CAPN5.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CAPN5
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CAPN5.md]]
23
+
29 24
## References
30 25
31 26
CAPN7.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CAPN7
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CAPN7.md]]
23
+
29 24
## References
30 25
31 26
CARD11.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CARD11
6
+[[_TOC_]]
7 7
8 8
Mutations in CARD11 were initially described as enriched in the ABC subgroup of DLBCL.[@lenzOncogenicCARD11Mutations2008]
9 9
More recent data contradicts this association and has implicated CARD11 in FL and additional B-cell lymphomas including FL and MCL.[@morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016]
... ...
@@ -12,22 +12,7 @@ More recent data contradicts this association and has implicated CARD11 in FL an
12 12
13 13
The functional effect of CARD11 mutations in DLBCL was explored in the original study.[@lenzOncogenicCARD11Mutations2008]
14 14
15
-## History
16
-
17
-```mermaid
18
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
19
-timeline
20
- title Publication timing
21
-2008-03-03 : Lenz : DLBCL
22
-2011-07-27 : Morin : DLBCL
23
-2012-03-06 : Lohr : DLBCL
24
-2012-04-01 : Yan : MZL
25
-2013-01-01 : Zhang : DLBCL
26
-2013-08-15 : Morin : DLBCL
27
-2016-06-21 : Wu : MCL
28
-2017-05-01 : Albuquerque : DLBCL
29
-2017-10-10 : Reddy : DLBCL
30
-```
15
+
31 16
32 17
## Relevance tier by entity
33 18
... ...
@@ -86,4 +71,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
86 71
<!-- MZL: yanBCRTLRSignaling2012a -->
87 72
<!-- DLBCL: lenzOncogenicCARD11Mutations2008 -->
88 73
74
+[[include:mermaid_CARD11.md]]
75
+
89 76
## References
CARD4.md
... ...
@@ -3,19 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CARD4
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
*CARD4 is now known as NOD1.*
10 10
11
-## History
12 11
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2012-12-01 : Love : BL
18
-```
19 12
20 13
## Relevance tier by entity
21 14
... ...
@@ -54,4 +47,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
54 47
[674](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/674_reports.html)
55 48
[747](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/747_reports.html)
56 49
50
+[[include:mermaid_CARD4.md]]
51
+
57 52
## References
CASP8.md
... ...
@@ -3,20 +3,13 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CASP8
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
10 10
Caspase-8 mutations are relatively rare but have been documented in various non-Hodgkin lymphomas (NHLs). One study found no CASP8 mutations in gastrointestinal lymphomas, suggesting that these mutations may not be prevalent in all lymphoma types. Due to the rarity of these mutations, their role remains poorly understood. Loss of caspase-8 may promote lymphomagenesis by impairing cytokinesis and increasing chromosomal aberrations.
11
-## History
12 11
Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.<sup>1</sup>
13 12
14
-```mermaid
15
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
16
-timeline
17
- title Publication timing
18
- 2017-10-10 : Reddy : DLBCL
19
-```
20 13
21 14
## Relevance tier by entity
22 15
... ...
@@ -55,6 +48,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
55 48
## CASP8 Expression
56 49
![](images/gene_expression/CASP8_by_pathology.svg)
57 50
51
+[[include:mermaid_CASP8.md]]
52
+
58 53
## References
59 54
60 55
CBFA2T3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CBFA2T3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-12-13 : Parry : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|MCL|GAMBL Genome |0.585 |
35 28
36 29
30
+[[include:mermaid_CBFA2T3.md]]
31
+
37 32
## References
38 33
39 34
CBLB.md
... ...
@@ -3,19 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CBLB
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
9 9
10
-## History
11 10
Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.<sup>1</sup> Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.
12 11
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2017-10-10 : Reddy : DLBCL
18
-```
19 12
20 13
## Relevance tier by entity
21 14
... ...
@@ -89,6 +82,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
89 82
[Reddy_3999T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3999T.html)
90 83
[Reddy_4000T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_4000T.html)
91 84
85
+[[include:mermaid_CBLB.md]]
86
+
92 87
## References
93 88
94 89
<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
CBX3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CBX3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CBX3.md]]
23
+
29 24
## References
30 25
31 26
CCDC132.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CCDC132
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CCDC132.md]]
23
+
29 24
## References
30 25
31 26
CCDC46.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CCDC46
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CCDC46.md]]
23
+
29 24
## References
30 25
31 26
CCDC97.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CCDC97
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CCDC97.md]]
23
+
29 24
## References
30 25
31 26
CCL4.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CCL4
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2018-05-01 : Chapuy : DLBCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -53,4 +46,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
53 46
<!-- ORIGIN: chapuyMolecularSubtypesDiffuse2018b -->
54 47
<!-- DLBCL: chapuyMolecularSubtypesDiffuse2018b -->
55 48
49
+[[include:mermaid_CCL4.md]]
50
+
56 51
## References
CCND1.md
... ...
@@ -3,15 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CCND1
6
+[[_TOC_]]
7 7
8
-## History
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2013-11-05 : Bea : MCL
14
-```
15 8
16 9
## Relevance tier by entity
17 10
... ...
@@ -49,4 +42,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
49 42
<!-- ORIGIN: beaLandscapeSomaticMutations2013 -->
50 43
<!-- MCL: beaLandscapeSomaticMutations2013 -->
51 44
45
+[[include:mermaid_CCND1.md]]
46
+
52 47
## References
CCND3.md
... ...
@@ -4,7 +4,7 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CCND3
7
+[[_TOC_]]
8 8
9 9
## Overview
10 10
CCND3 (Cyclin D3) is a gene that encodes a protein involved in the regulation of the cell cycle. Mutations in CCND3 are implicated in various types of B-cell lymphomas, including Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL).[@richterRecurrentMutationID32012; @morinFrequentMutationHistonemodifying2011]
... ...
@@ -12,21 +12,6 @@ CCND3 (Cyclin D3) is a gene that encodes a protein involved in the regulation of
12 12
## Experimental Evidence
13 13
Somatic mutations in CCND3 often stabilize the Cyclin D3 protein by altering the phosphorylation motif, which is crucial for proteasomal degradation. These mutations are associated with an increase in Cyclin D3 protein stability and oncogenic potential.[@schmitzBurkittLymphomaPathogenesis2012]
14 14
15
-```mermaid
16
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
17
-timeline
18
- title Publication timing
19
-2011-07-27 : Morin : DLBCL
20
-2012-03-06 : Lohr : DLBCL
21
- 2012-11-11 : Richter : BL
22
- 2017-07-27 : Jallades : MZL
23
-2017-10-10 : Reddy : DLBCL
24
-2018-05-01 : Chapuy : DLBCL
25
-2018-10-01 : Arthur : DLBCL
26
-2019-08-20 : Desch : PMBL
27
-2021-05-05 : Hubschmann : DLBCL
28
-
29
-```
30 15
31 16
## Relevance tier by entity
32 17
... ...
@@ -108,6 +93,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
108 93
<!-- MZL: jalladesExomeSequencingIdentifies2017 -->
109 94
<!-- PMBL: deschGenotypingCirculatingTumor2020 -->
110 95
96
+[[include:mermaid_CCND3.md]]
97
+
111 98
## References
112 99
113 100
CCNF.md
... ...
@@ -3,16 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CCNF
6
+[[_TOC_]]
7 7
8
-## History
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2013-01-01 : Zhang : DLBCL
14
- 2015-10-15 : Abate : BL
15
-```
16 8
17 9
## Relevance tier by entity
18 10
... ...
@@ -50,4 +42,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
50 42
<!-- ORIGIN: abateDistinctViralMutational2015a -->
51 43
<!-- BL: abateDistinctViralMutational2015a -->
52 44
45
+[[include:mermaid_CCNF.md]]
46
+
53 47
## References
CCT6B.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CCT6B
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -11,14 +11,7 @@ Due to [minimal support](CCT6B#representative-mutations) in the original primary
11 11
12 12
<<Warn("The variants reported in this gene failed QC")>>
13 13
14
-## History
15 14
16
-```mermaid
17
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
18
-timeline
19
- title Publication timing
20
- 2012-12-01 : Love : BL
21
-```
22 15
23 16
## Relevance tier by entity
24 17
... ...
@@ -70,4 +63,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
70 63
[515](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/515_reports.html)
71 64
[670](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/670_reports.html)
72 65
66
+[[include:mermaid_CCT6B.md]]
67
+
73 68
## References
CD22.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD22
6
+[[_TOC_]]
7 7
8
-## History
9 8
Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.<sup>1</sup> Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-10-10 : Reddy : DLBCL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -50,6 +43,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
50 43
## CD22 Expression
51 44
![](images/gene_expression/CD22_by_pathology.svg)
52 45
46
+[[include:mermaid_CD22.md]]
47
+
53 48
## References
54 49
55 50
CD274.md
... ...
@@ -3,19 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD274
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
the CD274 gene encodes the programmed death-ligand 1 (PD-L1). Mutations in B-cell lymphomas, such as DLBCL, are relatively rare.
10 10
Although rare, mutations have the potential to impact PD-L1 expression and could be relevant in the context of immune checkpoint inhibitors.
11 11
12
-## History
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2011-07-27 : Morin : DLBCL
18
-```
19 12
20 13
## Relevance tier by entity
21 14
... ...
@@ -55,6 +48,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
55 48
## CD274 Expression
56 49
![](images/gene_expression/CD274_by_pathology.svg)
57 50
51
+[[include:mermaid_CD274.md]]
52
+
58 53
## References
59 54
60 55
CD36.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD36
6
+[[_TOC_]]
7 7
8 8
CD36 is a transmembrane glycoprotein involved in fatty acid metabolism, glucose intolerance, and immune responses. It is expressed on various cell types, including platelets, monocytes, and some lymphocytes. One study showed higher rates of CD36 mutations in FL relative to DLBCLs.<sup>1</sup>
9 9
10
-## History
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-31 : Pasqualucci : DLBCL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -49,6 +42,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
49 42
50 43
![](images/proteinpaint/CD36.svg)
51 44
45
+[[include:mermaid_CD36.md]]
46
+
52 47
## References
53 48
54 49
CD44.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD44
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2018-10-01 : Arthur : DLBCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -58,4 +51,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
58 51
<!-- ORIGIN: arthurGenomewideDiscoverySomatic2018 -->
59 52
<!-- DLBCL: arthurGenomewideDiscoverySomatic2018 -->
60 53
54
+[[include:mermaid_CD44.md]]
55
+
61 56
## References
CD58.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD58
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -14,20 +14,6 @@ CD58, also known as lymphocyte function-associated antigen 3 (LFA-3), is crucial
14 14
In DLBCL, mutations prevent the expression of CD58 on the cell surface, impairing the ability of T and NK cells to recognize and attack the tumor cells.
15 15
This is often accompanied by mutations in the β2-Microglobulin gene, which further aids in immune evasion.[@challa-malladiCombinedGeneticInactivation2011]
16 16
17
-## History
18
-```mermaid
19
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
20
-timeline
21
- title Publication timing
22
-2011-07-27 : Morin : DLBCL
23
-2012-03-06 : Lohr : DLBCL
24
-2013-08-15 : Morin : DLBCL
25
- 2015-10-01 : Schneider : PMBL
26
-2017-05-01 : Albuquerque : DLBCL
27
-2017-10-10 : Reddy : DLBCL
28
-2018-04-12 : Schmitz : DLBCL
29
-2018-05-01 : Chapuy : DLBCL
30
-```
31 17
32 18
## Relevance tier by entity
33 19
... ...
