DLBCL_genes.md
... ...
@@ -11,36 +11,36 @@ link-citations: true
11 11
12 12
## Tier 1 DLBCL genes
13 13
14
-### *125 total*
14
+### *124 total*
15 15
16 16
|Gene|Tier| First DLBCL evidence | Other entities |
17 17
|:-:|:-:|:--|:-|
18 18
|[ACTB](ACTB)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@wienandGenomicAnalysesFlowsorted2019b]|
19
-|[ACTG1](ACTG1)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@spinaGeneticsNodalMarginal2016b; @deschGenotypingCirculatingTumor2020]|
20
-|[ARID1A](ARID1A)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@wienandGenomicAnalysesFlowsorted2019b; @loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c]|
21
-|[ATM](ATM)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@beaLandscapeSomaticMutations2013; @braggioGenomicAnalysisMarginal2012]|
19
+|[ACTG1](ACTG1)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@deschGenotypingCirculatingTumor2020; @spinaGeneticsNodalMarginal2016b]|
20
+|[ARID1A](ARID1A)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @wienandGenomicAnalysesFlowsorted2019b; @krysiakRecurrentSomaticMutations2017b]|
21
+|[ATM](ATM)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@braggioGenomicAnalysisMarginal2012; @beaLandscapeSomaticMutations2013]|
22 22
|[B2M](B2M)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @pararajalingamCodingNoncodingDrivers2020]|
23
-|[BCL10](BCL10)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@spinaGeneticsNodalMarginal2016b; @russler-germainMutationsAssociatedProgression2023b]|
24
-|[BCL2](BCL2)|1|[Tanaka et al](papers/tanakaFrequentIncidenceSomatic1992)[@tanakaFrequentIncidenceSomatic1992]|[@sarkozyMutationalLandscapeGray2021a; @burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011]|
23
+|[BCL10](BCL10)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b; @spinaGeneticsNodalMarginal2016b]|
24
+|[BCL2](BCL2)|1|[Tanaka et al](papers/tanakaFrequentIncidenceSomatic1992)[@tanakaFrequentIncidenceSomatic1992]|[@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a; @morinFrequentMutationHistonemodifying2011]|
25 25
|[BCL6](BCL6)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|
26
-|[BCL7A](BCL7A)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b]|
26
+|[BCL7A](BCL7A)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019]|
27 27
|[BIRC6](BIRC6)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@sarkozyMutationalLandscapeGray2021a]|
28 28
|[BRAF](BRAF)|1|[Tiacci et al](papers/tiacciBRAFMutationsHairycell2011a)[@tiacciBRAFMutationsHairycell2011a]|[@loveGeneticLandscapeMutations2012]|
29
-|[BTG1](BTG1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@sarkozyMutationalLandscapeGray2021a; @burkhardtClinicalRelevanceMolecular2022b]|
29
+|[BTG1](BTG1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]|
30 30
|[BTG2](BTG2)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|
31 31
|[BTK](BTK)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@krysiakRecurrentSomaticMutations2017b]|
32
-|[CARD11](CARD11)|1|[Lenz et al](papers/lenzOncogenicCARD11Mutations2008)[@lenzOncogenicCARD11Mutations2008]|[@yanBCRTLRSignaling2012a; @wuGeneticHeterogeneityPrimary2016; @morinFrequentMutationHistonemodifying2011]|
32
+|[CARD11](CARD11)|1|[Lenz et al](papers/lenzOncogenicCARD11Mutations2008)[@lenzOncogenicCARD11Mutations2008]|[@morinFrequentMutationHistonemodifying2011; @yanBCRTLRSignaling2012a; @wuGeneticHeterogeneityPrimary2016]|
33 33
|[CCND3](CCND3)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@deschGenotypingCirculatingTumor2020; @richterRecurrentMutationID32012a; @jalladesExomeSequencingIdentifies2017]|
34 34
|[CD58](CD58)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@schneiderAlterationsCD58Gene2015a]|
35 35
|[CD70](CD70)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b]|
36 36
|[CD79B](CD79B)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|
37
-|[CD83](CD83)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@russler-germainMutationsAssociatedProgression2023b; @dunsCharacterizationDLBCLPMBL2021b; @paneaWholeGenomeLandscape2019]|
37
+|[CD83](CD83)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@dunsCharacterizationDLBCLPMBL2021b; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b]|
38 38
|[CDKN2A](CDKN2A)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019; @spinaGeneticsNodalMarginal2016b]|
