Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)||| |
|
| 30 | +|[CREBBP](CREBBP)|Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@pasqualucciInactivatingMutationsAcetyltransferase2011]|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011]|| |
|
| 31 | +|[CSF2RB](CSF2RB)|Tier 1 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 32 | +|[DDX3X](DDX3X)|Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019], FE[@gongSequentialInverseDysregulation2021]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@reddyGeneticFunctionalDrivers2017; @schmitzBurkittLymphomaPathogenesis2012]|| |
|
| 33 | +|[DTX1](DTX1)|Tier 1 GE[@gomezUltraDeepSequencingReveals2023], aSHM|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012; @zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 34 | +|[DUSP2](DUSP2)|Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], aSHM|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 35 | +|[EBF1](EBF1)|Tier 1 GE[@reichelFlowSortingExome2015], FE[@ramirez-komoSpontaneousLossLineage2017], aSHM|[Reichel et al](papers/reichelFlowSortingExome2015)|[@bohleRoleEarlyBcell2013; @drevalGeneticSubdivisionsFollicular2023; @thomasGeneticSubgroupsInform2023]|| |
|
| 36 | +|[EEF1A1](EEF1A1)|Tier 1 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@chapuyMolecularSubtypesDiffuse2018; @hubschmannMutationalMechanismsShaping2021]|| |
|
| 37 | +|[ETS1](ETS1)|Tier 1 GE[@], aSHM||[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]|| |
|
| 38 | +|[EWSR1](EWSR1)|Tier 1 GE[@]||[@pararajalingamCodingNoncodingDrivers2020]|| |
|
| 39 | +|[EZH2](EZH2)|Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019], FE[@sneeringerCoordinatedActivitiesWildtype2010]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@loveGeneticLandscapeMutations2012; @morinSomaticMutationsAltering2010]|| |
|
| 40 | +|[FAS](FAS)|Tier 1 GE[@], FE[@wangFasFADDDeathDomain2010]||[@morinFrequentMutationHistonemodifying2011; @schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016]|| |
|
| 41 | +|[FAT1](FAT1)|Tier 1 GE[@]||[@spinaGeneticsNodalMarginal2016]|| |
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| 42 | +|[FAT4](FAT4)|Tier 1 GE[@]||[@morinMutationalStructuralAnalysis2013; @parryWholeExomeSequencing2013; @zhangGenomicLandscapeMantle2014]|| |
|
| 43 | +|[GNA13](GNA13)|Tier 1 GE[@reichelFlowSortingExome2015], FE[@muppidiLossSignalingGa132014]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]|| |
|
| 44 | +|[HIST1H1B](HIST1H1B)|Tier 1 GE[@sarkozyMutationalLandscapeGray2021], aSHM|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@chapuyMolecularSubtypesDiffuse2018; @krysiakRecurrentSomaticMutations2017]|| |
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| 45 | +|[HIST1H1C](HIST1H1C)|Tier 1 GE[@], aSHM||[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]|| |
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| 46 | +|[HIST1H1D](HIST1H1D)|Tier 1 GE[@], aSHM||[@jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017; @morinMutationalStructuralAnalysis2013]|| |
|
| 47 | +|[HIST1H1E](HIST1H1E)|Tier 1 GE[@reichelFlowSortingExome2015], aSHM|[Reichel et al](papers/reichelFlowSortingExome2015)|[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017; @lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 48 | +|[HLA-B](HLA-B)|Tier 1 GE[@wienandGenomicAnalysesFlowsorted2019], FE[@fangazioGeneticMechanismsHLAI2021]|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019)|[@lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 49 | +|[IL4R](IL4R)|Tier 1 GE[@viganoSomaticIL4RMutations2018], FE[@viganoSomaticIL4RMutations2018], aSHM|[Vigano et al](papers/viganoSomaticIL4RMutations2018)|[@dunsCharacterizationDLBCLPMBL2021]|| |
|
| 50 | +|[IRF8](IRF8)|Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019], FE[@qiuIRF8mutantCellLymphoma2024], aSHM|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]|| |
|
