690661f3842f7eb97d6e5ca35341eec4baf43264
FZD3.md
| ... | ... | @@ -16,7 +16,7 @@ timeline |
| 16 | 16 | |
| 17 | 17 | |Entity|Tier|Description | |
| 18 | 18 | |:------:|:----:|--------------------------------------| |
| 19 | -| |2 |relevance in BL not firmly established| |
|
| 19 | +| |2-F |Failed QC| |
|
| 20 | 20 | |
| 21 | 21 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 22 |
HIST1H1C.md
| ... | ... | @@ -1,10 +1,7 @@ |
| 1 | 1 | # HIST1H1C |
| 2 | 2 | |
| 3 | -<<Warn("The variants reported in this gene in BL failed QC")>> |
|
| 4 | - |
|
| 5 | -**[See below ](#representative-mutations) or [the study page ](papers/paneaWholeGenomeLandscape2019.md#tier-2) for more information** |
|
| 6 | - |
|
| 7 | 3 | ## Overview |
| 4 | + |
|
| 8 | 5 | This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.<sup>1,2</sup> Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins. |
| 9 | 6 | |
| 10 | 7 | ## History |
| ... | ... | @@ -26,7 +23,7 @@ timeline |
| 26 | 23 | ||1|high-confidence PMBL/cHL/GZL gene| |
| 27 | 24 | | |1 |high-confidence DLBCL gene | |
| 28 | 25 | | |1 |high-confidence FL gene | |
| 29 | -| |2 |relevance in BL not firmly established| |
|
| 26 | +| |2-F |Failed QC| |
|
| 30 | 27 | |
| 31 | 28 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 32 | 29 |