39
-|[CREBBP](CREBBP)|1|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@loveGeneticLandscapeMutations2012; @dunsCharacterizationDLBCLPMBL2021b; @parryWholeExomeSequencing2013]|
40
-|[CXCR4](CXCR4)|1|[Khodabakhshi et al](papers/khodabakhshiRecurrentTargetsAberrant2012)[@khodabakhshiRecurrentTargetsAberrant2012]|[@krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019]|
39
+|[CREBBP](CREBBP)|1|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013; @dunsCharacterizationDLBCLPMBL2021b]|
40
+|[CXCR4](CXCR4)|1|[Khodabakhshi et al](papers/khodabakhshiRecurrentTargetsAberrant2012)[@khodabakhshiRecurrentTargetsAberrant2012]|[@paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]|
41 41
|[CXCR5](CXCR5)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@mottokIntegrativeGenomicAnalysis2019b]|
42 42
|[DDX3X](DDX3X)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@mottokIntegrativeGenomicAnalysis2019b; @schmitzBurkittLymphomaPathogenesis2012]|
43
-|[DTX1](DTX1)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c; @gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012]|
43
+|[DTX1](DTX1)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @gomezUltraDeepSequencingReveals2023]|
44 44
|[DUSP2](DUSP2)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@dunsCharacterizationDLBCLPMBL2021b]|
45 45
|[EBF1](EBF1)|1|[Bohle et al](papers/bohleRoleEarlyBcell2013)[@bohleRoleEarlyBcell2013]|[@thomasGeneticSubgroupsInform2023; @reichelFlowSortingExome2015a]|
46 46
|[EEF1A1](EEF1A1)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@reichelFlowSortingExome2015a]|
... ...
@@ -51,19 +51,19 @@ link-citations: true
51 51
|[FAS](FAS)|1|[Scholl et al](papers/schollMutationsRegionFAS2007)[@schollMutationsRegionFAS2007]|[@spinaGeneticsNodalMarginal2016b]|
52 52
|[FBXO11](FBXO11)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@parryWholeExomeSequencing2013; @richterRecurrentMutationID32012a]|
53 53
|[FBXW7](FBXW7)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
54
-|[FOXO1](FOXO1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@schmitzBurkittLymphomaPathogenesis2012; @dunsCharacterizationDLBCLPMBL2021b]|
55
-|[GNA13](GNA13)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @loveGeneticLandscapeMutations2012]|
54
+|[FOXO1](FOXO1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]|
55
+|[GNA13](GNA13)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012; @reichelFlowSortingExome2015a]|
56 56
|[GNAI2](GNAI2)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019]|
57 57
|[GRB2](GRB2)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]||
58 58
|[GRHPR](GRHPR)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||
59 59
|[HIST1H1B](HIST1H1B)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@krysiakRecurrentSomaticMutations2017b; @sarkozyMutationalLandscapeGray2021a]|
60 60
|[HIST1H1C](HIST1H1C)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|
61 61
|[HIST1H1D](HIST1H1D)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017b]|
62
-|[HIST1H1E](HIST1H1E)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @reichelFlowSortingExome2015a]|
62
+|[HIST1H1E](HIST1H1E)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019]|
63 63
|[HIST1H2AC](HIST1H2AC)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b]|
64
-|[HIST1H2AM](HIST1H2AM)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019]|
65
-|[HIST1H2BC](HIST1H2BC)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b; @mottokIntegrativeGenomicAnalysis2019b]|
66
-|[HIST1H2BK](HIST1H2BK)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]|
64
+|[HIST1H2AM](HIST1H2AM)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]|
65
+|[HIST1H2BC](HIST1H2BC)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@mottokIntegrativeGenomicAnalysis2019b; @krysiakRecurrentSomaticMutations2017b]|
66
+|[HIST1H2BK](HIST1H2BK)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]|
67 67
|[HIST1H3B](HIST1H3B)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@reichelFlowSortingExome2015a]|
68 68
|[HIST2H2BE](HIST2H2BE)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]||
69 69
|[HLA-A](HLA-A)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@deschGenotypingCirculatingTumor2020]|
... ...