| 51 | +|[ITPKB](ITPKB)|Tier 1 GE[@reichelFlowSortingExome2015], FE[@tiacciPervasiveMutationsJAKSTAT2018], aSHM|[Reichel et al](papers/reichelFlowSortingExome2015)|[@drevalGeneticSubdivisionsFollicular2023; @schmitzGeneticsPathogenesisDiffuse2018]|| |
|
| 52 | +|[JAK1](JAK1)|Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@reddyGeneticFunctionalDrivers2017]|| |
|
| 53 | +|[KMT2C](KMT2C)|Tier 1 GE[@sarkozyMutationalLandscapeGray2021]|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@zhangGeneticHeterogeneityDiffuse2013; @zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019]|| |
|
| 54 | +|[LTB](LTB)|Tier 1 GE[@deschGenotypingCirculatingTumor2020], aSHM|[Desch et al](papers/deschGenotypingCirculatingTumor2020)|[@chapuyMolecularSubtypesDiffuse2018; @drevalGeneticSubdivisionsFollicular2023]|| |
|
| 55 | +|[MAP3K14](MAP3K14)|Tier 1 GE[@ottoGeneticLesionsTRAF32012]|[Otto et al](papers/ottoGeneticLesionsTRAF32012)|[@rossiAlterationBIRC3Multiple2011]|| |
|
| 56 | +|[MS4A1](MS4A1)|Tier 1 GE[@mottokIntegrativeGenomicAnalysis2019], FE[@rushtonGeneticEvolutionaryPatterns2020], aSHM|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@rushtonGeneticEvolutionaryPatterns2020]|| |
|
| 57 | +|[NFKBIA](NFKBIA)|Tier 1 GE[@wienandGenomicAnalysesFlowsorted2019], FE[@jungnickelClonalDeleteriousMutations2000]|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019)|[@russler-germainMutationsAssociatedProgression2023; @thomasMutationalAnalysisIkappaBalpha2004]|| |
|
| 58 | +|[NFKBIE](NFKBIE)|Tier 1 GE[@mansouriFrequentNFKBIEDeletions2016], FE[@mansouriFunctionalLossIkBe2015]|[Mansouri et al](papers/mansouriFrequentNFKBIEDeletions2016)|[@morinGeneticLandscapesRelapsed2016; @pararajalingamCodingNoncodingDrivers2020]|| |
|
| 59 | +|[OSBPL10](OSBPL10)|Tier 1 GE[@], aSHM||[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 60 | +|[P2RY8](P2RY8)|Tier 1 GE[@], FE[@muppidiLossSignalingGa132014]||[@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012; @muppidiLossSignalingGa132014]|| |
|
| 61 | +|[PCLO](PCLO)|Tier 1 GE[@]||[@lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 62 | +|[PHIP](PHIP)|Tier 1 GE[@]|||| |
|
| 63 | +|[PIM1](PIM1)|Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@kuoRolePIM1Ibrutinibresistant2016], aSHM|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@burkhardtClinicalRelevanceMolecular2022; @drevalGeneticSubdivisionsFollicular2023; @pasqualucciHypermutationMultipleProtooncogenes2001]|| |
|
| 64 | +|[PIM2](PIM2)|Tier 1 GE[@reichelFlowSortingExome2015], aSHM|[Reichel et al](papers/reichelFlowSortingExome2015)|[@reddyGeneticFunctionalDrivers2017]|| |
|
| 65 | +|[PRKDC](PRKDC)|Tier 1 GE[@]||[@hubschmannMutationalMechanismsShaping2021; @schmitzGeneticsPathogenesisDiffuse2018]|| |
|
| 66 | +|[PTPN1](PTPN1)|Tier 1 GE[@gunawardanaRecurrentSomaticMutations2014]|[Gunawardana et al](papers/gunawardanaRecurrentSomaticMutations2014)||| |
|
| 67 | +|[PTPRD](PTPRD)|Tier 1 GE[@]||[@drevalGeneticSubdivisionsFollicular2023; @spinaGeneticsNodalMarginal2016]|| |
|
| 68 | +|[RHOA](RHOA)|Tier 1 GE[@], FE[@ohayreInactivatingMutationsGNA132016]||[@richterRecurrentMutationID32012; @zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 69 | +|[S1PR2](S1PR2)|Tier 1 GE[@], FE[@muppidiLossSignalingGa132014], aSHM||[@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014]|| |
|
| 70 | +|[SGK1](SGK1)|Tier 1 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@gaoSGK1MutationsDLBCL2021], aSHM|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@morinFrequentMutationHistonemodifying2011]|| |
|
| 71 | +|[SIN3A](SIN3A)|Tier 1 GE[@]||[@chapuyMolecularSubtypesDiffuse2018; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012]|| |
|
| 72 | +|[SMARCA2](SMARCA2)|Tier 1 GE[@]|||| |
|
| 73 | +|[SMARCA4](SMARCA4)|Tier 1 GE[@], FE[@fernandoFunctionalCharacterizationSMARCA42020]||[@krysiakRecurrentSomaticMutations2017; @nadeuGenomicEpigenomicInsights2020b; @reddyGeneticFunctionalDrivers2017; @richterRecurrentMutationID32012]|| |
|
