XPO1.md
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## Clinical Relevance
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-Selinexor (XPOVIO), an inhibitor of the nuclear export activity of XPO1 protein, has received [FDA approval](https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-relapsedrefractory-diffuse-large-b-cell-lymphoma?utm_source=chatgpt.com) *for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from follicular lymphoma, after at least 2 lines of systemic therapy.*.
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+Selinexor (XPOVIO), an inhibitor of the nuclear export activity of XPO1 protein, has received [FDA approval](https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-relapsedrefractory-diffuse-large-b-cell-lymphoma?utm_source=chatgpt.com) *for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from follicular lymphoma, after at least 2 lines of systemic therapy.*. Importantly, eligibility does not depend on the presence of mutations in XPO1.
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## Relevance tier by entity
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