@@ -75,14 +75,14 @@ link-citations: true
75 75
|[IKZF3](IKZF3)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|
76 76
|[IL4R](IL4R)|1|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@viganoSomaticIL4RMutations2018b]|
77 77
|[IRF4](IRF4)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@mottokIntegrativeGenomicAnalysis2019b]|
78
-|[IRF8](IRF8)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019; @mottokIntegrativeGenomicAnalysis2019b]|
78
+|[IRF8](IRF8)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@mottokIntegrativeGenomicAnalysis2019b; @paneaWholeGenomeLandscape2019]|
79 79
|[ITPKB](ITPKB)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@reichelFlowSortingExome2015a]|
80 80
|[JUNB](JUNB)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@mottokIntegrativeGenomicAnalysis2019b]|
81 81
|[KLF2](KLF2)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017]|
82 82
|[KLHL14](KLHL14)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
83 83
|[KLHL6](KLHL6)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@ganapathiGeneticLandscapeDural2016]|
84 84
|[KMT2C](KMT2C)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a; @zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019]|
85
-|[KMT2D](KMT2D)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]|
85
+|[KMT2D](KMT2D)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]|
86 86
|[KRAS](KRAS)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
87 87
|[LCOR](LCOR)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||
88 88
|[LRRN3](LRRN3)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a]|
... ...
@@ -93,14 +93,14 @@ link-citations: true
93 93
|[MPEG1](MPEG1)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||
94 94
|[MS4A1](MS4A1)|1|[Rushton et al](papers/rushtonGeneticEvolutionaryPatterns2020)[@rushtonGeneticEvolutionaryPatterns2020]|[@mottokIntegrativeGenomicAnalysis2019b]|
95 95
|[MTOR](MTOR)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019]|
96
-|[MYC](MYC)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @dunsCharacterizationDLBCLPMBL2021b]|
96
+|[MYC](MYC)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@johnstonCmycHypermutationBurkitt1992; @dunsCharacterizationDLBCLPMBL2021b; @jalladesExomeSequencingIdentifies2017]|
97 97
|[MYD88](MYD88)|1|[Ngo et al](papers/ngoOncogenicallyActiveMYD882011a)[@ngoOncogenicallyActiveMYD882011a]|[@yanBCRTLRSignaling2012a]|
98
-|[NFKBIA](NFKBIA)|1|[Lake et al](papers/lakeMutationsNFKBIAEncoding2009)[@lakeMutationsNFKBIAEncoding2009]|[@wienandGenomicAnalysesFlowsorted2019b; @russler-germainMutationsAssociatedProgression2023b]|
99
-|[NFKBIE](NFKBIE)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]|[@pararajalingamCodingNoncodingDrivers2020; @mansouriFrequentNFKBIEDeletions2016]|
98
+|[NFKBIA](NFKBIA)|1|[Lake et al](papers/lakeMutationsNFKBIAEncoding2009)[@lakeMutationsNFKBIAEncoding2009]|[@russler-germainMutationsAssociatedProgression2023b; @wienandGenomicAnalysesFlowsorted2019b]|
99
+|[NFKBIE](NFKBIE)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]|[@mansouriFrequentNFKBIEDeletions2016; @pararajalingamCodingNoncodingDrivers2020]|
100 100
|[NFKBIZ](NFKBIZ)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]||
101 101
|[NOL9](NOL9)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@spinaGeneticsNodalMarginal2016b]|
102
-|[NOTCH1](NOTCH1)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@beaLandscapeSomaticMutations2013; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c]|
103
-|[NOTCH2](NOTCH2)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013]|
102
+|[NOTCH1](NOTCH1)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013]|
103
+|[NOTCH2](NOTCH2)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]|
104 104
|[OSBPL10](OSBPL10)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
105 105
|[P2RY8](P2RY8)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@muppidiLossSignalingGa132014b]|
106 106
|[PIM1](PIM1)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@dunsCharacterizationDLBCLPMBL2021b; @burkhardtClinicalRelevanceMolecular2022b]|
... ...
@@ -109,7 +109,6 @@ link-citations: true
109 109
|[POU2F2](POU2F2)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b]|
110 110
|[PRDM1](PRDM1)|1|[Pasqualucci et al](papers/pasqualucciInactivationPRDM1BLIMP12006a)[@pasqualucciInactivationPRDM1BLIMP12006a]||
111 111
|[PTEN](PTEN)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@loveGeneticLandscapeMutations2012]|
112
-|[PTPRD](PTPRD)|1||[@spinaGeneticsNodalMarginal2016b]|
113 112
|[RB1](RB1)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@zhangGenomicLandscapeMantle2014]|
114 113
|[RFX7](RFX7)|1||[@grandeGenomewideDiscoverySomatic2019]|
115 114
|[RHOA](RHOA)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@richterRecurrentMutationID32012a]|
... ...