| 74 | +|[SOCS1](SOCS1)|Tier 1 GE[@wenigerMutationsTumorSuppressor2006], FE[@melznerBiallelicMutationSOCS12005], aSHM|[Weniger et al](papers/wenigerMutationsTumorSuppressor2006)|[@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011]|| |
|
| 75 | +|[SPEN](SPEN)|Tier 1 GE[@sarkozyMutationalLandscapeGray2021]|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@albuquerqueEnhancingKnowledgeDiscovery2017; @rossiCodingGenomeSplenic2012]|| |
|
| 76 | +|[STAT3](STAT3)|Tier 1 GE[@], FE[@huNovelMissenseM206K2013]||[@morinFrequentMutationHistonemodifying2011]|| |
|
| 77 | +|[STAT6](STAT6)|Tier 1 GE[@ritzRecurrentMutationsSTAT62009], FE[@mentzPARP14NovelTarget2022]|[Ritz et al](papers/ritzRecurrentMutationsSTAT62009)|[@yildizActivatingSTAT6Mutations2015]|| |
|
| 78 | +|[TAP1](TAP1)|Tier 1 GE[@]||[@schmitzGeneticsPathogenesisDiffuse2018]|| |
|
| 79 | +|[TBL1XR1](TBL1XR1)|Tier 1 GE[@], FE[@venturuttiTBL1XR1MutationsDrive2020]||[@drevalGeneticSubdivisionsFollicular2023; @lohrDiscoveryPrioritizationSomatic2012; @rossiCodingGenomeSplenic2012]|| |
|
| 80 | +|[TCF3](TCF3)|Tier 1 GE[@]||[@schmitzBurkittLymphomaPathogenesis2012]|| |
|
| 81 | +|[TET3](TET3)|Tier 1 GE[@]|||| |
|
| 82 | +|[TMSB4X](TMSB4X)|Tier 1 GE[@], aSHM||[@drevalGeneticSubdivisionsFollicular2023; @reddyGeneticFunctionalDrivers2017]|| |
|
| 83 | +|[TNFAIP3](TNFAIP3)|Tier 1 GE[@schmitzTNFAIP3A20Tumor2009], FE[@compagnoMutationsMultipleGenes2009]|[Schmitz et al](papers/schmitzTNFAIP3A20Tumor2009)|[@compagnoMutationsMultipleGenes2009; @drevalGeneticSubdivisionsFollicular2023; @rossiAlterationBIRC3Multiple2011]|| |
|
| 84 | +|[TNFRSF1B](TNFRSF1B)|Tier 1 GE[@]|||| |
|
| 85 | +|[TP53](TP53)|Tier 1 GE[@tiacciPervasiveMutationsJAKSTAT2018], FE[@katoUnderstandingFunctionstructureFunctionmutation2003]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)|[@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012; @wildaInactivationARFMDM2p53Pathway2004]|| |
|
| 86 | +|[TRAF3](TRAF3)|Tier 1 GE[@ottoGeneticLesionsTRAF32012]|[Otto et al](papers/ottoGeneticLesionsTRAF32012)|[@pasqualucciAnalysisCodingGenome2011; @rossiAlterationBIRC3Multiple2011]|| |
|
| 87 | +|[UBE2A](UBE2A)|Tier 1 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 88 | +|[UBR5](UBR5)|Tier 1 GE[@]||[@albuquerqueEnhancingKnowledgeDiscovery2017; @pararajalingamCodingNoncodingDrivers2020]|| |
|
| 89 | +|[UNC5C](UNC5C)|Tier 1 GE[@]||[@lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 90 | +|[VPS13B](VPS13B)|Tier 1 GE[@]|||| |
|
| 91 | +|[WEE1](WEE1)|Tier 1 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@schmitzGeneticsPathogenesisDiffuse2018]|| |
|
| 92 | +|[XPO1](XPO1)|Tier 1 GE[@jardinRecurrentMutationsExportin2016], FE[@miloudiXPO1E571KMutationModifies2020]|[Jardin et al](papers/jardinRecurrentMutationsExportin2016)|[@mareschalWholeExomeSequencing2016]|| |
|
| 93 | +|[ZFP36L1](ZFP36L1)|Tier 1 GE[@reichelFlowSortingExome2015], aSHM|[Reichel et al](papers/reichelFlowSortingExome2015)|[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]|| |
|
| 94 | 94 | |
| 95 | -## Tier 2 PMBL genes |
|
| 95 | +## Tier 2, low-confidence PMBL genes |
|
| 96 | 96 | |
| 97 | 97 | ### *82 total* |
| 98 | 98 | |
| 99 | -|Gene|Tier| First PMBL evidence | Other entities | |
|
| 100 | -|:-:|:-:|:--|:-| |
|
| 101 | -|[ABCA13](ABCA13)|2|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@spinaGeneticsNodalMarginal2016b]| |
|
| 102 | -|[ACTG1](ACTG1)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|[@spinaGeneticsNodalMarginal2016b; @hubschmannMutationalMechanismsShaping2021b]| |
|
| 103 | -|[AKAP6](AKAP6)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|| |
|
| 104 | -|[ARIH2](ARIH2)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 105 | -|[AXDND1](AXDND1)|2|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)[@gomezUltraDeepSequencingReveals2023]|| |
|
| 106 | -|[BCL2](BCL2)|2|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@tanakaFrequentIncidenceSomatic1992; @burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011]| |
|
| 107 | -|[BCL7A](BCL7A)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @zhangGeneticHeterogeneityDiffuse2013]| |
