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rdmorin committed 2024-07-03 12:52:46 -0700 commit 56231db49b40de99aa1f17b9873a9345742d98be

				CDKN2A.md
			
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           ## Overview

           Although CDKN2A aberrations are common in DLBCL, this gene is predominantly affected by copy number alterations. One study found that deletions of the CDKN2A locus occur in about one-third of DLBCL patients.<sup>1</sup> The mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations*. This gene has some recurrent sites of mutations (hotspots) with the most common mutation causing a truncation at codon 80 (R80*). 

          -## History

          -Mutations in this gene were first described in DLBCL and FL in 2013 by Morin et al<sup>2</sup> and in BL in 2019 by Grande et al.<sup>3</sup>

          -

          -

           ```mermaid

           %%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

           timeline

...	...	@@ -8,10 +8,6 @@ link-citations: true
8	8	## Overview
9	9	Although CDKN2A aberrations are common in DLBCL, this gene is predominantly affected by copy number alterations. One study found that deletions of the CDKN2A locus occur in about one-third of DLBCL patients.<sup>1</sup> The mutation pattern in DLBCL and FL implies the preferential accumulation of inactivating mutations. This gene has some recurrent sites of mutations (hotspots) with the most common mutation causing a truncation at codon 80 (R80*).
10	10
11		-## History
12		-Mutations in this gene were first described in DLBCL and FL in 2013 by Morin et al<sup>2</sup> and in BL in 2019 by Grande et al.<sup>3</sup>
13		-
14		-
15	11	```mermaid
16	12	%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
17	13	timeline