@@ -119,7 +118,7 @@ link-citations: true
119 118
|[SF3B1](SF3B1)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@loveGeneticLandscapeMutations2012]|
120 119
|[SGK1](SGK1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b]|
121 120
|[SIN3A](SIN3A)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@rossiCodingGenomeSplenic2012c; @grandeGenomewideDiscoverySomatic2019]|
122
-|[SMARCA4](SMARCA4)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b; @richterRecurrentMutationID32012a]|
121
+|[SMARCA4](SMARCA4)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@richterRecurrentMutationID32012a; @nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b]|
123 122
|[SOCS1](SOCS1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@wenigerMutationsTumorSuppressor2006a]|
124 123
|[SPEN](SPEN)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@rossiCodingGenomeSplenic2012c; @sarkozyMutationalLandscapeGray2021a]|
125 124
|[STAT3](STAT3)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
... ...
@@ -132,18 +131,18 @@ link-citations: true
132 131
|[TNFAIP3](TNFAIP3)|1|[Compagno et al](papers/compagnoMutationsMultipleGenes2009a)[@compagnoMutationsMultipleGenes2009a]|[@schmitzTNFAIP3A20Tumor2009a; @rossiAlterationBIRC3Multiple2011a]|
133 132
|[TNFRSF14](TNFRSF14)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@spinaGeneticsNodalMarginal2016b; @cheungAcquiredTNFRSF14Mutations2010a]|
134 133
|[TOX](TOX)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
135
-|[TP53](TP53)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b; @beaLandscapeSomaticMutations2013; @wildaInactivationARFMDM2p53Pathway2004; @morinFrequentMutationHistonemodifying2011]|
134
+|[TP53](TP53)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b; @wildaInactivationARFMDM2p53Pathway2004; @beaLandscapeSomaticMutations2013; @morinFrequentMutationHistonemodifying2011]|
136 135
|[UBE2A](UBE2A)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@reichelFlowSortingExome2015a]|
137 136
|[WEE1](WEE1)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@reichelFlowSortingExome2015a]|
138 137
|[XPO1](XPO1)|1|[Mareschal et al](papers/mareschalWholeExomeSequencing2016)[@mareschalWholeExomeSequencing2016]|[@jardinRecurrentMutationsExportin2016a]|
139 138
|[ZC3H12A](ZC3H12A)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||
140
-|[ZFP36L1](ZFP36L1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @paneaWholeGenomeLandscape2019]|
139
+|[ZFP36L1](ZFP36L1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019; @reichelFlowSortingExome2015a]|
141 140
|[ZNF292](ZNF292)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
142 141
|[ZNF608](ZNF608)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b]|
143 142
144 143
## Tier 2 DLBCL genes
145 144
146
-### *180 total*
145
+### *181 total*
147 146
148 147
|Gene|Tier| First DLBCL evidence | Other entities |
149 148
|:-:|:-:|:--|:-|
... ...
@@ -156,9 +155,9 @@ link-citations: true
156 155
|[ASXL3](ASXL3)|2|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]||
157 156
|[ATR](ATR)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
158 157
|[BCL11A](BCL11A)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||
159
-|[BCOR](BCOR)|2||[@jalladesExomeSequencingIdentifies2017; @nadeuGenomicEpigenomicInsights2020b]|
158
+|[BCOR](BCOR)|2||[@nadeuGenomicEpigenomicInsights2020b; @jalladesExomeSequencingIdentifies2017]|
160 159
|[BCR](BCR)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
161
-|[BIRC3](BIRC3)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|[@beaLandscapeSomaticMutations2013; @rossiAlterationBIRC3Multiple2011a; @dunsCharacterizationDLBCLPMBL2021b]|
160
+|[BIRC3](BIRC3)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|[@rossiAlterationBIRC3Multiple2011a; @beaLandscapeSomaticMutations2013; @dunsCharacterizationDLBCLPMBL2021b]|
162 161
|[BLK](BLK)|2|||
163 162
|[BRINP3](BRINP3)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
164 163
|[BTBD3](BTBD3)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
... ...
@@ -191,7 +190,7 @@ link-citations: true
191 190
|[FAM102A](FAM102A)|2|||
192 191
|[FANK1](FANK1)|2|||
193 192
|[FAT2](FAT2)|2|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]||
194
-|[FAT4](FAT4)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@parryWholeExomeSequencing2013; @zhangGenomicLandscapeMantle2014]|
193
+|[FAT4](FAT4)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@zhangGenomicLandscapeMantle2014; @parryWholeExomeSequencing2013]|
195 194
|[FCRL3](FCRL3)|2|||
196 195
|[FNBP1](FNBP1)|2|||
197 196
|[FOXC1](FOXC1)|2|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]||
... ...