@@ -55,6 +41,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
55 41
## CD58 Expression
56 42
![](images/gene_expression/CD58_by_pathology.svg)
57 43
44
+[[include:mermaid_CD58.md]]
45
+
58 46
## References
59 47
60 48
<!-- ORIGIN: schneiderAlterationsCD58Gene2015a -->
CD70.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD70
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
CD70 is a costimulatory molecule expressed on some activated lymphocytes and has a role in T-cell-mediated immune responses.
... ...
@@ -13,20 +13,6 @@ The mutation pattern in CD70 is consistent with the preferential accumulation of
13 13
Genetic perturbation limits the development of an effective CD8+ T-cell immune response in Bcl6-driven DLBCL. [@nieDualRoleCD702022]
14 14
In mouse models, CD70 loss promoted lymphomagenesis, consistent with its role as a tumor suppressor gene in B-cell lymphomas.[@mandatoAbstractA38Cd702022]
15 15
16
-## History
17
-```mermaid
18
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
19
-timeline
20
- title Publication timing
21
-2011-07-27 : Morin : DLBCL
22
-2012-03-06 : Lohr : DLBCL
23
-2013-08-15 : Morin : DLBCL
24
-2017-05-01 : Albuquerque : DLBCL
25
-2017-10-10 : Reddy : DLBCL
26
-2018-04-12 : Schmitz : DLBCL
27
-2018-05-01 : Chapuy : DLBCL
28
- 2023-07-26 : Russler-Germain : FL
29
-```
30 16
31 17
## Relevance tier by entity
32 18
... ...
@@ -68,6 +54,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
68 54
<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->
69 55
<!-- FL: russler-germainMutationsAssociatedProgression2023b -->
70 56
57
+[[include:mermaid_CD70.md]]
58
+
71 59
## References
72 60
73 61
CD74.md
... ...
@@ -3,15 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD74
7
-##History
6
+[[_TOC_]]
8 7
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2018-10-01 : Arthur : DLBCL
14
-```
15 8
16 9
## Relevance tier by entity
17 10
... ...
@@ -57,4 +50,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
57 50
<!-- ORIGIN: arthurGenomewideDiscoverySomatic2018 -->
58 51
<!-- DLBCL: arthurGenomewideDiscoverySomatic2018 -->
59 52
53
+[[include:mermaid_CD74.md]]
54
+
60 55
## References
CD79A.md
... ...
@@ -3,17 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD79A
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2012-08-27 : Rossi : MZL
15
- 2022-07-06 : Burkhardt : BL
16
-```
17 9
18 10
## Relevance tier by entity
19 11
... ...
@@ -62,6 +54,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
62 54
<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->
63 55
<!-- MZL: rossiCodingGenomeSplenic2012c -->
64 56
57
+[[include:mermaid_CD79A.md]]
58
+
65 59
## References
66 60
1. Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med. 2012 Aug 27;209(9):1537–1551. PMCID: PMC3428941
67 61
2. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584
CD79B.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD79B
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
CD79B mutations significantly contribute to the pathogenesis of DLBCL by enhancing BCR signaling and promoting tumor survival.
... ...
@@ -15,22 +15,6 @@ The most common hotspot mutation in CD79B is at the tyrosine residue 196 (Y196).
15 15
This and other common mutations primarily occur in the immunoreceptor tyrosine-based activation motif (ITAM) domain and prevent the negative regulatory feedback provided by Lyn kinase thereby enhancing BCR signaling.[@kimCD79BMYD88Mutations2014; @davisChronicActiveBcellreceptor2010]
16 16
17 17
18
-## History
19
-```mermaid
20
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
21
-timeline
22
- title Publication timing
23
-2011-07-27 : Morin : DLBCL
24
-2012-03-06 : Lohr : DLBCL
25
-2013-01-01 : Zhang : DLBCL
26
-2013-08-15 : Morin : DLBCL
27
-2017-05-01 : Albuquerque : DLBCL
28
-2017-10-10 : Reddy : DLBCL
29
-2018-04-12 : Schmitz : DLBCL
30
-2018-05-01 : Chapuy : DLBCL
31
-2018-10-01 : Arthur : DLBCL
32
- 2019-09-26 : Panea : BL
33
-```
34 18
35 19
## Relevance tier by entity
36 20
... ...
@@ -96,6 +80,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
96 80
&starf; &starf; &starf; &star; &star;
97 81
98 82
83
+[[include:mermaid_CD79B.md]]
84
+
99 85
## References
100 86
<!-- ORIGIN: morinFrequentMutationHistonemodifying2011 -->
101 87
<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->
CD83.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CD83
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -11,23 +11,9 @@ CD83 is a transmembrane protein that plays a role in the immune system, particul
11 11
CD83 mutations in B-cell lymphomas have not been as extensively studied as mutations in some other genes. CD83 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
12 12
No notable hot spots have been described in this gene in the context of the cancers listed below.
13 13
14
-## History
15 14
Mutations in this gene were first described in DLBCL in 2013 by Morin et al<sup>2</sup>, in BL in 2019 by Panea et al<sup>3</sup> and in FL in 2023 by Russler-Germain et al.<sup>4</sup>
16 15
17 16
18
-```mermaid
19
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
20
-timeline
21
- title Publication timing
22
- 2013-08-15 : Morin : DLBCL
23
- 2017-10-10 : Reddy : DLBCL
24
- 2018-04-12 : Schmitz : DLBCL
25
-2018-05-01 : Chapuy : DLBCL
26
- 2019-09-26 : Panea : BL
27
-2021-05-05 : Hubschmann : DLBCL
28
- 2021-07-15 : Duns : PMBL
29
- 2023-07-26 : Russler-Germain : FL
30
-```
31 17
32 18
## Relevance tier by entity
33 19
... ...
@@ -79,6 +65,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
79 65
&starf; &starf; &starf; &starf; &star;
80 66
81 67
68
+[[include:mermaid_CD83.md]]
69
+
82 70
## References
83 71
<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->
84 72
<!-- BL: paneaWholeGenomeLandscape2019 -->
CD9B.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CD9B
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2016-06-14 : van : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -29,6 +22,8 @@ timeline
29 22
|:------:|:----:|:----:|
30 23
31 24
25
+[[include:mermaid_CD9B.md]]
26
+
32 27
## References
33 28
34 29
CDC123.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDC123
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CDC123.md]]
23
+
29 24
## References
30 25
31 26
CDC27.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDC27
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2022-03-01 : Ma : BL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CDC27.md]]
23
+
29 24
## References
30 25
31 26
CDC42BPB.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CDC42BPB
6
+[[_TOC_]]
7 7
8
-## History
9 8
Mutations in this gene were first described in FL in 2021 by Hübschmann et al.<sup>1</sup>
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2021-05-05 : Hübschmann : FL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -35,6 +28,8 @@ timeline
35 28
[SP194134](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP194134.html)
36 29
37 30
31
+[[include:mermaid_CDC42BPB.md]]
32
+
38 33
## References
39 34
40 35
CDC73.md
... ...
@@ -3,20 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CDC73
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
9 9
10
-## History
11 10
Mutations in this gene were first described in BL in 2012 by Love et al<sup>1</sup> and subsequently in DLBCL by Reddy et al.<sup>2</sup> Subsequent exome and genome-wide studies of DLBCL and BL did not reproduce these observations.
12 11
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2012-12-01 : Love : BL
18
- 2017-10-10 : Reddy : DLBCL
19
-```
20 12
21 13
## Relevance tier by entity
22 14
... ...
@@ -78,6 +70,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
78 70
[1065](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1065_reports.html)
79 71
[847](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/847_reports.html)
80 72
73
+[[include:mermaid_CDC73.md]]
74
+
81 75
## References
82 76
83 77
CDH1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDH1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CDH1.md]]
23
+
29 24
## References
30 25
31 26
CDH10.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDH10
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CDH10.md]]
23
+
29 24
## References
30 25
31 26
CDH17.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CDH17
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -11,13 +11,6 @@ Due to [minimal support](CDH17#representative-mutations) in the original primary
11 11
12 12
<<Warn("The variants reported in this gene failed QC")>>
13 13
14
-## History
15
-```mermaid
16
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
17
-timeline
18
- title Publication timing
19
- 2012-12-01 : Love : BL
20
-```
21 14
22 15
## Relevance tier by entity
23 16
... ...
@@ -68,4 +61,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
68 61
[1102](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1102_reports.html)
69 62
[322](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/322_reports.html)
70 63
64
+[[include:mermaid_CDH17.md]]
65
+
71 66
## References
CDH2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDH2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2019-08-20 : Desch : PMBL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |0.585 |
36 29
37 30
31
+[[include:mermaid_CDH2.md]]
32
+
38 33
## References
39 34
40 35
CDH5.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDH5
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2023-11-15 : Gomez : PMBL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|FL|GAMBL Exome |0.573 |
35 28
36 29
30
+[[include:mermaid_CDH5.md]]
31
+
37 32
## References
38 33
39 34
CDH7.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDH7
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CDH7.md]]
23
+
29 24
## References
30 25
31 26
CDH8.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CDH8
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2014-05-08 : Zhang : MCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
50 43
<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->
51 44
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
52 45
46
+[[include:mermaid_CDH8.md]]
47
+
53 48
## References
CDH9.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CDH9
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2013-08-15 : Morin : DLBCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -59,4 +52,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
59 52
[RG034](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG034.html)
60 53
[RG065](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG065.html)
61 54
55
+[[include:mermaid_CDH9.md]]
56
+
62 57
## References
CDK3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDK3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CDK3.md]]
23
+
29 24
## References
30 25
31 26
CDKN1A.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CDKN1A
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CDKN1A.md]]
23
+
29 24
## References
30 25
31 26
CDKN2A.md
... ...
@@ -3,22 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CDKN2A
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
Although CDKN2A aberrations are common in DLBCL, this gene is predominantly affected by copy number alterations. One study found that deletions of the CDKN2A locus occur in about one-third of DLBCL patients.<sup>1</sup> The mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations*. This gene has some recurrent sites of mutations (hotspots) with the most common mutation causing a truncation at codon 80 (R80*).
10 10
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
-2013-08-15 : Morin : DLBCL
16
-2016-09-08 : Spina : MZL
17
-2017-10-10 : Reddy : DLBCL
18
-2018-04-12 : Schmitz : DLBCL
19
-2019-03-21 : Grande : BL
20
-2021-05-05 : Hubschmann : DLBCL
21
-```
22 11
23 12
## Relevance tier by entity
24 13
... ...
@@ -62,6 +51,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
62 51
63 52
![](images/gene_expression/CDKN2A_by_pathology.svg)
64 53
54
+[[include:mermaid_CDKN2A.md]]
55
+
65 56
## References
66 57
67 58
CDKN2C.md
... ...
@@ -3,15 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CDKN2C
6
+[[_TOC_]]
7 7
8
-## History
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2023-02-03 : Thomas : BL
14
-```
15 8
16 9
## Relevance tier by entity
17 10
... ...
@@ -51,4 +44,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
51 44
<!-- ORIGIN: thomasGeneticSubgroupsInform2023 -->
52 45
<!-- BL: thomasGeneticSubgroupsInform2023 -->
53 46
47
+[[include:mermaid_CDKN2C.md]]
48
+
54 49
## References
CECR1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CECR1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CECR1.md]]
23
+
29 24
## References
30 25
31 26
CELSR2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CELSR2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CELSR2.md]]
23
+
29 24
## References
30 25
31 26
CEP164.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CEP164
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-05-01 : Albuquerque : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CEP164.md]]
23
+
29 24
## References
30 25
31 26
CGN.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CGN
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CGN.md]]
23
+
29 24
## References
30 25
31 26
CHD1.md
... ...
@@ -3,19 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CHD1
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
9 9
10
-## History
11 10
Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.<sup>1</sup> Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.
12 11
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2017-10-10 : Reddy : DLBCL
18
-```
19 12
20 13
## Relevance tier by entity
21 14
... ...
