Changes in 5b8f96c: CREBBP

				CREBBP.md
			
          @@ -4,6 +4,15 @@ CREBBP mutations are highly prevalent in both DLBCL and FL. These mutations ofte

           ## Relevance tier by entity

          +```mermaid

          +%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

          +timeline

          +    title Publication timing

          +      2011-03-10 : Pasqualucci : DLBCL

          +      2012-12-01 : Love : BL

          +      2013-12-13 : Parry : MZL

          +      2021-07-15 : Duns : PMBL

          +```

           |Entity|Tier|Description                           |

           |:------:|:----:|--------------------------------------|

           |![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|

          @@ -76,9 +85,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C

           ![image](images/proteinpaint/CREBBP.svg)

          -## References

          -1. *Pasqualucci, L., Dominguez-Sola, D., Chiarenza, A., Fabbri, G., Grunn, A., Trifonov, V., Kasper, L., Lerach, S., Tang, H., Ma, J., Rossi, D., Chadburn, A., Murty, V., Mullighan, C., Gaidano, G., Rabadán, R., Brindle, P., & Dalla-Favera, R. (2010). Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature, 471, 189 - 195. https://doi.org/10.1038/nature09730.*

          -2. *Dreval K, Hilton LK, Cruz M, Shaalan H, Ben-Neriah S, Boyle M, Collinge B, Coyle KM, Duns G, Farinha P, Grande BM, Meissner B, Pararajalingam P, Rushton CK, Slack GW, Wong J, Mungall AJ, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns. Blood. 2023 Aug 10;142(6):561-573. doi: 10.1182/blood.2022018719. PMID: 37084389; PMCID: PMC10644066.*

           ## CREBBP Expression

           ![image](images/gene_expression/CREBBP_by_pathology.svg)

           <!-- ORIGIN: pasqualucciInactivatingMutationsAcetyltransferase2011a -->

          @@ -87,3 +93,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C

           <!-- BL: loveGeneticLandscapeMutations2012 -->

           <!-- DLBCL: pasqualucciInactivatingMutationsAcetyltransferase2011a -->

           <!-- MZL: parryWholeExomeSequencing2013 -->

          +

          +## References

          +1. *Pasqualucci, L., Dominguez-Sola, D., Chiarenza, A., Fabbri, G., Grunn, A., Trifonov, V., Kasper, L., Lerach, S., Tang, H., Ma, J., Rossi, D., Chadburn, A., Murty, V., Mullighan, C., Gaidano, G., Rabadán, R., Brindle, P., & Dalla-Favera, R. (2010). Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature, 471, 189 - 195. https://doi.org/10.1038/nature09730.*

          +2. *Dreval K, Hilton LK, Cruz M, Shaalan H, Ben-Neriah S, Boyle M, Collinge B, Coyle KM, Duns G, Farinha P, Grande BM, Meissner B, Pararajalingam P, Rushton CK, Slack GW, Wong J, Mungall AJ, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns. Blood. 2023 Aug 10;142(6):561-573. doi: 10.1182/blood.2022018719. PMID: 37084389; PMCID: PMC10644066.*

          +

...	...	@@ -4,6 +4,15 @@ CREBBP mutations are highly prevalent in both DLBCL and FL. These mutations ofte
4	4
5	5	## Relevance tier by entity
6	6
	7	+```mermaid
	8	+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
	9	+timeline
	10	+ title Publication timing
	11	+ 2011-03-10 : Pasqualucci : DLBCL
	12	+ 2012-12-01 : Love : BL
	13	+ 2013-12-13 : Parry : MZL
	14	+ 2021-07-15 : Duns : PMBL
	15	+```
7	16	\|Entity\|Tier\|Description \|
8	17	\|:------:\|:----:\|--------------------------------------\|
9	18	\|![MZL](images/icons/MZL_tier2.png)\|2\|relevance in MZL not firmly established\|
...	...	@@ -76,9 +85,6 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
76	85
77	86	![image](images/proteinpaint/CREBBP.svg)
78	87
79		-## References
80		-1. Pasqualucci, L., Dominguez-Sola, D., Chiarenza, A., Fabbri, G., Grunn, A., Trifonov, V., Kasper, L., Lerach, S., Tang, H., Ma, J., Rossi, D., Chadburn, A., Murty, V., Mullighan, C., Gaidano, G., Rabadán, R., Brindle, P., & Dalla-Favera, R. (2010). Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature, 471, 189 - 195. https://doi.org/10.1038/nature09730.
81		-2. Dreval K, Hilton LK, Cruz M, Shaalan H, Ben-Neriah S, Boyle M, Collinge B, Coyle KM, Duns G, Farinha P, Grande BM, Meissner B, Pararajalingam P, Rushton CK, Slack GW, Wong J, Mungall AJ, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns. Blood. 2023 Aug 10;142(6):561-573. doi: 10.1182/blood.2022018719. PMID: 37084389; PMCID: PMC10644066.
82	88	## CREBBP Expression
83	89	![image](images/gene_expression/CREBBP_by_pathology.svg)
84	90	<!-- ORIGIN: pasqualucciInactivatingMutationsAcetyltransferase2011a -->
...	...	@@ -87,3 +93,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
87	93	<!-- BL: loveGeneticLandscapeMutations2012 -->
88	94	<!-- DLBCL: pasqualucciInactivatingMutationsAcetyltransferase2011a -->
89	95	<!-- MZL: parryWholeExomeSequencing2013 -->
	96	+
	97	+## References
	98	+1. Pasqualucci, L., Dominguez-Sola, D., Chiarenza, A., Fabbri, G., Grunn, A., Trifonov, V., Kasper, L., Lerach, S., Tang, H., Ma, J., Rossi, D., Chadburn, A., Murty, V., Mullighan, C., Gaidano, G., Rabadán, R., Brindle, P., & Dalla-Favera, R. (2010). Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature, 471, 189 - 195. https://doi.org/10.1038/nature09730.
	99	+2. Dreval K, Hilton LK, Cruz M, Shaalan H, Ben-Neriah S, Boyle M, Collinge B, Coyle KM, Duns G, Farinha P, Grande BM, Meissner B, Pararajalingam P, Rushton CK, Slack GW, Wong J, Mungall AJ, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns. Blood. 2023 Aug 10;142(6):561-573. doi: 10.1182/blood.2022018719. PMID: 37084389; PMCID: PMC10644066.
	100	+