CARD11.md
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[[_TOC_]]
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+## History
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Mutations in CARD11 were initially described as enriched in the ABC subgroup of DLBCL.[@lenzOncogenicCARD11Mutations2008]
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More recent data contradicts this association and has implicated CARD11 in FL and additional B-cell lymphomas including FL and MCL.[@morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016]
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@yanBCRTLRSignaling2012]|
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1-EE |high-confidence DLBCL gene [@lenzOncogenicCARD11Mutations2008]|
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+|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene [@lenzOncogenicCARD11Mutations2008]|
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|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene [@morinFrequentMutationHistonemodifying2011]|
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|![MCL](images/icons/MCL_tier1.png) |1 |high-confidence MCL gene [@wuGeneticHeterogeneityPrimary2016]|
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