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**Tier 1** - Genes can transition to Tier 1 only after additional studies have demonstrated the recurrence of mutations in the same entity.
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-### Additional Designations
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-**aSHM** - Denotes genes as affected by aberrant somatic hypermutation (aSHM). Tier 1 and Tier 2 genes can have this designation, respectively abbreviated as *1-a* and *2-a*. For example, see [BCL7A](BCL7A).
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-**Fail** - Some studies with large additions to Tier 2 lists have undergone manual review of the primary data. If the majority of mutations in a gene fail QC, the gene will be given the designation *2-F*. For example, see [MARK1](MARK1).
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+**Tier 3** - Tier 3 is reserved for genes that were once nominated as a driver but have since been retired due to a lack of support in the original study nominating them.
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## Other resources available for each gene
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