more diagrams

+2011, Morin 2011, 15

+Morin 2011, Tier 1 FL genes, 14

+Morin 2011, Tier 2 FL genes, 1

+2011, Pasqualucci 2011b, 2

+Pasqualucci 2011b, Tier 1 FL genes, 2

+

+WGS, 2016 WGS, 2

+2016 WGS, Okosun 2016, 2

+Okosun 2016, Tier 1 FL genes, 2

+

+exome, 2017 exome, 22

+2017 exome, Krysiak 2017, 22

+Krysiak 2017, Tier 2 FL genes, 5

+Krysiak 2017, Tier 1 FL genes, 17

+

+WGS, 2021 WGS, 17

+2021 WGS, Hubschmann 2021, 17

+Hubschmann 2021, Tier 2 FL genes, 15

+Hubschmann 2021, Tier 1 FL genes, 2

+

+exome, 2023 exome, 20

+2023 exome, Russler-Germain 2023, 20

+Russler-Germain 2023, Tier 1 FL genes, 1

+Russler-Germain 2023, Tier 2 FL genes, 19

+<!-- PMBL: dunsCharacterizationDLBCLPMBL2021b -->

+

+<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->

+<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

+<!-- PMBL: reichelFlowSortingExome2015a -->

+<!-- PMBL: reichelFlowSortingExome2015a -->

+

+<!-- PMBL: mottokIntegrativeGenomicAnalysis2019b -->

+<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->

+<!-- BL: paneaWholeGenomeLandscape2019 -->

+<!-- BL: paneaWholeGenomeLandscape2019 -->

+<!-- ORIGIN: Unknown -->

+<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->

+<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

+<!-- BL: paneaWholeGenomeLandscape2019 -->

+

+<!-- PMBL: deschGenotypingCirculatingTumor2020 -->

+<!-- ORIGIN: deschGenotypingCirculatingTumor2020 -->

+<!-- BL: paneaWholeGenomeLandscape2019 -->

+<!-- FL: russler-germainMutationsAssociatedProgression2023a -->

+<!-- BL: paneaWholeGenomeLandscape2019 -->

+<!-- BL: paneaWholeGenomeLandscape2019 -->

+

+

+

+<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

+<!-- BL: loveGeneticLandscapeMutations2012 -->

+<!-- PMBL: tiacciPervasiveMutationsJAKSTAT2018b -->

+<!-- PMBL: sarkozyMutationalLandscapeGray2021a -->

+

+<!-- ORIGIN: morinFrequentMutationHistonemodifying2011 -->

+<!-- FL: morinFrequentMutationHistonemodifying2011 -->

+<!-- BL: grandeGenomewideDiscoverySomatic2019 -->

+<!-- BL: grandeGenomewideDiscoverySomatic2019 -->

+<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->

+<!-- MCL: beaLandscapeSomaticMutations2013 -->

+<!-- MZL: rossiCodingGenomeSplenic2012c -->

+ <!-- PMBL: deschGenotypingCirculatingTumor2020 -->

+

+<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->

+<!-- BL: paneaWholeGenomeLandscape2019 -->

+<!-- BL: paneaWholeGenomeLandscape2019 -->

+<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

+<!-- PMBL: dunsCharacterizationDLBCLPMBL2021b -->

+<!-- PMBL: dunsCharacterizationDLBCLPMBL2021b -->

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2012-12-01 : Love : BL

+```

+## References

+1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2012-10-04 : Schmitz : BL

+```

+

+## References

+1. Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012 Oct 4;490(7418):116–120. PMCID: PMC3609867

+

+<!-- BL: schmitzBurkittLymphomaPathogenesis2012 -->

+## References

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2021-05-05 : H : DLBCL

+```

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2018-05-01 : Chapuy : DLBCL

+```

+## References

+1. Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh M, Trümper L, Getz G, Shipp MA. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 May;24(5):679–690. PMCID: PMC6613387

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2018-05-01 : Chapuy : DLBCL

+```

+## References

+1. Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh M, Trümper L, Getz G, Shipp MA. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 May;24(5):679–690. PMCID: PMC6613387

