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+One study reported BTK mutations in approximately 7% of FL and 11% of transformed FL cases.^{[@krysiakRecurrentSomaticMutations2017]} Another showed these mutations were more common, and typically co-occur in tumours with BCL2 translocations. Despite the known role of certain BTK mutations in acquired resistance to BTK inhibitors, these mutations were found in BTK inhibitor-naïve patients.^{[@albuquerqueEnhancingKnowledgeDiscovery2017]} These mutations often occur in treatment-naive patients and lead to inactivation of the BTK protein through destabilization or by altering key residues involved in enzymatic activity.^{[@krysiakRecurrentSomaticMutations2017]} The mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations*^{[@huFollicularLymphomaassociatedBTK2021; @schejbelInactivatingBTKMutations2022]}. No notable hot spots have been described in this gene in the context of the cancers listed below.