ACTB.md
... ...
@@ -10,17 +10,8 @@ link-citations: true
10 10
11 11
ACTB is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas. The function of mutations in ACTB and ACTG1 have not yet been determined.[@witjesPrevalenceCytoplasmicActin2020b]
12 12
13
-## Relevance tier by entity
14
-
15
-|Entity|Tier|Description |
16
-|:------:|:----:|--------------------------|
17
-|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
18
-|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@wienandGenomicAnalysesFlowsorted2019b]|
19
-|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene, hypermutated[@lohrDiscoveryPrioritizationSomatic2012a]|
20
-|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene, hypermutated |
21
-
22
-
23 13
## History
14
+
24 15
```mermaid
25 16
%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
26 17
timeline
... ...
@@ -34,6 +25,16 @@ timeline
34 25
2021-05-05 : Hubschmann : DLBCL
35 26
```
36 27
28
+## Relevance tier by entity
29
+
30
+|Entity|Tier|Description |
31
+|:------:|:----:|--------------------------|
32
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
33
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@wienandGenomicAnalysesFlowsorted2019b]|
34
+|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene, hypermutated[@lohrDiscoveryPrioritizationSomatic2012a]|
35
+|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene, hypermutated |
36
+
37
+
37 38
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
38 39
39 40
|Entity|source |frequency (%)|