DAZAP1.md
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# DAZAP1
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+## Overview
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+This gene has some recurrent sites of mutations (hot spots). The mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations* however the pattern is notable. These mutations often result in truncations affecting the DAZAP1 C-terminus, which are predicted to alter protein sub-cellular localization and disrupt protein-protein interactions.<sup>1</sup>
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## Relevance tier by entity
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View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DAZAP1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DAZAP1_hg38.html)
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![image](images/proteinpaint/DAZAP1.svg)
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+
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+## References
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+1. *Pararajalingam, P., Coyle, K., Arthur, S., Thomas, N., Alcaide, M., Meissner, B., Boyle, M., Grande, B., Slack, G., Mungall, A., Gascoyne, R., Steidl, C., Connors, J., Villa, D., Marra, M., Johnson, N., Scott, D., & Morin, R. (2019). Coding and non-coding drivers of mantle cell lymphoma identified through exome and genome sequencing. bioRxiv. https://doi.org/10.1101/686956.*
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