@@ -204,16 +203,16 @@ link-citations: true
204 203
|[GSG2](GSG2)|2|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]||
205 204
|[H1FOO](H1FOO)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
206 205
|[HDAC7](HDAC7)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||
207
-|[HIST1H2AG](HIST1H2AG)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]|
206
+|[HIST1H2AG](HIST1H2AG)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]|
208 207
|[HIST1H2AL](HIST1H2AL)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
209 208
|[HIST1H2BO](HIST1H2BO)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
210 209
|[HLA-DMA](HLA-DMA)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||
211 210
|[HNF1B](HNF1B)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]||
212 211
|[HNRNPD](HNRNPD)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
213 212
|[HNRNPH1](HNRNPH1)|2|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]||
214
-|[ID3](ID3)|2|[Schmitz et al](papers/schmitzBurkittLymphomaPathogenesis2012)[@schmitzBurkittLymphomaPathogenesis2012]|[@richterRecurrentMutationID32012a; @spinaGeneticsNodalMarginal2016b]|
213
+|[ID3](ID3)|2|[Schmitz et al](papers/schmitzBurkittLymphomaPathogenesis2012)[@schmitzBurkittLymphomaPathogenesis2012]|[@spinaGeneticsNodalMarginal2016b; @richterRecurrentMutationID32012a]|
215 214
|[IFNGR1](IFNGR1)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||
216
-|[IGLL5](IGLL5)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@russler-germainMutationsAssociatedProgression2023b; @deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]|
215
+|[IGLL5](IGLL5)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b; @deschGenotypingCirculatingTumor2020]|
217 216
|[IKBKB](IKBKB)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@rossiAlterationBIRC3Multiple2011a; @wienandGenomicAnalysesFlowsorted2019b]|
218 217
|[IKBKE](IKBKE)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]||
219 218
|[IL16](IL16)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
... ...
@@ -233,7 +232,7 @@ link-citations: true
233 232
|[MAGT1](MAGT1)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
234 233
|[MALAT1](MALAT1)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||
235 234
|[MAP2K1](MAP2K1)|2|[Shin et al](papers/shinBRAFV600EMAP2K12015)[@shinBRAFV600EMAP2K12015]|[@louissaintPediatrictypeNodalFollicular2016a]|
236
-|[MCL1](MCL1)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@dunsCharacterizationDLBCLPMBL2021b; @paneaWholeGenomeLandscape2019]|
235
+|[MCL1](MCL1)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@paneaWholeGenomeLandscape2019; @dunsCharacterizationDLBCLPMBL2021b]|
237 236
|[MECOM](MECOM)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
238 237
|[MET](MET)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
239 238
|[MIR142](MIR142)|2|[Kwanhian et al](papers/kwanhianMicroRNA142Mutated202012b)[@kwanhianMicroRNA142Mutated202012b]|[@grandeGenomewideDiscoverySomatic2019]|
... ...
@@ -245,7 +244,7 @@ link-citations: true
245 244
|[MYOM2](MYOM2)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]||
246 245
|[NAV1](NAV1)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||
247 246
|[NCOA3](NCOA3)|2|||
248
-|[NCOR2](NCOR2)|2||[@schmitzBurkittLymphomaPathogenesis2012; @sarkozyMutationalLandscapeGray2021a; @spinaGeneticsNodalMarginal2016b]|
247
+|[NCOR2](NCOR2)|2||[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b; @sarkozyMutationalLandscapeGray2021a]|
249 248
|[NEAT1](NEAT1)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||
250 249
|[NF1](NF1)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||
251 250
|[NFKB1](NFKB1)|2|||
... ...
@@ -274,6 +273,7 @@ link-citations: true
274 273
|[PTMA](PTMA)|2|||
275 274
|[PTPN1](PTPN1)|2||[@gunawardanaRecurrentSomaticMutations2014c]|
276 275
|[PTPN6](PTPN6)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||
276
+|[PTPRD](PTPRD)|2||[@spinaGeneticsNodalMarginal2016b]|
277 277
|[RAC2](RAC2)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]||
278 278
|[RAPGEF1](RAPGEF1)|2|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]||
279 279
|[RCC](RCC)|2|||
... ...
@@ -308,7 +308,7 @@ link-citations: true
308 308
|[TLR2](TLR2)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@beaLandscapeSomaticMutations2013]|
309 309
|[TMSL3](TMSL3)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
310 310
|[TNF](TNF)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||
311
-|[TRAF3](TRAF3)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@ottoGeneticLesionsTRAF32012a; @rossiAlterationBIRC3Multiple2011a]|
311
+|[TRAF3](TRAF3)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@rossiAlterationBIRC3Multiple2011a; @ottoGeneticLesionsTRAF32012a]|
312 312
|[TRAF6](TRAF6)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]||
313 313
|[TRIP12](TRIP12)|2|||
314 314
|[UBE2J1](UBE2J1)|2|||