@@ -52,6 +45,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
52 45
## CHD1 Expression
53 46
![](images/gene_expression/CHD1_by_pathology.svg)
54 47
48
+[[include:mermaid_CHD1.md]]
49
+
55 50
## References
56 51
57 52
CHD3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CHD3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CHD3.md]]
23
+
29 24
## References
30 25
31 26
CHD4.md
... ...
@@ -3,15 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CHD4
6
+[[_TOC_]]
7 7
8
-## History
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2022-07-06 : Burkhardt : BL
14
-```
15 8
16 9
## Relevance tier by entity
17 10
... ...
@@ -51,4 +44,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
51 44
<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->
52 45
<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->
53 46
47
+[[include:mermaid_CHD4.md]]
48
+
54 49
## References
CHD8.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CHD8
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
9 9
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2017-10-10 : Reddy : DLBCL
15
- 2019-03-21 : Grande : BL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -107,6 +100,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
107 100
[Reddy_3992T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3992T.html)
108 101
[Reddy_830T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_830T.html)
109 102
103
+[[include:mermaid_CHD8.md]]
104
+
110 105
## References
111 106
112 107
CHEK2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CHEK2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CHEK2.md]]
23
+
29 24
## References
30 25
31 26
CHMP4C.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CHMP4C
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-11-05 : Be : MCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -32,6 +25,8 @@ timeline
32 25
|DLBCL|GAMBL Genome |0.376 |
33 26
34 27
28
+[[include:mermaid_CHMP4C.md]]
29
+
35 30
## References
36 31
37 32
CHRM5.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CHRM5
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CHRM5.md]]
23
+
29 24
## References
30 25
31 26
CHST2.md
... ...
@@ -3,19 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CHST2
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
9 9
10
-## History
11 10
Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.<sup>1</sup> Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.
12 11
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2017-10-10 : Reddy : DLBCL
18
-```
19 12
20 13
## Relevance tier by entity
21 14
... ...
@@ -88,6 +81,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
88 81
[Reddy_3917T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3917T.html)
89 82
[Reddy_3998T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3998T.html)
90 83
84
+[[include:mermaid_CHST2.md]]
85
+
91 86
## References
92 87
93 88
CIC.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CIC
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CIC.md]]
23
+
29 24
## References
30 25
31 26
CIITA.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CIITA
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
CIITA encodes the major histocompatibility complex (MHC) class II transactivator. CIITA mutations are frequent in PMBCL. These mutations often include structural genomic rearrangements, missense, nonsense, and frameshift mutations. In PMBCL, these mutations are thought to contribute to loss of MHC expression.<sup>1</sup> Although loss of CIITA and MHC Class II Expression is commonly observed in DLBCL, the role of mutations and methylation affecting this locus remains unclear.<sup>2</sup> CIITA is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
10 10
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-27 : Morin : DLBCL
16
- 2015-11-17 : Mottok : PMBL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -51,6 +44,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
51 44
## CIITA Expression
52 45
![](images/gene_expression/CIITA_by_pathology.svg)
53 46
47
+[[include:mermaid_CIITA.md]]
48
+
54 49
## References
55 50
56 51
<!-- ORIGIN: morinFrequentMutationHistonemodifying2011 -->
CILP.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CILP
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2023-07-26 : Russler : FL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
50 43
<!-- ORIGIN: russler-germainMutationsAssociatedProgression2023a -->
51 44
<!-- FL: russler-germainMutationsAssociatedProgression2023b -->
52 45
46
+[[include:mermaid_CILP.md]]
47
+
53 48
## References
CISH.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CISH
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2019-09-05 : Mottok : PMBL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -33,6 +26,8 @@ timeline
33 26
|FL|GAMBL Exome |0.573 |
34 27
35 28
29
+[[include:mermaid_CISH.md]]
30
+
36 31
## References
37 32
38 33
CLGN.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CLGN
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2016-09-08 : Spina : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|MCL|GAMBL Genome |0.585 |
35 28
36 29
30
+[[include:mermaid_CLGN.md]]
31
+
37 32
## References
38 33
39 34
CNBP.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CNBP
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2016-09-08 : Spina : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -29,6 +22,8 @@ timeline
29 22
|:------:|:----:|:----:|
30 23
31 24
25
+[[include:mermaid_CNBP.md]]
26
+
32 27
## References
33 28
34 29
CNGA4.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CNGA4
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CNGA4.md]]
23
+
29 24
## References
30 25
31 26
CNKSR2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CNKSR2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2016-09-08 : Spina : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |0.585 |
36 29
37 30
31
+[[include:mermaid_CNKSR2.md]]
32
+
38 33
## References
39 34
40 35
CNOT2.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CNOT2
6
+[[_TOC_]]
7 7
8
-## History
9 8
Mutations in this gene were first described in DLBCL in 2021 by Hübschmann et al.<sup>1</sup>
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2021-05-05 : Hübschmann : DLBCL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -57,6 +50,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
57 50
[SP116663](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP116663.html)
58 51
[SP192997](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP192997.html)
59 52
53
+[[include:mermaid_CNOT2.md]]
54
+
60 55
## References
61 56
62 57
<!-- ORIGIN: hubschmannMutationalMechanismsShaping2021b -->
CNOT6.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CNOT6
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CNOT6.md]]
23
+
29 24
## References
30 25
31 26
CNP.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CNP
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CNP.md]]
23
+
29 24
## References
30 25
31 26
CNTN6.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CNTN6
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CNTN6.md]]
23
+
29 24
## References
30 25
31 26
CNTNAP5.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CNTNAP5
6
+[[_TOC_]]
7 7
8
-## History
9 8
Mutations in this gene were first described in DLBCL in 2013 by Morin et al.<sup>1</sup>
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-08-15 : Morin : DLBCL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -57,6 +50,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
57 50
[RG115](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG115.html)
58 51
[RG136](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG136.html)
59 52
53
+[[include:mermaid_CNTNAP5.md]]
54
+
60 55
## References
61 56
62 57
<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->
COL11A1.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# COL11A1
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2014-05-08 : Zhang : MCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
50 43
<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->
51 44
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
52 45
46
+[[include:mermaid_COL11A1.md]]
47
+
53 48
## References
COL12A1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# COL12A1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_COL12A1.md]]
23
+
29 24
## References
30 25
31 26
COL16A1.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# COL16A1
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2014-05-08 : Zhang : MCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
50 43
<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->
51 44
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
52 45
46
+[[include:mermaid_COL16A1.md]]
47
+
53 48
## References
COL4A2.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# COL4A2
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -11,14 +11,7 @@ Due to [minimal support](COL4A2#representative-mutations) in the original primar
11 11
12 12
<<Warn("The variants reported in this gene failed QC")>>
13 13
14
-## History
15 14
16
-```mermaid
17
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
18
-timeline
19
- title Publication timing
20
- 2012-12-01 : Love : BL
21
-```
22 15
23 16
## Relevance tier by entity
24 17
... ...
@@ -70,4 +63,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
70 63
[747](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/747_reports.html)
71 64
72 65
66
+[[include:mermaid_COL4A2.md]]
67
+
73 68
## References
COL5A2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# COL5A2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_COL5A2.md]]
23
+
29 24
## References
30 25
31 26
COQ7.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# COQ7
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2018-05-01 : Chapuy : DLBCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -58,4 +51,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
58 51
[DLBCL-RICOVER_1032-Tumor](https://bcgsc.ca/downloads/morinlab/GAMBL/Chapuy_2018/DLBCL-RICOVER_1032-Tumor.html)
59 52
[DLBCL-RICOVER_181-Tumor](https://bcgsc.ca/downloads/morinlab/GAMBL/Chapuy_2018/DLBCL-RICOVER_181-Tumor.html)
60 53
54
+[[include:mermaid_COQ7.md]]
55
+
61 56
## References
CORO2A.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CORO2A
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CORO2A.md]]
23
+
29 24
## References
30 25
31 26
CORO7.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CORO7
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CORO7.md]]
23
+
29 24
## References
30 25
31 26
CPNE8.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CPNE8
6
+[[_TOC_]]
7 7
8
-## History
9 8
Mutations in this gene were first described in FL in 2021 by Hübschmann et al.<sup>1</sup>
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2021-05-05 : Hübschmann : FL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -57,6 +50,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
57 50
[SP193150](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193150.html)
58 51
[SP116720](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP116720.html)
59 52
53
+[[include:mermaid_CPNE8.md]]
54
+
60 55
## References
61 56
62 57
<!-- ORIGIN: hubschmannMutationalMechanismsShaping2021b -->
CPS1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CPS1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2012-03-06 : Lohr : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|FL|GAMBL Exome |1.146 |
35 28
36 29
30
+[[include:mermaid_CPS1.md]]
31
+
37 32
## References
38 33
39 34
CPXM2.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CPXM2
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2022-07-06 : Burkhardt : BL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -52,4 +45,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
52 45
<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->
53 46
<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->
54 47
48
+[[include:mermaid_CPXM2.md]]
49
+
55 50
## References
CRELD2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CRELD2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CRELD2.md]]
23
+
29 24
## References
30 25
31 26
CRIP1.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CRIP1
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2018-05-01 : Chapuy : DLBCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -58,4 +51,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
58 51
[DLBCL-RICOVER_361-Tumor](https://bcgsc.ca/downloads/morinlab/GAMBL/Chapuy_2018/DLBCL-RICOVER_361-Tumor.html)
59 52
[DLBCL-RICOVER_950-Tumor](https://bcgsc.ca/downloads/morinlab/GAMBL/Chapuy_2018/DLBCL-RICOVER_950-Tumor.html)
60 53
54
+[[include:mermaid_CRIP1.md]]
55
+
61 56
## References
CRTC3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CRTC3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CRTC3.md]]
23
+
29 24
## References
30 25
31 26
CRYBG3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CRYBG3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-11-05 : Be : MCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |2.339 |
36 29
37 30
31
+[[include:mermaid_CRYBG3.md]]
32
+
38 33
## References
39 34
40 35
CSF2RB.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CSF2RB
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2015-02-12 : Reichel : PMBL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -33,6 +26,8 @@ timeline
33 26
|DLBCL|GAMBL Genome |0.376 |
34 27
35 28
29
+[[include:mermaid_CSF2RB.md]]
30
+
36 31
## References
37 32
38 33
CSNK1A1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CSNK1A1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CSNK1A1.md]]
23
+
29 24
## References
30 25
31 26
CSNK2A1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CSNK2A1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CSNK2A1.md]]
23
+
29 24
## References
30 25
31 26
CST7.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CST7
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CST7.md]]
23
+
29 24
## References
30 25
31 26
CTCF.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CTCF
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in BL failed QC")>>
9 9
10
-## History
11 10
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2019-09-26 : Panea : BL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -66,4 +59,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
66 59
67 60
68 61
62
+[[include:mermaid_CTCF.md]]
63
+
69 64
## References
CTNNA2.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CTNNA2
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2014-05-08 : Zhang : MCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
50 43
<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->
51 44
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
52 45
46
+[[include:mermaid_CTNNA2.md]]
47
+
53 48
## References
CTNNA3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CTNNA3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CTNNA3.md]]
23
+
29 24
## References
30 25
31 26
CTSS.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CTSS
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2020-05-05 : Bararia : FL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -49,4 +42,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
49 42
<!-- ORIGIN: barariaCathepsinAlterationsInduce2020c -->
50 43
<!-- FL: barariaCathepsinAlterationsInduce2020c -->
51 44
45
+[[include:mermaid_CTSS.md]]
46
+
52 47
## References
CXCR4.md
... ...
