MEF2B.md
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@@ -51,6 +51,10 @@ Thus far, there is limited information about the consequence of MEF2B mutations
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### Transcriptional Activation Domain:
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**N81 (Asparagine 81)** A mutation hotspot within the transcriptional activation domain. Alterations at this position can enhance the transcriptional activity of MEF2B, contributing to the overexpression of target genes involved in cell survival and proliferation.
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+## Structure with HotMAPS hotspots
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+
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/MEF2B_1.png)
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+
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## Functional Impact of MEF2B Mutations
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### Altered Transcriptional Activity:
MYC.md
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@@ -75,6 +75,8 @@ Driver mutations affecting this gene in DLBCL/FL/BL have been experimentally dem
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| chr8 | 128750695 | C>T | P78S |
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| chr8 | 128750696 | C>G | P78R |
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/MYC_1.png)
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+
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[[include:tables/browser_MYC.md]]
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## Expression
MYD88.md
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| :---:| :---: | :--: | :---: |
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| chr3 | 38182641 | T>C | L265P |
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/MYD88_1.png)
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+
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[[include:tables/browser_MYD88.md]]
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## Expression
NFKBIA.md
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@@ -33,6 +33,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
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[[include:tables/browser_NFKBIA.md]]
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+## Structure with HotMAPS hotspots
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+
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/NFKBIA_1.png)
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+
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## Expression
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![](images/gene_expression/NFKBIA_by_pathology.svg)
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OSBPL10.md
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@@ -30,6 +30,7 @@ OSBPL10 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ash
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|:--------:|:----------:|:--------:|:-------------------------------------------------------------------------------------------:|:------------------:|
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|chr3 |32020518 |32024930|[TSS-1](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr3%3A32020518%2D32024930)|active_promoter |
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/OSBPL10_1.png)
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[[include:tables/browser_OSBPL10.md]]
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PIK3CD.md
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@@ -36,6 +36,8 @@ nocite: |
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| chr1 | 9787040 | G>A | R1024H |
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| chr1 | 9787043 | A>G | E1025G |
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/PIK3CD_1.png)
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+
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[[include:tables/browser_PIK3CD.md]]
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## Expression
PIM1.md
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| chr6 | 37138603 | GCG>- | G48del |
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| chr6 | 37138604 | C>A | S46R |
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/PIM1_1.png)
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+
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/PIM1_2.png)
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+
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[[include:tables/browser_PIM1.md]]
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## Expression
POU2F2.md
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| chr19 | 42600030 | T>C | T239A |
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| chr19 | 42600030 | T>A | T239S |
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+![Structure with HotMAPS hotspots](images/hotmaps_3d/POU2F2_1.png)
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+
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[[include:tables/browser_POU2F2.md]]
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## Expression