|
| 108 | -|[BIRC3](BIRC3)|2|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@rossiAlterationBIRC3Multiple2011a; @beaLandscapeSomaticMutations2013; @arthurGenomewideDiscoverySomatic2018]| |
|
| 109 | -|[CCND3](CCND3)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|[@morinFrequentMutationHistonemodifying2011; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]| |
|
| 110 | -|[CDH2](CDH2)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|| |
|
| 111 | -|[CDH5](CDH5)|2|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)[@gomezUltraDeepSequencingReveals2023]|| |
|
| 112 | -|[CXCR5](CXCR5)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@schmitzGeneticsPathogenesisDiffuse2018a]| |
|
| 113 | -|[DGKB](DGKB)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|| |
|
| 114 | -|[DMD](DMD)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 115 | -|[DNAH12](DNAH12)|2|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019b)[@wienandGenomicAnalysesFlowsorted2019b]|| |
|
| 116 | -|[EGR1](EGR1)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@rossiCodingGenomeSplenic2012c; @krysiakRecurrentSomaticMutations2017b]| |
|
| 117 | -|[EPHA7](EPHA7)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 118 | -|[EZR](EZR)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|| |
|
| 119 | -|[FOXO1](FOXO1)|2|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@schmitzBurkittLymphomaPathogenesis2012; @morinFrequentMutationHistonemodifying2011]| |
|
| 120 | -|[GCSAM](GCSAM)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 121 | -|[GPR126](GPR126)|2|[Weniger et al](papers/wenigerMutationsTumorSuppressor2006a)[@wenigerMutationsTumorSuppressor2006a]|| |
|
| 122 | -|[HECW2](HECW2)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 123 | -|[HELLS](HELLS)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 124 | -|[HIST1H2BC](HIST1H2BC)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@krysiakRecurrentSomaticMutations2017b; @lohrDiscoveryPrioritizationSomatic2012a]| |
|
| 125 | -|[HIST1H3B](HIST1H3B)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@lohrDiscoveryPrioritizationSomatic2012a]| |
|
| 126 | -|[HIST1H4C](HIST1H4C)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 127 | -|[HIST1H4E](HIST1H4E)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 128 | -|[HIST1H4J](HIST1H4J)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@paneaWholeGenomeLandscape2019]| |
|
| 129 | -|[HLA-A](HLA-A)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|[@lohrDiscoveryPrioritizationSomatic2012a]| |
|
| 130 | -|[HLA-C](HLA-C)|2|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)[@gomezUltraDeepSequencingReveals2023]|[@chapuyMolecularSubtypesDiffuse2018b]| |
|
| 131 | -|[HRNR](HRNR)|2|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|| |
|
| 132 | -|[IGLL5](IGLL5)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|[@paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b; @chapuyMolecularSubtypesDiffuse2018b]| |
|
| 133 | -|[IKBKB](IKBKB)|2|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019b)[@wienandGenomicAnalysesFlowsorted2019b]|[@reddyGeneticFunctionalDrivers2017; @rossiAlterationBIRC3Multiple2011a]| |
|
| 134 | -|[IL13RA1](IL13RA1)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 135 | -|[IL1RAPL2](IL1RAPL2)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 136 | -|[IRF2BP2](IRF2BP2)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 137 | -|[IRF4](IRF4)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@morinFrequentMutationHistonemodifying2011]| |
|
| 138 | -|[ITGB2](ITGB2)|2||| |
|
| 139 | -|[ITPR3](ITPR3)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|[@loveGeneticLandscapeMutations2012]| |
|
| 140 | -|[JUNB](JUNB)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@reddyGeneticFunctionalDrivers2017]| |
|
| 141 | -|[KLF2](KLF2)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|[@pasqualucciAnalysisCodingGenome2011; @jalladesExomeSequencingIdentifies2017]| |