@@ -3,27 +3,15 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CXCR4
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
10 10
CXCR4 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. No notable hot spots have been described in this gene in the context of the cancers listed below. The mutation pattern in DLBCL implies the preferential accumulation of *inactivating mutations*.
11 11
12
-## History
13 12
Mutations in this gene were first described in DLBCL in 2012 [@khodabakhshiRecurrentTargetsAberrant2012] in FL in 2021 [@hubschmannMutationalMechanismsShaping2021] and in BL in 2019.[@paneaWholeGenomeLandscape2019]
14 13
15 14
16
-```mermaid
17
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
18
-timeline
19
- title Publication timing
20
- 2012-11-12 : Khodabakhshi : DLBCL
21
-2017-01-26 : Krysiak : FL
22
-2017-10-10 : Reddy : DLBCL
23
-2018-05-01 : Chapuy : DLBCL
24
- 2019-09-26 : Panea : BL
25
-2021-05-05 : Hubschmann : DLBCL
26
-```
27 15
28 16
## Relevance tier by entity
29 17
... ...
@@ -72,6 +60,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
72 60
&starf; &starf; &starf; &starf; &starf;
73 61
74 62
63
+[[include:mermaid_CXCR4.md]]
64
+
75 65
## References
76 66
77 67
<!-- ORIGIN: khodabakhshiRecurrentTargetsAberrant2012 -->
CXCR5.md
... ...
@@ -3,20 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CXCR5
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
CXCR5 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. No notable hot spots have been described in this gene in the context of the cancers listed below. The mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations*.
10 10
11
-## History
12 11
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2018-04-12 : Schmitz : DLBCL
18
- 2019-09-05 : Mottok : PMBL
19
-```
20 12
21 13
## Relevance tier by entity
22 14
... ...
@@ -64,5 +56,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
64 56
<!-- PMBL: mottokIntegrativeGenomicAnalysis2019b -->
65 57
<!-- DLBCL: schmitzGeneticsPathogenesisDiffuse2018a -->
66 58
59
+[[include:mermaid_CXCR5.md]]
60
+
67 61
## References
68 62
CYB5D1.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CYB5D1
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene failed QC")>>
9 9
10
-## History
11 10
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2012-12-01 : Love : BL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -66,4 +59,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
66 59
[513](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/513_reports.html)
67 60
[670](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/670_reports.html)
68 61
62
+[[include:mermaid_CYB5D1.md]]
63
+
69 64
## References
CYP24A1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CYP24A1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CYP24A1.md]]
23
+
29 24
## References
30 25
31 26
CYP2A6.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CYP2A6
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2023-07-26 : Russler : FL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
50 43
<!-- ORIGIN: russler-germainMutationsAssociatedProgression2023a -->
51 44
<!-- FL: russler-germainMutationsAssociatedProgression2023b -->
52 45
46
+[[include:mermaid_CYP2A6.md]]
47
+
53 48
## References
CYP2C18.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CYP2C18
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CYP2C18.md]]
23
+
29 24
## References
30 25
31 26
CYP4F22.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# CYP4F22
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -11,14 +11,7 @@ Due to [minimal support](CYP4F22#representative-mutation) in the original primar
11 11
12 12
<<Warn("The variants reported in this gene failed QC")>>
13 13
14
-## History
15 14
16
-```mermaid
17
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
18
-timeline
19
- title Publication timing
20
- 2012-12-01 : Love : BL
21
-```
22 15
23 16
## Relevance tier by entity
24 17
... ...
@@ -71,5 +64,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
71 64
[747](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/747_reports.html)
72 65
73 66
67
+[[include:mermaid_CYP4F22.md]]
68
+
74 69
## References
75 70
CYTSB.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CYTSB
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-31 : Pasqualucci : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CYTSB.md]]
23
+
29 24
## References
30 25
31 26
CYYR1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# CYYR1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_CYYR1.md]]
23
+
29 24
## References
30 25
31 26
DAZAP1.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DAZAP1
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
This gene has some recurrent sites of mutations (hot spots). The mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations* however the pattern is notable. These mutations often result in truncations affecting the DAZAP1 C-terminus, which are predicted to alter protein sub-cellular localization and disrupt protein-protein interactions.<sup>1</sup>
10 10
11
-## History
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2020-07-30 : Pararajalingam : MCL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -63,6 +56,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
63 56
## DAZAP1 Expression
64 57
![](images/gene_expression/DAZAP1_by_pathology.svg)
65 58
59
+[[include:mermaid_DAZAP1.md]]
60
+
66 61
## References
67 62
68 63
<!-- ORIGIN: pararajalingamCodingNoncodingDrivers2020 -->
DCAF6.md
... ...
@@ -3,19 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DCAF6
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
9 9
10
-## History
11 10
Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.<sup>1</sup> Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.
12 11
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2017-10-10 : Reddy : DLBCL
18
-```
19 12
20 13
## Relevance tier by entity
21 14
... ...
@@ -96,6 +89,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
96 89
[Reddy_3987T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3987T.html)
97 90
[Reddy_705T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_705T.html)
98 91
92
+[[include:mermaid_DCAF6.md]]
93
+
99 94
## References
100 95
101 96
DCHS1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DCHS1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-31 : Pasqualucci : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DCHS1.md]]
23
+
29 24
## References
30 25
31 26
DCP1B.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DCP1B
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-11-05 : Be : MCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|MCL|GAMBL Genome |0.585 |
35 28
36 29
30
+[[include:mermaid_DCP1B.md]]
31
+
37 32
## References
38 33
39 34
DDB1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DDB1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DDB1.md]]
23
+
29 24
## References
30 25
31 26
DDX10.md
... ...
@@ -3,17 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DDX10
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2013-01-01 : Zhang : DLBCL
15
- 2017-10-10 : Reddy : DLBCL
16
-```
17 9
18 10
## Relevance tier by entity
19 11
... ...
@@ -85,4 +77,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
85 77
[Reddy_3982T](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Reddy/igv_reports/Reddy_3982T.html)
86 78
87 79
80
+[[include:mermaid_DDX10.md]]
81
+
88 82
## References
DDX3X.md
... ...
@@ -3,23 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DDX3X
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
Mutations in the DDX3X gene, which encodes an RNA helicase involved in various aspects of RNA metabolism, have significant implications in B-cell lymphomas, including BL, DLBCL, and other related malignancies and are particularly enriched within MYC-translocated tumors and those expressing the dark zone signature (DZsig).[@ennishiDoubleHitGeneExpression2019]
10 10
These mutations are predominantly loss-of-function (LOF) mutations, affecting the helicase domain of the protein. Missense mutations are predominantly found in male patients and rarely in females, hence showing a sex-specific pattern.[@gongSequentialInverseDysregulation2021]
11 11
12
-## History
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
-2012-10-04 : Schmitz : BL
18
-2017-10-10 : Reddy : DLBCL
19
-2018-04-12 : Schmitz : DLBCL
20
-2018-10-01 : Arthur : DLBCL
21
-2019-09-05 : Mottok : PMBL
22
-```
23 12
24 13
## Relevance tier by entity
25 14
... ...
@@ -64,6 +53,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
64 53
<!-- BL: schmitzBurkittLymphomaPathogenesis2012 -->
65 54
<!-- PMBL: mottokIntegrativeGenomicAnalysis2019b -->
66 55
56
+[[include:mermaid_DDX3X.md]]
57
+
67 58
## References
68 59
69 60
DGCR8.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DGCR8
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DGCR8.md]]
23
+
29 24
## References
30 25
31 26
DGKB.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DGKB
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2018-05-31 : Tiacci : PMBL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |0.585 |
36 29
37 30
31
+[[include:mermaid_DGKB.md]]
32
+
38 33
## References
39 34
40 35
DHCR7.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DHCR7
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2012-10-04 : Schmitz : BL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -33,6 +26,8 @@ timeline
33 26
|DLBCL|GAMBL Genome |0.188 |
34 27
35 28
29
+[[include:mermaid_DHCR7.md]]
30
+
36 31
## References
37 32
38 33
DHDH.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DHDH
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2014-05-08 : Zhang : MCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
50 43
<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->
51 44
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
52 45
46
+[[include:mermaid_DHDH.md]]
47
+
53 48
## References
DHX15.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DHX15
6
+[[_TOC_]]
7 7
8
-## History
9 8
Mutations in this gene were first described in FL in 2021 by Hübschmann et al.<sup>1</sup>
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2021-05-05 : Hübschmann : FL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -63,4 +56,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
63 56
[SP193017](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193017.html)
64 57
65 58
59
+[[include:mermaid_DHX15.md]]
60
+
66 61
## References
DHX16.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DHX16
6
+[[_TOC_]]
7 7
8
-## History
9 8
Mutations in this gene were first described in DLBCL in 2021 by Hübschmann et al.<sup>1</sup>
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2021-05-05 : Hübschmann : DLBCL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -60,6 +53,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
60 53
[SP194212](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP194212.html)
61 54
[SP193957](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193957.html)
62 55
56
+[[include:mermaid_DHX16.md]]
57
+
63 58
## References
64 59
65 60
DHX33.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DHX33
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DHX33.md]]
23
+
29 24
## References
30 25
31 26
DIAPH2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DIAPH2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DIAPH2.md]]
23
+
29 24
## References
30 25
31 26
DIAPH3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DIAPH3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DIAPH3.md]]
23
+
29 24
## References
30 25
31 26
DICER1.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DICER1
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
9 9
10
-## History
11 10
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2017-10-10 : Reddy : DLBCL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -58,5 +51,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
58 51
<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
59 52
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->
60 53
54
+[[include:mermaid_DICER1.md]]
55
+
61 56
## References
62 57
DIP2B.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DIP2B
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DIP2B.md]]
23
+
29 24
## References
30 25
31 26
DLC1.md
... ...
@@ -3,15 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DLC1
6
+[[_TOC_]]
7 7
8
-## History
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2014-05-08 : Zhang : MCL
14
-```
15 8
16 9
## Relevance tier by entity
17 10
... ...
@@ -49,4 +42,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
49 42
<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->
50 43
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
51 44
45
+[[include:mermaid_DLC1.md]]
46
+
52 47
## References
DLGAP1.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DLGAP1
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -11,15 +11,7 @@ Due to [minimal support](DLGAP1#representative-mutation) in the original primary
11 11
12 12
<<Warn("The variants reported in this gene in BL failed QC")>>
13 13
14
-## History
15 14
16
-```mermaid
17
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
18
-timeline
19
- title Publication timing
20
- 2012-12-01 : Love : BL
21
- 2013-01-01 : Zhang : DLBCL
22
-```
23 15
24 16
## Relevance tier by entity
25 17
... ...
@@ -71,4 +63,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
71 63
[508](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/508_reports.html)
72 64
[668](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/668_reports.html)
73 65
66
+[[include:mermaid_DLGAP1.md]]
67
+
74 68
## References
DLGAP2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DLGAP2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-11-05 : Be : MCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |1.17 |
36 29
37 30
31
+[[include:mermaid_DLGAP2.md]]
32
+
38 33
## References
39 34
40 35
DMD.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DMD
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2015-02-12 : Reichel : PMBL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |1.754 |
36 29
37 30
31
+[[include:mermaid_DMD.md]]
32
+
38 33
## References
39 34
40 35
DMXL1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DMXL1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DMXL1.md]]
23
+
29 24
## References
30 25
31 26
DNAH12.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DNAH12
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2019-12-10 : Wienand : PMBL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|MCL|GAMBL Genome |1.17 |
35 28
36 29
30
+[[include:mermaid_DNAH12.md]]
31
+
37 32
## References
38 33
39 34
DNAH5.md
... ...
@@ -3,16 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DNAH5
6
+[[_TOC_]]
7 7
8
-## History
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2013-08-15 : Morin : DLBCL
14
- 2017-07-27 : Jallades : MZL
15
-```
16 8
17 9
## Relevance tier by entity
18 10
... ...
