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KLHL6.md
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| 10 | 10 | ## Overview |
| 11 | -KLHL6 mutations appear to be relatively common in DLBCL, FL and possibly BL.[@morinFrequentMutationHistonemodifying2011]| KLHL6 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. KLHL6 mutations lead to the loss of its function as part of a cullin-RING ubiquitin ligase complex. |
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| 11 | +KLHL6 mutations appear to be relatively common in DLBCL, FL and possibly BL.[@morinFrequentMutationHistonemodifying2011] |
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| 12 | +KLHL6 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. KLHL6 mutations lead to the loss of its function as part of a cullin-RING ubiquitin ligase complex. |
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| 12 | 13 | KLHL6 is considered a tumor suppressor gene in DLBCL with mutations tending to disrupt its interaction with cullin3, leading to the loss of its ligase activity.[@choiLossKLHL6Promotes2018] |
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