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+@article{gonzalez-rinconUnravelingTransformationFollicular2019,

+ title = {Unraveling Transformation of Follicular Lymphoma to Diffuse Large {{B-cell}} Lymphoma},

+ author = {González-Rincón, Julia and Méndez, Miriam and Gómez, Sagrario and García, Juan F. and Martín, Paloma and Bellas, Carmen and Pedrosa, Lucía and Rodríguez-Pinilla, Socorro M. and Camacho, Francisca I. and Quero, Cristina and Pérez-Callejo, David and Rueda, Antonio and Llanos, Marta and Gómez-Codina, José and Piris, Miguel A. and Montes-Moreno, Santiago and Bárcena, Carmen and Rodríguez-Abreu, Delvys and Menárguez, Javier and family=Cruz-Merino, given=Luis, prefix=de la, useprefix=true and Monsalvo, Silvia and Parejo, Consuelo and Royuela, Ana and Kwee, Ivo and Cascione, Luciano and Arribas, Alberto and Bertoni, Francesco and Mollejo, Manuela and Provencio, Mariano and Sánchez-Beato, Margarita},

+ date = {2019},

+ journaltitle = {PloS One},

+ shortjournal = {PLoS One},

+ volume = {14},

+ number = {2},

+ eprint = {30802265},

+ eprinttype = {pmid},

+ pages = {e0212813},

+ issn = {1932-6203},

+ doi = {10.1371/journal.pone.0212813},

+ abstract = {Follicular lymphoma (FL) is an indolent but largely incurable disease. Some patients suffer histological transformation to a more aggressive subtype with poorer prognosis. This study aimed to improve our understanding of the genetics underlying FL histological transformation, and to identify genetic drivers or promoters of the transformation by elucidating the differences between FL samples from patients who did and did not transform. We conducted targeted massive parallel sequencing of 22 pre-transformed FL/transformed diffuse large B-cell lymphoma pairs and 20 diagnostic samples from non-transformed FL patients. Additionally, 22 matched samples from 11 transformed FL patients (pre-transformed FL and diffuse large B-cell lymphoma) and 9 non-transformed FLs were studied for copy number variation using SNP arrays. We identified recurrently mutated genes that were enriched at transformation, most notably LRP1B, GNA13 and POU2AF1, which have roles in B-cell differentiation, GC architecture and migration. Mutations in POU2AF1 might be associated with lower levels of expression, were more frequent in transformed FLs, and seemed to be specific to transformed- compared with de novo-diffuse large B-cell lymphomas. Pre-transformed FLs carried more mutations per sample and had greater subclonal heterogeneity than non-transformed FLs. Finally, we identified four mutated genes in FL samples that differed between patients who did and did not transform: NOTCH2, DTX1, UBE2A and HIST1H1E. The presence of mutations in these genes was associated with shorter time to transformation when mutated in the FL biopsies. This information might be useful for identifying patients at higher risk of transformation.},

+ langid = {english},

+ pmcid = {PMC6388933},

+ keywords = {Adult,Aged,B-Lymphocytes,Biopsy,Cell Differentiation,Cell Transformation Neoplastic,Female,Follow-Up Studies,Humans,Lymphoma Follicular,Lymphoma Large B-Cell Diffuse,Male,Middle Aged,Mutation,Neoplasm Proteins},

+ file = {/Users/rmorin/Zotero/storage/BBLFASN6/González-Rincón et al. - 2019 - Unraveling transformation of follicular lymphoma t.pdf}

+}

+