|
| 142 | -|[KMT2D](KMT2D)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|[@beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012c; @grandeGenomewideDiscoverySomatic2019]| |
|
| 143 | -|[LIMD2](LIMD2)|2|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)[@gomezUltraDeepSequencingReveals2023]|| |
|
| 144 | -|[LPHN3](LPHN3)|2|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|| |
|
| 145 | -|[LRRN3](LRRN3)|2|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 146 | -|[MAGEC2](MAGEC2)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 147 | -|[MCL1](MCL1)|2|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@reddyGeneticFunctionalDrivers2017; @paneaWholeGenomeLandscape2019]| |
|
| 148 | -|[MFHAS1](MFHAS1)|2|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|| |
|
| 149 | -|[MPDZ](MPDZ)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@morinMutationalStructuralAnalysis2013]| |
|
| 150 | -|[MYB](MYB)|2|[Desch et al](papers/deschGenotypingCirculatingTumor2020)[@deschGenotypingCirculatingTumor2020]|[@reddyGeneticFunctionalDrivers2017]| |
|
| 151 | -|[MYC](MYC)|2|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@pasqualucciHypermutationMultipleProtooncogenes2001a; @johnstonCmycHypermutationBurkitt1992; @jalladesExomeSequencingIdentifies2017]| |
|
| 152 | -|[NCOR2](NCOR2)|2|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b]| |
|
| 153 | -|[NEK1](NEK1)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 154 | -|[NFKB2](NFKB2)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@reddyGeneticFunctionalDrivers2017]| |
|
| 155 | -|[NSD2](NSD2)|2||[@zhangGeneticHeterogeneityDiffuse2013; @beaLandscapeSomaticMutations2013]| |
|
| 156 | -|[NUP214](NUP214)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|| |
|
| 157 | -|[OR13C2](OR13C2)|2|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)[@gomezUltraDeepSequencingReveals2023]|| |
|
| 158 | -|[PCBP1](PCBP1)|2||[@schmitzBurkittLymphomaPathogenesis2012]| |
|
| 159 | -|[PCDH7](PCDH7)|2||[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 160 | -|[PRUNE2](PRUNE2)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|| |
|
| 161 | -|[RANBP2](RANBP2)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 162 | -|[RBM38](RBM38)|2|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019b)[@wienandGenomicAnalysesFlowsorted2019b]|| |
|
| 163 | -|[RDH12](RDH12)|2||| |
|
| 164 | -|[RELN](RELN)|2|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021a)[@sarkozyMutationalLandscapeGray2021a]|[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 165 | -|[RFTN1](RFTN1)|2|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@arthurGenomewideDiscoverySomatic2018]| |
|
| 166 | -|[RGS1](RGS1)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 167 | -|[SCN9A](SCN9A)|2||| |
|
| 168 | -|[SENP7](SENP7)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 169 | -|[SETD5](SETD5)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|[@reddyGeneticFunctionalDrivers2017]| |
|
| 170 | -|[SETDB1](SETDB1)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 171 | -|[SIAH2](SIAH2)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@hubschmannMutationalMechanismsShaping2021b]| |
|
| 172 | -|[SMAD3](SMAD3)|2||| |
|
| 173 | -|[STAT5B](STAT5B)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 174 | -|[STRAP](STRAP)|2||| |
|
| 175 | -|[TBC1D15](TBC1D15)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 176 | -|[TICRR](TICRR)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|| |
|
| 177 | -|[TNIP1](TNIP1)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|| |
|
| 178 | -|[TRIP11](TRIP11)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 179 | -|[VMP1](VMP1)|2|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019b)[@mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 180 | -|[WDR87](WDR87)|2|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|| |
|
| 181 | -|[ZCCHC11](ZCCHC11)|2|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018b)[@tiacciPervasiveMutationsJAKSTAT2018b]|| |