@@ -64,4 +56,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
64 56
[RG036](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG036.html)
65 57
[RG130](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG130.html)
66 58
59
+[[include:mermaid_DNAH5.md]]
60
+
67 61
## References
DNAH7.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DNAH7
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-07-27 : Jallades : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |0.585 |
36 29
37 30
31
+[[include:mermaid_DNAH7.md]]
32
+
38 33
## References
39 34
40 35
DNAI1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DNAI1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-07-27 : Jallades : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |0.585 |
36 29
37 30
31
+[[include:mermaid_DNAI1.md]]
32
+
38 33
## References
39 34
40 35
DNAJC6.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DNAJC6
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-11-05 : Be : MCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|FL|GAMBL Exome |0.287 |
35 28
36 29
30
+[[include:mermaid_DNAJC6.md]]
31
+
37 32
## References
38 33
39 34
DNM2.md
... ...
@@ -3,17 +3,10 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DNM2
6
+[[_TOC_]]
7 7
8
-## History
9 8
Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschmann et al.<sup>1</sup>
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2021-05-05 : Hübschmann : DLBCL
16
-```
17 10
18 11
## Relevance tier by entity
19 12
... ...
@@ -66,6 +59,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
66 59
[SP124975](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP124975.html)
67 60
[SP193130](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193130.html)
68 61
62
+[[include:mermaid_DNM2.md]]
63
+
69 64
## References
70 65
71 66
DNMT1.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DNMT1
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in BL failed QC")>>
9 9
10
-## History
11 10
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2019-09-26 : Panea : BL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -65,6 +58,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
65 58
**Rating**
66 59
&starf; &star; &star; &star; &star;
67 60
61
+[[include:mermaid_DNMT1.md]]
62
+
68 63
## References
69 64
70 65
DNMT3A.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DNMT3A
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
9 9
10
-## History
11 10
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2017-10-10 : Reddy : DLBCL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -55,5 +48,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
55 48
<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
56 49
<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->
57 50
51
+[[include:mermaid_DNMT3A.md]]
52
+
58 53
## References
59 54
DNMT3B.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DNMT3B
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-05-01 : Albuquerque : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DNMT3B.md]]
23
+
29 24
## References
30 25
31 26
DOCK1.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DOCK1
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2018-05-01 : Chapuy : DLBCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -63,5 +56,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
63 56
[DLBCL-RICOVER_773-Tumor](https://bcgsc.ca/downloads/morinlab/GAMBL/Chapuy_2018/DLBCL-RICOVER_773-Tumor.html)
64 57
[DLBCL-RICOVER_977-Tumor](https://bcgsc.ca/downloads/morinlab/GAMBL/Chapuy_2018/DLBCL-RICOVER_977-Tumor.html)
65 58
59
+[[include:mermaid_DOCK1.md]]
60
+
66 61
## References
67 62
DOCK2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DOCK2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DOCK2.md]]
23
+
29 24
## References
30 25
31 26
DOCK5.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DOCK5
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DOCK5.md]]
23
+
29 24
## References
30 25
31 26
DOCK6.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DOCK6
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-07-27 : Jallades : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |1.754 |
36 29
37 30
31
+[[include:mermaid_DOCK6.md]]
32
+
38 33
## References
39 34
40 35
DOLK.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DOLK
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DOLK.md]]
23
+
29 24
## References
30 25
31 26
DPYD.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DPYD
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-31 : Pasqualucci : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DPYD.md]]
23
+
29 24
## References
30 25
31 26
DSC2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DSC2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DSC2.md]]
23
+
29 24
## References
30 25
31 26
DSC3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DSC3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-31 : Pasqualucci : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DSC3.md]]
23
+
29 24
## References
30 25
31 26
DSCAML1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DSCAML1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DSCAML1.md]]
23
+
29 24
## References
30 25
31 26
DSEL.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DSEL
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-08-15 : Morin : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DSEL.md]]
23
+
29 24
## References
30 25
31 26
DSG2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DSG2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DSG2.md]]
23
+
29 24
## References
30 25
31 26
DSG4.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DSG4
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2013-08-15 : Morin : DLBCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -60,5 +53,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
60 53
[RG054](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG054.html)
61 54
[RG067](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG067.html)
62 55
56
+[[include:mermaid_DSG4.md]]
57
+
63 58
## References
64 59
DSP.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DSP
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -27,6 +20,8 @@ timeline
27 20
28 21
29 22
23
+[[include:mermaid_DSP.md]]
24
+
30 25
## References
31 26
32 27
DTNB.md
... ...
@@ -4,15 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DTNB
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
-```
16 10
17 11
18 12
## Relevance tier by entity
... ...
@@ -25,6 +19,8 @@ timeline
25 19
26 20
27 21
22
+[[include:mermaid_DTNB.md]]
23
+
28 24
## References
29 25
30 26
DTX1.md
... ...
@@ -3,24 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DTX1
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
Mutations in the DTX1 gene, which encodes the E3 ubiquitin ligase Deltex 1, have been identified in various B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL). DTX1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. These mutations are associated with the BN2 genetic subgroup of DLBCL. There are numerous mutation hotspots in this gene with some leading to a truncated protein. DTX1 functions as a negative regulator of the Notch signaling pathway. Some DTX1 mutations impair its function, thereby dysregulating Notch signaling, which is crucial for normal B-cell development and function. *Due to [minimal support](DLGAP1#representative-mutation) in the original primary data and very few mutations reported in subsequent BL studies, this gene is very unlikely to be relevant in BL.*
10 10
11 11
12
-## History
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2012-08-27 : Rossi : MZL
18
- 2012-12-01 : Love : BL
19
- 2013-01-01 : Zhang : DLBCL
20
- 2018-04-12 : Schmitz : DLBCL
21
- 2018-05-01 : Chapuy : DLBCL
22
- 2023-11-15 : Gomez : PMBL
23
-```
24 12
25 13
## Relevance tier by entity
26 14
... ...
@@ -130,6 +118,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
130 118
[323](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/323_reports.html)
131 119
[742](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/742_reports.html)
132 120
121
+[[include:mermaid_DTX1.md]]
122
+
133 123
## References
134 124
135 125
<!-- BL: paneaWholeGenomeLandscape2019 -->
DTX3L.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DTX3L
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-07-27 : Jallades : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -24,6 +17,8 @@ timeline
24 17
25 18
26 19
20
+[[include:mermaid_DTX3L.md]]
21
+
27 22
## References
28 23
29 24
DUOXA2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DUOXA2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DUOXA2.md]]
23
+
29 24
## References
30 25
31 26
DUPD1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DUPD1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DUPD1.md]]
23
+
29 24
## References
30 25
31 26
DUSP2.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# DUSP2
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -14,16 +14,6 @@ These mutations are associated with the ST2 genetic subgroup of DLBCL.
14 14
This gene has some recurrent sites of mutations (hot spots).
15 15
The mutation pattern in DLBCL implies the preferential accumulation of *inactivating mutations*.
16 16
17
-## History
18
-```mermaid
19
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
20
-timeline
21
- title Publication timing
22
-2012-03-06 : Lohr : DLBCL
23
-2013-08-15 : Morin : DLBCL
24
-2017-10-10 : Reddy : DLBCL
25
-2018-04-12 : Schmitz : DLBCL
26
-```
27 17
28 18
## Relevance tier by entity
29 19
... ...
@@ -79,6 +69,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/D
79 69
<!-- PMBL: dunsCharacterizationDLBCLPMBL2021b -->
80 70
<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->
81 71
72
+[[include:mermaid_DUSP2.md]]
73
+
82 74
## References
83 75
84 76
DUSP27.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DUSP27
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-31 : Pasqualucci : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DUSP27.md]]
23
+
29 24
## References
30 25
31 26
DUSP9.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DUSP9
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-31 : Pasqualucci : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DUSP9.md]]
23
+
29 24
## References
30 25
31 26
DYNC1H1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DYNC1H1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DYNC1H1.md]]
23
+
29 24
## References
30 25
31 26
DYNC1I1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# DYNC1I1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_DYNC1I1.md]]
23
+
29 24
## References
30 25
31 26
E2F2.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# E2F2
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2022-07-06 : Burkhardt : BL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -52,5 +45,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
52 45
<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->
53 46
<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->
54 47
48
+[[include:mermaid_E2F2.md]]
49
+
55 50
## References
56 51
EBF1.md
... ...
@@ -3,27 +3,13 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EBF1
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
EBF1 is a critical transcription factor in early B-cell development, regulating the expression of key genes involved in B-cell differentiation, survival, and function. EBF1 is essential for proper B-cell receptor (BCR) signaling.<sup>1</sup> Mutations in EBF1 can impair BCR signaling pathways, affecting B-cell survival and proliferation.<sup>1</sup> EBF1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. This gene has some recurrent sites of mutations (hot spots) but the mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations*.
10 10
11 11
12
-## History
13 12
14
-```mermaid
15
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
16
-timeline
17
- title Publication timing
18
-2012-10-01 : Bohle : DLBCL
19
-2013-08-15 : Morin : DLBCL
20
-2015-02-12 : Reichel : PMBL
21
-2017-05-01 : Albuquerque : DLBCL
22
-2017-10-10 : Reddy : DLBCL
23
-2018-05-01 : Chapuy : DLBCL
24
-2018-10-01 : Arthur : DLBCL
25
-2021-05-05 : Hubschmann : DLBCL
26
-```
27 13
28 14
## Relevance tier by entity
29 15
... ...
@@ -82,6 +68,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
82 68
<!-- PMBL: reichelFlowSortingExome2015a -->
83 69
<!-- DLBCL: bohleRoleEarlyBcell2013 -->
84 70
71
+[[include:mermaid_EBF1.md]]
72
+
85 73
## References
86 74
1. *Györy I, Boller S, Nechanitzky R, Mandel E, Pott S, Liu E, Grosschedl R. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 2012 Apr 1;26(7):668-82. doi: 10.1101/gad.18$
87 75
ECGF1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# ECGF1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_ECGF1.md]]
23
+
29 24
## References
30 25
31 26
ECT2L.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# ECT2L
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_ECT2L.md]]
23
+
29 24
## References
30 25
31 26
EDNRB.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EDNRB
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2022-07-06 : Burkhardt : BL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -52,5 +45,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
52 45
<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->
53 46
<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->
54 47
48
+[[include:mermaid_EDNRB.md]]
49
+
55 50
## References
56 51
EEF1A1.md
... ...
@@ -3,22 +3,13 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EEF1A1
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
Mutations in the EEF1A1 gene, which encodes the eukaryotic translation elongation factor 1A1, have been reported in DLBCL and FL.<sup>1</sup> This gene has some recurrent sites of mutations (hot spots). The mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations*. Paradoxically, one study showed that EEF1A1 knock down reduced proliferation in vitro and in xenograft experiments.<sup>2</sup>
10 10
11
-## History
12 11
Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschmann et al.<sup>1</sup>
13 12
14
-```mermaid
15
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
16
-timeline
17
- title Publication timing
18
- 2015-02-12 : Reichel : PMBL
19
-2018-05-01 : Chapuy : DLBCL
20
-2021-05-05 : Hubschmann : DLBCL
21
-```
22 13
23 14
## Relevance tier by entity
24 15
... ...
@@ -69,4 +60,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
69 60
<!-- DLBCL: hubschmannMutationalMechanismsShaping2021b -->
70 61
<!-- FL: hubschmannMutationalMechanismsShaping2021b -->
71 62
<!-- PMBL: reichelFlowSortingExome2015a -->
63
+[[include:mermaid_EEF1A1.md]]
64
+
72 65
## References
EGFR.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# EGFR
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_EGFR.md]]
23
+
29 24
## References
30 25
31 26
EGR1.md
... ...
