Changes in 6f127cb: Updated KLHL14 (markdown)

				KLHL14.md
			
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           # KLHL14

           ## Overview

          -KLHL14 (Kelch-like family member 14) is a gene that has been identified as playing a role in B-cell lymphomas, particularly diffuse large B-cell lymphoma (DLBCL).<sup>1</sup> KLHL14 has been identified as a recurrent target of somatic mutations in ABC DLBCLs. These mutations are a feature of the MCD genetic subgroup of DLBCL. The gene encodes a protein involved in the ubiquitin-proteasome system, and its inactivation leads to increased cell proliferation and survival, suggesting its role as a tumor suppressor.<>2<> KLHL14 loss has been shown to BCR-dependent NF-κB activation and cell survival in DLBCL.<sup>2</sup> This gene has some mutation hotspots but the patter of mutation overall is consistent with its role as a tumor suppressor gene.

          +KLHL14 (Kelch-like family member 14) is a gene that has been identified as playing a role in B-cell lymphomas, particularly diffuse large B-cell lymphoma (DLBCL).<sup>1</sup> KLHL14 has been identified as a recurrent target of somatic mutations in ABC DLBCLs. These mutations are a feature of the MCD genetic subgroup of DLBCL. The gene encodes a protein involved in the ubiquitin-proteasome system, and its inactivation leads to increased cell proliferation and survival, suggesting its role as a tumor suppressor.<sup>2</sup> KLHL14 loss has been shown to BCR-dependent NF-κB activation and cell survival in DLBCL.<sup>2</sup> This gene has some mutation hotspots but the patter of mutation overall is consistent with its role as a tumor suppressor gene.

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1	1	# KLHL14
2	2	## Overview
3		-KLHL14 (Kelch-like family member 14) is a gene that has been identified as playing a role in B-cell lymphomas, particularly diffuse large B-cell lymphoma (DLBCL).<sup>1</sup> KLHL14 has been identified as a recurrent target of somatic mutations in ABC DLBCLs. These mutations are a feature of the MCD genetic subgroup of DLBCL. The gene encodes a protein involved in the ubiquitin-proteasome system, and its inactivation leads to increased cell proliferation and survival, suggesting its role as a tumor suppressor.<>2<> KLHL14 loss has been shown to BCR-dependent NF-κB activation and cell survival in DLBCL.<sup>2</sup> This gene has some mutation hotspots but the patter of mutation overall is consistent with its role as a tumor suppressor gene.
	3	+KLHL14 (Kelch-like family member 14) is a gene that has been identified as playing a role in B-cell lymphomas, particularly diffuse large B-cell lymphoma (DLBCL).<sup>1</sup> KLHL14 has been identified as a recurrent target of somatic mutations in ABC DLBCLs. These mutations are a feature of the MCD genetic subgroup of DLBCL. The gene encodes a protein involved in the ubiquitin-proteasome system, and its inactivation leads to increased cell proliferation and survival, suggesting its role as a tumor suppressor.<sup>2</sup> KLHL14 loss has been shown to BCR-dependent NF-κB activation and cell survival in DLBCL.<sup>2</sup> This gene has some mutation hotspots but the patter of mutation overall is consistent with its role as a tumor suppressor gene.
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