|
| 182 | -|[ZNF217](ZNF217)|2|[Reichel et al](papers/reichelFlowSortingExome2015a)[@reichelFlowSortingExome2015a]|[@hubschmannMutationalMechanismsShaping2021b]| |
|
| 99 | +|Gene|Summary| First PMBL study | Other entities | QC result | |
|
| 100 | +|:-:|:--:|:-:|:-|:-| |
|
| 101 | +|[ABCA13](ABCA13)|Tier 2 GE[@sarkozyMutationalLandscapeGray2021]|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@spinaGeneticsNodalMarginal2016]|| |
|
| 102 | +|[ACTG1](ACTG1)|Tier 2 GE[@deschGenotypingCirculatingTumor2020], aSHM|[Desch et al](papers/deschGenotypingCirculatingTumor2020)|[@fanComprehensiveCharacterizationDriver2020; @hubschmannMutationalMechanismsShaping2021; @spinaGeneticsNodalMarginal2016]|| |
|
| 103 | +|[AKAP6](AKAP6)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)||| |
|
| 104 | +|[ARIH2](ARIH2)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 105 | +|[AXDND1](AXDND1)|Tier 2 GE[@gomezUltraDeepSequencingReveals2023]|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)||| |
|
| 106 | +|[BCL2](BCL2)|Tier 2 GE[@sarkozyMutationalLandscapeGray2021], aSHM|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@burkhardtClinicalRelevanceMolecular2022; @morinFrequentMutationHistonemodifying2011; @tanakaFrequentIncidenceSomatic1992]|| |
|
| 107 | +|[BCL7A](BCL7A)|Tier 2 GE[@reichelFlowSortingExome2015], FE[@balinas-gaviraFrequentMutationsAminoterminal2020], aSHM|[Reichel et al](papers/reichelFlowSortingExome2015)|[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017; @morinFrequentMutationHistonemodifying2011]|| |
|
| 108 | +|[BIRC3](BIRC3)|Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021], aSHM|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@arthurGenomewideDiscoverySomatic2018; @beaLandscapeSomaticMutations2013; @rossiAlterationBIRC3Multiple2011]|| |
|
| 109 | +|[CCND3](CCND3)|Tier 2 GE[@deschGenotypingCirculatingTumor2020], FE[@schmitzBurkittLymphomaPathogenesis2012]|[Desch et al](papers/deschGenotypingCirculatingTumor2020)|[@jalladesExomeSequencingIdentifies2017; @morinFrequentMutationHistonemodifying2011; @richterRecurrentMutationID32012]|| |
|
| 110 | +|[CDH2](CDH2)|Tier 2 GE[@deschGenotypingCirculatingTumor2020]|[Desch et al](papers/deschGenotypingCirculatingTumor2020)||| |
|
| 111 | +|[CDH5](CDH5)|Tier 2 GE[@gomezUltraDeepSequencingReveals2023]|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)||| |
|
| 112 | +|[CXCR5](CXCR5)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@schmitzGeneticsPathogenesisDiffuse2018]|| |
|
| 113 | +|[DGKB](DGKB)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)||| |
|
| 114 | +|[DMD](DMD)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 115 | +|[DNAH12](DNAH12)|Tier 2 GE[@wienandGenomicAnalysesFlowsorted2019]|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019)||| |
|
| 116 | +|[EGR1](EGR1)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@krysiakRecurrentSomaticMutations2017; @rossiCodingGenomeSplenic2012]|| |
|
| 117 | +|[EPHA7](EPHA7)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 118 | +|[EZR](EZR)|Tier 2 GE[@deschGenotypingCirculatingTumor2020], aSHM|[Desch et al](papers/deschGenotypingCirculatingTumor2020)||| |
|
| 119 | +|[FOXO1](FOXO1)|Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@trinhAnalysisFOXO1Mutations]|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@morinFrequentMutationHistonemodifying2011; @schmitzBurkittLymphomaPathogenesis2012]|| |
|
| 120 | +|[GCSAM](GCSAM)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)||| |
|
| 121 | +|[GPR126](GPR126)|Tier 2 GE[@wenigerMutationsTumorSuppressor2006]|[Weniger et al](papers/wenigerMutationsTumorSuppressor2006)||| |
|