@@ -4,18 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# EGR1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2012-08-27 : Rossi : MZL
16
- 2015-02-12 : Reichel : PMBL
17
- 2017-01-26 : Krysiak : FL
18
-```
19 10
20 11
21 12
## Relevance tier by entity
... ...
@@ -38,6 +29,8 @@ timeline
38 29
|FL|GAMBL Exome |3.152 |
39 30
40 31
32
+[[include:mermaid_EGR1.md]]
33
+
41 34
## References
42 35
43 36
EGR2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# EGR2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2012-08-27 : Rossi : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|FL|GAMBL Exome |1.146 |
35 28
36 29
30
+[[include:mermaid_EGR2.md]]
31
+
37 32
## References
38 33
39 34
EIF2AK4.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EIF2AK4
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2014-05-08 : Zhang : MCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -48,4 +41,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
48 41
<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->
49 42
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
50 43
44
+[[include:mermaid_EIF2AK4.md]]
45
+
51 46
## References
EIF2C4.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EIF2C4
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene in BL failed QC")>>
9 9
10
-## History
11 10
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2012-12-01 : Love : BL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -52,4 +45,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
52 45
[1091](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1091_reports.html)
53 46
[698](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/698_reports.html)
54 47
48
+[[include:mermaid_EIF2C4.md]]
49
+
55 50
## References
EIF4A1.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EIF4A1
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2019-09-26 : Panea : BL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
50 43
<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->
51 44
<!-- BL: paneaWholeGenomeLandscape2019 -->
52 45
46
+[[include:mermaid_EIF4A1.md]]
47
+
53 48
## References
ELP2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# ELP2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2012-10-04 : Schmitz : BL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -34,6 +27,8 @@ timeline
34 27
|MCL|GAMBL Genome |0.585 |
35 28
36 29
30
+[[include:mermaid_ELP2.md]]
31
+
37 32
## References
38 33
39 34
EML2.md
... ...
@@ -3,20 +3,13 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EML2
6
+[[_TOC_]]
7 7
8 8
Due to [minimal support](EML2#representative-mutation) in the original primary data and very few mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL.
9 9
10 10
<<Warn("The variants reported in this gene in BL failed QC")>>
11 11
12
-## History
13 12
14
-```mermaid
15
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
16
-timeline
17
- title Publication timing
18
- 2012-12-01 : Love : BL
19
-```
20 13
21 14
## Relevance tier by entity
22 15
... ...
@@ -65,4 +58,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
65 58
[1060](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1060_reports.html)
66 59
[1096](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1096_reports.html)
67 60
61
+[[include:mermaid_EML2.md]]
62
+
68 63
## References
ENTPD3.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# ENTPD3
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene failed QC")>>
9 9
10
-## History
11 10
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2012-12-01 : Love : BL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -64,5 +57,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
64 57
65 58
[745](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/745_reports.html)
66 59
60
+[[include:mermaid_ENTPD3.md]]
61
+
67 62
## References
68 63
EP300.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EP300
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
Mutations in EP300 are significant contributors to the pathogenesis and progression of B-cell lymphomas such as DLBCL and FL.[@pasqualucciInactivatingMutationsAcetyltransferase2011] This gene has some recurrent sites of mutations (hot spots), which typically impact its HAT domain, a region crucial for acetylating histones and non-histone proteins.[@pasqualucciInactivatingMutationsAcetyltransferase2011]
... ...
@@ -12,19 +12,7 @@ Mutations in EP300 are significant contributors to the pathogenesis and progress
12 12
EP300 mutations impair histone acetylation, disrupt epigenetic gene regulation. Mutations in CREBBP and EP300 affect a common pathway and have been described as mutually exclusive due to some functional redundancy.[@pasqualucciInactivatingMutationsAcetyltransferase2011; @veazeyCARM1InhibitionReduces2020]
13 13
Studies using genome-wide CRISPR-Cas9 screens have identified synthetic lethal interactions between CREBBP and EP300, suggesting that targeting one may affect the viability of cells with mutations in the other.[@nieGenomewideCRISPRScreens2021]
14 14
15
-## History
16 15
17
-```mermaid
18
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
19
-timeline
20
- title Publication timing
21
- 2011-03-10 : Pasqualucci : FL
22
-2012-08-27 : Rossi : MZL
23
-2017-10-10 : Reddy : DLBCL
24
-2018-04-12 : Schmitz : DLBCL
25
-2018-05-01 : Chapuy : DLBCL
26
-2018-10-01 : Arthur : DLBCL
27
-```
28 16
29 17
## Relevance tier by entity
30 18
... ...
@@ -85,6 +73,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
85 73
## EP300 Expression
86 74
![](images/gene_expression/EP300_by_pathology.svg)
87 75
76
+[[include:mermaid_EP300.md]]
77
+
88 78
## References
89 79
90 80
<!-- ORIGIN: 21390126 -->
EPHA3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# EPHA3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_EPHA3.md]]
23
+
29 24
## References
30 25
31 26
EPHA5.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# EPHA5
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_EPHA5.md]]
23
+
29 24
## References
30 25
31 26
EPHA7.md
... ...
@@ -4,17 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# EPHA7
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
- 2019-09-05 : Mottok : PMBL
17
-```
18 10
19 11
20 12
## Relevance tier by entity
... ...
@@ -36,6 +28,8 @@ timeline
36 28
|MCL|GAMBL Genome |1.754 |
37 29
38 30
31
+[[include:mermaid_EPHA7.md]]
32
+
39 33
## References
40 34
41 35
EPHB2.md
... ...
@@ -3,19 +3,12 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EPHB2
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene failed QC")>>
9 9
10
-## History
11 10
12 11
13
-```mermaid
14
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
15
-timeline
16
- title Publication timing
17
- 2012-12-01 : Love : BL
18
-```
19 12
20 13
## Relevance tier by entity
21 14
... ...
@@ -72,4 +65,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
72 65
[516](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/516_reports.html)
73 66
[676](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/676_reports.html)
74 67
68
+[[include:mermaid_EPHB2.md]]
69
+
75 70
## References
EPPK1.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EPPK1
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2019-09-26 : Panea : BL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -56,4 +49,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
56 49
<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->
57 50
<!-- BL: paneaWholeGenomeLandscape2019 -->
58 51
52
+[[include:mermaid_EPPK1.md]]
53
+
59 54
## References
ERAP1.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# ERAP1
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2022-07-06 : Burkhardt : BL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -52,5 +45,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
52 45
<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->
53 46
<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->
54 47
48
+[[include:mermaid_ERAP1.md]]
49
+
55 50
## References
56 51
ERAP2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# ERAP2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-05-01 : Albuquerque : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_ERAP2.md]]
23
+
29 24
## References
30 25
31 26
ERBB3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# ERBB3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_ERBB3.md]]
23
+
29 24
## References
30 25
31 26
ERN2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# ERN2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_ERN2.md]]
23
+
29 24
## References
30 25
31 26
ESX1.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# ESX1
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2014-05-08 : Zhang : MCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -50,5 +43,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
50 43
<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->
51 44
<!-- MCL: zhangGenomicLandscapeMantle2014 -->
52 45
46
+[[include:mermaid_ESX1.md]]
47
+
53 48
## References
54 49
ETNPPL.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# ETNPPL
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_ETNPPL.md]]
23
+
29 24
## References
30 25
31 26
ETS1.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# ETS1
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
... ...
@@ -14,19 +14,6 @@ The mutation pattern in DLBCL implies the preferential accumulation of *inactiva
14 14
<<Warn("The variants reported in this gene in BL failed QC")>>
15 15
16 16
17
-## History
18
-```mermaid
19
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
20
-timeline
21
- title Publication timing
22
-2011-07-27 : Morin : DLBCL
23
-2013-08-15 : Morin : DLBCL
24
-2017-10-10 : Reddy : DLBCL
25
-2018-04-12 : Schmitz : DLBCL
26
-2018-05-01 : Chapuy : DLBCL
27
-2018-10-01 : Arthur : DLBCL
28
- 2019-09-26 : Panea : BL
29
-```
30 17
31 18
## Relevance tier by entity
32 19
... ...
@@ -100,6 +87,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
100 87
&starf; &star; &star; &star; &star;
101 88
102 89
90
+[[include:mermaid_ETS1.md]]
91
+
103 92
## References
104 93
105 94
ETV6.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# ETV6
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
ETV6 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
... ...
@@ -12,19 +12,7 @@ This gene has some recurrent sites of mutations (hot spots) including multiple m
12 12
The mutation pattern in DLBCL mplies the preferential accumulation of *inactivating mutations*.
13 13
Coding and non-coding mutations in this gene are associated with the MCD genetic subgroup of DLBCL.
14 14
15
-## History
16 15
17
-```mermaid
18
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
19
-timeline
20
- title Publication timing
21
-2012-03-06 : Lohr : DLBCL
22
-2017-05-01 : Albuquerque : DLBCL
23
-2017-10-10 : Reddy : DLBCL
24
-2018-04-12 : Schmitz : DLBCL
25
-2018-05-01 : Chapuy : DLBCL
26
-2018-10-01 : Arthur : DLBCL
27
-```
28 16
29 17
## Relevance tier by entity
30 18
... ...
@@ -69,5 +57,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
69 57
<!-- ORIGIN: arthurGenomewideDiscoverySomatic2018 -->
70 58
<!-- DLBCL: arthurGenomewideDiscoverySomatic2018 -->
71 59
60
+[[include:mermaid_ETV6.md]]
61
+
72 62
## References
73 63
EWSR1.md
... ...
@@ -3,14 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EWSR1
6
+[[_TOC_]]
7 7
8
-```mermaid
9
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
10
-timeline
11
- title Publication timing
12
- 2020-07-30 : Pararajalingam : MCL
13
-```
14 8
15 9
## Relevance tier by entity
16 10
... ...
@@ -49,4 +43,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
49 43
<!-- ORIGIN: pararajalingamCodingNoncodingDrivers2020 -->
50 44
<!-- MCL: pararajalingamCodingNoncodingDrivers2020 -->
51 45
46
+[[include:mermaid_EWSR1.md]]
47
+
52 48
## References
EXOSC6.md
... ...
@@ -3,15 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EXOSC6
6
+[[_TOC_]]
7 7
8
-## History
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2012-10-04 : Schmitz : BL
14
-```
15 8
16 9
## Relevance tier by entity
17 10
... ...
@@ -51,5 +44,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
51 44
<!-- ORIGIN: schmitzBurkittLymphomaPathogenesis2012 -->
52 45
<!-- BL: schmitzBurkittLymphomaPathogenesis2012 -->
53 46
47
+[[include:mermaid_EXOSC6.md]]
48
+
54 49
## References
55 50
EXTL3.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# EXTL3
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_EXTL3.md]]
23
+
29 24
## References
30 25
31 26
EZH1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# EZH1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2017-07-27 : Jallades : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -35,6 +28,8 @@ timeline
35 28
|MCL|GAMBL Genome |1.17 |
36 29
37 30
31
+[[include:mermaid_EZH1.md]]
32
+
38 33
## References
39 34
40 35
EZR.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# EZR
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2019-08-20 : Desch : PMBL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -58,4 +51,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E
58 51
<!-- ORIGIN: deschGenotypingCirculatingTumor2020 -->
59 52
<!-- PMBL: deschGenotypingCirculatingTumor2020 -->
60 53
54
+[[include:mermaid_EZR.md]]
55
+
61 56
## References
FAIM.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# FAIM
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_FAIM.md]]
23
+
29 24
## References
30 25
31 26
FAM129B.md
... ...
