4152d57ef5bfc6866fe8c73fa1dfe702da3462a1
P2RY8.md
| ... | ... | @@ -1,5 +1,5 @@ |
| 1 | 1 | # P2RY8 |
| 2 | -P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.<sup>1</sup> Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL<sup>2</sup> and BL. |
|
| 2 | +P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.<sup>1</sup> Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL<sup>2</sup> and BL.<sup>1</sup> |
|
| 3 | 3 | |
| 4 | 4 | ## Relevance tier by entity |
| 5 | 5 |