| 122 | +|[HECW2](HECW2)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 123 | +|[HELLS](HELLS)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 124 | +|[HIST1H2BC](HIST1H2BC)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019], aSHM|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@krysiakRecurrentSomaticMutations2017; @lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 125 | +|[HIST1H3B](HIST1H3B)|Tier 2 GE[@reichelFlowSortingExome2015], aSHM|[Reichel et al](papers/reichelFlowSortingExome2015)|[@lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 126 | +|[HIST1H4C](HIST1H4C)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 127 | +|[HIST1H4E](HIST1H4E)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)||| |
|
| 128 | +|[HIST1H4J](HIST1H4J)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@paneaWholeGenomeLandscape2019]|| |
|
| 129 | +|[HLA-A](HLA-A)|Tier 2 GE[@deschGenotypingCirculatingTumor2020], FE[@fangazioGeneticMechanismsHLAI2021]|[Desch et al](papers/deschGenotypingCirculatingTumor2020)|[@lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 130 | +|[HLA-C](HLA-C)|Tier 2 GE[@gomezUltraDeepSequencingReveals2023], FE[@fangazioGeneticMechanismsHLAI2021]|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)|[@chapuyMolecularSubtypesDiffuse2018]|| |
|
| 131 | +|[HRNR](HRNR)|Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021]|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)||| |
|
| 132 | +|[IGLL5](IGLL5)|Tier 2 GE[@deschGenotypingCirculatingTumor2020], aSHM|[Desch et al](papers/deschGenotypingCirculatingTumor2020)|[@chapuyMolecularSubtypesDiffuse2018; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023]|| |
|
| 133 | +|[IKBKB](IKBKB)|Tier 2 GE[@wienandGenomicAnalysesFlowsorted2019]|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019)|[@reddyGeneticFunctionalDrivers2017; @rossiAlterationBIRC3Multiple2011]|| |
|
| 134 | +|[IL13RA1](IL13RA1)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)||| |
|
| 135 | +|[IL1RAPL2](IL1RAPL2)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)||| |
|
| 136 | +|[IRF2BP2](IRF2BP2)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)||| |
|
| 137 | +|[IRF4](IRF4)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019], aSHM|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@drevalGeneticSubdivisionsFollicular2023; @morinFrequentMutationHistonemodifying2011]|| |
|
| 138 | +|[ITGB2](ITGB2)|Tier 2 GE[@]|||| |
|
| 139 | +|[ITPR3](ITPR3)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)|[@loveGeneticLandscapeMutations2012]|| |
|
| 140 | +|[JUNB](JUNB)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@lohrDiscoveryPrioritizationSomatic2012]|| |
|
| 141 | +|[KLF2](KLF2)|Tier 2 GE[@deschGenotypingCirculatingTumor2020], aSHM|[Desch et al](papers/deschGenotypingCirculatingTumor2020)|[@drevalGeneticSubdivisionsFollicular2023; @jalladesExomeSequencingIdentifies2017; @pasqualucciAnalysisCodingGenome2011]|| |
|
| 142 | +|[KMT2D](KMT2D)|Tier 2 GE[@deschGenotypingCirculatingTumor2020], FE[@zhangDisruptionKMT2DPerturbs2015]|[Desch et al](papers/deschGenotypingCirculatingTumor2020)|[@beaLandscapeSomaticMutations2013; @grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012]|| |
|
| 143 | +|[LIMD2](LIMD2)|Tier 2 GE[@gomezUltraDeepSequencingReveals2023]|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)||| |
|
| 144 | +|[LPHN3](LPHN3)|Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021]|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)||| |
|
| 145 | +|[LRRN3](LRRN3)|Tier 2 GE[@sarkozyMutationalLandscapeGray2021]|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 146 | +|[MAGEC2](MAGEC2)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)||| |
|
| 147 | +|[MCL1](MCL1)|Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021]|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@paneaWholeGenomeLandscape2019; @reddyGeneticFunctionalDrivers2017]|| |
|
| 148 | +|[MFHAS1](MFHAS1)|Tier 2 GE[@sarkozyMutationalLandscapeGray2021]|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)||| |
|
| 149 | +|[MPDZ](MPDZ)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@morinMutationalStructuralAnalysis2013]|| |
|
| 150 | +|[MYB](MYB)|Tier 2 GE[@deschGenotypingCirculatingTumor2020]|[Desch et al](papers/deschGenotypingCirculatingTumor2020)|[@reddyGeneticFunctionalDrivers2017]|| |
