B2M.md
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B2M mutations in B-cell lymphomas, particularly in DLBCL and PMBCL, lead to reduced MHC class I expression, enabling tumor cells to evade immune detection and destruction by cytotoxic T cells. This is often accompanied by mutations in the β2-Microglobulin gene, which further aids in immune evasion.[@challa-malladiCombinedGeneticInactivation2011]
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## Relevance tier by entity
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[[include:tables/table1_B2M.md]]
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| chr15 | 45003781 | C>T | L13F |
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| chr15 | 45003782 | T>C | L13P |
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/B2M_1.png)
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[[include:tables/browser_B2M.md]]
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## Expression