@@ -3,18 +3,11 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# FAM129B
6
+[[_TOC_]]
7 7
8 8
<<Warn("The variants reported in this gene failed QC")>>
9 9
10
-## History
11 10
12
-```mermaid
13
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
14
-timeline
15
- title Publication timing
16
- 2012-12-01 : Love : BL
17
-```
18 11
19 12
## Relevance tier by entity
20 13
... ...
@@ -63,5 +56,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/F
63 56
[1092](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/1092_reports.html)
64 57
[475](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/475_reports.html)
65 58
59
+[[include:mermaid_FAM129B.md]]
60
+
66 61
## References
67 62
FAM161A.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# FAM161A
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_FAM161A.md]]
23
+
29 24
## References
30 25
31 26
FAM38B.md
... ...
@@ -3,16 +3,9 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# FAM38B
6
+[[_TOC_]]
7 7
8
-## History
9 8
10
-```mermaid
11
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
12
-timeline
13
- title Publication timing
14
- 2013-08-15 : Morin : DLBCL
15
-```
16 9
17 10
## Relevance tier by entity
18 11
... ...
@@ -45,5 +38,7 @@ timeline
45 38
[RG081](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG081.html)
46 39
[RG130](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG130.html)
47 40
41
+[[include:mermaid_FAM38B.md]]
42
+
48 43
## References
49 44
FAM62C.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# FAM62C
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_FAM62C.md]]
23
+
29 24
## References
30 25
31 26
FANCD2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# FANCD2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2013-01-01 : Zhang : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_FANCD2.md]]
23
+
29 24
## References
30 25
31 26
FAS.md
... ...
@@ -3,7 +3,7 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# FAS
6
+[[_TOC_]]
7 7
8 8
## Overview
9 9
FAS encodes a cell surface receptor involved in the induction of apoptosis. FAS mutations are common in DLBCL and may be more frequent in primary gastric DLBCL.<sup>1,2</sup>
... ...
@@ -12,19 +12,6 @@ Mutations in FAS often lead to a loss of function, making lymphoma cells resista
12 12
thereby allowing malignant cells to evade immune surveillance.<sup>5</sup>
13 13
In mouse models, Fas mutations led to a significantly shorter lymphoma-specific survival and reduced sensitivity to chemotherapy.<sup>5</sup>
14 14
15
-## History
16
-```mermaid
17
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
18
-timeline
19
- title Publication timing
20
-2007-05-01 : Scholl : DLBCL
21
-2011-07-27 : Morin : DLBCL
22
-2016-09-08 : Spina : MZL
23
-2017-05-01 : Albuquerque : DLBCL
24
-2017-10-10 : Reddy : DLBCL
25
-2018-05-01 : Chapuy : DLBCL
26
-2018-10-01 : Arthur : DLBCL
27
-```
28 15
29 16
## Relevance tier by entity
30 17
... ...
@@ -55,6 +42,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/F
55 42
## FAS Expression
56 43
![](images/gene_expression/FAS_by_pathology.svg)
57 44
45
+[[include:mermaid_FAS.md]]
46
+
58 47
## References
59 48
60 49
1. *Wohlfart, S., Sebinger, D., Gruber, P., Buch, J., Polgar, D., Krupitza, G., Rosner, M., Hengstschläger, M., Raderer, M., Chott, A., & Müllauer, L. (2004). FAS (CD95) mutations are rare in gastric MALT lymphoma but occur more frequently in primary gastric diffuse large B-cell lymphoma.. The American journal of pathology, 164 3, 1081-9 . https://doi.org/10.1016/S0002-9440(10)63195-1.*
FAT1.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# FAT1
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2016-09-08 : Spina : MZL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -36,6 +29,8 @@ timeline
36 29
|MCL|GAMBL Genome |2.339 |
37 30
38 31
32
+[[include:mermaid_FAT1.md]]
33
+
39 34
## References
40 35
41 36
FAT2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# FAT2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- 2011-07-27 : Morin : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_FAT2.md]]
23
+
29 24
## References
30 25
31 26
FAT4.md
... ...
@@ -3,17 +3,8 @@ bibliography: 'morinlab.bib'
3 3
csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6
-# FAT4
7
-
8
-## History
9
-```mermaid
10
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
11
-timeline
12
- title Publication timing
13
- 2013-08-15 : Morin : DLBCL
14
- 2013-12-13 : Parry : MZL
15
- 2014-05-08 : Zhang : MCL
16
-```
6
+[[_TOC_]]
7
+
17 8
18 9
## Relevance tier by entity
19 10
... ...
@@ -72,4 +63,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/F
72 63
[RG081](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG081.html)
73 64
[RG111](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Morin_2013/RG111.html)
74 65
66
+[[include:mermaid_FAT4.md]]
67
+
75 68
## References
FBLN2.md
... ...
@@ -4,16 +4,9 @@ csl: 'NLM.csl'
4 4
link-citations: true
5 5
---
6 6
7
-# FBLN2
7
+[[_TOC_]]
8 8
9
-## History
10 9
11
-```mermaid
12
-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
13
-timeline
14
- title Publication timing
15
- : : DLBCL
16
-```
17 10
18 11
19 12
## Relevance tier by entity
... ...
@@ -26,6 +19,8 @@ timeline
26 19
27 20
28 21
22
+[[include:mermaid_FBLN2.md]]
23
+
29 24
## References
30 25
31 26
mermaid_CAPN5.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CAPN7.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CARD11.md
... ...
@@ -0,0 +1,15 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2008-03-03 : Lenz : DLBCL
7
+2011-07-27 : Morin : DLBCL
8
+2012-03-06 : Lohr : DLBCL
9
+2012-04-01 : Yan : MZL
10
+2013-01-01 : Zhang : DLBCL
11
+2013-08-15 : Morin : DLBCL
12
+2016-06-21 : Wu : MCL
13
+2017-05-01 : Albuquerque : DLBCL
14
+2017-10-10 : Reddy : DLBCL
15
+```
mermaid_CARD4.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_CASP8.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+```
mermaid_CBFA2T3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-12-13 : Parry : MZL
7
+```
mermaid_CBLB.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+```
mermaid_CBX3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_CCDC132.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CCDC46.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CCDC97.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CCL4.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2018-05-01 : Chapuy : DLBCL
7
+```
mermaid_CCND1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-11-05 : Bea : MCL
7
+```
mermaid_CCND3.md
... ...
@@ -0,0 +1,16 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2011-07-27 : Morin : DLBCL
7
+2012-03-06 : Lohr : DLBCL
8
+ 2012-11-11 : Richter : BL
9
+ 2017-07-27 : Jallades : MZL
10
+2017-10-10 : Reddy : DLBCL
11
+2018-05-01 : Chapuy : DLBCL
12
+2018-10-01 : Arthur : DLBCL
13
+2019-08-20 : Desch : PMBL
14
+2021-05-05 : Hubschmann : DLBCL
15
+
16
+```
mermaid_CCNF.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+ 2015-10-15 : Abate : BL
8
+```
mermaid_CCT6B.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_CD22.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+```
mermaid_CD274.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-27 : Morin : DLBCL
7
+```
mermaid_CD36.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-31 : Pasqualucci : DLBCL
7
+```
mermaid_CD44.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2018-10-01 : Arthur : DLBCL
7
+```
mermaid_CD58.md
... ...
@@ -0,0 +1,14 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2011-07-27 : Morin : DLBCL
7
+2012-03-06 : Lohr : DLBCL
8
+2013-08-15 : Morin : DLBCL
9
+ 2015-10-01 : Schneider : PMBL
10
+2017-05-01 : Albuquerque : DLBCL
11
+2017-10-10 : Reddy : DLBCL
12
+2018-04-12 : Schmitz : DLBCL
13
+2018-05-01 : Chapuy : DLBCL
14
+```
mermaid_CD70.md
... ...
@@ -0,0 +1,14 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2011-07-27 : Morin : DLBCL
7
+2012-03-06 : Lohr : DLBCL
8
+2013-08-15 : Morin : DLBCL
9
+2017-05-01 : Albuquerque : DLBCL
10
+2017-10-10 : Reddy : DLBCL
11
+2018-04-12 : Schmitz : DLBCL
12
+2018-05-01 : Chapuy : DLBCL
13
+ 2023-07-26 : Russler-Germain : FL
14
+```
mermaid_CD74.md
... ...
@@ -0,0 +1,7 @@
1
+##History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2018-10-01 : Arthur : DLBCL
7
+```
mermaid_CD79A.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-08-27 : Rossi : MZL
7
+ 2022-07-06 : Burkhardt : BL
8
+```
mermaid_CD79B.md
... ...
@@ -0,0 +1,16 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2011-07-27 : Morin : DLBCL
7
+2012-03-06 : Lohr : DLBCL
8
+2013-01-01 : Zhang : DLBCL
9
+2013-08-15 : Morin : DLBCL
10
+2017-05-01 : Albuquerque : DLBCL
11
+2017-10-10 : Reddy : DLBCL
12
+2018-04-12 : Schmitz : DLBCL
13
+2018-05-01 : Chapuy : DLBCL
14
+2018-10-01 : Arthur : DLBCL
15
+ 2019-09-26 : Panea : BL
16
+```
mermaid_CD83.md
... ...
@@ -0,0 +1,14 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-08-15 : Morin : DLBCL
7
+ 2017-10-10 : Reddy : DLBCL
8
+ 2018-04-12 : Schmitz : DLBCL
9
+2018-05-01 : Chapuy : DLBCL
10
+ 2019-09-26 : Panea : BL
11
+2021-05-05 : Hubschmann : DLBCL
12
+ 2021-07-15 : Duns : PMBL
13
+ 2023-07-26 : Russler-Germain : FL
14
+```
mermaid_CD9B.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2016-06-14 : van : MZL
7
+```
mermaid_CDC123.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CDC27.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2022-03-01 : Ma : BL
7
+```
mermaid_CDC42BPB.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2021-05-05 : Hübschmann : FL
7
+```
mermaid_CDC73.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+ 2017-10-10 : Reddy : DLBCL
8
+```
mermaid_CDH1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_CDH10.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CDH17.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_CDH2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2019-08-20 : Desch : PMBL
7
+```
mermaid_CDH5.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2023-11-15 : Gomez : PMBL
7
+```
mermaid_CDH7.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CDH8.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2014-05-08 : Zhang : MCL
7
+```
mermaid_CDH9.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-08-15 : Morin : DLBCL
7
+```
mermaid_CDK3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CDKN1A.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_CDKN2A.md
... ...
