XPO1.md
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csl: 'NLM.csl'
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- @jardinRecurrentMutationsExportin2016, @mareschalWholeExomeSequencing2016, @reddyGeneticFunctionalDrivers2017,
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+ @jardinRecurrentMutationsExportin2016, @mareschalWholeExomeSequencing2016, @reddyGeneticFunctionalDrivers2017
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---
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[[_TOC_]]
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+## Overview
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+XPO1 encodes exportin-1 (CRM1), a key nuclear export protein that regulates the cytoplasmic trafficking of many tumour suppressors and growth regulators, including TP53, RB, and FOXO family members[@balasubramanianSelectiveInhibitionNuclear2022]. In mature B-cell neoplasms, XPO1 is frequently overexpressed and recurrently mutated (most commonly E571K), particularly in primary mediastinal B-cell lymphoma, classical Hodgkin lymphoma, and subsets of DLBCL[@miloudiXPO1E571KMutationModifies2020; @camusXPO1CellHematological2017]. These alterations are thought to enhance nuclear export efficiency, functionally dampening tumour suppressor activity without requiring their genetic loss[@balasubramanianSelectiveInhibitionNuclear2022]. As a result, many B-cell lymphomas exhibit a shared dependency on XPO1-mediated nuclear export, providing a biologic rationale for XPO1 inhibition independent of mutation status.
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## Experimental Evidence
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