add refs

+@article{maSubtypespecificCooccurringGenetic2022,

+ title = {Subtype-specific and co-occurring genetic alterations in {B}-cell non-{Hodgkin} lymphoma},

+ volume = {107},

+ issn = {1592-8721},

+ doi = {10.3324/haematol.2020.274258},

+ abstract = {B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B-NHL, such as diffuse large B-cell lymphoma, have been comprehensively interrogated at the genomic level, but rarer subtypes, such as mantle cell lymphoma, remain less extensively characterized. Furthermore, multiple B-NHL subtypes have thus far not been comprehensively compared using the same methodology to identify conserved or subtype-specific patterns of genomic alterations. Here, we employed a large targeted hybrid-capture sequencing approach encompassing 380 genes to interrogate the genomic landscapes of 685 B-NHL tumors at high depth, including diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, and Burkitt lymphoma. We identified conserved hallmarks of B-NHL that were deregulated in the majority of tumors from each subtype, including frequent genetic deregulation of the ubiquitin proteasome system. In addition, we identified subtype-specific patterns of genetic alterations, including clusters of co-occurring mutations and DNA copy number alterations. The cumulative burden of mutations within a single cluster were more discriminatory of B-NHL subtypes than individual mutations, implicating likely patterns of genetic cooperation that contribute to disease etiology. We therefore provide the first cross-sectional analysis of mutations and DNA copy number alterations across major B-NHL subtypes and a framework of co-occurring genetic alterations that deregulate genetic hallmarks and likely cooperate in lymphomagenesis.},

+ language = {eng},

+ number = {3},

+ journal = {Haematologica},

+ author = {Ma, Man Chun John and Tadros, Saber and Bouska, Alyssa and Heavican, Tayla and Yang, Haopeng and Deng, Qing and Moore, Dalia and Akhter, Ariz and Hartert, Keenan and Jain, Neeraj and Showell, Jordan and Ghosh, Sreejoyee and Street, Lesley and Davidson, Marta and Carey, Christopher and Tobin, Joshua and Perumal, Deepak and Vose, Julie M. and Lunning, Matthew A. and Sohani, Aliyah R. and Chen, Benjamin J. and Buckley, Shannon and Nastoupil, Loretta J. and Davis, R. Eric and Westin, Jason R. and Fowler, Nathan H. and Parekh, Samir and Gandhi, Maher and Neelapu, Sattva and Stewart, Douglas and Bhalla, Kapil and Iqbal, Javeed and Greiner, Timothy and Rodig, Scott J. and Mansoor, Adnan and Green, Michael R.},

+ month = mar,

+ year = {2022},

+ pmid = {33792219},

+ pmcid = {PMC8883549},

+ keywords = {Humans, Mutation, Adult, Lymphoma, Large B-Cell, Diffuse, Burkitt Lymphoma, Lymphoma, Follicular, Cross-Sectional Studies},

+ pages = {690--701},

+ file = {Full Text:/Users/rmorin/Zotero/storage/3K8ZEXTA/Ma et al. - 2022 - Subtype-specific and co-occurring genetic alterati.pdf:application/pdf},

+}

+