HIST1H2BK.md
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# HIST1H2BK
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-<<Warn("The variants reported in this gene failed QC")>>
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-**[See below ](#representative-mutations) or [the study page ](papers/paneaWholeGenomeLandscape2019.md#tier-2) for more information**
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## Overview
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This gene encodes the H2A protein, one of the core proteins comprising nucleosomes. Although relatively common in DLBCL, little is known about the function of these mutations.
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## History
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
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-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
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+|![BL](images/icons/BL_tier2.png) |2-F |Failed QC|
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|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)