|
| 151 | +|[MYC](MYC)|Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021], FE[@freieGermlinePointMutation2024], aSHM|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @pasqualucciHypermutationMultipleProtooncogenes2001]|| |
|
| 152 | +|[NCOR2](NCOR2)|Tier 2 GE[@sarkozyMutationalLandscapeGray2021]|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016]|| |
|
| 153 | +|[NEK1](NEK1)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 154 | +|[NFKB2](NFKB2)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@reddyGeneticFunctionalDrivers2017]|| |
|
| 155 | +|[NSD2](NSD2)|Tier 2 GE[@]||[@beaLandscapeSomaticMutations2013; @zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 156 | +|[NUP214](NUP214)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)||| |
|
| 157 | +|[OR13C2](OR13C2)|Tier 2 GE[@gomezUltraDeepSequencingReveals2023]|[Gomez et al](papers/gomezUltraDeepSequencingReveals2023)||| |
|
| 158 | +|[PCBP1](PCBP1)|Tier 2 GE[@]||[@schmitzBurkittLymphomaPathogenesis2012]|| |
|
| 159 | +|[PCDH7](PCDH7)|Tier 2 GE[@]||[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 160 | +|[PRUNE2](PRUNE2)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)||| |
|
| 161 | +|[RANBP2](RANBP2)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 162 | +|[RBM38](RBM38)|Tier 2 GE[@wienandGenomicAnalysesFlowsorted2019]|[Wienand et al](papers/wienandGenomicAnalysesFlowsorted2019)||| |
|
| 163 | +|[RDH12](RDH12)|Tier 2 GE[@]|||| |
|
| 164 | +|[RELN](RELN)|Tier 2 GE[@sarkozyMutationalLandscapeGray2021]|[Sarkozy et al](papers/sarkozyMutationalLandscapeGray2021)|[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 165 | +|[RFTN1](RFTN1)|Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021], aSHM|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)|[@arthurGenomewideDiscoverySomatic2018]|| |
|
| 166 | +|[RGS1](RGS1)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)|[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 167 | +|[SCN9A](SCN9A)|Tier 2 GE[@]|||| |
|
| 168 | +|[SENP7](SENP7)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 169 | +|[SETD5](SETD5)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)|[@reddyGeneticFunctionalDrivers2017]|| |
|
| 170 | +|[SETDB1](SETDB1)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 171 | +|[SIAH2](SIAH2)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@hubschmannMutationalMechanismsShaping2021]|| |
|
| 172 | +|[SMAD3](SMAD3)|Tier 2 GE[@]|||| |
|
| 173 | +|[STAT5B](STAT5B)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)|[@reddyGeneticFunctionalDrivers2017]|| |
|
| 174 | +|[STRAP](STRAP)|Tier 2 GE[@]|||| |
|
| 175 | +|[TBC1D15](TBC1D15)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 176 | +|[TICRR](TICRR)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)||| |
|
| 177 | +|[TNIP1](TNIP1)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)||| |
|
| 178 | +|[TRIP11](TRIP11)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 179 | +|[VMP1](VMP1)|Tier 2 GE[@mottokIntegrativeGenomicAnalysis2019]|[Mottok et al](papers/mottokIntegrativeGenomicAnalysis2019)||| |
|
| 180 | +|[WDR87](WDR87)|Tier 2 GE[@dunsCharacterizationDLBCLPMBL2021]|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021)||| |
|
| 181 | +|[ZCCHC11](ZCCHC11)|Tier 2 GE[@tiacciPervasiveMutationsJAKSTAT2018]|[Tiacci et al](papers/tiacciPervasiveMutationsJAKSTAT2018)||| |
|
| 182 | +|[ZNF217](ZNF217)|Tier 2 GE[@reichelFlowSortingExome2015]|[Reichel et al](papers/reichelFlowSortingExome2015)|[@hubschmannMutationalMechanismsShaping2021]|| |
|
| 183 | 183 | |
| 184 | -## Tier 3 PMBL genes |
|
| 184 | +## Tier 3, retired PMBL genes |
|
| 185 | 185 | |
| 186 | 186 | ### *0 total* |
| 187 | 187 | |
| 188 | -|Gene|Tier| First PMBL evidence | Other entities | |
|
| 189 | -|:-:|:-:|:--|:-| |
|
| 188 | +|Gene|Summary| First PMBL study | Other entities | QC result | |
|
| 189 | +|:-:|:--:|:-:|:-|:-| |
|
| 190 | 190 | |
| 191 | 191 | |
| 192 | 192 | # References |