@@ -0,0 +1,12 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2013-08-15 : Morin : DLBCL
7
+2016-09-08 : Spina : MZL
8
+2017-10-10 : Reddy : DLBCL
9
+2018-04-12 : Schmitz : DLBCL
10
+2019-03-21 : Grande : BL
11
+2021-05-05 : Hubschmann : DLBCL
12
+```
mermaid_CDKN2C.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2023-02-03 : Thomas : BL
7
+```
mermaid_CECR1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CELSR2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CEP164.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-05-01 : Albuquerque : DLBCL
7
+```
mermaid_CGN.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_CHD1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+```
mermaid_CHD3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CHD4.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2022-07-06 : Burkhardt : BL
7
+```
mermaid_CHD8.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+ 2019-03-21 : Grande : BL
8
+```
mermaid_CHEK2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_CHMP4C.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-11-05 : Be : MCL
7
+```
mermaid_CHRM5.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CHST2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+```
mermaid_CIC.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CIITA.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-27 : Morin : DLBCL
7
+ 2015-11-17 : Mottok : PMBL
8
+```
mermaid_CILP.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2023-07-26 : Russler : FL
7
+```
mermaid_CISH.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2019-09-05 : Mottok : PMBL
7
+```
mermaid_CLGN.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2016-09-08 : Spina : MZL
7
+```
mermaid_CNBP.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2016-09-08 : Spina : MZL
7
+```
mermaid_CNGA4.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CNKSR2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2016-09-08 : Spina : MZL
7
+```
mermaid_CNOT2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2021-05-05 : Hübschmann : DLBCL
7
+```
mermaid_CNOT6.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CNP.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CNTN6.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CNTNAP5.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-08-15 : Morin : DLBCL
7
+```
mermaid_COL11A1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2014-05-08 : Zhang : MCL
7
+```
mermaid_COL12A1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_COL16A1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2014-05-08 : Zhang : MCL
7
+```
mermaid_COL4A2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_COL5A2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_COQ7.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2018-05-01 : Chapuy : DLBCL
7
+```
mermaid_CORO2A.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CORO7.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CPNE8.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2021-05-05 : Hübschmann : FL
7
+```
mermaid_CPS1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-03-06 : Lohr : DLBCL
7
+```
mermaid_CPXM2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2022-07-06 : Burkhardt : BL
7
+```
mermaid_CRELD2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CRIP1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2018-05-01 : Chapuy : DLBCL
7
+```
mermaid_CRTC3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CRYBG3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-11-05 : Be : MCL
7
+```
mermaid_CSF2RB.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2015-02-12 : Reichel : PMBL
7
+```
mermaid_CSNK1A1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_CSNK2A1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_CST7.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CTCF.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2019-09-26 : Panea : BL
7
+```
mermaid_CTNNA2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2014-05-08 : Zhang : MCL
7
+```
mermaid_CTNNA3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CTSS.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2020-05-05 : Bararia : FL
7
+```
mermaid_CXCR4.md
... ...
@@ -0,0 +1,12 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-11-12 : Khodabakhshi : DLBCL
7
+2017-01-26 : Krysiak : FL
8
+2017-10-10 : Reddy : DLBCL
9
+2018-05-01 : Chapuy : DLBCL
10
+ 2019-09-26 : Panea : BL
11
+2021-05-05 : Hubschmann : DLBCL
12
+```
mermaid_CXCR5.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2018-04-12 : Schmitz : DLBCL
7
+ 2019-09-05 : Mottok : PMBL
8
+```
mermaid_CYB5D1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_CYP24A1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CYP2A6.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2023-07-26 : Russler : FL
7
+```
mermaid_CYP2C18.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_CYP4F22.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_CYTSB.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-31 : Pasqualucci : DLBCL
7
+```
mermaid_CYYR1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_DAZAP1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2020-07-30 : Pararajalingam : MCL
7
+```
mermaid_DCAF6.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+```
mermaid_DCHS1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-31 : Pasqualucci : DLBCL
7
+```
mermaid_DCP1B.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-11-05 : Be : MCL
7
+```
mermaid_DDB1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DDX10.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+ 2017-10-10 : Reddy : DLBCL
8
+```
mermaid_DDX3X.md
... ...
@@ -0,0 +1,11 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2012-10-04 : Schmitz : BL
7
+2017-10-10 : Reddy : DLBCL
8
+2018-04-12 : Schmitz : DLBCL
9
+2018-10-01 : Arthur : DLBCL
10
+2019-09-05 : Mottok : PMBL
11
+```
mermaid_DGCR8.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_DGKB.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2018-05-31 : Tiacci : PMBL
7
+```
mermaid_DHCR7.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-10-04 : Schmitz : BL
7
+```
mermaid_DHDH.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2014-05-08 : Zhang : MCL
7
+```
mermaid_DHX15.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2021-05-05 : Hübschmann : FL
7
+```
mermaid_DHX16.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2021-05-05 : Hübschmann : DLBCL
7
+```
mermaid_DHX33.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_DIAPH2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_DIAPH3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DICER1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+```
mermaid_DIP2B.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DLC1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2014-05-08 : Zhang : MCL
7
+```
mermaid_DLGAP1.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+ 2013-01-01 : Zhang : DLBCL
8
+```
mermaid_DLGAP2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-11-05 : Be : MCL
7
+```
mermaid_DMD.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2015-02-12 : Reichel : PMBL
7
+```
mermaid_DMXL1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DNAH12.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2019-12-10 : Wienand : PMBL
7
+```
mermaid_DNAH5.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-08-15 : Morin : DLBCL
7
+ 2017-07-27 : Jallades : MZL
8
+```
mermaid_DNAH7.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-07-27 : Jallades : MZL
7
+```
mermaid_DNAI1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-07-27 : Jallades : MZL
7
+```
mermaid_DNAJC6.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-11-05 : Be : MCL
7
+```
mermaid_DNM2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2021-05-05 : Hübschmann : DLBCL
7
+```
mermaid_DNMT1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2019-09-26 : Panea : BL
7
+```
mermaid_DNMT3A.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-10-10 : Reddy : DLBCL
7
+```
mermaid_DNMT3B.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-05-01 : Albuquerque : DLBCL
7
+```
mermaid_DOCK1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2018-05-01 : Chapuy : DLBCL
7
+```
mermaid_DOCK2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DOCK5.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_DOCK6.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-07-27 : Jallades : MZL
7
+```
mermaid_DOLK.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DPYD.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-31 : Pasqualucci : DLBCL
7
+```
mermaid_DSC2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DSC3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-31 : Pasqualucci : DLBCL
7
+```
mermaid_DSCAML1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DSEL.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-08-15 : Morin : DLBCL
7
+```
mermaid_DSG2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DSG4.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-08-15 : Morin : DLBCL
7
+```
mermaid_DSP.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DTNB.md
... ...
@@ -0,0 +1,6 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+```
mermaid_DTX1.md
... ...
@@ -0,0 +1,12 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-08-27 : Rossi : MZL
7
+ 2012-12-01 : Love : BL
8
+ 2013-01-01 : Zhang : DLBCL
9
+ 2018-04-12 : Schmitz : DLBCL
10
+ 2018-05-01 : Chapuy : DLBCL
11
+ 2023-11-15 : Gomez : PMBL
12
+```
mermaid_DTX3L.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-07-27 : Jallades : MZL
7
+```
mermaid_DUOXA2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DUPD1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DUSP2.md
... ...
@@ -0,0 +1,10 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2012-03-06 : Lohr : DLBCL
7
+2013-08-15 : Morin : DLBCL
8
+2017-10-10 : Reddy : DLBCL
9
+2018-04-12 : Schmitz : DLBCL
10
+```
mermaid_DUSP27.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-31 : Pasqualucci : DLBCL
7
+```
mermaid_DUSP9.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-31 : Pasqualucci : DLBCL
7
+```
mermaid_DYNC1H1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_DYNC1I1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_E2F2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2022-07-06 : Burkhardt : BL
7
+```
mermaid_EBF1.md
... ...
@@ -0,0 +1,14 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2012-10-01 : Bohle : DLBCL
7
+2013-08-15 : Morin : DLBCL
8
+2015-02-12 : Reichel : PMBL
9
+2017-05-01 : Albuquerque : DLBCL
10
+2017-10-10 : Reddy : DLBCL
11
+2018-05-01 : Chapuy : DLBCL
12
+2018-10-01 : Arthur : DLBCL
13
+2021-05-05 : Hubschmann : DLBCL
14
+```
mermaid_ECGF1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_ECT2L.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_EDNRB.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2022-07-06 : Burkhardt : BL
7
+```
mermaid_EEF1A1.md
... ...
@@ -0,0 +1,9 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2015-02-12 : Reichel : PMBL
7
+2018-05-01 : Chapuy : DLBCL
8
+2021-05-05 : Hubschmann : DLBCL
9
+```
mermaid_EGFR.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_EGR1.md
... ...
@@ -0,0 +1,9 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-08-27 : Rossi : MZL
7
+ 2015-02-12 : Reichel : PMBL
8
+ 2017-01-26 : Krysiak : FL
9
+```
mermaid_EGR2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-08-27 : Rossi : MZL
7
+```
mermaid_EIF2AK4.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2014-05-08 : Zhang : MCL
7
+```
mermaid_EIF2C4.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_EIF4A1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2019-09-26 : Panea : BL
7
+```
mermaid_ELP2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-10-04 : Schmitz : BL
7
+```
mermaid_EML2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_ENTPD3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_EP300.md
... ...
@@ -0,0 +1,12 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-03-10 : Pasqualucci : FL
7
+2012-08-27 : Rossi : MZL
8
+2017-10-10 : Reddy : DLBCL
9
+2018-04-12 : Schmitz : DLBCL
10
+2018-05-01 : Chapuy : DLBCL
11
+2018-10-01 : Arthur : DLBCL
12
+```
mermaid_EPHA3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_EPHA5.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_EPHA7.md
... ...
@@ -0,0 +1,8 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+ 2019-09-05 : Mottok : PMBL
8
+```
mermaid_EPHB2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_EPPK1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2019-09-26 : Panea : BL
7
+```
mermaid_ERAP1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2022-07-06 : Burkhardt : BL
7
+```
mermaid_ERAP2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-05-01 : Albuquerque : DLBCL
7
+```
mermaid_ERBB3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_ERN2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_ESX1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2014-05-08 : Zhang : MCL
7
+```
mermaid_ETNPPL.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_ETS1.md
... ...
@@ -0,0 +1,13 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2011-07-27 : Morin : DLBCL
7
+2013-08-15 : Morin : DLBCL
8
+2017-10-10 : Reddy : DLBCL
9
+2018-04-12 : Schmitz : DLBCL
10
+2018-05-01 : Chapuy : DLBCL
11
+2018-10-01 : Arthur : DLBCL
12
+ 2019-09-26 : Panea : BL
13
+```
mermaid_ETV6.md
... ...
@@ -0,0 +1,12 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2012-03-06 : Lohr : DLBCL
7
+2017-05-01 : Albuquerque : DLBCL
8
+2017-10-10 : Reddy : DLBCL
9
+2018-04-12 : Schmitz : DLBCL
10
+2018-05-01 : Chapuy : DLBCL
11
+2018-10-01 : Arthur : DLBCL
12
+```
mermaid_EWSR1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2020-07-30 : Pararajalingam : MCL
7
+```
mermaid_EXOSC6.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-10-04 : Schmitz : BL
7
+```
mermaid_EXTL3.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_EZH1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2017-07-27 : Jallades : MZL
7
+```
mermaid_EZR.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2019-08-20 : Desch : PMBL
7
+```
mermaid_FAIM.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_FAM129B.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2012-12-01 : Love : BL
7
+```
mermaid_FAM161A.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```
mermaid_FAM38B.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-08-15 : Morin : DLBCL
7
+```
mermaid_FAM62C.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_FANCD2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-01-01 : Zhang : DLBCL
7
+```
mermaid_FAS.md
... ...
@@ -0,0 +1,13 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+2007-05-01 : Scholl : DLBCL
7
+2011-07-27 : Morin : DLBCL
8
+2016-09-08 : Spina : MZL
9
+2017-05-01 : Albuquerque : DLBCL
10
+2017-10-10 : Reddy : DLBCL
11
+2018-05-01 : Chapuy : DLBCL
12
+2018-10-01 : Arthur : DLBCL
13
+```
mermaid_FAT1.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2016-09-08 : Spina : MZL
7
+```
mermaid_FAT2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2011-07-27 : Morin : DLBCL
7
+```
mermaid_FAT4.md
... ...
@@ -0,0 +1,9 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ 2013-08-15 : Morin : DLBCL
7
+ 2013-12-13 : Parry : MZL
8
+ 2014-05-08 : Zhang : MCL
9
+```
mermaid_FBLN2.md
... ...
@@ -0,0 +1,7 @@
1
+## History
2
+```mermaid
3
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
4
+timeline
5
+ title Publication timing
6
+ : : DLBCL
7
+```