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2012-12-01 : Love : BL

+```

+## References

+1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

+## References

+<!-- PMBL: sarkozyMutationalLandscapeGray2021a -->

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2014-05-08 : Zhang : MCL

+```

+## References

+1. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2013-08-15 : Morin : DLBCL

+```

+## References

+1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992

+## History

+

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2018-05-01 : Chapuy : DLBCL

+```

+## References

+1. Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh M, Trümper L, Getz G, Shipp MA. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 May;24(5):679–690. PMCID: PMC6613387

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2022-07-06 : Burkhardt : BL

+```

+## References

+1. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2018-05-01 : Chapuy : DLBCL

+```

+## References

+1. Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh M, Trümper L, Getz G, Shipp MA. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 May;24(5):679–690. PMCID: PMC6613387

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2019-09-26 : Panea : BL

+```

+## References

+1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2019-09-26 : Panea : BL

+```

+## References

+1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2012-08-27 : Rossi : MZL

+ 2021-04-01 : Sarkozy : PMBL

+```

+## References

+1. Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med. 2012 Aug 27;209(9):1537–1551. PMCID: PMC3428941

+2. Sarkozy C, Hung SS, Chavez EA, Duns G, Takata K, Chong LC, Aoki T, Jiang A, Miyata-Takata T, Telenius A, Slack GW, Molina TJ, Ben-Neriah S, Farinha P, Dartigues P, Damotte D, Mottok A, Salles GA, Casasnovas RO, Savage KJ, Laurent C, Scott DW, Traverse-Glehen A, Steidl C. Mutational landscape of gray zone lymphoma. Blood. 2021 Apr 1;137(13):1765–1776. PMID: 32961552

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2013-08-15 : Morin : DLBCL

+ 2023-07-26 : Russler-Germain : FL

+```

+## References

+1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992

+2. Russler-Germain DA, Krysiak K, Ramirez CA, Mosior M, Watkins MP, Gomez F, Skidmore ZL, Trani L, Gao F, Geyer S, Cashen A, Mehta-Shah N, Kahl B, Bartlett N, Alderuccio J, Lossos I, Ondrejka S, Hsi E, Martin P, Leonard J, Griffith M, Griffith O, Fehniger T. Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303. Blood Advances. 2023;7:5524–5539.

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2023-07-26 : Russler-Germain : FL

+```

+## References

+1. Russler-Germain DA, Krysiak K, Ramirez CA, Mosior M, Watkins MP, Gomez F, Skidmore ZL, Trani L, Gao F, Geyer S, Cashen A, Mehta-Shah N, Kahl B, Bartlett N, Alderuccio J, Lossos I, Ondrejka S, Hsi E, Martin P, Leonard J, Griffith M, Griffith O, Fehniger T. Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303. Blood Advances. 2023;7:5524–5539.

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2013-01-01 : Zhang : DLBCL

+ 2018-05-31 : Tiacci : PMBL

+```

+## References

+1. Zhang J, Grubor V, Love CL, Banerjee A, Richards KL, Mieczkowski PA, Dunphy C, Choi W, Au WY, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers C, Naresh K, Evens A, Gordon LI, Czader M, Gill JI, Hsi ED, Liu Q, Fan A, Walsh K, Jima D, Smith LL, Johnson AJ, Byrd JC, Luftig MA, Ni T, Zhu J, Chadburn A, Levy S, Dunson D, Dave SS. Genetic heterogeneity of diffuse large B-cell lymphoma. 2013 Jan;

+2. Tiacci E, Ladewig E, Schiavoni G, Penson A, Fortini E, Pettirossi V, Wang Y, Rosseto A, Venanzi A, Vlasevska S, Pacini R, Piattoni S, Tabarrini A, Pucciarini A, Bigerna B, Santi A, Gianni AM, Viviani S, Cabras A, Ascani S, Crescenzi B, Mecucci C, Pasqualucci L, Rabadan R, Falini B. Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma. Blood. 2018 May 31;131(22):2454–2465. PMCID: PMC6634958

