Home.md
... ...
@@ -16,7 +16,7 @@ To get started, select one of the gene lists from the table below then select th
16 16
17 17
**aSHM** - Denotes genes as affected by aberrant somatic hypermutation (aSHM). Tier 1 and Tier 2 genes can have this designation, respectively abbreviated as *1-a* and *2-a*. For example, see [BCL7A](BCL7A).
18 18
19
-**orphan** - Designates a gene whose mutation pattern has not been reproduced in subsequent comprehensive studies of the same entity. These genes remain in Tier 2 but should be approached with caution.
19
+**Fail** - Some studies with large additions to Tier 2 lists have undergon manual review of the primary data. If the majority of mutations in a gene fail QC, the gene will be given this designation.
20 20
21 21
```mermaid
22 22
---