49c8c06a04f2950b72d4c772501fee10865d99bb
XPO1.md
| ... | ... | @@ -15,7 +15,7 @@ In DLBCL, mutations at the canonical hotspot (E571) have been experimentally dem |
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| 16 | 16 | ## Clinical Relevance |
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| 18 | -Selinexor (XPOVIO), an inhibitor of the nuclear export activity of XPO1 protein, has received [FDA approval](https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-relapsedrefractory-diffuse-large-b-cell-lymphoma?utm_source=chatgpt.com) *for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from follicular lymphoma, after at least 2 lines of systemic therapy.*. |
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| 18 | +Selinexor (XPOVIO), an inhibitor of the nuclear export activity of XPO1 protein, has received [FDA approval](https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-relapsedrefractory-diffuse-large-b-cell-lymphoma?utm_source=chatgpt.com) *for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from follicular lymphoma, after at least 2 lines of systemic therapy.*. Importantly, eligibility does not depend on the presence of mutations in XPO1. |
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| 20 | 20 | ## Relevance tier by entity |
| 21 | 21 |