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2019-09-26 : Panea : BL

+```

+## References

+1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2012-12-01 : Love : BL

+```

+## References

+1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2013-08-15 : Morin : DLBCL

+```

+## References

+1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2018-04-12 : Schmitz : DLBCL

+```

+## References

+1. Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med. 2018 Apr 12;378(15):1396–1407. PMCID: PMC6010183

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2014-05-08 : Zhang : MCL

+```

+## References

+1. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2018-10-01 : Arthur : DLBCL

+```

+## References

+1. Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. PMCID: PMC6167379

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2012-12-01 : Love : BL

+```

+## References

+1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2017-10-10 : Reddy : DLBCL

+```

+## References

+1. Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481-494.e15.

+<!DOCTYPE html>

+<html>

+<head>

+<title>TGFBR2.md</title>

+<meta http-equiv="Content-type" content="text/html;charset=UTF-8">

+

+<style>

+/* https://github.com/microsoft/vscode/blob/master/extensions/markdown-language-features/media/markdown.css */

+/*---------------------------------------------------------------------------------------------

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+ </script>

+<h1 id="tgfbr2">TGFBR2</h1>

+<h2 id="history">History</h2>

+<pre><code class="language-mermaid"><div class="mermaid">%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2017-10-10 : Reddy : DLBCL

+</div></code></pre>

+<h2 id="relevance-tier-by-entity">Relevance tier by entity</h2>

+<table>

+<thead>

+<tr>

+<th style="text-align:center">Entity</th>

+<th style="text-align:center">Tier</th>

+<th>Description</th>

+</tr>

+</thead>

+<tbody>

+<tr>

+<td style="text-align:center"><img src="file:///Users/rmorin/git/LLMPP.wiki/images/icons/DLBCL_tier2.png" alt="DLBCL"></td>

+<td style="text-align:center">2</td>

+<td>relevance in DLBCL not firmly established</td>

+</tr>

+</tbody>

+</table>

+<h2 id="mutation-incidence-in-large-patient-cohorts-gambl-reanalysis">Mutation incidence in large patient cohorts (GAMBL reanalysis)</h2>

+<table>

+<thead>

+<tr>

+<th style="text-align:center">Entity</th>

+<th style="text-align:center">source</th>

+<th style="text-align:center">frequency (%)</th>

+</tr>

+</thead>

+<tbody>

+<tr>

+<td style="text-align:center">DLBCL</td>

+<td style="text-align:center">GAMBL genomes</td>

+<td style="text-align:center">2.10</td>

+</tr>

+<tr>

+<td style="text-align:center">DLBCL</td>

+<td style="text-align:center">Schmitz cohort</td>

+<td style="text-align:center">1.91</td>

+</tr>

+<tr>

+<td style="text-align:center">DLBCL</td>

+<td style="text-align:center">Reddy cohort</td>

+<td style="text-align:center">1.90</td>

+</tr>

+<tr>

+<td style="text-align:center">DLBCL</td>

+<td style="text-align:center">Chapuy cohort</td>

+<td style="text-align:center">1.28</td>

+</tr>

+</tbody>

+</table>

+<h2 id="mutation-pattern-and-selective-pressure-estimates">Mutation pattern and selective pressure estimates</h2>

