70f2e9209f53d81ad10f815bfadeb4d822a8ca36
KMT2D.md
| ... | ... | @@ -6,23 +6,23 @@ KMT2D (also known as MLL2) encodes a histone H3K4 methyltransferase, playing a c |
| 6 | 6 | |
| 7 | 7 | |Entity|Tier|Description | |
| 8 | 8 | |:------:|:----:|--------------------------| |
| 9 | -|BL |1 |high-confidence BL gene | |
|
| 10 | -|DLBCL |1 |high-confidence DLBCL gene| |
|
| 11 | 9 | |FL |1 |high-confidence FL gene | |
| 10 | +|DLBCL |1 |high-confidence DLBCL gene| |
|
| 11 | +|BL |1 |high-confidence BL gene | |
|
| 12 | 12 | |MCL |1 |high-confidence MCL gene | |
| 13 | 13 | |
| 14 | 14 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 15 | 15 | |
| 16 | 16 | |Entity|source |frequency (%)| |
| 17 | 17 | |:------:|:---------------------:|:-------------:| |
| 18 | -|BL |GAMBL genomes+capture|11.32 | |
|
| 19 | -|BL |Thomas cohort |14.00 | |
|
| 20 | -|BL |Panea cohort |15.80 | |
|
| 18 | +|FL |GAMBL genomes |67.67 | |
|
| 21 | 19 | |DLBCL |GAMBL genomes |33.46 | |
| 22 | 20 | |DLBCL |Schmitz cohort |34.47 | |
| 23 | 21 | |DLBCL |Reddy cohort |22.32 | |
| 24 | 22 | |DLBCL |Chapuy cohort |26.07 | |
| 25 | -|FL |GAMBL genomes |67.67 | |
|
| 23 | +|BL |GAMBL genomes+capture|11.32 | |
|
| 24 | +|BL |Thomas cohort |14.00 | |
|
| 25 | +|BL |Panea cohort |15.80 | |
|
| 26 | 26 | |MCL |GAMBL genomes |16.59 | |
| 27 | 27 | |
| 28 | 28 | ## Mutation pattern and selective pressure estimates |