ABL2.md
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# ABL2
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## History
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```mermaid
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%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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title Publication timing
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2023-07-26 : Russler : FL
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```
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## Relevance tier by entity
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|Entity|Tier|Description |
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View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ABL2_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ABL2_protein_hg38.html)
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-![image](images/proteinpaint/ABL2_NM_007314.svg)
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+![](images/proteinpaint/ABL2_NM_007314.svg)
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View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ABL2.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ABL2_hg38.html)
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-![image](images/proteinpaint/ABL2.svg)
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## ABL2 Expression
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-![image](images/gene_expression/ABL2_by_pathology.svg)
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## References
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1. *Russler-Germain DA, Krysiak K, Ramirez CA, Mosior M, Watkins MP, Gomez F, Skidmore ZL, Trani L, Gao F, Geyer S, Cashen A, Mehta-Shah N, Kahl B, Bartlett N, Alderuccio J, Lossos I, Ondrejka S, Hsi E, Martin P, Leonard J, Griffith M, Griffith O, Fehniger T. Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303. Blood Advances. 2023;7:5524–5539.*
ACAD9.md
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# ACAD9
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## History
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```mermaid
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%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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title Publication timing
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2012-12-01 : Love : BL
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```
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## Relevance tier by entity
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|Entity|Tier|Description |
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View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ACAD9_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ACAD9_protein_hg38.html)
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-![image](images/proteinpaint/ACAD9_NM_014049.svg)
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+![](images/proteinpaint/ACAD9_NM_014049.svg)
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View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ACAD9.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ACAD9_hg38.html)
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-![image](images/proteinpaint/ACAD9.svg)
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## ACAD9 Expression
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-![image](images/gene_expression/ACAD9_by_pathology.svg)
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+![](images/gene_expression/ACAD9_by_pathology.svg)
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## References
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1. *Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561*
ACTB.md
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# ACTB
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## Overview
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ACTB is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas.
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2012-03-06 : Lohr : DLBCL
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2019-12-10 : Wienand : PMBL
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```
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## Relevance tier by entity
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|Entity|Tier|Description |
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View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ACTB_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ACTB_protein_hg38.html)
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-![image](images/proteinpaint/ACTB_NM_001101.svg)
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+![](images/proteinpaint/ACTB_NM_001101.svg)
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View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ACTB.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ACTB_hg38.html)
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-![image](images/proteinpaint/ACTB.svg)
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## ACTB Expression
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-![image](images/gene_expression/ACTB_by_pathology.svg)
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## References
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1. *Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3879-84. doi: 10.1073/pnas.1121343109. Epub 2012 Feb 17. PMID: 22343534; PMCID: PMC3309757.*
ACTG1.md
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# ACTG1
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## Overview
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## History
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2019-08-20 : Desch : PMBL
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2021-05-05 : H : DLBCL
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```
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## Relevance tier by entity
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|Entity|Tier|Description |
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View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ACTG1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ACTG1_protein_hg38.html)
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-![image](images/proteinpaint/ACTG1_NM_001614.svg)
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+![](images/proteinpaint/ACTG1_NM_001614.svg)
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View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ACTG1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ACTG1_hg38.html)
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-![image](images/proteinpaint/ACTG1.svg)
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+![](images/proteinpaint/ACTG1.svg)
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## ACTG1 Expression
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-![image](images/gene_expression/ACTG1_by_pathology.svg)
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## References
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1. Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Küppers R, Schlesner M, Siebert R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 Jul;35(7):2002–2016. PMCID: PMC8257491