+<table>

+<thead>

+<tr>

+<th style="text-align:center">Entity</th>

+<th style="text-align:center">aSHM</th>

+<th style="text-align:center">Significant selection</th>

+<th style="text-align:center">dN/dS (missense)</th>

+<th style="text-align:center">dN/dS (nonsense)</th>

+</tr>

+</thead>

+<tbody>

+<tr>

+<td style="text-align:center">BL</td>

+<td style="text-align:center">No</td>

+<td style="text-align:center">No</td>

+<td style="text-align:center">0.941</td>

+<td style="text-align:center">0.000</td>

+</tr>

+<tr>

+<td style="text-align:center">DLBCL</td>

+<td style="text-align:center">No</td>

+<td style="text-align:center">No</td>

+<td style="text-align:center">0.599</td>

+<td style="text-align:center">8.085</td>

+</tr>

+<tr>

+<td style="text-align:center">FL</td>

+<td style="text-align:center">No</td>

+<td style="text-align:center">No</td>

+<td style="text-align:center">2.530</td>

+<td style="text-align:center">0.000</td>

+</tr>

+</tbody>

+</table>

+<p>View coding variants in ProteinPaint <a href="https://morinlab.github.io/LLMPP/GAMBL/TGFBR2_protein.html">hg19</a> or <a href="https://morinlab.github.io/LLMPP/GAMBL/TGFBR2_protein_hg38.html">hg38</a></p>

+<p><img src="file:///Users/rmorin/git/LLMPP.wiki/images/proteinpaint/TGFBR2_NM_001024847.svg" alt="image"></p>

+<p>View all variants in GenomePaint <a href="https://morinlab.github.io/LLMPP/GAMBL/TGFBR2.html">hg19</a> or <a href="https://morinlab.github.io/LLMPP/GAMBL/TGFBR2_hg38.html">hg38</a></p>

+<p><img src="file:///Users/rmorin/git/LLMPP.wiki/images/proteinpaint/TGFBR2.svg" alt="image"></p>

+<h2 id="tgfbr2-expression">TGFBR2 Expression</h2>

+<p><img src="file:///Users/rmorin/git/LLMPP.wiki/images/gene_expression/TGFBR2_by_pathology.svg" alt="image"></p>

+<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->

+<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

+<h2 id="references">References</h2>

+<ol>

+<li>Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481-494.e15.</li>

+</ol>

+

+</body>

+</html>

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2012-12-01 : Love : BL

+```

+## References

+1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

+

+<!-- PMBL: tiacciPervasiveMutationsJAKSTAT2018b -->

+## References

+1. Wilda M, Bruch J, Harder L, Rawer D, Reiter A, Borkhardt A, Woessmann W. Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt’s lymphoma in children. Leukemia. 2004 Mar;18(3):584–588. PMID: 14712292

+2. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJM, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298–303. PMCID: PMC3210554

+3. Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med. 2012 Aug 27;209(9):1537–1551. PMCID: PMC3428941

+4. Beà S, Valdés-Mas R, Navarro A, Salaverria I, Martín-Garcia D, Jares P, Giné E, Pinyol M, Royo C, Nadeu F, Conde L, Juan M, Clot G, Vizán P, Croce LD, Puente DA, López-Guerra M, Moros A, Roue G, Aymerich M, Villamor N, Colomo L, Martínez A, Valera A, Martín-Subero JI, Amador V, Hernández L, Rozman M, Enjuanes A, Forcada P, Muntañola A, Hartmann EM, Calasanz MJ, Rosenwald A, Ott G, Hernández-Rivas JM, Klapper W, Siebert R, Wiestner A, Wilson WH, Colomer D, López-Guillermo A, López-Otín C, Puente XS, Campo E. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. PNAS. 2013 Nov 5;110(45):18250–18255. PMID: 24145436

+5. Tiacci E, Ladewig E, Schiavoni G, Penson A, Fortini E, Pettirossi V, Wang Y, Rosseto A, Venanzi A, Vlasevska S, Pacini R, Piattoni S, Tabarrini A, Pucciarini A, Bigerna B, Santi A, Gianni AM, Viviani S, Cabras A, Ascani S, Crescenzi B, Mecucci C, Pasqualucci L, Rabadan R, Falini B. Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma. Blood. 2018 May 31;131(22):2454–2465. PMCID: PMC6634958

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2021-05-05 : H : FL

+```

+## References

+1. Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Küppers R, Schlesner M, Siebert R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 Jul;35(7):2002–2016. PMCID: PMC8257491

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2012-12-01 : Love : BL

+```

+## References

+1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

+## References

+## History

+```mermaid

+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

+timeline

+ title Publication timing

+ 2022-07-06 : Burkhardt : BL

+```

+## References

+1. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

+## References